"clickable" Organic Electrochemical Transistors

Autores
Fenoy, Gonzalo Eduardo; Hasler, Roger; Quartinello, Felice; Marmisollé, Waldemar Alejandro; Lorenz, Christoph; Azzaroni, Omar; Bäuerle, Peter; Knoll, Wolfgang
Año de publicación
2022
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Interfacing the surface of an organic semiconductor with biological elements is a central quest when it comes to the development of efficient organic bioelectronic devices. Here, we present the first example of "clickable"organic electrochemical transistors (OECTs). The synthesis and characterization of an azide-derivatized EDOT monomer (azidomethyl-EDOT, EDOT-N3) are reported, as well as its deposition on Au-interdigitated electrodes through electropolymerization to yield PEDOT-N3-OECTs. The electropolymerization protocol allows for a straightforward and reliable tuning of the characteristics of the OECTs, yielding transistors with lower threshold voltages than PEDOT-based state-of-the-art devices and maximum transconductance voltage values close to 0 V, a key feature for the development of efficient organic bioelectronic devices. Subsequently, the azide moieties are employed to click alkyne-bearing molecules such as redox probes and biorecognition elements. The clicking of an alkyne-modified PEG4-biotin allows for the use of the avidin-biotin interactions to efficiently generate bioconstructs with proteins and enzymes. In addition, a dibenzocyclooctyne-modified thrombin-specific HD22 aptamer is clicked on the PEDOT-N3-OECTs, showing the application of the devices toward the development of organic transistors-based biosensors. Finally, the clicked OECTs preserve their electronic features after the different clicking procedures, demonstrating the stability and robustness of the fabricated transistors.
Fil: Fenoy, Gonzalo Eduardo. Austrian Institute Of Technology; Austria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina
Fil: Hasler, Roger. AIT Austrian Institute of Technology GmbH; Austria
Fil: Quartinello, Felice. Institute of Environmental Biotechnology; Austria
Fil: Marmisollé, Waldemar Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina
Fil: Lorenz, Christoph. Universitat Ulm; Alemania
Fil: Azzaroni, Omar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina
Fil: Bäuerle, Peter. Universitat Ulm; Alemania
Fil: Knoll, Wolfgang. Danube Private University; Austria. Austrian Institute Of Technology; Austria
Materia
BIOTIN-AVIDIN
CLICK CHEMISTRY
ORGANIC BIOELECTRONICS
ORGANIC ELECTROCHEMICAL TRANSISTORS
THROMBIN
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/203415
Acceder
id CONICETDig_584772a049ad957dd59178f6604b0412
oai_identifier_str oai:ri.conicet.gov.ar:11336/203415
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling "clickable" Organic Electrochemical TransistorsFenoy, Gonzalo EduardoHasler, RogerQuartinello, FeliceMarmisollé, Waldemar AlejandroLorenz, ChristophAzzaroni, OmarBäuerle, PeterKnoll, WolfgangBIOTIN-AVIDINCLICK CHEMISTRYORGANIC BIOELECTRONICSORGANIC ELECTROCHEMICAL TRANSISTORSTHROMBINhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1Interfacing the surface of an organic semiconductor with biological elements is a central quest when it comes to the development of efficient organic bioelectronic devices. Here, we present the first example of "clickable"organic electrochemical transistors (OECTs). The synthesis and characterization of an azide-derivatized EDOT monomer (azidomethyl-EDOT, EDOT-N3) are reported, as well as its deposition on Au-interdigitated electrodes through electropolymerization to yield PEDOT-N3-OECTs. The electropolymerization protocol allows for a straightforward and reliable tuning of the characteristics of the OECTs, yielding transistors with lower threshold voltages than PEDOT-based state-of-the-art devices and maximum transconductance voltage values close to 0 V, a key feature for the development of efficient organic bioelectronic devices. Subsequently, the azide moieties are employed to click alkyne-bearing molecules such as redox probes and biorecognition elements. The clicking of an alkyne-modified PEG4-biotin allows for the use of the avidin-biotin interactions to efficiently generate bioconstructs with proteins and enzymes. In addition, a dibenzocyclooctyne-modified thrombin-specific HD22 aptamer is clicked on the PEDOT-N3-OECTs, showing the application of the devices toward the development of organic transistors-based biosensors. Finally, the clicked OECTs