Trypanosoma cruzi: Infectivity modulation of a clone after passages through different hosts
- Autores
- Pérez Brandan, Cecilia María; Padilla, Ángel Marcelo; Diosque, Patricio; Basombrío, Miguel Ángel Manuel
- Año de publicación
- 2006
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Although Trypanosoma cruzi virulence can be modified through passages in vivo or long-term in vitro culture, the mechanisms involved are poorly understood. Here we report modifications in the infectivity of a T. cruzi clone after passages in different hosts without detectable changes in parasite genetic patterns. A clone was obtained from a T. cruzi IIe isolate and showed to be less virulent than the original isolate (p < 0.05). This clone was enzymatically similar to the original isolate as shown by multilocus enzyme electrophoresis. Infection of this clone was compared by successive passages in mice and guinea pigs. The mouse-passaged subline became more virulent for both host species compared to the guinea pig-passaged subline (p < 0.05). The clone line displayed similar random amplified polymorphic DNA patterns before and after passages in different hosts suggesting that alterations in virulence could be a result of a differential expression of virulence factors.
Fil: Pérez Brandan, Cecilia María. Universidad Nacional de Salta; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta. Instituto de Patología Experimental. Universidad Nacional de Salta. Facultad de Ciencias de la Salud. Instituto de Patología Experimental; Argentina
Fil: Padilla, Ángel Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta. Instituto de Patología Experimental. Universidad Nacional de Salta. Facultad de Ciencias de la Salud. Instituto de Patología Experimental; Argentina. Universidad Nacional de Salta; Argentina
Fil: Diosque, Patricio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta. Instituto de Patología Experimental. Universidad Nacional de Salta. Facultad de Ciencias de la Salud. Instituto de Patología Experimental; Argentina. Universidad Nacional de Salta; Argentina
Fil: Basombrío, Miguel Ángel Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta. Instituto de Patología Experimental. Universidad Nacional de Salta. Facultad de Ciencias de la Salud. Instituto de Patología Experimental; Argentina. Universidad Nacional de Salta; Argentina - Materia
-
Clone Line from Tolac1 Isolate
Clones
Cta1
Deoxyribonucleic Acid
Dna
Glucose-6-Phosphate Isomerase
Gpi
Infectivity
Lit
Lit Plus Fetal Bovine Serum, Hemin, And Penicillin-Streptomycin
Lit-Hsp
Liver Infusion Tryptose Medium
Mlee
Multilocus Enzyme Electrophoresis
Random Amplified Polymorphic Dna
Rapd
Ribonucleic Acid
Rna
Selection
Tae
Tris-Acetate Edta
Trypanosoma Cruzi - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/36596
Ver los metadatos del registro completo
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oai:ri.conicet.gov.ar:11336/36596 |
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spelling |
Trypanosoma cruzi: Infectivity modulation of a clone after passages through different hostsPérez Brandan, Cecilia MaríaPadilla, Ángel MarceloDiosque, PatricioBasombrío, Miguel Ángel ManuelClone Line from Tolac1 IsolateClonesCta1Deoxyribonucleic AcidDnaGlucose-6-Phosphate IsomeraseGpiInfectivityLitLit Plus Fetal Bovine Serum, Hemin, And Penicillin-StreptomycinLit-HspLiver Infusion Tryptose MediumMleeMultilocus Enzyme ElectrophoresisRandom Amplified Polymorphic DnaRapdRibonucleic AcidRnaSelectionTaeTris-Acetate EdtaTrypanosoma Cruzihttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Although Trypanosoma cruzi virulence can be modified through passages in vivo or long-term in vitro culture, the mechanisms involved are poorly understood. Here we report modifications in the infectivity of a T. cruzi clone after passages in different hosts without detectable changes in parasite genetic patterns. A clone was obtained from a T. cruzi IIe isolate and showed to be less virulent than the original isolate (p < 0.05). This clone was enzymatically similar to the original isolate as shown by multilocus enzyme electrophoresis. Infection of this clone was compared by successive passages in mice and guinea pigs. The mouse-passaged subline became more virulent for both host species compared to the guinea pig-passaged