Need for a paradigm shift in soil-transmitted helminthiasis control: Targeting the right people, in the right place, and with the right drug(s)
- Autores
- Emerson, Paul M.; Evans, Darin; Freeman, Matthew C.; Hanson, Christy; Kalua, Khumbo; Keiser, Jennifer; Krolewiecki, Alejandro Javier; Leonard, Lynn; Levecke, Bruno; Matendechero, Sultani; Means, Arianna Rubin; Montresor, Antonio; Mupfasoni, Denise; Pullan, Rachel L.; Rotondo, Lisa A.; Stephens, Mariana; Sullivan, Kristin M.; Walson, Judd L.; Williams, Tijana; Utzinger, Jürg
- Año de publicación
- 2024
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- “The worst form of inequality is to try to make unequal things equal”—AristotleSoil-transmitted helminthiasis (STH) is caused by intestinal parasites that require an obligatedevelopment period in the soil [1,2], predominantly roundworm (Ascaris lumbricoides),whipworm (Trichuris trichiura), and hookworms (Ancylostoma duodenale and Necator americanus),with the recent addition of threadworm (Strongyloides stercoralis). Historically, theseparasites have been among the most common infections in humans, disproportionately affectingthe world’s most disadvantaged and marginalized people.The current approach to STH control and elimination as a public health problem is population-based, eschews adequate monitoring, assumes unlimited donated drugs which are notoptimal against all STH species, and accepts massive programmatic inefficiencies. Hence, anew paradigm is needed. The burden of infection and morbidity due to these parasitic wormsis rapidly declining, likely due to social and economic development and improvements inhygiene and living conditions, as well as the widespread distribution of donated or procuredanthelmintic drugs. Despite this progress, there have been few changes in the structure of theglobal control program. The World Health Organization (WHO), which coordinates drugdonations, reports that between 2010 and 2020, over 9 billion tablets were donated and distributedthrough STH-specific school-based programming, or to entire communities as part of the lymphatic filariasis (LF) elimination program [3]. In addition to the distributions reported byWHO, numerous other organizations, including UNICEF, have procured and distributed billionsmore deworming tablets. Collectively, there has been over a decade of extensive and continuousdistribution of anthelmintic drugs reaching most at-risk populations (but crucially,not all).
Fil: Emerson, Paul M.. Task Force For Global Health; Estados Unidos
Fil: Evans, Darin. United States Agency For International Development; Estados Unidos
Fil: Freeman, Matthew C.. University of Emory; Estados Unidos
Fil: Hanson, Christy. Gates Foundation; Estados Unidos
Fil: Kalua, Khumbo. Blantyre Institute For Community Outreach; Malaui
Fil: Keiser, Jennifer. Swiss Tropical And Public Health Institute; Suiza
Fil: Krolewiecki, Alejandro Javier. Fundación Mundo Sano; Argentina. Universidad Nacional de Salta. Sede Regional Orán. Instituto de Investigación de Enfermedades Tropicales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta; Argentina
Fil: Leonard, Lynn. Johnson & Johnson; Estados Unidos
Fil: Levecke, Bruno. University of Ghent; Bélgica
Fil: Matendechero, Sultani. Kenya National Public Health Institute; Kenia
Fil: Means, Arianna Rubin. University of Washington; Estados Unidos
Fil: Montresor, Antonio. Organización Mundial de la Salud; Suiza
Fil: Mupfasoni, Denise. Organización Mundial de la Salud; Suiza
Fil: Pullan, Rachel L.. London School Of Hygiene & Tropical Medicine; Reino Unido
Fil: Rotondo, Lisa A.. Rti International; Estados Unidos
Fil: Stephens, Mariana. Task Force For Global Health; Estados Unidos
Fil: Sullivan, Kristin M.. Task Force For Global Health; Estados Unidos
Fil: Walson, Judd L.. University of Washington; Estados Unidos
Fil: Williams, Tijana. University Johns Hopkins; Estados Unidos
Fil: Utzinger, Jürg. Swiss Tropical And Public Health Institute; Suiza - Materia
-
SOIL TRANSMITTED HELMINTHS
NEGLECTED TROPICAL DISEASES
HOOKWORMS
ASCARIS
TRICHURIS - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/publicdomain/zero/1.0/
- Repositorio
.jpg)
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/259358
Ver los metadatos del registro completo