preserve their electronic features after the different clicking procedures, demonstrating the stability and robustness of the fabricated transistors.Fil: Fenoy, Gonzalo Eduardo. Austrian Institute Of Technology; Austria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; ArgentinaFil: Hasler, Roger. AIT Austrian Institute of Technology GmbH; AustriaFil: Quartinello, Felice. Institute of Environmental Biotechnology; AustriaFil: Marmisollé, Waldemar Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; ArgentinaFil: Lorenz, Christoph. Universitat Ulm; AlemaniaFil: Azzaroni, Omar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; ArgentinaFil: Bäuerle, Peter. Universitat Ulm; AlemaniaFil: Knoll, Wolfgang. Danube Private University; Austria. Austrian Institute Of Technology; AustriaAmerican Chemical Society2022-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/203415Fenoy, Gonzalo Eduardo; Hasler, Roger; Quartinello, Felice; Marmisollé, Waldemar Alejandro; Lorenz, Christoph; et al.; "clickable" Organic Electrochemical Transistors; American Chemical Society; Journal of the American Chemical Society; 2022; 2; 11-2022; 2778–27902691-3704CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1021/jacsau.2c00515info:eu-repo/semantics/altIdentifier/url/https://pubs.acs.org/doi/10.1021/jacsau.2c00515info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:58:19Zoai:ri.conicet.gov.ar:11336/203415instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:58:19.667CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv "clickable" Organic Electrochemical Transistors
title "clickable" Organic Electrochemical Transistors
spellingShingle "clickable" Organic Electrochemical Transistors
Fenoy, Gonzalo Eduardo
BIOTIN-AVIDIN
CLICK CHEMISTRY
ORGANIC BIOELECTRONICS
ORGANIC ELECTROCHEMICAL TRANSISTORS
THROMBIN
title_short "clickable" Organic Electrochemical Transistors
title_full "clickable" Organic Electrochemical Transistors
title_fullStr "clickable" Organic Electrochemical Transistors
title_full_unstemmed "clickable" Organic Electrochemical Transistors
title_sort "clickable" Organic Electrochemical Transistors
dc.creator.none.fl_str_mv Fenoy, Gonzalo Eduardo
Hasler, Roger
Quartinello, Felice
Marmisollé, Waldemar Alejandro
Lorenz, Christoph
Azzaroni, Omar
Bäuerle, Peter
Knoll, Wolfgang
author Fenoy, Gonzalo Eduardo
author_facet Fenoy, Gonzalo Eduardo
Hasler, Roger
Quartinello, Felice
Marmisollé, Waldemar Alejandro
Lorenz, Christoph
Azzaroni, Omar
Bäuerle, Peter
Knoll, Wolfgang
author_role author
author2 Hasler, Roger
Quartinello, Felice
Marmisollé, Waldemar Alejandro
Lorenz, Christoph
Azzaroni, Omar
Bäuerle, Peter
Knoll, Wolfgang
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv BIOTIN-AVIDIN
CLICK CHEMISTRY
ORGANIC BIOELECTRONICS
ORGANIC ELECTROCHEMICAL TRANSISTORS
THROMBIN
topic BIOTIN-AVIDIN
CLICK CHEMISTRY
ORGANIC BIOELECTRONICS
ORGANIC ELECTROCHEMICAL TRANSISTORS
THROMBIN
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Interfacing the surface of an organic semiconductor with biological elements is a central quest when it comes to the development of efficient organic bioelectronic devices. Here, we present the first example of "clickable"organic electrochemical transistors (OECTs). The synthesis and characterization of an azide-derivatized EDOT monomer (azidomethyl-EDOT, EDOT-N3) are reported, as well as its deposition on Au-interdigitated electrodes through electropolymerization to yield PEDOT-N3-OECTs. The electropolymerization protocol allows for a straightforward and reliable tuning of the characteristics of the OECTs, yielding transistors with lower threshold voltages than PEDOT-based state-of-the-art devices and maximum transconductance voltage values close to 0 V, a key feature for the development of efficient organic bioelectronic devices. Subsequently, the azide moieties are employed to click alkyne-bearing molecules such as redox probes and biorecognition elements. The clicking of an alkyne-modified PEG4-biotin allows for the use of the avidin-biotin interactions to efficiently generate bioconstructs with proteins and enzymes. In addition, a dibenzocyclooctyne-modified thrombin-specific HD22 aptamer is clicked on the PEDOT-N3-OECTs, showing the application of the devices toward the development of organic transistors-based biosensors. Finally, the clicked OECTs preserve their electronic features after the different clicking procedures, demonstrating the stability and robustness of the fabricated transistors.
