What kind of noise is brain noise: Anomalous scaling behavior of the resting brain activity fluctuations

• Autores: Fraiman Borrazás, Daniel Edmundo; Chialvo, Dante Renato
• Año de publicación: 2012
• Idioma: inglés
• Tipo de recurso: artículo
• Materia: BRAIN NOISE; CORRELATIONS LENGTH; CRITICALITY; FMRI; SCALING
• Institución: Consejo Nacional de Investigaciones Científicas y Técnicas

The study of spontaneous fluctuations of brain activity, often referred as brain noise, is getting increasing attention in functional magnetic resonance imaging (fMRI) studies. Despite important efforts, much of the statistical properties of such fluctuations remain largely unknown. This work scrutinizes these fluctuations looking at specific statistical properties which are relevant to clarify its dynamical origins. Here, three statistical features which clearly differentiate brain data from naive expectations for random processes are uncovered: First, the variance of the fMRI mean signal as a function of the number of averaged voxels remains constant across a wide range of observed clusters sizes. Second, the anomalous behavior of the variance is originated by bursts of synchronized activity across regions, regardless of their widely different sizes. Finally, the correlation length (i.e., the length at which the correlation strength between two regions vanishes) as well as mutual information diverges with the cluster's size considered, such that arbitrarily large clusters exhibit the same collective dynamics than smaller ones. These three properties are known to be exclusive of complex systems exhibiting critical dynamics, where the spatio-temporal dynamics show these peculiar type of fluctuations. Thus, these findings are fully consistent with previous reports of brain critical dynamics, and are relevant for the interpretation of the role of fluctuations and variability in brain function in health and disease.
Fil: Fraiman Borrazás, Daniel Edmundo. Universidad de San Andrés. Departamento de Matemáticas y Ciencias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Chialvo, Dante Renato. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; Argentina. University of California at Los Angeles. School of Medicine; Estados Unidos