Need for a paradigm shift in soil-transmitted helminthiasis control: Targeting the right people, in the right place, and with the right drug(s)

Autores
Emerson, Paul M.; Evans, Darin; Freeman, Matthew C.; Hanson, Christy; Kalua, Khumbo; Keiser, Jennifer; Krolewiecki, Alejandro Javier; Leonard, Lynn; Levecke, Bruno; Matendechero, Sultani; Means, Arianna Rubin; Montresor, Antonio; Mupfasoni, Denise; Pullan, Rachel L.; Rotondo, Lisa A.; Stephens, Mariana; Sullivan, Kristin M.; Walson, Judd L.; Williams, Tijana; Utzinger, Jürg
Año de publicación
2024
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
“The worst form of inequality is to try to make unequal things equal”—AristotleSoil-transmitted helminthiasis (STH) is caused by intestinal parasites that require an obligatedevelopment period in the soil [1,2], predominantly roundworm (Ascaris lumbricoides),whipworm (Trichuris trichiura), and hookworms (Ancylostoma duodenale and Necator americanus),with the recent addition of threadworm (Strongyloides stercoralis). Historically, theseparasites have been among the most common infections in humans, disproportionately affectingthe world’s most disadvantaged and marginalized people.The current approach to STH control and elimination as a public health problem is population-based, eschews adequate monitoring, assumes unlimited donated drugs which are notoptimal against all STH species, and accepts massive programmatic inefficiencies. Hence, anew paradigm is needed. The burden of infection and morbidity due to these parasitic wormsis rapidly declining, likely due to social and economic development and improvements inhygiene and living conditions, as well as the widespread distribution of donated or procuredanthelmintic drugs. Despite this progress, there have been few changes in the structure of theglobal control program. The World Health Organization (WHO), which coordinates drugdonations, reports that between 2010 and 2020, over 9 billion tablets were donated and distributedthrough STH-specific school-based programming, or to entire communities as part of the lymphatic filariasis (LF) elimination program [3]. In addition to the distributions reported byWHO, numerous other organizations, including UNICEF, have procured and distributed billionsmore deworming tablets. Collectively, there has been over a decade of extensive and continuousdistribution of anthelmintic drugs reaching most at-risk populations (but crucially,not all).
Fil: Emerson, Paul M.. Task Force For Global Health; Estados Unidos
Fil: Evans, Darin. United States Agency For International Development; Estados Unidos
Fil: Freeman, Matthew C.. University of Emory; Estados Unidos
Fil: Hanson, Christy. Gates Foundation; Estados Unidos
Fil: Kalua, Khumbo. Blantyre Institute For Community Outreach; Malaui
Fil: Keiser, Jennifer. Swiss Tropical And Public Health Institute; Suiza
Fil: Krolewiecki, Alejandro Javier. Fundación Mundo Sano; Argentina. Universidad Nacional de Salta. Sede Regional Orán. Instituto de Investigación de Enfermedades Tropicales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta; Argentina
Fil: Leonard, Lynn. Johnson & Johnson; Estados Unidos
Fil: Levecke, Bruno. University of Ghent; Bélgica
Fil: Matendechero, Sultani. Kenya National Public Health Institute; Kenia
Fil: Means, Arianna Rubin. University of Washington; Estados Unidos
Fil: Montresor, Antonio. Organización Mundial de la Salud; Suiza
Fil: Mupfasoni, Denise. Organización Mundial de la Salud; Suiza
Fil: Pullan, Rachel L.. London School Of Hygiene & Tropical Medicine; Reino Unido
Fil: Rotondo, Lisa A.. Rti International; Estados Unidos
Fil: Stephens, Mariana. Task Force For Global Health; Estados Unidos
Fil: Sullivan, Kristin M.. Task Force For Global Health; Estados Unidos
Fil: Walson, Judd L.. University of Washington; Estados Unidos
Fil: Williams, Tijana. University Johns Hopkins; Estados Unidos
Fil: Utzinger, Jürg. Swiss Tropical And Public Health Institute; Suiza
Materia
SOIL TRANSMITTED HELMINTHS
NEGLECTED TROPICAL DISEASES
HOOKWORMS
ASCARIS
TRICHURIS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/publicdomain/zero/1.0/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/259358

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network_name_str CONICET Digital (CONICET)
