Interface Engineering of “Clickable” Organic Electrochemical Transistors toward Biosensing Devices
- Autores
- Fenoy, Gonzalo Eduardo; Hasler, Roger; Lorenz, Christoph; Movilli, Jacopo; Marmisollé, Waldemar Alejandro; Azzaroni, Omar; Huskens, Jurriaan; Bäuerle, Peter; Knoll, Wolfgang
- Año de publicación
- 2023
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- “Clickable” organic electrochemical transistors (OECTs) allow the reliable and straightforward functionalization of electronic devices through the well-known click chemistry toolbox. In this work, we study various aspects of the click chemistry-based interface engineering of “clickable” OECTs. First, different channel architectures are investigated, showing that PEDOT-N3 films can properly work as a channel of the transistors. Furthermore, the Cu(I)-catalyzed click reaction of ethynyl-ferrocene is studied under different reaction conditions, endowing the spatial control of the functionalization. The strain-promoted and catalyst-free cycloaddition of a dibenzocyclooctyne-derivatized poly-l-lysine (PLL-DBCO) is also performed on the OECTs and validated by a fiber optic (FO)-SPR setup. The further immobilization of an azido-modified HD22 aptamer yields OECT-based biosensors that are employed for the recognition of thrombin. Finally, their performance is evaluated against previously reported architectures, showing higher density of the immobilized HD22 aptamer, and originating similar KD values and higher maximum signal change upon analyte recognition.
Fil: Fenoy, Gonzalo Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina
Fil: Hasler, Roger. No especifíca;
Fil: Lorenz, Christoph. Universitat Ulm; Alemania
Fil: Movilli, Jacopo. Universiteit Twente (ut);
Fil: Marmisollé, Waldemar Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina
Fil: Azzaroni, Omar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina
Fil: Huskens, Jurriaan. Universiteit Twente (ut);
Fil: Bäuerle, Peter. Universidad Nacional de La Plata; Argentina
Fil: Knoll, Wolfgang. No especifíca; - Materia
-
BIOSENSORS
CLICK CHEMISTRY
ORGANIC ELECTROCHEMICAL TRANSISTORS
POLY-
THROMBIN - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/227319
Ver los metadatos del registro completo
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Interface Engineering of “Clickable” Organic Electrochemical Transistors toward Biosensing DevicesFenoy, Gonzalo EduardoHasler, RogerLorenz, ChristophMovilli, JacopoMarmisollé, Waldemar AlejandroAzzaroni, OmarHuskens, JurriaanBäuerle, PeterKnoll, WolfgangBIOSENSORSCLICK CHEMISTRYORGANIC ELECTROCHEMICAL TRANSISTORSPOLY-THROMBINhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1“Clickable” organic electrochemical transistors (OECTs) allow the reliable and straightforward functionalization of electronic devices through the well-known click chemistry toolbox. In this work, we study various aspects of the click chemistry-based interface engineering of “clickable” OECTs. First, different channel architectures are investigated, showing that PEDOT-N3 films can properly work as a channel of the transistors. Furthermore, the Cu(I)-catalyzed click reaction of ethynyl-ferrocene is studied under different reaction conditions, endowing the spatial control of the functionalization. The strain-promoted and catalyst-free cycloaddition of a dibenzocyclooctyne-derivatized poly-l-lysine (PLL-DBCO) is also performed on the OECTs and validated by a fiber optic (FO)-SPR setup. The further immobilization of an azido-modified HD22 aptamer yields OECT-based biosensors that are employed for the recognition of thrombin. Finally, their performance is evaluated against previously reported architectures, showing higher density of the immobilized HD22 aptamer, and originating similar KD values and higher maximum signal change upon analyte recognition.Fil: Fenoy, Gonzalo Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; ArgentinaFil: Hasler, Roger. No especifíca;Fil: Lorenz, Christoph. Universitat Ulm; AlemaniaFil: Movilli, Jacopo. Universiteit Twente (ut);Fil: Marmisollé, Waldemar Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; ArgentinaFil: Azzaroni, Omar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; ArgentinaFil: Huskens, Jurriaan. Universiteit Twente (ut);Fil: Bäuerle, Peter. Universidad Nacional de La Plata; ArgentinaFil: Knoll, Wolfgang. No especifíca;American Chemical Society2023-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/227319Fenoy, Gonzalo Eduardo; Hasler, Roger; Lorenz, Christoph; Movilli, Jacopo; Marmisollé, Waldemar Alejandro; et al.; Interface Engineering of “Clickable” Organic Electrochemical Transistors toward Biosensing Devices; American Chemical Society; ACS Applied Materials & Interfaces; 15; 8; 3-2023; 10885-108961944-8244CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://pubs.acs.org/doi/10.1021/acsami.2c21493info:eu-repo/semantics/altIdentifier/doi/10.1021/acsami.2c21493info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:39:37Zoai:ri.conicet.gov.ar:11336/227319instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:39:38.114CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Interface Engineering of “Clickable” Organic Electrochemical Transistors toward Biosensing Devices |
title |
Interface Engineering of “Clickable” Organic Electrochemical Transistors toward Biosensing Devices |
spellingShingle |
Interface Engineering of “Clickable” Organic Electrochemical Transistors toward Biosensing Devices Fenoy, Gonzalo Eduardo BIOSENSORS CLICK CHEMISTRY ORGANIC ELECTROCHEMICAL TRANSISTORS POLY- THROMBIN |
title_short |