Fil: Fenoy, Gonzalo Eduardo. Austrian Institute Of Technology; Austria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina
Fil: Hasler, Roger. AIT Austrian Institute of Technology GmbH; Austria
Fil: Quartinello, Felice. Institute of Environmental Biotechnology; Austria
Fil: Marmisollé, Waldemar Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina
Fil: Lorenz, Christoph. Universitat Ulm; Alemania
Fil: Azzaroni, Omar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina
Fil: Bäuerle, Peter. Universitat Ulm; Alemania
Fil: Knoll, Wolfgang. Danube Private University; Austria. Austrian Institute Of Technology; Austria
description Interfacing the surface of an organic semiconductor with biological elements is a central quest when it comes to the development of efficient organic bioelectronic devices. Here, we present the first example of "clickable"organic electrochemical transistors (OECTs). The synthesis and characterization of an azide-derivatized EDOT monomer (azidomethyl-EDOT, EDOT-N3) are reported, as well as its deposition on Au-interdigitated electrodes through electropolymerization to yield PEDOT-N3-OECTs. The electropolymerization protocol allows for a straightforward and reliable tuning of the characteristics of the OECTs, yielding transistors with lower threshold voltages than PEDOT-based state-of-the-art devices and maximum transconductance voltage values close to 0 V, a key feature for the development of efficient organic bioelectronic devices. Subsequently, the azide moieties are employed to click alkyne-bearing molecules such as redox probes and biorecognition elements. The clicking of an alkyne-modified PEG4-biotin allows for the use of the avidin-biotin interactions to efficiently generate bioconstructs with proteins and enzymes. In addition, a dibenzocyclooctyne-modified thrombin-specific HD22 aptamer is clicked on the PEDOT-N3-OECTs, showing the application of the devices toward the development of organic transistors-based biosensors. Finally, the clicked OECTs preserve their electronic features after the different clicking procedures, demonstrating the stability and robustness of the fabricated transistors.
publishDate 2022
dc.date.none.fl_str_mv 2022-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/203415
Fenoy, Gonzalo Eduardo; Hasler, Roger; Quartinello, Felice; Marmisollé, Waldemar Alejandro; Lorenz, Christoph; et al.; "clickable" Organic Electrochemical Transistors; American Chemical Society; Journal of the American Chemical Society; 2022; 2; 11-2022; 2778–2790
2691-3704
CONICET Digital
CONICET
url http://hdl.handle.net/11336/203415
identifier_str_mv Fenoy, Gonzalo Eduardo; Hasler, Roger; Quartinello, Felice; Marmisollé, Waldemar Alejandro; Lorenz, Christoph; et al.; "clickable" Organic Electrochemical Transistors; American Chemical Society; Journal of the American Chemical Society; 2022; 2; 11-2022; 2778–2790
2691-3704
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1021/jacsau.2c00515
info:eu-repo/semantics/altIdentifier/url/https://pubs.acs.org/doi/10.1021/jacsau.2c00515
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv American Chemical Society
publisher.none.fl_str_mv American Chemical Society
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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