Trial-by-trial variability in cortical responses exhibits scaling of spatial correlations predicted from critical dynamics

Autores
Ribeiro, Tiago L.; Jendrichovsky, Peter; Yu, Shan; Mártin, Daniel Alejandro; Kanold, Patrick O.; Chialvo, Dante Renato; Plenz, Dietmar
Año de publicación
2024
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
In the mammalian cortex, even simple sensory inputs or movements activate many neurons, with eachneuron responding variably to repeated stimuli—a phenomenon known as trial-by-trial variability. Understanding the spatial patterns and dynamics of this variability is challenging. Using cellular 2-photon imaging,we study visual and auditory responses in the primary cortices of awake mice. We focus on how individualneurons’ responses differed from the overall population. We find consistent spatial correlations in thesedifferences that are unique to each trial and linearly scale with the cortical area observed, a characteristicof critical dynamics as confirmed in our neuronal simulations. Using chronic multi-electrode recordings,we observe similar scaling in the prefrontal and premotor cortex of non-human primates during self-initiatedand visually cued motor tasks. These results suggest that trial-by-trial variability, rather than being randomnoise, reflects a critical, fluctuation-dominated state in the cortex, supporting the brain’s efficiency in processing information.
Fil: Ribeiro, Tiago L.. Public Health Service. National Institute Of Health; Estados Unidos
Fil: Jendrichovsky, Peter. University Johns Hopkins; Estados Unidos
Fil: Yu, Shan. Chinese Academy of Sciences; República de China. Public Health Service. National Institute Of Health; Estados Unidos
Fil: Mártin, Daniel Alejandro. Universidad Nacional de San Martin. Escuela de Ciencia y Tecnologia. Centro de Estudios Multidisciplinarios En Sistemas Complejos y Ciencias del Cerebro.; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Ciencias Físicas. - Universidad Nacional de San Martín. Instituto de Ciencias Físicas; Argentina
Fil: Kanold, Patrick O.. University Johns Hopkins; Estados Unidos
Fil: Chialvo, Dante Renato. Universidad Nacional de San Martin. Escuela de Ciencia y Tecnologia. Centro de Estudios Multidisciplinarios En Sistemas Complejos y Ciencias del Cerebro.; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Ciencias Físicas. - Universidad Nacional de San Martín. Instituto de Ciencias Físicas; Argentina
Fil: Plenz, Dietmar. Public Health Service. National Institute Of Health; Estados Unidos
Materia
MOUSE
PRIMARY SENSORY CORTEX
SPATIAL CORRELATION
CRITICALITY
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/258208
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Trial-by-trial variability in cortical responses exhibits scaling of spatial correlations predicted from critical dynamicsRibeiro, Tiago L.Jendrichovsky, PeterYu, ShanMártin, Daniel AlejandroKanold, Patrick O.Chialvo, Dante RenatoPlenz, DietmarMOUSEPRIMARY SENSORY CORTEXSPATIAL CORRELATIONCRITICALITYhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1In the mammalian cortex, even simple sensory inputs or movements activate many neurons, with eachneuron responding variably to repeated stimuli—a phenomenon known as trial-by-trial variability. Understanding the spatial patterns and dynamics of this variability is challenging. Using cellular 2-photon imaging,we study visual and auditory responses in the primary cortices of awake mice. We focus on how individualneurons’ responses differed from the overall population. We find consistent spatial correlations in thesedifferences that are unique to each trial and linearly scale with the cortical area observed, a characteristicof critical dynamics as confirmed in our neuronal simulations. Using chronic multi-electrode recordings,we observe similar scaling in the prefrontal and premotor cortex of non-human primates during self-initiatedand visually cued motor tasks. These results suggest that trial-by-trial variability, rather than being randomnoise, reflects a critical, fluctuation-dominated state in the cortex, supporting the brain’s efficiency in processing information.Fil: Ribeiro, Tiago L.. Public Health Service. National Institute Of Health; Estados UnidosFil: Jendrichovsky, Peter. University Johns Hopkins; Estados UnidosFil: Yu, Shan. Chinese Academy of Sciences; República de China. Public Health Service. National Institute Of Health; Estados UnidosFil: Mártin, Daniel Alejandro. Universidad Nacional de San Martin. Escuela de Ciencia y Tecnologia. Centro de Estudios Multidisciplinarios En Sistemas Complejos y Ciencias del Cerebro.; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Ciencias Físicas. - Universidad Nacional de San Martín. Instituto de Ciencias Físicas; ArgentinaFil: Kanold, Patrick O.. University Johns Hopkins; Estados UnidosFil: Chialvo, Dante Renato. Universidad Nacional de San Martin. Escuela de Ciencia y Tecnologia. Centro de Estudios Multidisciplinarios En Sistemas Complejos y Ciencias del Cerebro.; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Ciencias Físicas. - Universidad Nacional de San Martín. Instituto de Ciencias Físicas; ArgentinaFil: Plenz, Dietmar. Public Health Service. National Institute Of Health; Estados UnidosCell Press2024-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/258208Ribeiro, Tiago L.; Jendrichovsky, Peter; Yu, Shan; Mártin, Daniel Alejandro; Kanold, Patrick O.; et al.; Trial-by-trial variability in cortical responses exhibits scaling of spatial correlations predicted from critical dynamics; Cell Press; Plant Cell Reports; 43; 2; 2-20242211-1247CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.celrep.2024.113762info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:02:54Zoai:ri.conicet.gov.ar:11336/258208instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:02:54.88CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Trial-by-trial variability in cortical responses exhibits scaling of spatial correlations predicted from critical dynamics
title Trial-by-trial variability in cortical responses exhibits scaling of spatial correlations predicted from critical dynamics
spellingShingle Trial-by-trial variability in cortical responses exhibits scaling of spatial correlations predicted from critical dynamics
Ribeiro, Tiago L.
