Patient-Reported Outcomes After Platelet-Rich Plasma, Bone Marrow Aspirate, and Adipose-Derived Mesenchymal Stem Cell Injections for Symptomatic Knee Osteoarthritis

Autores
Estrada, Esteban; Décima, Jose L.; Rodríguez, Marcelo; Di Tomaso, Marianela; Roberti, Javier Eugenio
Año de publicación
2020
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Objective: The objective of this study was to compare platelet-rich plasma (PRP), bone marrow aspirate concentrate (BMAC), and adipose-derived mesenchymal stem cell (MSC) injections in the treatment of osteoarthritis (OA) of the knee using functional scores. Methods: A total of 89 patients with painful knee OA were included in this study. Patients were assigned to one of the 3 treatments according to severity of OA as indicated by symptoms and radiography to PRP (stage I), BMAC (stage II), or adipose-derived MSC (stage III). Clinical assessment was performed using the Knee Society Score, which combines the Knee Score, based on the clinical parameters, and the Functional Score, and IKDC score. Surveys were completed at preoperative and at 90, 180, and 265 days postoperative. The follow-up responses were compared with baseline and between treatment groups. Results: Treatment with PRP, BMAC, and adipose-derived MSC included 29 (32.6%), 27 (30.3%), and 33 (37.1%) patients, respectively. For the total group, median age was 61 years (range: 22-84 years). Score values were comparable among treatment groups at baseline. Statistically significant improvement was observed in the 3 groups according to the 3 scores at all time points during follow-up compared with baseline. No difference was found among treatment type. Conclusions: Our findings support previous reports and encourage further research on the use of these cost-effective treatments for OA of the knee.
Fil: Estrada, Esteban. Gobierno de la Provincia de San Luis. Hospital Policlinico Regional Juan Domingo Peron.; Argentina
Fil: Décima, Jose L.. Gobierno de la Provincia de San Luis. Hospital Policlinico Regional Juan Domingo Peron.; Argentina
Fil: Rodríguez, Marcelo. Gobierno de la Provincia de San Luis. Hospital Policlinico Regional Juan Domingo Peron.; Argentina
Fil: Di Tomaso, Marianela. Gobierno de la Provincia de San Luis. Hospital Policlinico Regional Juan Domingo Peron.; Argentina
Fil: Roberti, Javier Eugenio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; Argentina. Gobierno de la Provincia de San Luis. Hospital Policlinico Regional Juan Domingo Peron.; Argentina
Materia
ADIPOSE-DERIVED MESENCHYMAL STEM CELL
BONE MARROW ASPIRATE CONCENTRATE
KNEE
OSTEOARTHRITIS
PLATELET-RICH PLASMA
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/145180
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/145180
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Patient-Reported Outcomes After Platelet-Rich Plasma, Bone Marrow Aspirate, and Adipose-Derived Mesenchymal Stem Cell Injections for Symptomatic Knee OsteoarthritisEstrada, EstebanDécima, Jose L.Rodríguez, MarceloDi Tomaso, MarianelaRoberti, Javier EugenioADIPOSE-DERIVED MESENCHYMAL STEM CELLBONE MARROW ASPIRATE CONCENTRATEKNEEOSTEOARTHRITISPLATELET-RICH PLASMAhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Objective: The objective of this study was to compare platelet-rich plasma (PRP), bone marrow aspirate concentrate (BMAC), and adipose-derived mesenchymal stem cell (MSC) injections in the treatment of osteoarthritis (OA) of the knee using functional scores. Methods: A total of 89 patients with painful knee OA were included in this study. Patients were assigned to one of the 3 treatments according to severity of OA as indicated by symptoms and radiography to PRP (stage I), BMAC (stage II), or adipose-derived MSC (stage III). Clinical assessment was performed using the Knee Society Score, which combines the Knee Score, based on the clinical parameters, and the Functional Score, and IKDC score. Surveys were completed at preoperative and at 90, 180, and 