Dentate network activity is necessary for spatial working memory by supporting CA3 sharp-wave ripple generation and prospective firing of CA3 neurons
- Autores
- Sasaki, Takuya; Piatti, Veronica del Carmen; Hwaun, Ernie; Ahmadi, Siavash; Lisman, John E.; Leutgeb, Stefan; Leutgeb, Jill K.
- Año de publicación
- 2018
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Complex spatial working memory tasks have been shown to require both hippocampal sharp-wave ripple (SWR) activity and dentate gyrus (DG) neuronal activity. We therefore asked whether DG inputs to CA3 contribute to spatial working memory by promoting SWR generation. Recordings from DG and CA3 while rats performed a dentate-dependent working memory task on an eight-arm radial maze revealed that the activity of dentate neurons and the incidence rate of SWRs both increased during reward consumption. We then found reduced reward-related CA3 SWR generation without direct input from dentate granule neurons. Furthermore, CA3 cells with place fields in not-yet-visited arms preferentially fired during SWRs at reward locations, and these prospective CA3 firing patterns were more pronounced for correct trials and were dentate-dependent. These results indicate that coordination of CA3 neuronal activity patterns by DG is necessary for the generation of neuronal firing patterns that support goal-directed behavior and memory.
Fil: Sasaki, Takuya. University of California at San Diego; Estados Unidos. The University of Tokyo; Japón. Japan Science and Technology Agency; Japón
Fil: Piatti, Veronica del Carmen. University of California at San Diego; Estados Unidos
Fil: Hwaun, Ernie. University of California at San Diego; Estados Unidos
Fil: Ahmadi, Siavash. University of California at San Diego; Estados Unidos
Fil: Lisman, John E.. Brandeis University; Estados Unidos
Fil: Leutgeb, Stefan. University of California at San Diego; Estados Unidos
Fil: Leutgeb, Jill K.. University of California at San Diego; Estados Unidos - Materia
-
HIPPOCAMPUS
NEURAL CIRCUITS - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/91142
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spelling |
Dentate network activity is necessary for spatial working memory by supporting CA3 sharp-wave ripple generation and prospective firing of CA3 neuronsSasaki, TakuyaPiatti, Veronica del CarmenHwaun, ErnieAhmadi, SiavashLisman, John E.Leutgeb, StefanLeutgeb, Jill K.HIPPOCAMPUSNEURAL CIRCUITShttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Complex spatial working memory tasks have been shown to require both hippocampal sharp-wave ripple (SWR) activity and dentate gyrus (DG) neuronal activity. We therefore asked whether DG inputs to CA3 contribute to spatial working memory by promoting SWR generation. Recordings from DG and CA3 while rats performed a dentate-dependent working memory task on an eight-arm radial maze revealed that the activity of dentate neurons and the incidence rate of SWRs both increased during reward consumption. We then found reduced reward-related CA3 SWR generation without direct input from dentate granule neurons. Furthermore, CA3 cells with place fields in not-yet-visited arms preferentially fired during SWRs at reward locations, and these prospective CA3 firing patterns were more pronounced for correct trials and were dentate-dependent. These results indicate that coordination of CA3 neuronal activity patterns by DG is necessary for the generation of neuronal firing patterns that support goal-directed behavior and memory.Fil: Sasaki, Takuya. University of California at San Diego; Estados Unidos. The University of Tokyo; Japón. Japan Science and Technology Agency; JapónFil: Piatti, Veronica del Carmen. University of California at San Diego; Estados UnidosFil: Hwaun, Ernie. University of California at San Diego; Estados UnidosFil: Ahmadi, Siavash. University of California at San Diego; Estados UnidosFil: Lisman, John E.. Brandeis University; Estados UnidosFil: Leutgeb, Stefan. University of California at San Diego; Estados UnidosFil: Leutgeb, Jill K.. University of California at San Diego; Estados UnidosNature Publishing Group2018-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/91142Sasaki, Takuya; Piatti, Veronica del Carmen; Hwaun, Ernie; Ahmadi, Siavash; Lisman, John E.; et al.; Dentate network activity is necessary for spatial working memory by supporting CA3 sharp-wave ripple generation and prospective firing of CA3 neurons; Nature Publishing Group; Nature Neuroscience.; 21; 2; 2-2018; 258-2691097-6256CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1038/s41593-017-0061-5info:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/s41593-017-0061-5info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:20:29Zoai:ri.conicet.gov.ar:11336/91142instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:20:29.539CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Dentate network activity is necessary for spatial working memory by supporting CA3 sharp-wave ripple generation and prospective firing of CA3 neurons |
title |
Dentate network activity is necessary for spatial working memory by supporting CA3 sharp-wave ripple generation and prospective firing of CA3 neurons |
spellingShingle |
Dentate network activity is necessary for spatial working memory by supporting CA3 sharp-wave ripple generation and prospective firing of CA3 neurons Sasaki, Takuya HIPPOCAMPUS NEURAL CIRCUITS |
