Picrotoxin but not bicuculline partially abolishes the cardio-inhibitory responses induced by visual stimulation in the crab Neohelice granulata

Autores
Yang, M.; Carbo, Martin; Hermitte, Gabriela
Año de publicación
2012
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Conspicuous and sustained heart arrests, revealed as an increase in the magnitude of cardiac interbeat intervals, are elicited in the crab Neohelice granulata upon the presentation of a visual danger stimulus (VDS). Aiming to study the regulation of cardio-inhibitory responses (CIR) in vivo, we investigated whether GABA mediates the extrinsic regulation of the cardiac activity. We examined the possibility of abolishing CIR by injecting the GABAergic antagonists picrotoxin and bicuculline, right before sensory stimulation. Picrotoxin partially abolished the reversible cardiac arrests induced by VDS, whereas bicuculline showed no effects. These results suggest that the rapid responses of the cardiac system of the crab Neohelice to environmental disturbances, reminiscent of an autonomic-like regulation associated with fear, flight or fight, may be extrinsically regulated by the GABAergic system.
Fil: Yang, M.. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina
Fil: Carbo, Martin. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina
Fil: Hermitte, Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina
Materia
Invertebrate
Gaba
Autonomic System
Cardiac Response
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/20107
Acceder
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repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Picrotoxin but not bicuculline partially abolishes the cardio-inhibitory responses induced by visual stimulation in the crab Neohelice granulataYang, M.Carbo, MartinHermitte, GabrielaInvertebrateGabaAutonomic SystemCardiac Responsehttps://purl.org/becyt/ford/1.7https://purl.org/becyt/ford/1Conspicuous and sustained heart arrests, revealed as an increase in the magnitude of cardiac interbeat intervals, are elicited in the crab Neohelice granulata upon the presentation of a visual danger stimulus (VDS). Aiming to study the regulation of cardio-inhibitory responses (CIR) in vivo, we investigated whether GABA mediates the extrinsic regulation of the cardiac activity. We examined the possibility of abolishing CIR by injecting the GABAergic antagonists picrotoxin and bicuculline, right before sensory stimulation. Picrotoxin partially abolished the reversible cardiac arrests induced by VDS, whereas bicuculline showed no effects. These results suggest that the rapid responses of the cardiac system of the crab Neohelice to environmental disturbances, reminiscent of an autonomic-like regulation associated with fear, flight or fight, may be extrinsically regulated by the GABAergic system.Fil: Yang, M.. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; ArgentinaFil: Carbo, Martin. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; ArgentinaFil: Hermitte, Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; ArgentinaElsevier Inc2012-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/20107Yang, M.; Carbo, Martin; Hermitte, Gabriela; Picrotoxin but not bicuculline partially abolishes the cardio-inhibitory responses induced by visual stimulation in the crab Neohelice granulata; Elsevier Inc; Physiology And Behavior; 110-111; 12-2012; 198-2050031-9384CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.physbeh.2012.12.013info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0031938412004192info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:15:53Zoai:ri.conicet.gov.ar:11336/20107instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:15:53.943CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Picrotoxin but not bicuculline partially abolishes the cardio-inhibitory responses induced by visual stimulation in the crab Neohelice granulata
title Picrotoxin but not bicuculline partially abolishes the cardio-inhibitory responses induced by visual stimulation in the crab Neohelice granulata
spellingShingle Picrotoxin but not bicuculline partially abolishes the cardio-inhibitory responses induced by visual stimulation in the crab Neohelice granulata
Yang, M.
Invertebrate
Gaba
Autonomic System
Cardiac Response
title_short Picrotoxin but not bicuculline partially abolishes the cardio-inhibitory responses induced by visual stimulation in the crab Neohelice granulata
title_full Picrotoxin but not bicuculline partially abolishes the cardio-inhibitory responses induced by visual stimulation in the crab Neohelice granulata
title_fullStr Picrotoxin but not bicuculline partially abolishes the cardio-inhibitory responses induced by visual stimulation in the crab Neohelice granulata
title_full_unstemmed Picrotoxin but not bicuculline partially abolishes the cardio-inhibitory responses induced by visual stimulation in the crab Neohelice granulata
title_sort Picrotoxin but not bicuculline partially abolishes the cardio-inhibitory responses induced by visual stimulation in the crab Neohelice granulata
dc.creator.none.fl_str_mv Yang, M.
Carbo, Martin
Hermitte, Gabriela
author Yang, M.
author_facet Yang, M.
Carbo, Martin
Hermitte, Gabriela
author_role author
author2 Carbo, Martin
Hermitte, Gabriela
author2_role author
author
dc.subject.none.fl_str_mv Invertebrate
Gaba
Autonomic System
Cardiac Response
topic Invertebrate
Gaba
Autonomic System
Cardiac Response
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.7
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Conspicuous and sustained heart arrests, revealed as an increase in the magnitude of cardiac interbeat intervals, are elicited in the crab Neohelice granulata upon the presentation of a visual danger stimulus (VDS). Aiming to study the regulation of cardio-inhibitory responses (CIR) in vivo, we investigated whether GABA mediates the extrinsic regulation of the cardiac activity. We examined the possibility of abolishing CIR by injecting the GABAergic antagonists picrotoxin and bicuculline, right before sensory stimulation. Picrotoxin partially abolished the reversible cardiac arrests induced by VDS, whereas bicuculline showed no effects. These results suggest that the rapid responses of the cardiac system of the crab Neohelice to environmental disturbances, reminiscent of an autonomic-like regulation associated with fear, flight or fight, may be extrinsically regulated by the GABAergic system.
Fil: Yang, M.. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina
Fil: Carbo, Martin. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina
Fil: Hermitte, Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina
description Conspicuous and sustained heart arrests, revealed as an increase in the magnitude of cardiac interbeat intervals, are elicited in the crab Neohelice granulata upon the presentation of a visual danger stimulus (VDS). Aiming to study the regulation of cardio-inhibitory responses (CIR) in vivo, we investigated whether GABA mediates the extrinsic regulation of the cardiac activity. We examined the possibility of abolishing CIR by injecting the GABAergic antagonists picrotoxin and bicuculline, right before sensory stimulation. Picrotoxin partially abolished the reversible cardiac arrests induced by VDS, whereas bicuculline showed no effects. These results suggest that the rapid responses of the cardiac system of the crab Neohelice to environmental disturbances, reminiscent of an autonomic-like regulation associated with fear, flight or fight, may be extrinsically regulated by the GABAergic system.
publishDate 2012
dc.date.none.fl_str_mv 2012-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/20107
Yang, M.; Carbo, Martin; Hermitte, Gabriela; Picrotoxin but not bicuculline partially abolishes the cardio-inhibitory responses induced by visual stimulation in the crab Neohelice granulata; Elsevier Inc; Physiology And Behavior; 110-111; 12-2012; 198-205
0031-9384
CONICET Digital
CONICET
url http://hdl.handle.net/11336/20107
identifier_str_mv Yang, M.; Carbo, Martin; Hermitte, Gabriela; Picrotoxin but not bicuculline partially abolishes the cardio-inhibitory responses induced by visual stimulation in the crab Neohelice granulata; Elsevier Inc; Physiology And Behavior; 110-111; 12-2012; 198-205
0031-9384
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.physbeh.2012.12.013
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0031938412004192
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Inc
publisher.none.fl_str_mv Elsevier Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.22299

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