subline (p < 0.05). The clone line displayed similar random amplified polymorphic DNA patterns before and after passages in different hosts suggesting that alterations in virulence could be a result of a differential expression of virulence factors.Fil: Pérez Brandan, Cecilia María. Universidad Nacional de Salta; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta. Instituto de Patología Experimental. Universidad Nacional de Salta. Facultad de Ciencias de la Salud. Instituto de Patología Experimental; ArgentinaFil: Padilla, Ángel Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta. Instituto de Patología Experimental. Universidad Nacional de Salta. Facultad de Ciencias de la Salud. Instituto de Patología Experimental; Argentina. Universidad Nacional de Salta; ArgentinaFil: Diosque, Patricio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta. Instituto de Patología Experimental. Universidad Nacional de Salta. Facultad de Ciencias de la Salud. Instituto de Patología Experimental; Argentina. Universidad Nacional de Salta; ArgentinaFil: Basombrío, Miguel Ángel Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta. Instituto de Patología Experimental. Universidad Nacional de Salta. Facultad de Ciencias de la Salud. Instituto de Patología Experimental; Argentina. Universidad Nacional de Salta; ArgentinaElsevier2006-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/36596Pérez Brandan, Cecilia María; Padilla, Ángel Marcelo; Diosque, Patricio; Basombrío, Miguel Ángel Manuel; Trypanosoma cruzi: Infectivity modulation of a clone after passages through different hosts; Elsevier; Experimental Parasitology; 114; 2; 10-2006; 89-930014-4894CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.exppara.2006.02.014info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0014489406000439info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:20:34Zoai:ri.conicet.gov.ar:11336/36596instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:20:35.188CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Trypanosoma cruzi: Infectivity modulation of a clone after passages through different hosts |
title |
Trypanosoma cruzi: Infectivity modulation of a clone after passages through different hosts |
spellingShingle |
Trypanosoma cruzi: Infectivity modulation of a clone after passages through different hosts Pérez Brandan, Cecilia María Clone Line from Tolac1 Isolate Clones Cta1 Deoxyribonucleic Acid Dna Glucose-6-Phosphate Isomerase Gpi Infectivity Lit Lit Plus Fetal Bovine Serum, Hemin, And Penicillin-Streptomycin Lit-Hsp Liver Infusion Tryptose Medium Mlee Multilocus Enzyme Electrophoresis Random Amplified Polymorphic Dna Rapd Ribonucleic Acid Rna Selection Tae Tris-Acetate Edta Trypanosoma Cruzi |
title_short |
Trypanosoma cruzi: Infectivity modulation of a clone after passages through different hosts |
title_full |
Trypanosoma cruzi: Infectivity modulation of a clone after passages through different hosts |
title_fullStr |
Trypanosoma cruzi: Infectivity modulation of a clone after passages through different hosts |
title_full_unstemmed |
Trypanosoma cruzi: Infectivity modulation of a clone after passages through different hosts |
title_sort |
Trypanosoma cruzi: Infectivity modulation of a clone after passages through different hosts |
dc.creator.none.fl_str_mv |
Pérez Brandan, Cecilia María Padilla, Ángel Marcelo Diosque, Patricio Basombrío, Miguel Ángel Manuel |
author |
Pérez Brandan, Cecilia María |
author_facet |
Pérez Brandan, Cecilia María Padilla, Ángel Marcelo Diosque, Patricio Basombrío, Miguel Ángel Manuel |
author_role |
author |
author2 |
Padilla, Ángel Marcelo Diosque, Patricio Basombrío, Miguel Ángel Manuel |
author2_role |
author author author |
dc.subject.none.fl_str_mv |
Clone Line from Tolac1 Isolate Clones Cta1 Deoxyribonucleic Acid Dna Glucose-6-Phosphate Isomerase Gpi Infectivity Lit Lit Plus Fetal Bovine Serum, Hemin, And Penicillin-Streptomycin Lit-Hsp Liver Infusion Tryptose Medium Mlee Multilocus Enzyme Electrophoresis Random Amplified Polymorphic Dna Rapd Ribonucleic Acid Rna Selection Tae Tris-Acetate Edta Trypanosoma Cruzi |
topic |