spelling Need for a paradigm shift in soil-transmitted helminthiasis control: Targeting the right people, in the right place, and with the right drug(s)Emerson, Paul M.Evans, DarinFreeman, Matthew C.Hanson, ChristyKalua, KhumboKeiser, JenniferKrolewiecki, Alejandro JavierLeonard, LynnLevecke, BrunoMatendechero, SultaniMeans, Arianna RubinMontresor, AntonioMupfasoni, DenisePullan, Rachel L.Rotondo, Lisa A.Stephens, MarianaSullivan, Kristin M.Walson, Judd L.Williams, TijanaUtzinger, JürgSOIL TRANSMITTED HELMINTHSNEGLECTED TROPICAL DISEASESHOOKWORMSASCARISTRICHURIShttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3“The worst form of inequality is to try to make unequal things equal”—AristotleSoil-transmitted helminthiasis (STH) is caused by intestinal parasites that require an obligatedevelopment period in the soil [1,2], predominantly roundworm (Ascaris lumbricoides),whipworm (Trichuris trichiura), and hookworms (Ancylostoma duodenale and Necator americanus),with the recent addition of threadworm (Strongyloides stercoralis). Historically, theseparasites have been among the most common infections in humans, disproportionately affectingthe world’s most disadvantaged and marginalized people.The current approach to STH control and elimination as a public health problem is population-based, eschews adequate monitoring, assumes unlimited donated drugs which are notoptimal against all STH species, and accepts massive programmatic inefficiencies. Hence, anew paradigm is needed. The burden of infection and morbidity due to these parasitic wormsis rapidly declining, likely due to social and economic development and improvements inhygiene and living conditions, as well as the widespread distribution of donated or procuredanthelmintic drugs. Despite this progress, there have been few changes in the structure of theglobal control program. The World Health Organization (WHO), which coordinates drugdonations, reports that between 2010 and 2020, over 9 billion tablets were donated and distributedthrough STH-specific school-based programming, or to entire communities as part of the lymphatic filariasis (LF) elimination program [3]. In addition to the distributions reported byWHO, numerous other organizations, including UNICEF, have procured and distributed billionsmore deworming tablets. Collectively, there has been over a decade of extensive and continuousdistribution of anthelmintic drugs reaching most at-risk populations (but crucially,not all).Fil: Emerson, Paul M.. Task Force For Global Health; Estados UnidosFil: Evans, Darin. United States Agency For International Development; Estados UnidosFil: Freeman, Matthew C.. University of Emory; Estados UnidosFil: Hanson, Christy. Gates Foundation; Estados UnidosFil: Kalua, Khumbo. Blantyre Institute For Community Outreach; MalauiFil: Keiser, Jennifer. Swiss Tropical And Public Health Institute; SuizaFil: Krolewiecki, Alejandro Javier. Fundación Mundo Sano; Argentina. Universidad Nacional de Salta. Sede Regional Orán. Instituto de Investigación de Enfermedades Tropicales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta; ArgentinaFil: Leonard, Lynn. Johnson & Johnson; Estados UnidosFil: Levecke, Bruno. University of Ghent; BélgicaFil: Matendechero, Sultani. Kenya National Public Health Institute; KeniaFil: Means, Arianna Rubin. University of Washington; Estados UnidosFil: Montresor, Antonio. Organización Mundial de la Salud; SuizaFil: Mupfasoni, Denise. Organización Mundial de la Salud; SuizaFil: Pullan, Rachel L.. London School Of Hygiene & Tropical Medicine; Reino UnidoFil: Rotondo, Lisa A.. Rti International; Estados UnidosFil: Stephens, Mariana. Task Force For Global Health; Estados UnidosFil: Sullivan, Kristin M.. Task Force For Global Health; Estados UnidosFil: Walson, Judd L.. University of Washington; Estados UnidosFil: Williams, Tijana. University Johns Hopkins; Estados UnidosFil: Utzinger, Jürg. Swiss Tropical And Public Health Institute; SuizaPublic Library of Science2024-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/259358Emerson, Paul M.; Evans, Darin; Freeman, Matthew C.; Hanson, Christy; Kalua, Khumbo; et al.; Need for a paradigm shift in soil-transmitted helminthiasis control: Targeting the right people, in the right place, and with the right drug(s); Public Library of Science; Neglected Tropical Diseases; 18; 10; 10-2024; 1-71935-2735CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://dx.plos.org/10.1371/journal.pntd.0012521info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pntd.0012521info:eu-repo/semantics/openAccesshttps://creativecommons.org/publicdomain/zero/1.0/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:56:30Zoai:ri.conicet.gov.ar:11336/259358instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:56:30.337CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Need for a paradigm shift in soil-transmitted helminthiasis control: Targeting the right people, in the right place, and with the right drug(s)
title Need for a paradigm shift in soil-transmitted helminthiasis control: Targeting the right people, in the right place, and with the right drug(s)
spellingShingle Need for a paradigm shift in soil-transmitted helminthiasis control: Targeting the right people, in the right place, and with the right drug(s)
Emerson, Paul M.