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Need for a paradigm shift in soil-transmitted helminthiasis control: Targeting the right people, in the right place, and with the right drug(s)Emerson, Paul M.Evans, DarinFreeman, Matthew C.Hanson, ChristyKalua, KhumboKeiser, JenniferKrolewiecki, Alejandro JavierLeonard, LynnLevecke, BrunoMatendechero, SultaniMeans, Arianna RubinMontresor, AntonioMupfasoni, DenisePullan, Rachel L.Rotondo, Lisa A.Stephens, MarianaSullivan, Kristin M.Walson, Judd L.Williams, TijanaUtzinger, JürgSOIL TRANSMITTED HELMINTHSNEGLECTED TROPICAL DISEASESHOOKWORMSASCARISTRICHURIShttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3“The worst form of inequality is to try to make unequal things equal”—AristotleSoil-transmitted helminthiasis (STH) is caused by intestinal parasites that require an obligatedevelopment period in the soil [1,2], predominantly roundworm (Ascaris lumbricoides),whipworm (Trichuris trichiura), and hookworms (Ancylostoma duodenale and Necator americanus),with the recent addition of threadworm (Strongyloides stercoralis). Historically, theseparasites have been among the most common infections in humans, disproportionately affectingthe world’s most disadvantaged and marginalized people.The current approach to STH control and elimination as a public health problem is population-based, eschews adequate monitoring, assumes unlimited donated drugs which are notoptimal against all STH species, and accepts massive programmatic inefficiencies. Hence, anew paradigm is needed. The burden of infection and morbidity due to these parasitic wormsis rapidly declining, likely due to social and economic development and improvements inhygiene and living conditions, as well as the widespread distribution of donated or procuredanthelmintic drugs. Despite this progress, there have been few changes in the structure of theglobal control program. The World Health Organization (WHO), which coordinates drugdonations, reports that between 2010 and 2020, over 9 billion tablets were donated and distributedthrough STH-specific school-based programming, or to entire communities as part of the lymphatic filariasis (LF) elimination program [3]. In addition to the distributions reported byWHO, numerous other organizations, including UNICEF, have procured and distributed billionsmore deworming tablets. Collectively, there has been over a decade of extensive and continuousdistribution of anthelmintic drugs reaching most at-risk populations (but crucially,not all).Fil: Emerson, Paul M.. Task Force For Global Health; Estados UnidosFil: Evans, Darin. United States Agency For International Development; Estados UnidosFil: Freeman, Matthew C.. University of Emory; Estados UnidosFil: Hanson, Christy. Gates Foundation; Estados UnidosFil: Kalua, Khumbo. Blantyre Institute For Community Outreach; MalauiFil: Keiser, Jennifer. Swiss Tropical And Public Health Institute; SuizaFil: Krolewiecki, Alejandro Javier. Fundación Mundo Sano; Argentina. Universidad Nacional de Salta. Sede Regional Orán. Instituto de Investigación de Enfermedades Tropicales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta; ArgentinaFil: Leonard, Lynn. Johnson & Johnson; Estados UnidosFil: Levecke, Bruno. University of Ghent; BélgicaFil: Matendechero, Sultani. Kenya National Public Health Institute; KeniaFil: Means, Arianna Rubin. University of Washington; Estados UnidosFil: Montresor, Antonio. Organización Mundial de la Salud; SuizaFil: Mupfasoni, Denise. Organización Mundial de la Salud; SuizaFil: Pullan, Rachel L.. London School Of Hygiene & Tropical Medicine; Reino UnidoFil: Rotondo, Lisa A.. Rti International; Estados UnidosFil: Stephens, Mariana. Task Force For Global Health; Estados UnidosFil: Sullivan, Kristin M.. Task Force For Global Health; Estados UnidosFil: Walson, Judd L.. University of Washington; Estados UnidosFil: Williams, Tijana. University Johns Hopkins; Estados UnidosFil: Utzinger, Jürg. Swiss Tropical And Public Health Institute; SuizaPublic Library of Science2024-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/259358Emerson, Paul M.; Evans, Darin; Freeman, Matthew C.; Hanson, Christy; Kalua, Khumbo; et al.; Need for a paradigm shift in soil-transmitted helminthiasis control: Targeting the right people, in the right place, and with the right drug(s); Public Library of Science; Neglected Tropical Diseases; 18; 10; 10-2024; 1-71935-2735CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://dx.plos.org/10.1371/journal.pntd.0012521info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pntd.0012521info:eu-repo/semantics/openAccesshttps://creativecommons.org/publicdomain/zero/1.0/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:00:48Zoai:ri.conicet.gov.ar:11336/259358instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:00:48.981CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
| dc.title.none.fl_str_mv |
Need for a paradigm shift in soil-transmitted helminthiasis control: Targeting the right people, in the right place, and with the right drug(s) |
| title |
