Ripples Have Distinct Spectral Properties and Phase-Amplitude Coupling With Slow Waves, but Indistinct Unit Firing, in Human Epileptogenic Hippocampus

Autores
Weiss, Shennan A.; Song, Inkyung; Leng, Mei; Pastore, Tomás; Fernandez Slezak, Diego; Waldman, Zachary; Orosz, Iren; Gorniak, Richard; Donmez, Mustafa; Sharan, Ashwini; Wu, Chengyuan; Fried, Itzhak; Sperling, Michael R.; Bragin, Anatol; Engel, Jerome; Nir, Yuval; Staba, Richard
Año de publicación
2020
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Ripple oscillations (80–200 Hz) in the normal hippocampus are involved in memory consolidation during rest and sleep. In the epileptic brain, increased ripple and fast ripple (200–600 Hz) rates serve as a biomarker of epileptogenic brain. We report that both ripples and fast ripples exhibit a preferred phase angle of coupling with the trough-peak (or On-Off) state transition of the sleep slow wave in the hippocampal seizure onset zone (SOZ). Ripples on slow waves in the hippocampal SOZ also had a lower power, greater spectral frequency, and shorter duration than those in the non-SOZ. Slow waves in the mesial temporal lobe modulated the baseline firing rate of excitatory neurons, but did not significantly influence the increased firing rate associated with ripples. In summary, pathological ripples and fast ripples occur preferentially during the On-Off state transition of the slow wave in the epileptogenic hippocampus, and ripples do not require the increased recruitment of excitatory neurons.
Fil: Weiss, Shennan A.. Thomas Jefferson University; Estados Unidos
Fil: Song, Inkyung. Thomas Jefferson University; Estados Unidos
Fil: Leng, Mei. University of California at Los Angeles; Estados Unidos
Fil: Pastore, Tomás. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Computación; Argentina
Fil: Fernandez Slezak, Diego. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Investigación en Ciencias de la Computación. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Investigación en Ciencias de la Computación; Argentina
Fil: Waldman, Zachary. Thomas Jefferson University; Estados Unidos
Fil: Orosz, Iren. University of California at Los Angeles; Estados Unidos
Fil: Gorniak, Richard. Thomas Jefferson University; Estados Unidos
Fil: Donmez, Mustafa. Thomas Jefferson University; Estados Unidos
Fil: Sharan, Ashwini. Thomas Jefferson University; Estados Unidos
Fil: Wu, Chengyuan. Thomas Jefferson University; Estados Unidos
Fil: Fried, Itzhak. University of California at Los Angeles; Estados Unidos
Fil: Sperling, Michael R.. Thomas Jefferson University; Estados Unidos
Fil: Bragin, Anatol. University of California at Los Angeles; Estados Unidos
Fil: Engel, Jerome. University of California at Los Angeles; Estados Unidos
Fil: Nir, Yuval. Tel Aviv University; Israel
Fil: Staba, Richard. University of California at Los Angeles; Estados Unidos
Materia
EPILEPSY
FAST RIPPLE
HIGH-FREQUENCY OSCILLATION
HIPPOCAMPUS
RIPPLE
SLEEP
SLOW WAVE
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/141615
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/141615
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Ripples Have Distinct Spectral Properties and Phase-Amplitude Coupling With Slow Waves, but Indistinct Unit Firing, in Human Epileptogenic HippocampusWeiss, Shennan A.Song, InkyungLeng, MeiPastore, TomásFernandez Slezak, DiegoWaldman, ZacharyOrosz, IrenGorniak, RichardDonmez, MustafaSharan, AshwiniWu, ChengyuanFried, ItzhakSperling, Michael R.Bragin, AnatolEngel, JeromeNir, YuvalStaba, RichardEPILEPSYFAST RIPPLEHIGH-FREQUENCY OSCILLATIONHIPPOCAMPUSRIPPLESLEEPSLOW WAVEhttps://purl.org/becyt/ford/1.2https://purl.org/becyt/ford/1Ripple oscillations (80–200 Hz) in the normal hippocampus are involved in memory consolidation during rest and sleep. In the epileptic brain, increased ripple and fast ripple (200–600 Hz) rates serve as a biomarker of epileptogenic brain. We report that both ripples and fast ripples exhibit a preferred phase angle of coupling with the trough-peak (or On-Off) state transition of the sleep slow wave in the hippocampal seizure onset zone (SOZ). Ripples on slow waves in the hippocampal SOZ also had a lower power, greater spectral frequency, and shorter duration than those in the non-SOZ. Slow waves in the mesial temporal lobe modulated the baseline firing rate of excitatory neurons, but did not significantly influence the increased firing rate associated with ripples. In summary, pathological ripples and fast ripples occur preferentially during the On-Off state transition of the slow wave in the epileptogenic hippocampus, and ripples do not require the increased recruitment of excitatory neurons.Fil: Weiss, Shennan A.. Thomas Jefferson University; Estados UnidosFil: Song, Inkyung. Thomas Jefferson University; Estados UnidosFil: Leng, Mei. University of California at Los Angeles; Estados UnidosFil: Pastore, Tomás. