Role of DNA-detection–based tools for monitoring the soil-transmitted helminth treatment response in drug-efficacy trials

Autores
Gandasegui, Javier; Martínez Valladares, María; Grau Pujol, Berta; Krolewiecki, Alejandro Javier; Balaña Fouce, Rafael; Gelaye, Woyneshet; Van Lieshout, Lisette; Kepha, Stella; Mandomando, Inácio; Muñoz, José
Año de publicación
2020
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
More than 1 billion people have been reported to be infected with at least one soil-transmitted helminth (STH) worldwide, according to the last published report of the World Health Organization (WHO). WHO guidelines for STH control mainly encompass periodic administration of benzimidazoles (albendazole or mebendazole) to at-risk people of the endemic areas. However, extended use of benzimidazoles could entail a great selection pressure for parasitic-resistant strains. In veterinary medicine, anthelmintic resistance in gastrointestinal nematodes has been developed in response to their excessive use, and it is currently considered a serious threat to livestock health and welfare. In humans, the estimated efficacy of albendazole and mebendazole against Trichuris trichiura has been observed to significantly decrease over time. This observed decrement in drug efficacy could be due to the development of anthelmintic resistance (among other reasons such as drug quality and administration, the increasing of drug-efficacy studies, improvements in sensitivity of diagnostic tools after treatment, etc) after years of mass drug-administration campaigns, which is one of the major concerns in STH control. Monitoring anthelmintic efficacy trials have been traditionally done by microscopic approaches, although it is well known that microscopy’s sensitivity may be insufficient in this context. We think that DNA-detection–based tools represent an accurate alternative to parasitological methods, and they should be evaluated and validated not only for monitoring worm burden before and after treatment but also for detecting genetic markers related to anthelmintic resistance.
Fil: Gandasegui, Javier. Universidad de Barcelona; España
Fil: Martínez Valladares, María. Instituto de Ganadería de Montaña; España. Universidad de León; España
Fil: Grau Pujol, Berta. Universidad de Barcelona; España. Fundación Mundo Sano; Argentina
Fil: Krolewiecki, Alejandro Javier. Universidad de Barcelona; España. Universidad Nacional de Salta. Sede Regional Orán. Instituto de Investigación de Enfermedades Tropicales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta; Argentina
Fil: Balaña Fouce, Rafael. Universidad de León; España
Fil: Gelaye, Woyneshet. Bahir Dar University; Etiopía
Fil: Van Lieshout, Lisette. Leiden University. Leiden University Medical Center.; Países Bajos
Fil: Kepha, Stella. Kenya Medical Research Institute. Eastern and Southern Africa Centre of International Parasite Control; Kenia. London School of Hygiene and Tropical Medical Medicine. Faculty of Infectious and Tropical Diseases; Reino Unido. Pwani University; Kenia
Fil: Mandomando, Inácio. Centro de investigação de Saúde de Manhiça; Mozambique. Instituto Nacional de Saúde; Mozambique
Fil: Muñoz, José. Universidad de Barcelona; España
Materia
MOLECULAR BIOLOGY
SOIL TRANSMITTED HELMINTHS
NEGLECTED TROPICAL DISEASES
DIAGNOSTICS
DRUG RESISTANCE
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/128854
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/128854
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Role of DNA-detection–based tools for monitoring the soil-transmitted helminth treatment response in drug-efficacy trialsGandasegui, JavierMartínez Valladares, MaríaGrau Pujol, BertaKrolewiecki, Alejandro JavierBalaña Fouce, RafaelGelaye, WoyneshetVan Lieshout, LisetteKepha, StellaMandomando, InácioMuñoz, JoséMOLECULAR BIOLOGYSOIL TRANSMITTED HELMINTHSNEGLECTED TROPICAL DISEASESDIAGNOSTICSDRUG RESISTANCEhttps://purl.org/becyt/ford/3.4https://purl.org/becyt/ford/3More than 1 billion people have been reported to be infected with at least one soil-transmitted helminth (STH) worldwide, according to the last published report of the World Health Organization (WHO). WHO guidelines for STH control mainly encompass periodic administration of benzimidazoles (albendazole or mebendazole) to at-risk people of the endemic areas. However, extended use of benzimidazoles could entail a great selection pressure for parasitic-resistant strains. In veterinary medicine, anthelmintic resistance in gastrointestinal nematodes has been developed in response to their excessive use, and it is currently considered a serious threat to livestock health and welfare. In humans, the estimated efficacy of albendazole and mebendazole against Trichuris trichiura has been observed to significantly decrease over time. This observed decrement in drug efficacy could be due to the development of anthelmintic resistance (among other reasons such as drug quality and administration, the increasing of drug-efficacy studies, improvements in sensitivity of diagnostic tools after treatment, etc) after years of mass drug-administration campaigns, which is one of the major concerns in STH control. Monitoring anthelmintic efficacy trials have been traditionally done by microscopic approaches, although it is well known that microscopy’s sensitivity may be insufficient in this context. We think that DNA-detection–based tools represent an accurate alternative to parasitological methods, and they should be evaluated and validated not only for monitoring worm burden before and after treatment but also for detecting genetic markers related to anthelmintic resistance.Fil: Gandasegui, Javier. Universidad de Barcelona; EspañaFil: Martínez Valladares, María. Instituto de Ganadería de Montaña; España. Universidad