Combination of Amphotericin B and Terbinafine against Melanized Fungi Associated with Chromoblastomycosis

Autores
Deng, S.; Lei, W.; de Hoog, G. S.; Yang, L.; Vitale, Roxana Gabriela; Rafati, H.; Seyedmousavi, M.; Tolooe, A.; van der Lee, H.; Liao, W.; Verweij, P. E.; Seyedmousavi, S.
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Chromoblastomycosis (CBM) is a recalcitrant fungal skin disease which is difficult to treat, the infection leading to excessive proliferation of host tissues. Therefore, search for appropriate antifungal strategies is urgently needed. Our in vitro studies showed that combination of amphotericin B and terbinafine had synergistic effects against the majority of melanized fungi associated with CBM and similar infections, including Cladophialophora carrionii, C. arxii, Exophiala dermatitidis, E. spinifera, Fonsecaea monophora, F. nubica, F. pedrosoi, and Phialophora verrucosa, with a fractional inhibitory concentration (FIC) value ranging from 0.25 to 1. No synergistic interaction was found for Veronaea botryosa isolates. The results of FIC analysis were supported by response surface analysis using Bliss independence no-interaction model for the isolates tested. Our study suggests that amphotericin B, when combined with terbinafine, allows a significant reduction of MICs. This could provide an option for treatment of severe or unresponsive cases of CBM, particularly in cases due to species of Fonsecaea and Cladophialophora.
Fil: Deng, S.. Department of Medical Microbiology, People's Hospital of Suzhou National New and Hi-Tech Industrial; China
Fil: Lei, W.. Shanghai Institute Of Medical Mycology; China
Fil: de Hoog, G. S.. Shanghai Institute Of Medical Mycology; China. Westerdijk Fungal Biodiversity Institute; Países Bajos. Radboud Universiteit Nijmegen; Países Bajos. Universidade Federal do Paraná; Brasil
Fil: Yang, L.. Westerdijk Fungal Biodiversity Institute; Países Bajos
Fil: Vitale, Roxana Gabriela. Gobierno de la Ciudad de Buenos Aires. Hospital Gral.de Agudos "ramos Mejia". Departamento de Diagnostico y Tratamiento; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Rafati, H.. Center of Excellence for Infection Biology and Antimicrobial Pharmacology; Irán
Fil: Seyedmousavi, M.. Center of Excellence for Infection Biology and Antimicrobial Pharmacology; Irán
Fil: Tolooe, A.. Center of Excellence for Infection Biology and Antimicrobial Pharmacology; Irán
Fil: van der Lee, H.. Radboud Universiteit Nijmegen; Países Bajos
Fil: Liao, W.. Shanghai Institute Of Medical Mycology; China
Fil: Verweij, P. E.. Radboud Universiteit Nijmegen; Países Bajos
Fil: Seyedmousavi, S.. Radboud Universiteit Nijmegen; Países Bajos. Center of Excellence for Infection Biology and Antimicrobial Pharmacology; Irán. Mazandaran University of Medical Sciences; Irán
Materia
Combination therapy
Amphotericin B
Terbinafine
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/98645
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/98645
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Combination of Amphotericin B and Terbinafine against Melanized Fungi Associated with ChromoblastomycosisDeng, S.Lei, W.de Hoog, G. S.Yang, L.Vitale, Roxana GabrielaRafati, H.Seyedmousavi, M.Tolooe, A.van der Lee, H.Liao, W.Verweij, P. E.Seyedmousavi, S.Combination therapyAmphotericin BTerbinafinehttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Chromoblastomycosis (CBM) is a recalcitrant fungal skin disease which is difficult to treat, the infection leading to excessive proliferation of host tissues. Therefore, search for appropriate antifungal strategies is urgently needed. Our in vitro studies showed that combination of amphotericin B and terbinafine had synergistic effects against the majority of melanized fungi associated with CBM and similar infections, including Cladophialophora carrionii, C. arxii, Exophiala dermatitidis, E. spinifera, Fonsecaea monophora, F. nubica, F. pedrosoi, and Phialophora verrucosa, with a fractional inhibitory concentration (FIC) value ranging from 0.25 to 1. No synergistic interaction was found for Veronaea botryosa isolates. The results of