SOIL TRANSMITTED HELMINTHS
NEGLECTED TROPICAL DISEASES
HOOKWORMS
ASCARIS
TRICHURIS
title_short Need for a paradigm shift in soil-transmitted helminthiasis control: Targeting the right people, in the right place, and with the right drug(s)
title_full Need for a paradigm shift in soil-transmitted helminthiasis control: Targeting the right people, in the right place, and with the right drug(s)
title_fullStr Need for a paradigm shift in soil-transmitted helminthiasis control: Targeting the right people, in the right place, and with the right drug(s)
title_full_unstemmed Need for a paradigm shift in soil-transmitted helminthiasis control: Targeting the right people, in the right place, and with the right drug(s)
title_sort Need for a paradigm shift in soil-transmitted helminthiasis control: Targeting the right people, in the right place, and with the right drug(s)
dc.creator.none.fl_str_mv Emerson, Paul M.
Evans, Darin
Freeman, Matthew C.
Hanson, Christy
Kalua, Khumbo
Keiser, Jennifer
Krolewiecki, Alejandro Javier
Leonard, Lynn
Levecke, Bruno
Matendechero, Sultani
Means, Arianna Rubin
Montresor, Antonio
Mupfasoni, Denise
Pullan, Rachel L.
Rotondo, Lisa A.
Stephens, Mariana
Sullivan, Kristin M.
Walson, Judd L.
Williams, Tijana
Utzinger, Jürg
author Emerson, Paul M.
author_facet Emerson, Paul M.
Evans, Darin
Freeman, Matthew C.
Hanson, Christy
Kalua, Khumbo
Keiser, Jennifer
Krolewiecki, Alejandro Javier
Leonard, Lynn
Levecke, Bruno
Matendechero, Sultani
Means, Arianna Rubin
Montresor, Antonio
Mupfasoni, Denise
Pullan, Rachel L.
Rotondo, Lisa A.
Stephens, Mariana
Sullivan, Kristin M.
Walson, Judd L.
Williams, Tijana
Utzinger, Jürg
author_role author
author2 Evans, Darin
Freeman, Matthew C.
Hanson, Christy
Kalua, Khumbo
Keiser, Jennifer
Krolewiecki, Alejandro Javier
Leonard, Lynn
Levecke, Bruno
Matendechero, Sultani
Means, Arianna Rubin
Montresor, Antonio
Mupfasoni, Denise
Pullan, Rachel L.
Rotondo, Lisa A.
Stephens, Mariana
Sullivan, Kristin M.
Walson, Judd L.
Williams, Tijana
Utzinger, Jürg
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv SOIL TRANSMITTED HELMINTHS
NEGLECTED TROPICAL DISEASES
HOOKWORMS
ASCARIS
TRICHURIS
topic SOIL TRANSMITTED HELMINTHS
NEGLECTED TROPICAL DISEASES
HOOKWORMS
ASCARIS
TRICHURIS
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv “The worst form of inequality is to try to make unequal things equal”—AristotleSoil-transmitted helminthiasis (STH) is caused by intestinal parasites that require an obligatedevelopment period in the soil [1,2], predominantly roundworm (Ascaris lumbricoides),whipworm (Trichuris trichiura), and hookworms (Ancylostoma duodenale and Necator americanus),with the recent addition of threadworm (Strongyloides stercoralis). Historically, theseparasites have been among the most common infections in humans, disproportionately affectingthe world’s most disadvantaged and marginalized people.The current approach to STH control and elimination as a public health problem is population-based, eschews adequate monitoring, assumes unlimited donated drugs which are notoptimal against all STH species, and accepts massive programmatic inefficiencies. Hence, anew paradigm is needed. The burden of infection and morbidity due to these parasitic wormsis rapidly declining, likely due to social and economic development and improvements inhygiene and living conditions, as well as the widespread distribution of donated or procuredanthelmintic drugs. Despite this progress, there have been few changes in the structure of theglobal control program. The World Health Organization (WHO), which coordinates drugdonations, reports that between 2010 and 2020, over 9 billion tablets were donated and distributedthrough STH-specific school-based programming, or to entire communities as part of the lymphatic filariasis (LF) elimination program [3]. In addition to the distributions reported byWHO, numerous other organizations, including UNICEF, have procured and distributed billionsmore deworming tablets. Collectively, there has been over a decade of extensive and continuousdistribution of anthelmintic drugs reaching most at-risk populations (but crucially,not all).
