A new design of silybum marianum tablets by direct compression

Autores
Cianchino, Valeria Andrea; Jofre, María Belén; Peralta, Cecilia Mariana; Favier, Laura Silvina; Ortega, Claudia Alicia; Cifuente, Diego Alberto
Año de publicación
2019
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
In the present paper we described a new design of herbal medicine tablets by direct compression using the ethanolic extract of Silybum marianum (L.) Gaertn. S. marianum extract is used in popular medicine as hepatoprotective herbal medicine. The alcoholic extract was obtained from seeds by soxhlet. Five pharmaceutical formulations were prepared using the extract as active principle, Aeroperl® 300 Pharma, as carrier and different diluents (CombiLac®, MicroceLac® 100, StarLac®, Cellactose® 80 and FlowLac® 90). The micromeritic properties were determined for all the physical mixtures. The results of angle of repose, compressibility and Hausner ratio indicated that the all powder mixtures had excellent flow properties and compressibility. In addition, the tablets properties and quality parameters were evaluated (weight variation, hardness, friability, disintegration test, drug content and dissolution test). One formulation (F5: herbal ethanolic extract 20 %, Aeroperl® 20 %, FlowLac® 90 57 %, Glycolate starch 2 % and magnesium stearate 1 %) showed excellent rheological properties and the best biopharmaceutical parameters in concordance with the pharmacopoeial specifications. Thus, taking into account the poor solubility of silymarin in water, this novel design could be easily applied to others poorly soluble drugs or herbal extract in order to improve its bioavailability.
Fil: Cianchino, Valeria Andrea. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; Argentina
Fil: Jofre, María Belén. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Investigaciones en Tecnología Química. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Investigaciones en Tecnología Química; Argentina
Fil: Peralta, Cecilia Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; Argentina
Fil: Favier, Laura Silvina. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; Argentina
Fil: Ortega, Claudia Alicia. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; Argentina
Fil: Cifuente, Diego Alberto. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Investigaciones en Tecnología Química. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Investigaciones en Tecnología Química; Argentina
Materia
HERBAL MEDICINE
SILYBUM MARIANUM
DIRECT COMPRESSION
RHEOLOGY
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/123384
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/123384
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling A new design of silybum marianum tablets by direct compressionCianchino, Valeria AndreaJofre, María BelénPeralta, Cecilia MarianaFavier, Laura SilvinaOrtega, Claudia AliciaCifuente, Diego AlbertoHERBAL MEDICINESILYBUM MARIANUMDIRECT COMPRESSIONRHEOLOGYhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1In the present paper we described a new design of herbal medicine tablets by direct compression using the ethanolic extract of Silybum marianum (L.) Gaertn. S. marianum extract is used in popular medicine as hepatoprotective herbal medicine. The alcoholic extract was obtained from seeds by soxhlet. Five pharmaceutical formulations were prepared using the extract as active principle, Aeroperl® 300 Pharma, as carrier and different diluents (CombiLac®, MicroceLac® 100, StarLac®, Cellactose® 80 and FlowLac® 90). The micromeritic properties were determined for all the physical mixtures. The results of angle of repose, compressibility and Hausner ratio indicated that the all powder mixtures had excellent flow properties and compressibility. In addition, the tablets properties and quality parameters were evaluated (weight variation, hardness, friability, disintegration test, drug content and dissolution test). One formulation (F5: herbal ethanolic extract 20 %, Aeroperl® 20 %, FlowLac® 90 57 %, Glycolate starch 2 % and magnesium stearate 1 %) showed excellent rheological properties and the best biopharmaceutical parameters in concordance with the pharmacopoeial specifications. Thus, taking into account the poor solubility of silymarin in water, this novel design could be easily applied to others poorly soluble drugs or herbal extract in order to improve its bioavailability.Fil: Cianchino, Valeria Andrea. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; ArgentinaFil: Jofre, María Belén. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Investigaciones en Tecnología Química. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Investigaciones en Tecnología Química; ArgentinaFil: Peralta, Cecilia Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; ArgentinaFil: Favier, Laura Silvina. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; ArgentinaFil: Ortega, Claudia Alicia. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; ArgentinaFil: Cifuente, Diego Alberto. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Investigaciones en Tecnología Química. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Investigaciones en Tecnología Química; ArgentinaLife Science Informatics Publications2019-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/123384Cianchino, Valeria Andrea; Jofre, María Belén; Peralta, Cecilia Mariana; Favier, Laura Silvina; Ortega, Claudia Alicia; et al.; A new design of silybum marianum tablets by direct compression; Life Science Informatics Publications; Research Journal of Life Sciences, Bioinformatics, Pharmaceutical and Chemical Science; 5; 2; 3-2019; 572-5822454-6348CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.rjlbpcs.com/article-pdf-downloads/2019/26/572.pdfinfo:eu-repo/semantics/altIdentifier/doi/10.26479/2019.0502.42info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:34:27Zoai:ri.conicet.gov.ar:11336/123384instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:34:27.295CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv A new design of silybum marianum tablets by direct compression
title A new design of silybum marianum tablets by direct compression