FIC analysis were supported by response surface analysis using Bliss independence no-interaction model for the isolates tested. Our study suggests that amphotericin B, when combined with terbinafine, allows a significant reduction of MICs. This could provide an option for treatment of severe or unresponsive cases of CBM, particularly in cases due to species of Fonsecaea and Cladophialophora.Fil: Deng, S.. Department of Medical Microbiology, People's Hospital of Suzhou National New and Hi-Tech Industrial; ChinaFil: Lei, W.. Shanghai Institute Of Medical Mycology; ChinaFil: de Hoog, G. S.. Shanghai Institute Of Medical Mycology; China. Westerdijk Fungal Biodiversity Institute; Países Bajos. Radboud Universiteit Nijmegen; Países Bajos. Universidade Federal do Paraná; BrasilFil: Yang, L.. Westerdijk Fungal Biodiversity Institute; Países BajosFil: Vitale, Roxana Gabriela. Gobierno de la Ciudad de Buenos Aires. Hospital Gral.de Agudos "ramos Mejia". Departamento de Diagnostico y Tratamiento; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Rafati, H.. Center of Excellence for Infection Biology and Antimicrobial Pharmacology; IránFil: Seyedmousavi, M.. Center of Excellence for Infection Biology and Antimicrobial Pharmacology; IránFil: Tolooe, A.. Center of Excellence for Infection Biology and Antimicrobial Pharmacology; IránFil: van der Lee, H.. Radboud Universiteit Nijmegen; Países BajosFil: Liao, W.. Shanghai Institute Of Medical Mycology; ChinaFil: Verweij, P. E.. Radboud Universiteit Nijmegen; Países BajosFil: Seyedmousavi, S.. Radboud Universiteit Nijmegen; Países Bajos. Center of Excellence for Infection Biology and Antimicrobial Pharmacology; Irán. Mazandaran University of Medical Sciences; IránAmerican Society for Microbiology2018-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/mswordapplication/pdfhttp://hdl.handle.net/11336/98645Deng, S.; Lei, W.; de Hoog, G. S.; Yang, L.; Vitale, Roxana Gabriela; et al.; Combination of Amphotericin B and Terbinafine against Melanized Fungi Associated with Chromoblastomycosis; American Society for Microbiology; Antimicrobial Agents and Chemotherapy; 62; 6; 5-2018; 1-70066-4804CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1128/AAC.00270-18info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5971613/info:eu-repo/semantics/altIdentifier/url/https://aac.asm.org/content/62/6/e00270-18info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:43:55Zoai:ri.conicet.gov.ar:11336/98645instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:43:55.576CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Combination of Amphotericin B and Terbinafine against Melanized Fungi Associated with Chromoblastomycosis
title Combination of Amphotericin B and Terbinafine against Melanized Fungi Associated with Chromoblastomycosis
spellingShingle Combination of Amphotericin B and Terbinafine against Melanized Fungi Associated with Chromoblastomycosis
Deng, S.
Combination therapy
Amphotericin B
Terbinafine
title_short Combination of Amphotericin B and Terbinafine against Melanized Fungi Associated with Chromoblastomycosis
title_full Combination of Amphotericin B and Terbinafine against Melanized Fungi Associated with Chromoblastomycosis
title_fullStr Combination of Amphotericin B and Terbinafine against Melanized Fungi Associated with Chromoblastomycosis
title_full_unstemmed Combination of Amphotericin B and Terbinafine against Melanized Fungi Associated with Chromoblastomycosis
title_sort Combination of Amphotericin B and Terbinafine against Melanized Fungi Associated with Chromoblastomycosis
dc.creator.none.fl_str_mv Deng, S.
Lei, W.
de Hoog, G. S.
Yang, L.
Vitale, Roxana Gabriela
Rafati, H.
Seyedmousavi, M.
Tolooe, A.
van der Lee, H.
Liao, W.
Verweij, P. E.
Seyedmousavi, S.
author Deng, S.
author_facet Deng, S.
Lei, W.
de Hoog, G. S.
Yang, L.
Vitale, Roxana Gabriela
Rafati, H.
Seyedmousavi, M.
Tolooe, A.
van der Lee, H.
Liao, W.
Verweij, P. E.
Seyedmousavi, S.
author_role author
author2 Lei, W.
de Hoog, G. S.
Yang, L.
Vitale, Roxana Gabriela
Rafati, H.
Seyedmousavi, M.
Tolooe, A.
van der Lee, H.
Liao, W.
Verweij, P. E.
Seyedmousavi, S.