title_short |
Dentate network activity is necessary for spatial working memory by supporting CA3 sharp-wave ripple generation and prospective firing of CA3 neurons |
title_full |
Dentate network activity is necessary for spatial working memory by supporting CA3 sharp-wave ripple generation and prospective firing of CA3 neurons |
title_fullStr |
Dentate network activity is necessary for spatial working memory by supporting CA3 sharp-wave ripple generation and prospective firing of CA3 neurons |
title_full_unstemmed |
Dentate network activity is necessary for spatial working memory by supporting CA3 sharp-wave ripple generation and prospective firing of CA3 neurons |
title_sort |
Dentate network activity is necessary for spatial working memory by supporting CA3 sharp-wave ripple generation and prospective firing of CA3 neurons |
dc.creator.none.fl_str_mv |
Sasaki, Takuya Piatti, Veronica del Carmen Hwaun, Ernie Ahmadi, Siavash Lisman, John E. Leutgeb, Stefan Leutgeb, Jill K. |
author |
Sasaki, Takuya |
author_facet |
Sasaki, Takuya Piatti, Veronica del Carmen Hwaun, Ernie Ahmadi, Siavash Lisman, John E. Leutgeb, Stefan Leutgeb, Jill K. |
author_role |
author |
author2 |
Piatti, Veronica del Carmen Hwaun, Ernie Ahmadi, Siavash Lisman, John E. Leutgeb, Stefan Leutgeb, Jill K. |
author2_role |
author author author author author author |
dc.subject.none.fl_str_mv |
HIPPOCAMPUS NEURAL CIRCUITS |
topic |
HIPPOCAMPUS NEURAL CIRCUITS |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
Complex spatial working memory tasks have been shown to require both hippocampal sharp-wave ripple (SWR) activity and dentate gyrus (DG) neuronal activity. We therefore asked whether DG inputs to CA3 contribute to spatial working memory by promoting SWR generation. Recordings from DG and CA3 while rats performed a dentate-dependent working memory task on an eight-arm radial maze revealed that the activity of dentate neurons and the incidence rate of SWRs both increased during reward consumption. We then found reduced reward-related CA3 SWR generation without direct input from dentate granule neurons. Furthermore, CA3 cells with place fields in not-yet-visited arms preferentially fired during SWRs at reward locations, and these prospective CA3 firing patterns were more pronounced for correct trials and were dentate-dependent. These results indicate that coordination of CA3 neuronal activity patterns by DG is necessary for the generation of neuronal firing patterns that support goal-directed behavior and memory. Fil: Sasaki, Takuya. University of California at San Diego; Estados Unidos. The University of Tokyo; Japón. Japan Science and Technology Agency; Japón Fil: Piatti, Veronica del Carmen. University of California at San Diego; Estados Unidos Fil: Hwaun, Ernie. University of California at San Diego; Estados Unidos Fil: Ahmadi, Siavash. University of California at San Diego; Estados Unidos Fil: Lisman, John E.. Brandeis University; Estados Unidos Fil: Leutgeb, Stefan. University of California at San Diego; Estados Unidos Fil: Leutgeb, Jill K.. University of California at San Diego; Estados Unidos |
description |
Complex spatial working memory tasks have been shown to require both hippocampal sharp-wave ripple (SWR) activity and dentate gyrus (DG) neuronal activity. We therefore asked whether DG inputs to CA3 contribute to spatial working memory by promoting SWR generation. Recordings from DG and CA3 while rats performed a dentate-dependent working memory task on an eight-arm radial maze revealed that the activity of dentate neurons and the incidence rate of SWRs both increased during reward consumption. We then found reduced reward-related CA3 SWR generation without direct input from dentate granule neurons. Furthermore, CA3 cells with place fields in not-yet-visited arms preferentially fired during SWRs at reward locations, and these prospective CA3 firing patterns were more pronounced for correct trials and were dentate-dependent. These results indicate that coordination of CA3 neuronal activity patterns by DG is necessary for the generation of neuronal firing patterns that support goal-directed behavior and memory. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-02 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/91142 Sasaki, Takuya; Piatti, Veronica del Carmen; Hwaun, Ernie; Ahmadi, Siavash; Lisman, John E.; et al.; Dentate network activity is necessary for spatial working memory by supporting CA3 sharp-wave ripple generation and prospective firing of CA3 neurons; Nature Publishing Group; Nature Neuroscience.; 21; 2; 2-2018; 258-269 1097-6256 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/91142 |
identifier_str_mv |
Sasaki, Takuya; Piatti, Veronica del Carmen; Hwaun, Ernie; Ahmadi, Siavash; Lisman, John E.; et al.; Dentate network activity is necessary for spatial working memory by supporting CA3 sharp-wave ripple generation and prospective firing of CA3 neurons; Nature Publishing Group; Nature Neuroscience.; 21; 2; 2-2018; 258-269 1097-6256 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.1038/s41593-017-0061-5 info:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/s41593-017-0061-5 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Nature Publishing Group |
publisher.none.fl_str_mv |
Nature Publishing Group |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1844614185537765376 |
score |
13.070432 |