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Computación; ArgentinaFil: Fernandez Slezak, Diego. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Investigación en Ciencias de la Computación. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Investigación en Ciencias de la Computación; ArgentinaFil: Waldman, Zachary. Thomas Jefferson University; Estados UnidosFil: Orosz, Iren. University of California at Los Angeles; Estados UnidosFil: Gorniak, Richard. Thomas Jefferson University; Estados UnidosFil: Donmez, Mustafa. Thomas Jefferson University; Estados UnidosFil: Sharan, Ashwini. Thomas Jefferson University; Estados UnidosFil: Wu, Chengyuan. Thomas Jefferson University; Estados UnidosFil: Fried, Itzhak. University of California at Los Angeles; Estados UnidosFil: Sperling, Michael R.. Thomas Jefferson University; Estados UnidosFil: Bragin, Anatol. University of California at Los Angeles; Estados UnidosFil: Engel, Jerome. University of California at Los Angeles; Estados UnidosFil: Nir, Yuval. Tel Aviv University; IsraelFil: Staba, Richard. University of California at Los Angeles; Estados UnidosFrontiers Media2020-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/141615Weiss, Shennan A.; Song, Inkyung; Leng, Mei; Pastore, Tomás; Fernandez Slezak, Diego; et al.; Ripples Have Distinct Spectral Properties and Phase-Amplitude Coupling With Slow Waves, but Indistinct Unit Firing, in Human Epileptogenic Hippocampus; Frontiers Media; Frontiers in Neurology; 11; 3-20201664-2295CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/article/10.3389/fneur.2020.00174/fullinfo:eu-repo/semantics/altIdentifier/doi/10.3389/fneur.2020.00174info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:04:58Zoai:ri.conicet.gov.ar:11336/141615instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:04:59.118CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Ripples Have Distinct Spectral Properties and Phase-Amplitude Coupling With Slow Waves, but Indistinct Unit Firing, in Human Epileptogenic Hippocampus
title Ripples Have Distinct Spectral Properties and Phase-Amplitude Coupling With Slow Waves, but Indistinct Unit Firing, in Human Epileptogenic Hippocampus
spellingShingle Ripples Have Distinct Spectral Properties and Phase-Amplitude Coupling With Slow Waves, but Indistinct Unit Firing, in Human Epileptogenic Hippocampus
Weiss, Shennan A.
EPILEPSY
FAST RIPPLE
HIGH-FREQUENCY OSCILLATION
HIPPOCAMPUS
RIPPLE
SLEEP
SLOW WAVE
title_short Ripples Have Distinct Spectral Properties and Phase-Amplitude Coupling With Slow Waves, but Indistinct Unit Firing, in Human Epileptogenic Hippocampus
title_full Ripples Have Distinct Spectral Properties and Phase-Amplitude Coupling With Slow Waves, but Indistinct Unit Firing, in Human Epileptogenic Hippocampus
title_fullStr Ripples Have Distinct Spectral Properties and Phase-Amplitude Coupling With Slow Waves, but Indistinct Unit Firing, in Human Epileptogenic Hippocampus
title_full_unstemmed Ripples Have Distinct Spectral Properties and Phase-Amplitude Coupling With Slow Waves, but Indistinct Unit Firing, in Human Epileptogenic Hippocampus
title_sort Ripples Have Distinct Spectral Properties and Phase-Amplitude Coupling With Slow Waves, but Indistinct Unit Firing, in Human Epileptogenic Hippocampus
dc.creator.none.fl_str_mv Weiss, Shennan A.
Song, Inkyung
Leng, Mei
Pastore, Tomás
Fernandez Slezak, Diego
Waldman, Zachary
Orosz, Iren
Gorniak, Richard
Donmez, Mustafa
Sharan, Ashwini
Wu, Chengyuan
Fried, Itzhak
Sperling, Michael R.
Bragin, Anatol
Engel, Jerome
Nir, Yuval
Staba, Richard
author Weiss, Shennan A.
author_facet Weiss, Shennan A.
Song, Inkyung
Leng, Mei
Pastore, Tomás
Fernandez Slezak, Diego
Waldman, Zachary
Orosz, Iren
Gorniak, Richard
Donmez, Mustafa
Sharan, Ashwini
Wu, Chengyuan
Fried, Itzhak
Sperling, Michael R.
Bragin, Anatol
Engel, Jerome
Nir, Yuval
Staba, Richard
author_role author
author2 Song, Inkyung
Leng, Mei
Pastore, Tomás
Fernandez Slezak, Diego
Waldman, Zachary
Orosz, Iren
Gorniak, Richard
Donmez, Mustafa
Sharan, Ashwini
Wu, Chengyuan
Fried, Itzhak
Sperling, Michael R.