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Combination therapy
Amphotericin B
Terbinafine
topic Combination therapy
Amphotericin B
Terbinafine
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Chromoblastomycosis (CBM) is a recalcitrant fungal skin disease which is difficult to treat, the infection leading to excessive proliferation of host tissues. Therefore, search for appropriate antifungal strategies is urgently needed. Our in vitro studies showed that combination of amphotericin B and terbinafine had synergistic effects against the majority of melanized fungi associated with CBM and similar infections, including Cladophialophora carrionii, C. arxii, Exophiala dermatitidis, E. spinifera, Fonsecaea monophora, F. nubica, F. pedrosoi, and Phialophora verrucosa, with a fractional inhibitory concentration (FIC) value ranging from 0.25 to 1. No synergistic interaction was found for Veronaea botryosa isolates. The results of FIC analysis were supported by response surface analysis using Bliss independence no-interaction model for the isolates tested. Our study suggests that amphotericin B, when combined with terbinafine, allows a significant reduction of MICs. This could provide an option for treatment of severe or unresponsive cases of CBM, particularly in cases due to species of Fonsecaea and Cladophialophora.
Fil: Deng, S.. Department of Medical Microbiology, People's Hospital of Suzhou National New and Hi-Tech Industrial; China
Fil: Lei, W.. Shanghai Institute Of Medical Mycology; China
Fil: de Hoog, G. S.. Shanghai Institute Of Medical Mycology; China. Westerdijk Fungal Biodiversity Institute; Países Bajos. Radboud Universiteit Nijmegen; Países Bajos. Universidade Federal do Paraná; Brasil
Fil: Yang, L.. Westerdijk Fungal Biodiversity Institute; Países Bajos
Fil: Vitale, Roxana Gabriela. Gobierno de la Ciudad de Buenos Aires. Hospital Gral.de Agudos "ramos Mejia". Departamento de Diagnostico y Tratamiento; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Rafati, H.. Center of Excellence for Infection Biology and Antimicrobial Pharmacology; Irán
Fil: Seyedmousavi, M.. Center of Excellence for Infection Biology and Antimicrobial Pharmacology; Irán
Fil: Tolooe, A.. Center of Excellence for Infection Biology and Antimicrobial Pharmacology; Irán
Fil: van der Lee, H.. Radboud Universiteit Nijmegen; Países Bajos
Fil: Liao, W.. Shanghai Institute Of Medical Mycology; China
Fil: Verweij, P. E.. Radboud Universiteit Nijmegen; Países Bajos
Fil: Seyedmousavi, S.. Radboud Universiteit Nijmegen; Países Bajos. Center of Excellence for Infection Biology and Antimicrobial Pharmacology; Irán. Mazandaran University of Medical Sciences; Irán
description Chromoblastomycosis (CBM) is a recalcitrant fungal skin disease which is difficult to treat, the infection leading to excessive proliferation of host tissues. Therefore, search for appropriate antifungal strategies is urgently needed. Our in vitro studies showed that combination of amphotericin B and terbinafine had synergistic effects against the majority of melanized fungi associated with CBM and similar infections, including Cladophialophora carrionii, C. arxii, Exophiala dermatitidis, E. spinifera, Fonsecaea monophora, F. nubica, F. pedrosoi, and Phialophora verrucosa, with a fractional inhibitory concentration (FIC) value ranging from 0.25 to 1. No synergistic interaction was found for Veronaea botryosa isolates. The results of FIC analysis were supported by response surface analysis using Bliss independence no-interaction model for the isolates tested. Our study suggests that amphotericin B, when combined with terbinafine, allows a significant reduction of MICs. This could provide an option for treatment of severe or unresponsive cases of CBM, particularly in cases due to species of Fonsecaea and Cladophialophora.
publishDate 2018
dc.date.none.fl_str_mv 2018-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/98645
Deng, S.; Lei, W.; de Hoog, G. S.; Yang, L.; Vitale, Roxana Gabriela; et al.; Combination of Amphotericin B and Terbinafine against Melanized Fungi Associated with Chromoblastomycosis; American Society for Microbiology; Antimicrobial Agents and Chemotherapy; 62; 6; 5-2018; 1-7
0066-4804
CONICET Digital
CONICET
url http://hdl.handle.net/11336/98645
identifier_str_mv Deng, S.; Lei, W.; de Hoog, G. S.; Yang, L.; Vitale, Roxana Gabriela; et al.; Combination of Amphotericin B and Terbinafine against Melanized Fungi Associated with Chromoblastomycosis; American Society for Microbiology; Antimicrobial Agents and Chemotherapy; 62; 6; 5-2018; 1-7
0066-4804
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1128/AAC.00270-18
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5971613/
info:eu-repo/semantics/altIdentifier/url/https://aac.asm.org/content/62/6/e00270-18
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/msword
application/pdf
dc.publisher.none.fl_str_mv American Society for Microbiology
publisher.none.fl_str_mv American Society for Microbiology
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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