The involvement of the GABAergic system in the formation and expression of the extinction memory in the crab Neohelice granulata

Autores
Carbo, Martin; Molina, Victor Alejandro; Pedreira, Maria Eugenia
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
There is growing interest in the neurobiological mechanisms involved in the extinction of aversive memory. This cognitive process usually occurs after repeated or prolonged presentation of a conditioned stimulus that was previously associated with an unconditioned stimulus. If extinction is considered to be a new memory, the role of the γ-aminobutyric acid system (GABAergic system) during extinction memory consolidation should be similar to that described for the original trace. It is also accepted that negative modulation of the GABAergic system before testing can impair extinction memory expression. However, it seems possible to speculate that inhibitory mechanisms may be required in order to acquire a memory that is inhibitory in nature. Using a combination of behavioral protocols, such as weak and robust extinction training procedures, and pharmacological treatments, such as the systemic administration of GABAA agonist (muscimol) and antagonist (bicuculline), we investigated the role of the GABAergic system in the different phases of the extinction memory in the crab Neohelice granulata. We show that the stimulation of the GABAergic system impairs and its inactivation facilitates the extinction memory consolidation. Moreover, fine variations in the GABAergic tone affect its expression at testing. Finally, an active GABAergic system is necessary for the acquisition of the extinction memory. This detailed description may contribute to the understanding of the role of the GABAergic system in diverse aspects of the extinction memory.
Fil: Carbo, Martin. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina
Fil: Molina, Victor Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Farmacología Experimental de Córdoba. Universidad Nacional de Córdoba. Facultad de Cs.químicas. Instituto de Farmacología Experimental de Córdoba; Argentina
Fil: Pedreira, Maria Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina
Materia
Gaba
Extincion
Condicionamiento Contextual Pavloviano
Neohelice Granulata
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/20138
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling The involvement of the GABAergic system in the formation and expression of the extinction memory in the crab Neohelice granulataCarbo, MartinMolina, Victor AlejandroPedreira, Maria EugeniaGabaExtincionCondicionamiento Contextual PavlovianoNeohelice Granulatahttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1There is growing interest in the neurobiological mechanisms involved in the extinction of aversive memory. This cognitive process usually occurs after repeated or prolonged presentation of a conditioned stimulus that was previously associated with an unconditioned stimulus. If extinction is considered to be a new memory, the role of the γ-aminobutyric acid system (GABAergic system) during extinction memory consolidation should be similar to that described for the original trace. It is also accepted that negative modulation of the GABAergic system before testing can impair extinction memory expression. However, it seems possible to speculate that inhibitory mechanisms may be required in order to acquire a memory that is inhibitory in nature. Using a combination of behavioral protocols, such as weak and robust extinction training procedures, and pharmacological treatments, such as the systemic administration of GABAA agonist (muscimol) and antagonist (bicuculline), we investigated the role of the GABAergic system in the different phases of the extinction memory in the crab Neohelice granulata. We show that the stimulation of the GABAergic system impairs and its inactivation facilitates the extinction memory consolidation. Moreover, fine variations in the GABAergic tone affect its expression at testing. Finally, an active GABAergic system is necessary for the acquisition of the extinction memory. This detailed description may contribute to the understanding of the role of the GABAergic system in diverse aspects of the extinction memory.Fil: Carbo, Martin. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; ArgentinaFil: Molina, Victor Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Farmacología Experimental de Córdoba. Universidad Nacional de Córdoba. Facultad de Cs.químicas. Instituto de Farmacología Experimental de Córdoba; ArgentinaFil: Pedreira, Maria Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; ArgentinaWiley2013-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/20138Carbo, Martin; Molina, Victor Alejandro; Pedreira, Maria Eugenia; The involvement of the GABAergic system in the formation and expression of the extinction memory in the crab Neohelice granulata; Wiley; European Journal Of Neuroscience; 38; 9; 11-2013; 3302-33130953-816XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1111/ejn.12328info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1111/ejn.12328/abstractinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:05:49Zoai:ri.conicet.gov.ar:11336/20138instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:05:49.499CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv The involvement of the GABAergic system in the formation and expression of the extinction memory in the crab Neohelice granulata
title The involvement of the GABAergic system in the formation and expression of the extinction memory in the crab Neohelice granulata
spellingShingle The involvement of the GABAergic system in the formation and expression of the extinction memory in the crab Neohelice granulata
Carbo, Martin
Gaba