265 days postoperative. The follow-up responses were compared with baseline and between treatment groups. Results: Treatment with PRP, BMAC, and adipose-derived MSC included 29 (32.6%), 27 (30.3%), and 33 (37.1%) patients, respectively. For the total group, median age was 61 years (range: 22-84 years). Score values were comparable among treatment groups at baseline. Statistically significant improvement was observed in the 3 groups according to the 3 scores at all time points during follow-up compared with baseline. No difference was found among treatment type. Conclusions: Our findings support previous reports and encourage further research on the use of these cost-effective treatments for OA of the knee.Fil: Estrada, Esteban. Gobierno de la Provincia de San Luis. Hospital Policlinico Regional Juan Domingo Peron.; ArgentinaFil: Décima, Jose L.. Gobierno de la Provincia de San Luis. Hospital Policlinico Regional Juan Domingo Peron.; ArgentinaFil: Rodríguez, Marcelo. Gobierno de la Provincia de San Luis. Hospital Policlinico Regional Juan Domingo Peron.; ArgentinaFil: Di Tomaso, Marianela. Gobierno de la Provincia de San Luis. Hospital Policlinico Regional Juan Domingo Peron.; ArgentinaFil: Roberti, Javier Eugenio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; Argentina. Gobierno de la Provincia de San Luis. Hospital Policlinico Regional Juan Domingo Peron.; ArgentinaSAGE Publications2020-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/145180Estrada, Esteban; Décima, Jose L.; Rodríguez, Marcelo; Di Tomaso, Marianela; Roberti, Javier Eugenio; Patient-Reported Outcomes After Platelet-Rich Plasma, Bone Marrow Aspirate, and Adipose-Derived Mesenchymal Stem Cell Injections for Symptomatic Knee Osteoarthritis; SAGE Publications; Clinical Medicine Insights: Arthritis and Musculoskeletal Disorders; 13; 7-2020; 1-41179-5441CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1177/1179544120931086info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:53:15Zoai:ri.conicet.gov.ar:11336/145180instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:53:15.72CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Patient-Reported Outcomes After Platelet-Rich Plasma, Bone Marrow Aspirate, and Adipose-Derived Mesenchymal Stem Cell Injections for Symptomatic Knee Osteoarthritis
title Patient-Reported Outcomes After Platelet-Rich Plasma, Bone Marrow Aspirate, and Adipose-Derived Mesenchymal Stem Cell Injections for Symptomatic Knee Osteoarthritis
spellingShingle Patient-Reported Outcomes After Platelet-Rich Plasma, Bone Marrow Aspirate, and Adipose-Derived Mesenchymal Stem Cell Injections for Symptomatic Knee Osteoarthritis
Estrada, Esteban
ADIPOSE-DERIVED MESENCHYMAL STEM CELL
BONE MARROW ASPIRATE CONCENTRATE
KNEE
OSTEOARTHRITIS
PLATELET-RICH PLASMA
title_short Patient-Reported Outcomes After Platelet-Rich Plasma, Bone Marrow Aspirate, and Adipose-Derived Mesenchymal Stem Cell Injections for Symptomatic Knee Osteoarthritis
title_full Patient-Reported Outcomes After Platelet-Rich Plasma, Bone Marrow Aspirate, and Adipose-Derived Mesenchymal Stem Cell Injections for Symptomatic Knee Osteoarthritis
title_fullStr Patient-Reported Outcomes After Platelet-Rich Plasma, Bone Marrow Aspirate, and Adipose-Derived Mesenchymal Stem Cell Injections for Symptomatic Knee Osteoarthritis
title_full_unstemmed Patient-Reported Outcomes After Platelet-Rich Plasma, Bone Marrow Aspirate, and Adipose-Derived Mesenchymal Stem Cell Injections for Symptomatic Knee Osteoarthritis
title_sort Patient-Reported Outcomes After Platelet-Rich Plasma, Bone Marrow Aspirate, and Adipose-Derived Mesenchymal Stem Cell Injections for Symptomatic Knee Osteoarthritis
dc.creator.none.fl_str_mv Estrada, Esteban
Décima, Jose L.
Rodríguez, Marcelo
Di Tomaso, Marianela
Roberti, Javier Eugenio
author Estrada, Esteban
author_facet Estrada, Esteban
Décima, Jose L.
Rodríguez, Marcelo
Di Tomaso, Marianela
Roberti, Javier Eugenio
author_role author
author2 Décima, Jose L.