Clone Line from Tolac1 Isolate Clones Cta1 Deoxyribonucleic Acid Dna Glucose-6-Phosphate Isomerase Gpi Infectivity Lit Lit Plus Fetal Bovine Serum, Hemin, And Penicillin-Streptomycin Lit-Hsp Liver Infusion Tryptose Medium Mlee Multilocus Enzyme Electrophoresis Random Amplified Polymorphic Dna Rapd Ribonucleic Acid Rna Selection Tae Tris-Acetate Edta Trypanosoma Cruzi |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 |
dc.description.none.fl_txt_mv |
Although Trypanosoma cruzi virulence can be modified through passages in vivo or long-term in vitro culture, the mechanisms involved are poorly understood. Here we report modifications in the infectivity of a T. cruzi clone after passages in different hosts without detectable changes in parasite genetic patterns. A clone was obtained from a T. cruzi IIe isolate and showed to be less virulent than the original isolate (p < 0.05). This clone was enzymatically similar to the original isolate as shown by multilocus enzyme electrophoresis. Infection of this clone was compared by successive passages in mice and guinea pigs. The mouse-passaged subline became more virulent for both host species compared to the guinea pig-passaged subline (p < 0.05). The clone line displayed similar random amplified polymorphic DNA patterns before and after passages in different hosts suggesting that alterations in virulence could be a result of a differential expression of virulence factors. Fil: Pérez Brandan, Cecilia María. Universidad Nacional de Salta; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta. Instituto de Patología Experimental. Universidad Nacional de Salta. Facultad de Ciencias de la Salud. Instituto de Patología Experimental; Argentina Fil: Padilla, Ángel Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta. Instituto de Patología Experimental. Universidad Nacional de Salta. Facultad de Ciencias de la Salud. Instituto de Patología Experimental; Argentina. Universidad Nacional de Salta; Argentina Fil: Diosque, Patricio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta. Instituto de Patología Experimental. Universidad Nacional de Salta. Facultad de Ciencias de la Salud. Instituto de Patología Experimental; Argentina. Universidad Nacional de Salta; Argentina Fil: Basombrío, Miguel Ángel Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta. Instituto de Patología Experimental. Universidad Nacional de Salta. Facultad de Ciencias de la Salud. Instituto de Patología Experimental; Argentina. Universidad Nacional de Salta; Argentina |
description |
Although Trypanosoma cruzi virulence can be modified through passages in vivo or long-term in vitro culture, the mechanisms involved are poorly understood. Here we report modifications in the infectivity of a T. cruzi clone after passages in different hosts without detectable changes in parasite genetic patterns. A clone was obtained from a T. cruzi IIe isolate and showed to be less virulent than the original isolate (p < 0.05). This clone was enzymatically similar to the original isolate as shown by multilocus enzyme electrophoresis. Infection of this clone was compared by successive passages in mice and guinea pigs. The mouse-passaged subline became more virulent for both host species compared to the guinea pig-passaged subline (p < 0.05). The clone line displayed similar random amplified polymorphic DNA patterns before and after passages in different hosts suggesting that alterations in virulence could be a result of a differential expression of virulence factors. |
publishDate |
2006 |
dc.date.none.fl_str_mv |
2006-10 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/36596 Pérez Brandan, Cecilia María; Padilla, Ángel Marcelo; Diosque, Patricio; Basombrío, Miguel Ángel Manuel; Trypanosoma cruzi: Infectivity modulation of a clone after passages through different hosts; Elsevier; Experimental Parasitology; 114; 2; 10-2006; 89-93 0014-4894 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/36596 |
identifier_str_mv |
Pérez Brandan, Cecilia María; Padilla, Ángel Marcelo; Diosque, Patricio; Basombrío, Miguel Ángel Manuel; Trypanosoma cruzi: Infectivity modulation of a clone after passages through different hosts; Elsevier; Experimental Parasitology; 114; 2; 10-2006; 89-93 0014-4894 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.exppara.2006.02.014 info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0014489406000439 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1844614188069027840 |
score |
13.070432 |