spellingShingle A new design of silybum marianum tablets by direct compression
Cianchino, Valeria Andrea
HERBAL MEDICINE
SILYBUM MARIANUM
DIRECT COMPRESSION
RHEOLOGY
title_short A new design of silybum marianum tablets by direct compression
title_full A new design of silybum marianum tablets by direct compression
title_fullStr A new design of silybum marianum tablets by direct compression
title_full_unstemmed A new design of silybum marianum tablets by direct compression
title_sort A new design of silybum marianum tablets by direct compression
dc.creator.none.fl_str_mv Cianchino, Valeria Andrea
Jofre, María Belén
Peralta, Cecilia Mariana
Favier, Laura Silvina
Ortega, Claudia Alicia
Cifuente, Diego Alberto
author Cianchino, Valeria Andrea
author_facet Cianchino, Valeria Andrea
Jofre, María Belén
Peralta, Cecilia Mariana
Favier, Laura Silvina
Ortega, Claudia Alicia
Cifuente, Diego Alberto
author_role author
author2 Jofre, María Belén
Peralta, Cecilia Mariana
Favier, Laura Silvina
Ortega, Claudia Alicia
Cifuente, Diego Alberto
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv HERBAL MEDICINE
SILYBUM MARIANUM
DIRECT COMPRESSION
RHEOLOGY
topic HERBAL MEDICINE
SILYBUM MARIANUM
DIRECT COMPRESSION
RHEOLOGY
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv In the present paper we described a new design of herbal medicine tablets by direct compression using the ethanolic extract of Silybum marianum (L.) Gaertn. S. marianum extract is used in popular medicine as hepatoprotective herbal medicine. The alcoholic extract was obtained from seeds by soxhlet. Five pharmaceutical formulations were prepared using the extract as active principle, Aeroperl® 300 Pharma, as carrier and different diluents (CombiLac®, MicroceLac® 100, StarLac®, Cellactose® 80 and FlowLac® 90). The micromeritic properties were determined for all the physical mixtures. The results of angle of repose, compressibility and Hausner ratio indicated that the all powder mixtures had excellent flow properties and compressibility. In addition, the tablets properties and quality parameters were evaluated (weight variation, hardness, friability, disintegration test, drug content and dissolution test). One formulation (F5: herbal ethanolic extract 20 %, Aeroperl® 20 %, FlowLac® 90 57 %, Glycolate starch 2 % and magnesium stearate 1 %) showed excellent rheological properties and the best biopharmaceutical parameters in concordance with the pharmacopoeial specifications. Thus, taking into account the poor solubility of silymarin in water, this novel design could be easily applied to others poorly soluble drugs or herbal extract in order to improve its bioavailability.
Fil: Cianchino, Valeria Andrea. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; Argentina
Fil: Jofre, María Belén. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Investigaciones en Tecnología Química. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Investigaciones en Tecnología Química; Argentina
Fil: Peralta, Cecilia Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; Argentina
Fil: Favier, Laura Silvina. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; Argentina
Fil: Ortega, Claudia Alicia. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; Argentina
Fil: Cifuente, Diego Alberto. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Investigaciones en Tecnología Química. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Investigaciones en Tecnología Química; Argentina
description In the present paper we described a new design of herbal medicine tablets by direct compression using the ethanolic extract of Silybum marianum (L.) Gaertn. S. marianum extract is used in popular medicine as hepatoprotective herbal medicine. The alcoholic extract was obtained from seeds by soxhlet. Five pharmaceutical formulations were prepared using the extract as active principle, Aeroperl® 300 Pharma, as carrier and different diluents (CombiLac®, MicroceLac® 100, StarLac®, Cellactose® 80 and FlowLac® 90). The micromeritic properties were determined for all the physical mixtures. The results of angle of repose, compressibility and Hausner ratio indicated that the all powder mixtures had excellent flow properties and compressibility. In addition, the tablets properties and quality parameters were evaluated (weight variation, hardness, friability, disintegration test, drug content and dissolution test). One formulation (F5: herbal ethanolic extract 20 %, Aeroperl® 20 %, FlowLac® 90 57 %, Glycolate starch 2 % and magnesium stearate 1 %) showed excellent rheological properties and the best biopharmaceutical parameters in concordance with the pharmacopoeial specifications. Thus, taking into account the poor solubility of silymarin in water, this novel design could be easily applied to others poorly soluble drugs or herbal extract in order to improve its bioavailability.
publishDate 2019
dc.date.none.fl_str_mv 2019-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/123384
Cianchino, Valeria Andrea; Jofre, María Belén; Peralta, Cecilia Mariana; Favier, Laura Silvina; Ortega, Claudia Alicia; et al.; A new design of silybum marianum tablets by direct compression; Life Science Informatics Publications; Research Journal of Life Sciences, Bioinformatics, Pharmaceutical and Chemical Science; 5; 2; 3-2019; 572-582
2454-6348
CONICET Digital
CONICET
url http://hdl.handle.net/11336/123384
identifier_str_mv Cianchino, Valeria Andrea; Jofre, María Belén; Peralta, Cecilia Mariana; Favier, Laura Silvina; Ortega, Claudia Alicia; et al.; A new design of silybum marianum tablets by direct compression; Life Science Informatics Publications; Research Journal of Life Sciences, Bioinformatics, Pharmaceutical and Chemical Science; 5; 2; 3-2019; 572-582
2454-6348
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.rjlbpcs.com/article-pdf-downloads/2019/26/572.pdf
info:eu-repo/semantics/altIdentifier/doi/10.26479/2019.0502.42
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Life Science Informatics Publications
publisher.none.fl_str_mv Life Science Informatics Publications
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.928904

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