Bragin, Anatol
Engel, Jerome
Nir, Yuval
Staba, Richard
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv EPILEPSY
FAST RIPPLE
HIGH-FREQUENCY OSCILLATION
HIPPOCAMPUS
RIPPLE
SLEEP
SLOW WAVE
topic EPILEPSY
FAST RIPPLE
HIGH-FREQUENCY OSCILLATION
HIPPOCAMPUS
RIPPLE
SLEEP
SLOW WAVE
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.2
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Ripple oscillations (80–200 Hz) in the normal hippocampus are involved in memory consolidation during rest and sleep. In the epileptic brain, increased ripple and fast ripple (200–600 Hz) rates serve as a biomarker of epileptogenic brain. We report that both ripples and fast ripples exhibit a preferred phase angle of coupling with the trough-peak (or On-Off) state transition of the sleep slow wave in the hippocampal seizure onset zone (SOZ). Ripples on slow waves in the hippocampal SOZ also had a lower power, greater spectral frequency, and shorter duration than those in the non-SOZ. Slow waves in the mesial temporal lobe modulated the baseline firing rate of excitatory neurons, but did not significantly influence the increased firing rate associated with ripples. In summary, pathological ripples and fast ripples occur preferentially during the On-Off state transition of the slow wave in the epileptogenic hippocampus, and ripples do not require the increased recruitment of excitatory neurons.
Fil: Weiss, Shennan A.. Thomas Jefferson University; Estados Unidos
Fil: Song, Inkyung. Thomas Jefferson University; Estados Unidos
Fil: Leng, Mei. University of California at Los Angeles; Estados Unidos
Fil: Pastore, Tomás. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Computación; Argentina
Fil: Fernandez Slezak, Diego. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Investigación en Ciencias de la Computación. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Investigación en Ciencias de la Computación; Argentina
Fil: Waldman, Zachary. Thomas Jefferson University; Estados Unidos
Fil: Orosz, Iren. University of California at Los Angeles; Estados Unidos
Fil: Gorniak, Richard. Thomas Jefferson University; Estados Unidos
Fil: Donmez, Mustafa. Thomas Jefferson University; Estados Unidos
Fil: Sharan, Ashwini. Thomas Jefferson University; Estados Unidos
Fil: Wu, Chengyuan. Thomas Jefferson University; Estados Unidos
Fil: Fried, Itzhak. University of California at Los Angeles; Estados Unidos
Fil: Sperling, Michael R.. Thomas Jefferson University; Estados Unidos
Fil: Bragin, Anatol. University of California at Los Angeles; Estados Unidos
Fil: Engel, Jerome. University of California at Los Angeles; Estados Unidos
Fil: Nir, Yuval. Tel Aviv University; Israel
Fil: Staba, Richard. University of California at Los Angeles; Estados Unidos
description Ripple oscillations (80–200 Hz) in the normal hippocampus are involved in memory consolidation during rest and sleep. In the epileptic brain, increased ripple and fast ripple (200–600 Hz) rates serve as a biomarker of epileptogenic brain. We report that both ripples and fast ripples exhibit a preferred phase angle of coupling with the trough-peak (or On-Off) state transition of the sleep slow wave in the hippocampal seizure onset zone (SOZ). Ripples on slow waves in the hippocampal SOZ also had a lower power, greater spectral frequency, and shorter duration than those in the non-SOZ. Slow waves in the mesial temporal lobe modulated the baseline firing rate of excitatory neurons, but did not significantly influence the increased firing rate associated with ripples. In summary, pathological ripples and fast ripples occur preferentially during the On-Off state transition of the slow wave in the epileptogenic hippocampus, and ripples do not require the increased recruitment of excitatory neurons.
publishDate 2020
dc.date.none.fl_str_mv 2020-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/141615
Weiss, Shennan A.; Song, Inkyung; Leng, Mei; Pastore, Tomás; Fernandez Slezak, Diego; et al.; Ripples Have Distinct Spectral Properties and Phase-Amplitude Coupling With Slow Waves, but Indistinct Unit Firing, in Human Epileptogenic Hippocampus; Frontiers Media; Frontiers in Neurology; 11; 3-2020
1664-2295
CONICET Digital
CONICET
url http://hdl.handle.net/11336/141615
identifier_str_mv Weiss, Shennan A.; Song, Inkyung; Leng, Mei; Pastore, Tomás; Fernandez Slezak, Diego; et al.; Ripples Have Distinct Spectral Properties and Phase-Amplitude Coupling With Slow Waves, but Indistinct Unit Firing, in Human Epileptogenic Hippocampus; Frontiers Media; Frontiers in Neurology; 11; 3-2020
1664-2295
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/article/10.3389/fneur.2020.00174/full
info:eu-repo/semantics/altIdentifier/doi/10.3389/fneur.2020.00174
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269884962045952
score 13.13397

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