Fil: Emerson, Paul M.. Task Force For Global Health; Estados Unidos
Fil: Evans, Darin. United States Agency For International Development; Estados Unidos
Fil: Freeman, Matthew C.. University of Emory; Estados Unidos
Fil: Hanson, Christy. Gates Foundation; Estados Unidos
Fil: Kalua, Khumbo. Blantyre Institute For Community Outreach; Malaui
Fil: Keiser, Jennifer. Swiss Tropical And Public Health Institute; Suiza
Fil: Krolewiecki, Alejandro Javier. Fundación Mundo Sano; Argentina. Universidad Nacional de Salta. Sede Regional Orán. Instituto de Investigación de Enfermedades Tropicales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta; Argentina
Fil: Leonard, Lynn. Johnson & Johnson; Estados Unidos
Fil: Levecke, Bruno. University of Ghent; Bélgica
Fil: Matendechero, Sultani. Kenya National Public Health Institute; Kenia
Fil: Means, Arianna Rubin. University of Washington; Estados Unidos
Fil: Montresor, Antonio. Organización Mundial de la Salud; Suiza
Fil: Mupfasoni, Denise. Organización Mundial de la Salud; Suiza
Fil: Pullan, Rachel L.. London School Of Hygiene & Tropical Medicine; Reino Unido
Fil: Rotondo, Lisa A.. Rti International; Estados Unidos
Fil: Stephens, Mariana. Task Force For Global Health; Estados Unidos
Fil: Sullivan, Kristin M.. Task Force For Global Health; Estados Unidos
Fil: Walson, Judd L.. University of Washington; Estados Unidos
Fil: Williams, Tijana. University Johns Hopkins; Estados Unidos
Fil: Utzinger, Jürg. Swiss Tropical And Public Health Institute; Suiza
description “The worst form of inequality is to try to make unequal things equal”—AristotleSoil-transmitted helminthiasis (STH) is caused by intestinal parasites that require an obligatedevelopment period in the soil [1,2], predominantly roundworm (Ascaris lumbricoides),whipworm (Trichuris trichiura), and hookworms (Ancylostoma duodenale and Necator americanus),with the recent addition of threadworm (Strongyloides stercoralis). Historically, theseparasites have been among the most common infections in humans, disproportionately affectingthe world’s most disadvantaged and marginalized people.The current approach to STH control and elimination as a public health problem is population-based, eschews adequate monitoring, assumes unlimited donated drugs which are notoptimal against all STH species, and accepts massive programmatic inefficiencies. Hence, anew paradigm is needed. The burden of infection and morbidity due to these parasitic wormsis rapidly declining, likely due to social and economic development and improvements inhygiene and living conditions, as well as the widespread distribution of donated or procuredanthelmintic drugs. Despite this progress, there have been few changes in the structure of theglobal control program. The World Health Organization (WHO), which coordinates drugdonations, reports that between 2010 and 2020, over 9 billion tablets were donated and distributedthrough STH-specific school-based programming, or to entire communities as part of the lymphatic filariasis (LF) elimination program [3]. In addition to the distributions reported byWHO, numerous other organizations, including UNICEF, have procured and distributed billionsmore deworming tablets. Collectively, there has been over a decade of extensive and continuousdistribution of anthelmintic drugs reaching most at-risk populations (but crucially,not all).
publishDate 2024
dc.date.none.fl_str_mv 2024-10
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/259358
Emerson, Paul M.; Evans, Darin; Freeman, Matthew C.; Hanson, Christy; Kalua, Khumbo; et al.; Need for a paradigm shift in soil-transmitted helminthiasis control: Targeting the right people, in the right place, and with the right drug(s); Public Library of Science; Neglected Tropical Diseases; 18; 10; 10-2024; 1-7
1935-2735
CONICET Digital
CONICET
url http://hdl.handle.net/11336/259358
identifier_str_mv Emerson, Paul M.; Evans, Darin; Freeman, Matthew C.; Hanson, Christy; Kalua, Khumbo; et al.; Need for a paradigm shift in soil-transmitted helminthiasis control: Targeting the right people, in the right place, and with the right drug(s); Public Library of Science; Neglected Tropical Diseases; 18; 10; 10-2024; 1-7
1935-2735
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
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info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pntd.0012521
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
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eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/publicdomain/zero/1.0/
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application/pdf
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
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