Whispering neurons fuel cortical highways

Autores
Schinder, Alejandro Fabián; Lanuza, Guillermo Marcos
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Synaptic communication accelerates neuronal migration in the developing brain. The mammalian neocortex is one of the most intricate entities found in nature, both in terms of structure and function. It is the brain region responsible for the execution of high-order functions, including sensory perception, motor control, cognition, and speech. Its development is equally complex because it requires that millions to billions (depending on the species) of neurons assemble in distinct layers and connect with exquisite precision to perform complicated information processing operations. During embryonic development, formation of the cerebral cortex involves the migration of excitatory neurons generated in the ventricular zone toward the cortical plate, where they establish their final position in six well-defined horizontal layers consisting of different types of neurons and architecture. Along this migratory phase, developing neurons undergo a morphological transition from multipolar shape to bipolar morphology. Bipolar neurons exhibit faster locomotion, quickly reaching their final destination. On page 313 of this issue, Ohtaka-Maruyama et al. (1) reveal that this important switch to bipolar neurons is influenced by glutamate release from neurons located at the subplate, just beneath the cortical plate. Subplate neurons trigger this transformation by making transient synaptic contacts with multipolar neurons in transit to the cortical laminae. Understanding this process is important because disruption of neocortical migration results in several human neuro-developmental diseases.
Fil: Schinder, Alejandro Fabián. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
Fil: Lanuza, Guillermo Marcos. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
Materia
Neuronal migration
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/91109

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spelling Whispering neurons fuel cortical highwaysSchinder, Alejandro FabiánLanuza, Guillermo MarcosNeuronal migrationhttps://purl.org/becyt/ford/3.5https://purl.org/becyt/ford/3Synaptic communication accelerates neuronal migration in the developing brain. The mammalian neocortex is one of the most intricate entities found in nature, both in terms of structure and function. It is the brain region responsible for the execution of high-order functions, including sensory perception, motor control, cognition, and speech. Its development is equally complex because it requires that millions to billions (depending on the species) of neurons assemble in distinct layers and connect with exquisite precision to perform complicated information processing operations. During embryonic development, formation of the cerebral cortex involves the migration of excitatory neurons generated in the ventricular zone toward the cortical plate, where they establish their final position in six well-defined horizontal layers consisting of different types of neurons and architecture. Along this migratory phase, developing neurons undergo a morphological transition from multipolar shape to bipolar morphology. Bipolar neurons exhibit faster locomotion, quickly reaching their final destination. On page 313 of this issue, Ohtaka-Maruyama et al. (1) reveal that this important switch to bipolar neurons is influenced by glutamate release from neurons located at the subplate, just beneath the cortical plate. Subplate neurons trigger this transformation by making transient synaptic contacts with multipolar neurons in transit to the cortical laminae. Understanding this process is important because disruption of neocortical migration results in several human neuro-developmental diseases.Fil: Schinder, Alejandro Fabián. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; ArgentinaFil: Lanuza, Guillermo Marcos. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; ArgentinaAmerican Association for the Advancement of Science2018-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/91109Schinder, Alejandro Fabián; Lanuza, Guillermo Marcos; Whispering neurons fuel cortical highways; American Association for the Advancement of Science; Science; 360; 6386; 4-2018; 265-2660036-8075CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1126/science.aat4587info:eu-repo/semantics/altIdentifier/url/https://science.sciencemag.org/content/360/6386/265info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:33:34Zoai:ri.conicet.gov.ar:11336/91109instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:33:34.361CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Whispering neurons fuel cortical highways
title Whispering neurons fuel cortical highways
spellingShingle Whispering neurons fuel cortical highways
Schinder, Alejandro Fabián
Neuronal migration
title_short Whispering neurons fuel cortical highways
title_full Whispering neurons fuel cortical highways
title_fullStr Whispering neurons fuel cortical highways
title_full_unstemmed Whispering neurons fuel cortical highways
title_sort Whispering neurons fuel cortical highways
dc.creator.none.fl_str_mv Schinder, Alejandro Fabián
Lanuza, Guillermo Marcos
author Schinder, Alejandro Fabián
author_facet Schinder, Alejandro Fabián
Lanuza, Guillermo Marcos
author_role author
author2 Lanuza, Guillermo Marcos
author2_role author
dc.subject.none.fl_str_mv Neuronal migration
topic Neuronal migration
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.5
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Synaptic communication accelerates neuronal migration in the developing brain. The mammalian neocortex is one of the most intricate entities found in nature, both in terms of structure and function. It is the brain region responsible for the execution of high-order functions, including sensory perception, motor control, cognition, and speech. Its development is equally complex because it requires that millions to billions (depending on the species) of neurons assemble in distinct layers and connect with exquisite precision to perform complicated information processing operations. During embryonic development, formation of the cerebral cortex involves the migration of excitatory neurons generated in the ventricular zone toward the cortical plate, where they establish their final position in six well-defined horizontal layers consisting of different types of neurons and architecture. Along this migratory phase, developing neurons undergo a morphological transition from multipolar shape to bipolar morphology. Bipolar neurons exhibit faster locomotion, quickly reaching their final destination. On page 313 of this issue, Ohtaka-Maruyama et al. (1) reveal that this important switch to bipolar neurons is influenced by glutamate release from neurons located at the subplate, just beneath the cortical plate. Subplate neurons trigger this transformation by making transient synaptic contacts with multipolar neurons in transit to the cortical laminae. Understanding this process is important because disruption of neocortical migration results in several human neuro-developmental diseases.
Fil: Schinder, Alejandro Fabián. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
Fil: Lanuza, Guillermo Marcos. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
description Synaptic communication accelerates neuronal migration in the developing brain. The mammalian neocortex is one of the most intricate entities found in nature, both in terms of structure and function. It is the brain region responsible for the execution of high-order functions, including sensory perception, motor control, cognition, and speech. Its development is equally complex because it requires that millions to billions (depending on the species) of neurons assemble in distinct layers and connect with exquisite precision to perform complicated information processing operations. During embryonic development, formation of the cerebral cortex involves the migration of excitatory neurons generated in the ventricular zone toward the cortical plate, where they establish their final position in six well-defined horizontal layers consisting of different types of neurons and architecture. Along this migratory phase, developing neurons undergo a morphological transition from multipolar shape to bipolar morphology. Bipolar neurons exhibit faster locomotion, quickly reaching their final destination. On page 313 of this issue, Ohtaka-Maruyama et al. (1) reveal that this important switch to bipolar neurons is influenced by glutamate release from neurons located at the subplate, just beneath the cortical plate. Subplate neurons trigger this transformation by making transient synaptic contacts with multipolar neurons in transit to the cortical laminae. Understanding this process is important because disruption of neocortical migration results in several human neuro-developmental diseases.
publishDate 2018
dc.date.none.fl_str_mv 2018-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/91109
Schinder, Alejandro Fabián; Lanuza, Guillermo Marcos; Whispering neurons fuel cortical highways; American Association for the Advancement of Science; Science; 360; 6386; 4-2018; 265-266
0036-8075
CONICET Digital
CONICET
url http://hdl.handle.net/11336/91109
identifier_str_mv Schinder, Alejandro Fabián; Lanuza, Guillermo Marcos; Whispering neurons fuel cortical highways; American Association for the Advancement of Science; Science; 360; 6386; 4-2018; 265-266
0036-8075
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1126/science.aat4587
info:eu-repo/semantics/altIdentifier/url/https://science.sciencemag.org/content/360/6386/265
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv American Association for the Advancement of Science
publisher.none.fl_str_mv American Association for the Advancement of Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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