Rodríguez, Marcelo
Di Tomaso, Marianela
Roberti, Javier Eugenio
author2_role author
author
author
author
dc.subject.none.fl_str_mv ADIPOSE-DERIVED MESENCHYMAL STEM CELL
BONE MARROW ASPIRATE CONCENTRATE
KNEE
OSTEOARTHRITIS
PLATELET-RICH PLASMA
topic ADIPOSE-DERIVED MESENCHYMAL STEM CELL
BONE MARROW ASPIRATE CONCENTRATE
KNEE
OSTEOARTHRITIS
PLATELET-RICH PLASMA
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Objective: The objective of this study was to compare platelet-rich plasma (PRP), bone marrow aspirate concentrate (BMAC), and adipose-derived mesenchymal stem cell (MSC) injections in the treatment of osteoarthritis (OA) of the knee using functional scores. Methods: A total of 89 patients with painful knee OA were included in this study. Patients were assigned to one of the 3 treatments according to severity of OA as indicated by symptoms and radiography to PRP (stage I), BMAC (stage II), or adipose-derived MSC (stage III). Clinical assessment was performed using the Knee Society Score, which combines the Knee Score, based on the clinical parameters, and the Functional Score, and IKDC score. Surveys were completed at preoperative and at 90, 180, and 265 days postoperative. The follow-up responses were compared with baseline and between treatment groups. Results: Treatment with PRP, BMAC, and adipose-derived MSC included 29 (32.6%), 27 (30.3%), and 33 (37.1%) patients, respectively. For the total group, median age was 61 years (range: 22-84 years). Score values were comparable among treatment groups at baseline. Statistically significant improvement was observed in the 3 groups according to the 3 scores at all time points during follow-up compared with baseline. No difference was found among treatment type. Conclusions: Our findings support previous reports and encourage further research on the use of these cost-effective treatments for OA of the knee.
Fil: Estrada, Esteban. Gobierno de la Provincia de San Luis. Hospital Policlinico Regional Juan Domingo Peron.; Argentina
Fil: Décima, Jose L.. Gobierno de la Provincia de San Luis. Hospital Policlinico Regional Juan Domingo Peron.; Argentina
Fil: Rodríguez, Marcelo. Gobierno de la Provincia de San Luis. Hospital Policlinico Regional Juan Domingo Peron.; Argentina
Fil: Di Tomaso, Marianela. Gobierno de la Provincia de San Luis. Hospital Policlinico Regional Juan Domingo Peron.; Argentina
Fil: Roberti, Javier Eugenio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; Argentina. Gobierno de la Provincia de San Luis. Hospital Policlinico Regional Juan Domingo Peron.; Argentina
description Objective: The objective of this study was to compare platelet-rich plasma (PRP), bone marrow aspirate concentrate (BMAC), and adipose-derived mesenchymal stem cell (MSC) injections in the treatment of osteoarthritis (OA) of the knee using functional scores. Methods: A total of 89 patients with painful knee OA were included in this study. Patients were assigned to one of the 3 treatments according to severity of OA as indicated by symptoms and radiography to PRP (stage I), BMAC (stage II), or adipose-derived MSC (stage III). Clinical assessment was performed using the Knee Society Score, which combines the Knee Score, based on the clinical parameters, and the Functional Score, and IKDC score. Surveys were completed at preoperative and at 90, 180, and 265 days postoperative. The follow-up responses were compared with baseline and between treatment groups. Results: Treatment with PRP, BMAC, and adipose-derived MSC included 29 (32.6%), 27 (30.3%), and 33 (37.1%) patients, respectively. For the total group, median age was 61 years (range: 22-84 years). Score values were comparable among treatment groups at baseline. Statistically significant improvement was observed in the 3 groups according to the 3 scores at all time points during follow-up compared with baseline. No difference was found among treatment type. Conclusions: Our findings support previous reports and encourage further research on the use of these cost-effective treatments for OA of the knee.
publishDate 2020
dc.date.none.fl_str_mv 2020-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/145180
Estrada, Esteban; Décima, Jose L.; Rodríguez, Marcelo; Di Tomaso, Marianela; Roberti, Javier Eugenio; Patient-Reported Outcomes After Platelet-Rich Plasma, Bone Marrow Aspirate, and Adipose-Derived Mesenchymal Stem Cell Injections for Symptomatic Knee Osteoarthritis; SAGE Publications; Clinical Medicine Insights: Arthritis and Musculoskeletal Disorders; 13; 7-2020; 1-4
1179-5441
CONICET Digital
CONICET
url http://hdl.handle.net/11336/145180
identifier_str_mv Estrada, Esteban; Décima, Jose L.; Rodríguez, Marcelo; Di Tomaso, Marianela; Roberti, Javier Eugenio; Patient-Reported Outcomes After Platelet-Rich Plasma, Bone Marrow Aspirate, and Adipose-Derived Mesenchymal Stem Cell Injections for Symptomatic Knee Osteoarthritis; SAGE Publications; Clinical Medicine Insights: Arthritis and Musculoskeletal Disorders; 13; 7-2020; 1-4
1179-5441
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1177/1179544120931086
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv SAGE Publications
publisher.none.fl_str_mv SAGE Publications
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269211940880384
score 13.13397

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