Need for a paradigm shift in soil-transmitted helminthiasis control: Targeting the right people, in the right place, and with the right drug(s) |
| spellingShingle |
Need for a paradigm shift in soil-transmitted helminthiasis control: Targeting the right people, in the right place, and with the right drug(s) Emerson, Paul M. SOIL TRANSMITTED HELMINTHS NEGLECTED TROPICAL DISEASES HOOKWORMS ASCARIS TRICHURIS |
| title_short |
Need for a paradigm shift in soil-transmitted helminthiasis control: Targeting the right people, in the right place, and with the right drug(s) |
| title_full |
Need for a paradigm shift in soil-transmitted helminthiasis control: Targeting the right people, in the right place, and with the right drug(s) |
| title_fullStr |
Need for a paradigm shift in soil-transmitted helminthiasis control: Targeting the right people, in the right place, and with the right drug(s) |
| title_full_unstemmed |
Need for a paradigm shift in soil-transmitted helminthiasis control: Targeting the right people, in the right place, and with the right drug(s) |
| title_sort |
Need for a paradigm shift in soil-transmitted helminthiasis control: Targeting the right people, in the right place, and with the right drug(s) |
| dc.creator.none.fl_str_mv |
Emerson, Paul M. Evans, Darin Freeman, Matthew C. Hanson, Christy Kalua, Khumbo Keiser, Jennifer Krolewiecki, Alejandro Javier Leonard, Lynn Levecke, Bruno Matendechero, Sultani Means, Arianna Rubin Montresor, Antonio Mupfasoni, Denise Pullan, Rachel L. Rotondo, Lisa A. Stephens, Mariana Sullivan, Kristin M. Walson, Judd L. Williams, Tijana Utzinger, Jürg |
| author |
Emerson, Paul M. |
| author_facet |
Emerson, Paul M. Evans, Darin Freeman, Matthew C. Hanson, Christy Kalua, Khumbo Keiser, Jennifer Krolewiecki, Alejandro Javier Leonard, Lynn Levecke, Bruno Matendechero, Sultani Means, Arianna Rubin Montresor, Antonio Mupfasoni, Denise Pullan, Rachel L. Rotondo, Lisa A. Stephens, Mariana Sullivan, Kristin M. Walson, Judd L. Williams, Tijana Utzinger, Jürg |
| author_role |
author |
| author2 |
Evans, Darin Freeman, Matthew C. Hanson, Christy Kalua, Khumbo Keiser, Jennifer Krolewiecki, Alejandro Javier Leonard, Lynn Levecke, Bruno Matendechero, Sultani Means, Arianna Rubin Montresor, Antonio Mupfasoni, Denise Pullan, Rachel L. Rotondo, Lisa A. Stephens, Mariana Sullivan, Kristin M. Walson, Judd L. Williams, Tijana Utzinger, Jürg |
| author2_role |
author author author author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
SOIL TRANSMITTED HELMINTHS NEGLECTED TROPICAL DISEASES HOOKWORMS ASCARIS TRICHURIS |
| topic |
SOIL TRANSMITTED HELMINTHS NEGLECTED TROPICAL DISEASES HOOKWORMS ASCARIS TRICHURIS |
| purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.3 https://purl.org/becyt/ford/3 |
| dc.description.none.fl_txt_mv |
“The worst form of inequality is to try to make unequal things equal”—AristotleSoil-transmitted helminthiasis (STH) is caused by intestinal parasites that require an obligatedevelopment period in the soil [1,2], predominantly roundworm (Ascaris lumbricoides),whipworm (Trichuris trichiura), and hookworms (Ancylostoma duodenale and Necator americanus),with the recent addition of threadworm (Strongyloides stercoralis). Historically, theseparasites have been among the most common infections in humans, disproportionately affectingthe world’s most disadvantaged and marginalized people.The current approach to STH control and elimination as a public health problem is population-based, eschews adequate monitoring, assumes unlimited donated drugs which are notoptimal against all STH species, and accepts massive programmatic inefficiencies. Hence, anew paradigm is needed. The burden of infection and morbidity due to these parasitic wormsis rapidly declining, likely due to social and economic development and improvements inhygiene and living conditions, as well as the widespread distribution of donated or procuredanthelmintic drugs. Despite this progress, there have been few changes in the structure of theglobal control program. The World Health Organization (WHO), which coordinates drugdonations, reports that between 2010 and 2020, over 9 billion tablets were donated and distributedthrough STH-specific school-based programming, or to entire communities as part of the lymphatic filariasis (LF) elimination program [3]. In addition to the distributions reported byWHO, numerous other organizations, including UNICEF, have procured and distributed billionsmore deworming tablets. Collectively, there has been over a decade of extensive and continuousdistribution of anthelmintic drugs reaching most at-risk populations (but crucially,not all). Fil: Emerson, Paul M.. Task Force For Global Health; Estados Unidos Fil: Evans, Darin. United