Interface Engineering of “Clickable” Organic Electrochemical Transistors toward Biosensing Devices

Autores
Fenoy, Gonzalo Eduardo; Hasler, Roger; Lorenz, Christoph; Movilli, Jacopo; Marmisollé, Waldemar Alejandro; Azzaroni, Omar; Huskens, Jurriaan; Bäuerle, Peter; Knoll, Wolfgang
Año de publicación
2023
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
“Clickable” organic electrochemical transistors (OECTs) allow the reliable and straightforward functionalization of electronic devices through the well-known click chemistry toolbox. In this work, we study various aspects of the click chemistry-based interface engineering of “clickable” OECTs. First, different channel architectures are investigated, showing that PEDOT-N3 films can properly work as a channel of the transistors. Furthermore, the Cu(I)-catalyzed click reaction of ethynyl-ferrocene is studied under different reaction conditions, endowing the spatial control of the functionalization. The strain-promoted and catalyst-free cycloaddition of a dibenzocyclooctyne-derivatized poly-l-lysine (PLL-DBCO) is also performed on the OECTs and validated by a fiber optic (FO)-SPR setup. The further immobilization of an azido-modified HD22 aptamer yields OECT-based biosensors that are employed for the recognition of thrombin. Finally, their performance is evaluated against previously reported architectures, showing higher density of the immobilized HD22 aptamer, and originating similar KD values and higher maximum signal change upon analyte recognition.
Fil: Fenoy, Gonzalo Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina
Fil: Hasler, Roger. No especifíca;
Fil: Lorenz, Christoph. Universitat Ulm; Alemania
Fil: Movilli, Jacopo. Universiteit Twente (ut);
Fil: Marmisollé, Waldemar Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina
Fil: Azzaroni, Omar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina
Fil: Huskens, Jurriaan. Universiteit Twente (ut);
Fil: Bäuerle, Peter. Universidad Nacional de La Plata; Argentina
Fil: Knoll, Wolfgang. No especifíca;
Materia
BIOSENSORS
CLICK CHEMISTRY
ORGANIC ELECTROCHEMICAL TRANSISTORS
POLY-
THROMBIN
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/227319
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/227319
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Interface Engineering of “Clickable” Organic Electrochemical Transistors toward Biosensing DevicesFenoy, Gonzalo EduardoHasler, RogerLorenz, ChristophMovilli, JacopoMarmisollé, Waldemar AlejandroAzzaroni, OmarHuskens, JurriaanBäuerle, PeterKnoll, WolfgangBIOSENSORSCLICK CHEMISTRYORGANIC ELECTROCHEMICAL TRANSISTORSPOLY-THROMBINhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1“Clickable” organic electrochemical transistors (OECTs) allow the reliable and straightforward functionalization of electronic devices through the well-known click chemistry toolbox. In this work, we study various aspects of the click chemistry-based interface engineering of “clickable” OECTs. First, different channel architectures are investigated, showing that PEDOT-N3 films can properly work as a channel of the transistors. Furthermore, the Cu(I)-catalyzed click reaction of ethynyl-ferrocene is studied under different reaction conditions, endowing the spatial control of the functionalization. The strain-promoted and catalyst-free cycloaddition of a dibenzocyclooctyne-derivatized poly-l-lysine (PLL-DBCO) is also performed on the OECTs and validated by a fiber optic (FO)-SPR setup. The further immobilization of an azido-modified HD22 aptamer yields OECT-based biosensors that are employed for the recognition of thrombin. Finally, their performance is evaluated against previously reported architectures, showing higher density of the immobilized HD22 aptamer, and originating similar KD values and higher maximum signal change upon analyte recognition.Fil: Fenoy, Gonzalo Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; ArgentinaFil: Hasler, Roger. No especifíca;Fil: Lorenz, Christoph. Universitat Ulm; AlemaniaFil: Movilli, Jacopo. Universiteit Twente (ut);Fil: Marmisollé, Waldemar Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; ArgentinaFil: Azzaroni, Omar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; ArgentinaFil: Huskens, Jurriaan. Universiteit Twente (ut);Fil: Bäuerle, Peter. Universidad Nacional de La Plata; ArgentinaFil: Knoll, Wolfgang. No especifíca;American Chemical Society2023-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/227319Fenoy, Gonzalo Eduardo; Hasler, Roger; Lorenz, Christoph; Movilli, Jacopo; Marmisollé, Waldemar Alejandro; et al.; Interface Engineering of “Clickable” Organic Electrochemical Transistors toward Biosensing Devices; American Chemical Society; ACS Applied Materials & Interfaces; 15; 8; 3-2023; 10885-108961944-8244CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://pubs.acs.org/doi/10.1021/acsami.2c21493info:eu-repo/semantics/altIdentifier/doi/10.1021/acsami.2c21493info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T12:11:56Zoai:ri.conicet.gov.ar:11336/227319instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 12:11:57.153CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Interface Engineering of “Clickable” Organic Electrochemical Transistors toward Biosensing Devices
title Interface Engineering of “Clickable” Organic Electrochemical Transistors toward Biosensing Devices
spellingShingle Interface Engineering of “Clickable” Organic Electrochemical Transistors toward Biosensing Devices
Fenoy, Gonzalo Eduardo
BIOSENSORS
CLICK CHEMISTRY