de León; EspañaFil: Grau Pujol, Berta. Universidad de Barcelona; España. Fundación Mundo Sano; ArgentinaFil: Krolewiecki, Alejandro Javier. Universidad de Barcelona; España. Universidad Nacional de Salta. Sede Regional Orán. Instituto de Investigación de Enfermedades Tropicales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta; ArgentinaFil: Balaña Fouce, Rafael. Universidad de León; EspañaFil: Gelaye, Woyneshet. Bahir Dar University; EtiopíaFil: Van Lieshout, Lisette. Leiden University. Leiden University Medical Center.; Países BajosFil: Kepha, Stella. Kenya Medical Research Institute. Eastern and Southern Africa Centre of International Parasite Control; Kenia. London School of Hygiene and Tropical Medical Medicine. Faculty of Infectious and Tropical Diseases; Reino Unido. Pwani University; KeniaFil: Mandomando, Inácio. Centro de investigação de Saúde de Manhiça; Mozambique. Instituto Nacional de Saúde; MozambiqueFil: Muñoz, José. Universidad de Barcelona; EspañaPublic Library of Science2020-02-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/128854Gandasegui, Javier; Martínez Valladares, María; Grau Pujol, Berta; Krolewiecki, Alejandro Javier; Balaña Fouce, Rafael; et al.; Role of DNA-detection–based tools for monitoring the soil-transmitted helminth treatment response in drug-efficacy trials; Public Library of Science; Neglected Tropical Diseases; 14; 2; 6-2-2020; 1-71935-2735CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pntd.0007931info:eu-repo/semantics/altIdentifier/url/https://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0007931info:eu-repo/semantics/altIdentifier/url/https://pubmed.ncbi.nlm.nih.gov/32027646/info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:31:12Zoai:ri.conicet.gov.ar:11336/128854instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:31:12.957CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Role of DNA-detection–based tools for monitoring the soil-transmitted helminth treatment response in drug-efficacy trials
title Role of DNA-detection–based tools for monitoring the soil-transmitted helminth treatment response in drug-efficacy trials
spellingShingle Role of DNA-detection–based tools for monitoring the soil-transmitted helminth treatment response in drug-efficacy trials
Gandasegui, Javier
MOLECULAR BIOLOGY
SOIL TRANSMITTED HELMINTHS
NEGLECTED TROPICAL DISEASES
DIAGNOSTICS
DRUG RESISTANCE
title_short Role of DNA-detection–based tools for monitoring the soil-transmitted helminth treatment response in drug-efficacy trials
title_full Role of DNA-detection–based tools for monitoring the soil-transmitted helminth treatment response in drug-efficacy trials
title_fullStr Role of DNA-detection–based tools for monitoring the soil-transmitted helminth treatment response in drug-efficacy trials
title_full_unstemmed Role of DNA-detection–based tools for monitoring the soil-transmitted helminth treatment response in drug-efficacy trials
title_sort Role of DNA-detection–based tools for monitoring the soil-transmitted helminth treatment response in drug-efficacy trials
dc.creator.none.fl_str_mv Gandasegui, Javier
Martínez Valladares, María
Grau Pujol, Berta
Krolewiecki, Alejandro Javier
Balaña Fouce, Rafael
Gelaye, Woyneshet
Van Lieshout, Lisette
Kepha, Stella
Mandomando, Inácio
Muñoz, José
author Gandasegui, Javier
author_facet Gandasegui, Javier
Martínez Valladares, María
Grau Pujol, Berta
Krolewiecki, Alejandro Javier
Balaña Fouce, Rafael
Gelaye, Woyneshet
Van Lieshout, Lisette
Kepha, Stella
Mandomando, Inácio
Muñoz, José
author_role author
author2 Martínez Valladares, María
Grau Pujol, Berta
Krolewiecki, Alejandro Javier
Balaña Fouce, Rafael
Gelaye, Woyneshet
Van Lieshout, Lisette
Kepha, Stella
Mandomando, Inácio
Muñoz, José
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv MOLECULAR BIOLOGY
SOIL TRANSMITTED HELMINTHS
NEGLECTED TROPICAL DISEASES
DIAGNOSTICS
DRUG RESISTANCE
topic MOLECULAR BIOLOGY
SOIL TRANSMITTED HELMINTHS
NEGLECTED TROPICAL DISEASES
DIAGNOSTICS
DRUG RESISTANCE
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.4
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv More than 1 billion people have been reported to be infected with at least one soil-transmitted helminth (STH) worldwide, according to the last published report of the World Health Organization (WHO). WHO guidelines for STH control mainly encompass periodic administration of benzimidazoles (albendazole or mebendazole) to at-risk people of the endemic areas. However, extended use of benzimidazoles could entail a great selection pressure for parasitic-resistant strains. In veterinary medicine, anthelmintic resistance in gastrointestinal nematodes has been developed in response to their excessive use, and it is currently considered a serious threat to livestock health and welfare. In humans, the estimated efficacy of albendazole and mebendazole against Trichuris trichiura has been observed to significantly decrease over time. This observed decrement in drug efficacy could be due to the development of anthelmintic resistance (among other reasons such as drug quality and administration, the increasing of drug-efficacy studies, improvements in sensitivity of diagnostic tools after treatment, etc) after years of mass drug-administration campaigns, which is one of the major concerns in STH control. Monitoring anthelmintic efficacy trials have been traditionally done by microscopic approaches, although it is well known that microscopy’s sensitivity may be insufficient in this context. We think that DNA-detection–based tools represent an accurate alternative to parasitological methods, and they should be evaluated and validated not only for monitoring worm burden before and after treatment but also for detecting genetic markers related to anthelmintic resistance.