States Agency For International Development; Estados Unidos Fil: Freeman, Matthew C.. University of Emory; Estados Unidos Fil: Hanson, Christy. Gates Foundation; Estados Unidos Fil: Kalua, Khumbo. Blantyre Institute For Community Outreach; Malaui Fil: Keiser, Jennifer. Swiss Tropical And Public Health Institute; Suiza Fil: Krolewiecki, Alejandro Javier. Fundación Mundo Sano; Argentina. Universidad Nacional de Salta. Sede Regional Orán. Instituto de Investigación de Enfermedades Tropicales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta; Argentina Fil: Leonard, Lynn. Johnson & Johnson; Estados Unidos Fil: Levecke, Bruno. University of Ghent; Bélgica Fil: Matendechero, Sultani. Kenya National Public Health Institute; Kenia Fil: Means, Arianna Rubin. University of Washington; Estados Unidos Fil: Montresor, Antonio. Organización Mundial de la Salud; Suiza Fil: Mupfasoni, Denise. Organización Mundial de la Salud; Suiza Fil: Pullan, Rachel L.. London School Of Hygiene & Tropical Medicine; Reino Unido Fil: Rotondo, Lisa A.. Rti International; Estados Unidos Fil: Stephens, Mariana. Task Force For Global Health; Estados Unidos Fil: Sullivan, Kristin M.. Task Force For Global Health; Estados Unidos Fil: Walson, Judd L.. University of Washington; Estados Unidos Fil: Williams, Tijana. University Johns Hopkins; Estados Unidos Fil: Utzinger, Jürg. Swiss Tropical And Public Health Institute; Suiza |
| description |
“The worst form of inequality is to try to make unequal things equal”—AristotleSoil-transmitted helminthiasis (STH) is caused by intestinal parasites that require an obligatedevelopment period in the soil [1,2], predominantly roundworm (Ascaris lumbricoides),whipworm (Trichuris trichiura), and hookworms (Ancylostoma duodenale and Necator americanus),with the recent addition of threadworm (Strongyloides stercoralis). Historically, theseparasites have been among the most common infections in humans, disproportionately affectingthe world’s most disadvantaged and marginalized people.The current approach to STH control and elimination as a public health problem is population-based, eschews adequate monitoring, assumes unlimited donated drugs which are notoptimal against all STH species, and accepts massive programmatic inefficiencies. Hence, anew paradigm is needed. The burden of infection and morbidity due to these parasitic wormsis rapidly declining, likely due to social and economic development and improvements inhygiene and living conditions, as well as the widespread distribution of donated or procuredanthelmintic drugs. Despite this progress, there have been few changes in the structure of theglobal control program. The World Health Organization (WHO), which coordinates drugdonations, reports that between 2010 and 2020, over 9 billion tablets were donated and distributedthrough STH-specific school-based programming, or to entire communities as part of the lymphatic filariasis (LF) elimination program [3]. In addition to the distributions reported byWHO, numerous other organizations, including UNICEF, have procured and distributed billionsmore deworming tablets. Collectively, there has been over a decade of extensive and continuousdistribution of anthelmintic drugs reaching most at-risk populations (but crucially,not all). |
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2024 |
| dc.date.none.fl_str_mv |
2024-10 |
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info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
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article |
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publishedVersion |
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http://hdl.handle.net/11336/259358 Emerson, Paul M.; Evans, Darin; Freeman, Matthew C.; Hanson, Christy; Kalua, Khumbo; et al.; Need for a paradigm shift in soil-transmitted helminthiasis control: Targeting the right people, in the right place, and with the right drug(s); Public Library of Science; Neglected Tropical Diseases; 18; 10; 10-2024; 1-7 1935-2735 CONICET Digital CONICET |
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http://hdl.handle.net/11336/259358 |
| identifier_str_mv |
Emerson, Paul M.; Evans, Darin; Freeman, Matthew C.; Hanson, Christy; Kalua, Khumbo; et al.; Need for a paradigm shift in soil-transmitted helminthiasis control: Targeting the right people, in the right place, and with the right drug(s); Public Library of Science; Neglected Tropical Diseases; 18; 10; 10-2024; 1-7 1935-2735 CONICET Digital CONICET |
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eng |
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eng |
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