ORGANIC ELECTROCHEMICAL TRANSISTORS
POLY-
THROMBIN
title_short Interface Engineering of “Clickable” Organic Electrochemical Transistors toward Biosensing Devices
title_full Interface Engineering of “Clickable” Organic Electrochemical Transistors toward Biosensing Devices
title_fullStr Interface Engineering of “Clickable” Organic Electrochemical Transistors toward Biosensing Devices
title_full_unstemmed Interface Engineering of “Clickable” Organic Electrochemical Transistors toward Biosensing Devices
title_sort Interface Engineering of “Clickable” Organic Electrochemical Transistors toward Biosensing Devices
dc.creator.none.fl_str_mv Fenoy, Gonzalo Eduardo
Hasler, Roger
Lorenz, Christoph
Movilli, Jacopo
Marmisollé, Waldemar Alejandro
Azzaroni, Omar
Huskens, Jurriaan
Bäuerle, Peter
Knoll, Wolfgang
author Fenoy, Gonzalo Eduardo
author_facet Fenoy, Gonzalo Eduardo
Hasler, Roger
Lorenz, Christoph
Movilli, Jacopo
Marmisollé, Waldemar Alejandro
Azzaroni, Omar
Huskens, Jurriaan
Bäuerle, Peter
Knoll, Wolfgang
author_role author
author2 Hasler, Roger
Lorenz, Christoph
Movilli, Jacopo
Marmisollé, Waldemar Alejandro
Azzaroni, Omar
Huskens, Jurriaan
Bäuerle, Peter
Knoll, Wolfgang
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv BIOSENSORS
CLICK CHEMISTRY
ORGANIC ELECTROCHEMICAL TRANSISTORS
POLY-
THROMBIN
topic BIOSENSORS
CLICK CHEMISTRY
ORGANIC ELECTROCHEMICAL TRANSISTORS
POLY-
THROMBIN
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv “Clickable” organic electrochemical transistors (OECTs) allow the reliable and straightforward functionalization of electronic devices through the well-known click chemistry toolbox. In this work, we study various aspects of the click chemistry-based interface engineering of “clickable” OECTs. First, different channel architectures are investigated, showing that PEDOT-N3 films can properly work as a channel of the transistors. Furthermore, the Cu(I)-catalyzed click reaction of ethynyl-ferrocene is studied under different reaction conditions, endowing the spatial control of the functionalization. The strain-promoted and catalyst-free cycloaddition of a dibenzocyclooctyne-derivatized poly-l-lysine (PLL-DBCO) is also performed on the OECTs and validated by a fiber optic (FO)-SPR setup. The further immobilization of an azido-modified HD22 aptamer yields OECT-based biosensors that are employed for the recognition of thrombin. Finally, their performance is evaluated against previously reported architectures, showing higher density of the immobilized HD22 aptamer, and originating similar KD values and higher maximum signal change upon analyte recognition.
Fil: Fenoy, Gonzalo Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina
Fil: Hasler, Roger. No especifíca;
Fil: Lorenz, Christoph. Universitat Ulm; Alemania
Fil: Movilli, Jacopo. Universiteit Twente (ut);
Fil: Marmisollé, Waldemar Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina
Fil: Azzaroni, Omar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina
Fil: Huskens, Jurriaan. Universiteit Twente (ut);
Fil: Bäuerle, Peter. Universidad Nacional de La Plata; Argentina
Fil: Knoll, Wolfgang. No especifíca;
description “Clickable” organic electrochemical transistors (OECTs) allow the reliable and straightforward functionalization of electronic devices through the well-known click chemistry toolbox. In this work, we study various aspects of the click chemistry-based interface engineering of “clickable” OECTs. First, different channel architectures are investigated, showing that PEDOT-N3 films can properly work as a channel of the transistors. Furthermore, the Cu(I)-catalyzed click reaction of ethynyl-ferrocene is studied under different reaction conditions, endowing the spatial control of the functionalization. The strain-promoted and catalyst-free cycloaddition of a dibenzocyclooctyne-derivatized poly-l-lysine (PLL-DBCO) is also performed on the OECTs and validated by a fiber optic (FO)-SPR setup. The further immobilization of an azido-modified HD22 aptamer yields OECT-based biosensors that are employed for the recognition of thrombin. Finally, their performance is evaluated against previously reported architectures, showing higher density of the immobilized HD22 aptamer, and originating similar KD values and higher maximum signal change upon analyte recognition.
publishDate 2023
dc.date.none.fl_str_mv 2023-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/227319
Fenoy, Gonzalo Eduardo; Hasler, Roger; Lorenz, Christoph; Movilli, Jacopo; Marmisollé, Waldemar Alejandro; et al.; Interface Engineering of “Clickable” Organic Electrochemical Transistors toward Biosensing Devices; American Chemical Society; ACS Applied Materials & Interfaces; 15; 8; 3-2023; 10885-10896
1944-8244
CONICET Digital
CONICET
url http://hdl.handle.net/11336/227319
identifier_str_mv Fenoy, Gonzalo Eduardo; Hasler, Roger; Lorenz, Christoph; Movilli, Jacopo; Marmisollé, Waldemar Alejandro; et al.; Interface Engineering of “Clickable” Organic Electrochemical Transistors toward Biosensing Devices; American Chemical Society; ACS Applied Materials & Interfaces; 15; 8; 3-2023; 10885-10896
1944-8244
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://pubs.acs.org/doi/10.1021/acsami.2c21493
info:eu-repo/semantics/altIdentifier/doi/10.1021/acsami.2c21493
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv American Chemical Society
publisher.none.fl_str_mv American Chemical Society
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.982451

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