Extincion
Condicionamiento Contextual Pavloviano
Neohelice Granulata
title_short The involvement of the GABAergic system in the formation and expression of the extinction memory in the crab Neohelice granulata
title_full The involvement of the GABAergic system in the formation and expression of the extinction memory in the crab Neohelice granulata
title_fullStr The involvement of the GABAergic system in the formation and expression of the extinction memory in the crab Neohelice granulata
title_full_unstemmed The involvement of the GABAergic system in the formation and expression of the extinction memory in the crab Neohelice granulata
title_sort The involvement of the GABAergic system in the formation and expression of the extinction memory in the crab Neohelice granulata
dc.creator.none.fl_str_mv Carbo, Martin
Molina, Victor Alejandro
Pedreira, Maria Eugenia
author Carbo, Martin
author_facet Carbo, Martin
Molina, Victor Alejandro
Pedreira, Maria Eugenia
author_role author
author2 Molina, Victor Alejandro
Pedreira, Maria Eugenia
author2_role author
author
dc.subject.none.fl_str_mv Gaba
Extincion
Condicionamiento Contextual Pavloviano
Neohelice Granulata
topic Gaba
Extincion
Condicionamiento Contextual Pavloviano
Neohelice Granulata
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv There is growing interest in the neurobiological mechanisms involved in the extinction of aversive memory. This cognitive process usually occurs after repeated or prolonged presentation of a conditioned stimulus that was previously associated with an unconditioned stimulus. If extinction is considered to be a new memory, the role of the γ-aminobutyric acid system (GABAergic system) during extinction memory consolidation should be similar to that described for the original trace. It is also accepted that negative modulation of the GABAergic system before testing can impair extinction memory expression. However, it seems possible to speculate that inhibitory mechanisms may be required in order to acquire a memory that is inhibitory in nature. Using a combination of behavioral protocols, such as weak and robust extinction training procedures, and pharmacological treatments, such as the systemic administration of GABAA agonist (muscimol) and antagonist (bicuculline), we investigated the role of the GABAergic system in the different phases of the extinction memory in the crab Neohelice granulata. We show that the stimulation of the GABAergic system impairs and its inactivation facilitates the extinction memory consolidation. Moreover, fine variations in the GABAergic tone affect its expression at testing. Finally, an active GABAergic system is necessary for the acquisition of the extinction memory. This detailed description may contribute to the understanding of the role of the GABAergic system in diverse aspects of the extinction memory.
Fil: Carbo, Martin. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina
Fil: Molina, Victor Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Farmacología Experimental de Córdoba. Universidad Nacional de Córdoba. Facultad de Cs.químicas. Instituto de Farmacología Experimental de Córdoba; Argentina
Fil: Pedreira, Maria Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina
description There is growing interest in the neurobiological mechanisms involved in the extinction of aversive memory. This cognitive process usually occurs after repeated or prolonged presentation of a conditioned stimulus that was previously associated with an unconditioned stimulus. If extinction is considered to be a new memory, the role of the γ-aminobutyric acid system (GABAergic system) during extinction memory consolidation should be similar to that described for the original trace. It is also accepted that negative modulation of the GABAergic system before testing can impair extinction memory expression. However, it seems possible to speculate that inhibitory mechanisms may be required in order to acquire a memory that is inhibitory in nature. Using a combination of behavioral protocols, such as weak and robust extinction training procedures, and pharmacological treatments, such as the systemic administration of GABAA agonist (muscimol) and antagonist (bicuculline), we investigated the role of the GABAergic system in the different phases of the extinction memory in the crab Neohelice granulata. We show that the stimulation of the GABAergic system impairs and its inactivation facilitates the extinction memory consolidation. Moreover, fine variations in the GABAergic tone affect its expression at testing. Finally, an active GABAergic system is necessary for the acquisition of the extinction memory. This detailed description may contribute to the understanding of the role of the GABAergic system in diverse aspects of the extinction memory.
publishDate 2013
dc.date.none.fl_str_mv 2013-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/20138
Carbo, Martin; Molina, Victor Alejandro; Pedreira, Maria Eugenia; The involvement of the GABAergic system in the formation and expression of the extinction memory in the crab Neohelice granulata; Wiley; European Journal Of Neuroscience; 38; 9; 11-2013; 3302-3313
0953-816X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/20138
identifier_str_mv Carbo, Martin; Molina, Victor Alejandro; Pedreira, Maria Eugenia; The involvement of the GABAergic system in the formation and expression of the extinction memory in the crab Neohelice granulata; Wiley; European Journal Of Neuroscience; 38; 9; 11-2013; 3302-3313
0953-816X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1111/ejn.12328
info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1111/ejn.12328/abstract
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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