MOUSE
PRIMARY SENSORY CORTEX
SPATIAL CORRELATION
CRITICALITY
title_short Trial-by-trial variability in cortical responses exhibits scaling of spatial correlations predicted from critical dynamics
title_full Trial-by-trial variability in cortical responses exhibits scaling of spatial correlations predicted from critical dynamics
title_fullStr Trial-by-trial variability in cortical responses exhibits scaling of spatial correlations predicted from critical dynamics
title_full_unstemmed Trial-by-trial variability in cortical responses exhibits scaling of spatial correlations predicted from critical dynamics
title_sort Trial-by-trial variability in cortical responses exhibits scaling of spatial correlations predicted from critical dynamics
dc.creator.none.fl_str_mv Ribeiro, Tiago L.
Jendrichovsky, Peter
Yu, Shan
Mártin, Daniel Alejandro
Kanold, Patrick O.
Chialvo, Dante Renato
Plenz, Dietmar
author Ribeiro, Tiago L.
author_facet Ribeiro, Tiago L.
Jendrichovsky, Peter
Yu, Shan
Mártin, Daniel Alejandro
Kanold, Patrick O.
Chialvo, Dante Renato
Plenz, Dietmar
author_role author
author2 Jendrichovsky, Peter
Yu, Shan
Mártin, Daniel Alejandro
Kanold, Patrick O.
Chialvo, Dante Renato
Plenz, Dietmar
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv MOUSE
PRIMARY SENSORY CORTEX
SPATIAL CORRELATION
CRITICALITY
topic MOUSE
PRIMARY SENSORY CORTEX
SPATIAL CORRELATION
CRITICALITY
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv In the mammalian cortex, even simple sensory inputs or movements activate many neurons, with eachneuron responding variably to repeated stimuli—a phenomenon known as trial-by-trial variability. Understanding the spatial patterns and dynamics of this variability is challenging. Using cellular 2-photon imaging,we study visual and auditory responses in the primary cortices of awake mice. We focus on how individualneurons’ responses differed from the overall population. We find consistent spatial correlations in thesedifferences that are unique to each trial and linearly scale with the cortical area observed, a characteristicof critical dynamics as confirmed in our neuronal simulations. Using chronic multi-electrode recordings,we observe similar scaling in the prefrontal and premotor cortex of non-human primates during self-initiatedand visually cued motor tasks. These results suggest that trial-by-trial variability, rather than being randomnoise, reflects a critical, fluctuation-dominated state in the cortex, supporting the brain’s efficiency in processing information.
Fil: Ribeiro, Tiago L.. Public Health Service. National Institute Of Health; Estados Unidos
Fil: Jendrichovsky, Peter. University Johns Hopkins; Estados Unidos
Fil: Yu, Shan. Chinese Academy of Sciences; República de China. Public Health Service. National Institute Of Health; Estados Unidos
Fil: Mártin, Daniel Alejandro. Universidad Nacional de San Martin. Escuela de Ciencia y Tecnologia. Centro de Estudios Multidisciplinarios En Sistemas Complejos y Ciencias del Cerebro.; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Ciencias Físicas. - Universidad Nacional de San Martín. Instituto de Ciencias Físicas; Argentina
Fil: Kanold, Patrick O.. University Johns Hopkins; Estados Unidos
Fil: Chialvo, Dante Renato. Universidad Nacional de San Martin. Escuela de Ciencia y Tecnologia. Centro de Estudios Multidisciplinarios En Sistemas Complejos y Ciencias del Cerebro.; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Ciencias Físicas. - Universidad Nacional de San Martín. Instituto de Ciencias Físicas; Argentina
Fil: Plenz, Dietmar. Public Health Service. National Institute Of Health; Estados Unidos
description In the mammalian cortex, even simple sensory inputs or movements activate many neurons, with eachneuron responding variably to repeated stimuli—a phenomenon known as trial-by-trial variability. Understanding the spatial patterns and dynamics of this variability is challenging. Using cellular 2-photon imaging,we study visual and auditory responses in the primary cortices of awake mice. We focus on how individualneurons’ responses differed from the overall population. We find consistent spatial correlations in thesedifferences that are unique to each trial and linearly scale with the cortical area observed, a characteristicof critical dynamics as confirmed in our neuronal simulations. Using chronic multi-electrode recordings,we observe similar scaling in the prefrontal and premotor cortex of non-human primates during self-initiatedand visually cued motor tasks. These results suggest that trial-by-trial variability, rather than being randomnoise, reflects a critical, fluctuation-dominated state in the cortex, supporting the brain’s efficiency in processing information.
publishDate 2024
dc.date.none.fl_str_mv 2024-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/258208
Ribeiro, Tiago L.; Jendrichovsky, Peter; Yu, Shan; Mártin, Daniel Alejandro; Kanold, Patrick O.; et al.; Trial-by-trial variability in cortical responses exhibits scaling of spatial correlations predicted from critical dynamics; Cell Press; Plant Cell Reports; 43; 2; 2-2024
2211-1247
CONICET Digital
CONICET
url http://hdl.handle.net/11336/258208
identifier_str_mv Ribeiro, Tiago L.; Jendrichovsky, Peter; Yu, Shan; Mártin, Daniel Alejandro; Kanold, Patrick O.; et al.; Trial-by-trial variability in cortical responses exhibits scaling of spatial correlations predicted from critical dynamics; Cell Press; Plant Cell Reports; 43; 2; 2-2024
2211-1247
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.celrep.2024.113762
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Cell Press
publisher.none.fl_str_mv Cell Press
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.982451

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