Fil: Gandasegui, Javier. Universidad de Barcelona; España
Fil: Martínez Valladares, María. Instituto de Ganadería de Montaña; España. Universidad de León; España
Fil: Grau Pujol, Berta. Universidad de Barcelona; España. Fundación Mundo Sano; Argentina
Fil: Krolewiecki, Alejandro Javier. Universidad de Barcelona; España. Universidad Nacional de Salta. Sede Regional Orán. Instituto de Investigación de Enfermedades Tropicales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta; Argentina
Fil: Balaña Fouce, Rafael. Universidad de León; España
Fil: Gelaye, Woyneshet. Bahir Dar University; Etiopía
Fil: Van Lieshout, Lisette. Leiden University. Leiden University Medical Center.; Países Bajos
Fil: Kepha, Stella. Kenya Medical Research Institute. Eastern and Southern Africa Centre of International Parasite Control; Kenia. London School of Hygiene and Tropical Medical Medicine. Faculty of Infectious and Tropical Diseases; Reino Unido. Pwani University; Kenia
Fil: Mandomando, Inácio. Centro de investigação de Saúde de Manhiça; Mozambique. Instituto Nacional de Saúde; Mozambique
Fil: Muñoz, José. Universidad de Barcelona; España
description More than 1 billion people have been reported to be infected with at least one soil-transmitted helminth (STH) worldwide, according to the last published report of the World Health Organization (WHO). WHO guidelines for STH control mainly encompass periodic administration of benzimidazoles (albendazole or mebendazole) to at-risk people of the endemic areas. However, extended use of benzimidazoles could entail a great selection pressure for parasitic-resistant strains. In veterinary medicine, anthelmintic resistance in gastrointestinal nematodes has been developed in response to their excessive use, and it is currently considered a serious threat to livestock health and welfare. In humans, the estimated efficacy of albendazole and mebendazole against Trichuris trichiura has been observed to significantly decrease over time. This observed decrement in drug efficacy could be due to the development of anthelmintic resistance (among other reasons such as drug quality and administration, the increasing of drug-efficacy studies, improvements in sensitivity of diagnostic tools after treatment, etc) after years of mass drug-administration campaigns, which is one of the major concerns in STH control. Monitoring anthelmintic efficacy trials have been traditionally done by microscopic approaches, although it is well known that microscopy’s sensitivity may be insufficient in this context. We think that DNA-detection–based tools represent an accurate alternative to parasitological methods, and they should be evaluated and validated not only for monitoring worm burden before and after treatment but also for detecting genetic markers related to anthelmintic resistance.
publishDate 2020
dc.date.none.fl_str_mv 2020-02-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/128854
Gandasegui, Javier; Martínez Valladares, María; Grau Pujol, Berta; Krolewiecki, Alejandro Javier; Balaña Fouce, Rafael; et al.; Role of DNA-detection–based tools for monitoring the soil-transmitted helminth treatment response in drug-efficacy trials; Public Library of Science; Neglected Tropical Diseases; 14; 2; 6-2-2020; 1-7
1935-2735
CONICET Digital
CONICET
url http://hdl.handle.net/11336/128854
identifier_str_mv Gandasegui, Javier; Martínez Valladares, María; Grau Pujol, Berta; Krolewiecki, Alejandro Javier; Balaña Fouce, Rafael; et al.; Role of DNA-detection–based tools for monitoring the soil-transmitted helminth treatment response in drug-efficacy trials; Public Library of Science; Neglected Tropical Diseases; 14; 2; 6-2-2020; 1-7
1935-2735
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pntd.0007931
info:eu-repo/semantics/altIdentifier/url/https://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0007931
info:eu-repo/semantics/altIdentifier/url/https://pubmed.ncbi.nlm.nih.gov/32027646/
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.982451

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