Interface Engineering of “Clickable” Organic Electrochemical Transistors toward Biosensing Devices |
title_full |
Interface Engineering of “Clickable” Organic Electrochemical Transistors toward Biosensing Devices |
title_fullStr |
Interface Engineering of “Clickable” Organic Electrochemical Transistors toward Biosensing Devices |
title_full_unstemmed |
Interface Engineering of “Clickable” Organic Electrochemical Transistors toward Biosensing Devices |
title_sort |
Interface Engineering of “Clickable” Organic Electrochemical Transistors toward Biosensing Devices |
dc.creator.none.fl_str_mv |
Fenoy, Gonzalo Eduardo Hasler, Roger Lorenz, Christoph Movilli, Jacopo Marmisollé, Waldemar Alejandro Azzaroni, Omar Huskens, Jurriaan Bäuerle, Peter Knoll, Wolfgang |
author |
Fenoy, Gonzalo Eduardo |
author_facet |
Fenoy, Gonzalo Eduardo Hasler, Roger Lorenz, Christoph Movilli, Jacopo Marmisollé, Waldemar Alejandro Azzaroni, Omar Huskens, Jurriaan Bäuerle, Peter Knoll, Wolfgang |
author_role |
author |
author2 |
Hasler, Roger Lorenz, Christoph Movilli, Jacopo Marmisollé, Waldemar Alejandro Azzaroni, Omar Huskens, Jurriaan Bäuerle, Peter Knoll, Wolfgang |
author2_role |
author author author author author author author author |
dc.subject.none.fl_str_mv |
BIOSENSORS CLICK CHEMISTRY ORGANIC ELECTROCHEMICAL TRANSISTORS POLY- THROMBIN |
topic |
BIOSENSORS CLICK CHEMISTRY ORGANIC ELECTROCHEMICAL TRANSISTORS POLY- THROMBIN |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.4 https://purl.org/becyt/ford/1 |
dc.description.none.fl_txt_mv |
“Clickable” organic electrochemical transistors (OECTs) allow the reliable and straightforward functionalization of electronic devices through the well-known click chemistry toolbox. In this work, we study various aspects of the click chemistry-based interface engineering of “clickable” OECTs. First, different channel architectures are investigated, showing that PEDOT-N3 films can properly work as a channel of the transistors. Furthermore, the Cu(I)-catalyzed click reaction of ethynyl-ferrocene is studied under different reaction conditions, endowing the spatial control of the functionalization. The strain-promoted and catalyst-free cycloaddition of a dibenzocyclooctyne-derivatized poly-l-lysine (PLL-DBCO) is also performed on the OECTs and validated by a fiber optic (FO)-SPR setup. The further immobilization of an azido-modified HD22 aptamer yields OECT-based biosensors that are employed for the recognition of thrombin. Finally, their performance is evaluated against previously reported architectures, showing higher density of the immobilized HD22 aptamer, and originating similar KD values and higher maximum signal change upon analyte recognition. Fil: Fenoy, Gonzalo Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina Fil: Hasler, Roger. No especifíca; Fil: Lorenz, Christoph. Universitat Ulm; Alemania Fil: Movilli, Jacopo. Universiteit Twente (ut); Fil: Marmisollé, Waldemar Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina Fil: Azzaroni, Omar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina Fil: Huskens, Jurriaan. Universiteit Twente (ut); Fil: Bäuerle, Peter. Universidad Nacional de La Plata; Argentina Fil: Knoll, Wolfgang. No especifíca; |
description |
“Clickable” organic electrochemical transistors (OECTs) allow the reliable and straightforward functionalization of electronic devices through the well-known click chemistry toolbox. In this work, we study various aspects of the click chemistry-based interface engineering of “clickable” OECTs. First, different channel architectures are investigated, showing that PEDOT-N3 films can properly work as a channel of the transistors. Furthermore, the Cu(I)-catalyzed click reaction of ethynyl-ferrocene is studied under different reaction conditions, endowing the spatial control of the functionalization. The strain-promoted and catalyst-free cycloaddition of a dibenzocyclooctyne-derivatized poly-l-lysine (PLL-DBCO) is also performed on the OECTs and validated by a fiber optic (FO)-SPR setup. The further immobilization of an azido-modified HD22 aptamer yields OECT-based biosensors that are employed for the recognition of thrombin. Finally, their performance is evaluated against previously reported architectures, showing higher density of the immobilized HD22 aptamer, and originating similar KD values and higher maximum signal change upon analyte recognition. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-03 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/227319 Fenoy, Gonzalo Eduardo; Hasler, Roger; Lorenz, Christoph; Movilli, Jacopo; Marmisollé, Waldemar Alejandro; et al.; Interface Engineering of “Clickable” Organic Electrochemical Transistors toward Biosensing Devices; American Chemical Society; ACS Applied Materials & Interfaces; 15; 8; 3-2023; 10885-10896 1944-8244 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/227319 |
identifier_str_mv |
Fenoy, Gonzalo Eduardo; Hasler, Roger; Lorenz, Christoph; Movilli, Jacopo; Marmisollé, Waldemar Alejandro; et al.; Interface Engineering of “Clickable” Organic Electrochemical Transistors toward Biosensing Devices; American Chemical Society; ACS Applied Materials & Interfaces; 15; 8; 3-2023; 10885-10896 1944-8244 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://pubs.acs.org/doi/10.1021/acsami.2c21493 info:eu-repo/semantics/altIdentifier/doi/10.1021/acsami.2c21493 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-nd/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
American Chemical Society |
publisher.none.fl_str_mv |
American Chemical Society |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1844614422009479168 |
score |
13.070432 |