A Linear Free Energy Relationship Treatment of the Affinity between Carboxymethylcellulose and Basic Drugs

Autores
Ramírez Rigo, María Veronica; Allemandi, Daniel Alberto; Manzo, Ruben Hilario
Año de publicación
2004
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
With the purpose of getting information about the factors that determine the affinity between basic drugs (B) and the acid form of carboxymethylcellulose (HCMC), the constant Kip for the equilibrium HCMC + B a CMC- BH+ was measured using a set of nine model B. A linear free energy relationship (LFER) was developed through a multiple correlation of log Kip against (pKa + log PC), in which the octanol-water partition coefficient (PC) was introduced as an indicator of the hydrophilicity of B. Both magnitudes, pKa and log PC, contribute to a rise in log Kip. In addition, water uptake and drug delivery were assayed with the product of neutralization of HCMC with atenolol, which was easily wetted, and the drug-HCMC interaction was found essentially reversible.
Fil: Ramírez Rigo, María Veronica. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia; Argentina
Fil: Allemandi, Daniel Alberto. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina
Fil: Manzo, Ruben Hilario. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia; Argentina
Materia
Polyelectrolytes
Carboxymethylcellulose
Amine drugs
Ion pair
LFER
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/240871
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/240871
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling A Linear Free Energy Relationship Treatment of the Affinity between Carboxymethylcellulose and Basic DrugsRamírez Rigo, María VeronicaAllemandi, Daniel AlbertoManzo, Ruben HilarioPolyelectrolytesCarboxymethylcelluloseAmine drugsIon pairLFERhttps://purl.org/becyt/ford/2.11https://purl.org/becyt/ford/2With the purpose of getting information about the factors that determine the affinity between basic drugs (B) and the acid form of carboxymethylcellulose (HCMC), the constant Kip for the equilibrium HCMC + B a CMC- BH+ was measured using a set of nine model B. A linear free energy relationship (LFER) was developed through a multiple correlation of log Kip against (pKa + log PC), in which the octanol-water partition coefficient (PC) was introduced as an indicator of the hydrophilicity of B. Both magnitudes, pKa and log PC, contribute to a rise in log Kip. In addition, water uptake and drug delivery were assayed with the product of neutralization of HCMC with atenolol, which was easily wetted, and the drug-HCMC interaction was found essentially reversible.Fil: Ramírez Rigo, María Veronica. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia; ArgentinaFil: Allemandi, Daniel Alberto. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; ArgentinaFil: Manzo, Ruben Hilario. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia; ArgentinaAmerican Chemical Society2004-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/240871Ramírez Rigo, María Veronica; Allemandi, Daniel Alberto; Manzo, Ruben Hilario; A Linear Free Energy Relationship Treatment of the Affinity between Carboxymethylcellulose and Basic Drugs; American Chemical Society; Molecular Pharmaceutics; 1; 5; 8-2004; 383-3861543-8384CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1021/mp0499353info:eu-repo/semantics/altIdentifier/url/https://pubs.acs.org/doi/10.1021/mp0499353info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:54:13Zoai:ri.conicet.gov.ar:11336/240871instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:54:13.734CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv A Linear Free Energy Relationship Treatment of the Affinity between Carboxymethylcellulose and Basic Drugs
title A Linear Free Energy Relationship Treatment of the Affinity between Carboxymethylcellulose and Basic Drugs
spellingShingle A Linear Free Energy Relationship Treatment of the Affinity between Carboxymethylcellulose and Basic Drugs
Ramírez Rigo, María Veronica
Polyelectrolytes
Carboxymethylcellulose
Amine drugs
Ion pair
LFER
title_short A Linear Free Energy Relationship Treatment of the Affinity between Carboxymethylcellulose and Basic Drugs
title_full A Linear Free Energy Relationship Treatment of the Affinity between Carboxymethylcellulose and Basic Drugs
title_fullStr A Linear Free Energy Relationship Treatment of the Affinity between Carboxymethylcellulose and Basic Drugs
title_full_unstemmed A Linear Free Energy Relationship Treatment of the Affinity between Carboxymethylcellulose and Basic Drugs
title_sort A Linear Free Energy Relationship Treatment of the Affinity between Carboxymethylcellulose and Basic Drugs
dc.creator.none.fl_str_mv Ramírez Rigo, María Veronica
Allemandi, Daniel Alberto
Manzo, Ruben Hilario
author Ramírez Rigo, María Veronica
author_facet Ramírez Rigo, María Veronica
Allemandi, Daniel Alberto
Manzo, Ruben Hilario
author_role author
author2 Allemandi, Daniel Alberto
Manzo, Ruben Hilario
author2_role author
author
dc.subject.none.fl_str_mv Polyelectrolytes
Carboxymethylcellulose
Amine drugs
Ion pair
LFER
topic Polyelectrolytes
Carboxymethylcellulose
Amine drugs
Ion pair
LFER
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.11
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv With the purpose of getting information about the factors that determine the affinity between basic drugs (B) and the acid form of carboxymethylcellulose (HCMC), the constant Kip for the equilibrium HCMC + B a CMC- BH+ was measured using a set of nine model B. A linear free energy relationship (LFER) was developed through a multiple correlation of log Kip against (pKa + log PC), in which the octanol-water partition coefficient (PC) was introduced as an indicator of the hydrophilicity of B. Both magnitudes, pKa and log PC, contribute to a rise in log Kip. In addition, water uptake and drug delivery were assayed with the product of neutralization of HCMC with atenolol, which was easily wetted, and the drug-HCMC interaction was found essentially reversible.
Fil: Ramírez Rigo, María Veronica. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia; Argentina
Fil: Allemandi, Daniel Alberto. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina
Fil: Manzo, Ruben Hilario. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia; Argentina
description With the purpose of getting information about the factors that determine the affinity between basic drugs (B) and the acid form of carboxymethylcellulose (HCMC), the constant Kip for the equilibrium HCMC + B a CMC- BH+ was measured using a set of nine model B. A linear free energy relationship (LFER) was developed through a multiple correlation of log Kip against (pKa + log PC), in which the octanol-water partition coefficient (PC) was introduced as an indicator of the hydrophilicity of B. Both magnitudes, pKa and log PC, contribute to a rise in log Kip. In addition, water uptake and drug delivery were assayed with the product of neutralization of HCMC with atenolol, which was easily wetted, and the drug-HCMC interaction was found essentially reversible.
publishDate 2004
dc.date.none.fl_str_mv 2004-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/240871
Ramírez Rigo, María Veronica; Allemandi, Daniel Alberto; Manzo, Ruben Hilario; A Linear Free Energy Relationship Treatment of the Affinity between Carboxymethylcellulose and Basic Drugs; American Chemical Society; Molecular Pharmaceutics; 1; 5; 8-2004; 383-386
1543-8384
CONICET Digital
CONICET
url http://hdl.handle.net/11336/240871
identifier_str_mv Ramírez Rigo, María Veronica; Allemandi, Daniel Alberto; Manzo, Ruben Hilario; A Linear Free Energy Relationship Treatment of the Affinity between Carboxymethylcellulose and Basic Drugs; American Chemical Society; Molecular Pharmaceutics; 1; 5; 8-2004; 383-386
1543-8384
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1021/mp0499353
info:eu-repo/semantics/altIdentifier/url/https://pubs.acs.org/doi/10.1021/mp0499353
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv American Chemical Society
publisher.none.fl_str_mv American Chemical Society
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844613648803168256
score 13.070432

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