Determination of Azithromycin by an alternative FIA amperometric method for different pharmaceutical applications

Autores
Pfaffen, Maria Valeria del Valle; Faudone, Sonia Nerina; Sperandeo, Norma Rebeca; Cuffini, Silvia Lucia; Ortiz, Patricia Ines
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
This work presents a fast and reliable electroanalytical procedure for the quantification of azithromycin (AZ) in different systems that couples flow injection analysis and amperometric detection (FIA-AM). The quantification was performed at a working potential of 1.20 V (vs Ag/AgCl/NaCl (3 M)) in 0.05 M phosphate buffer at a flow rate of 1.0 mL min−1 . Under these conditions a 1.00 × 10−6 −1.50 × 10−5 M linear range, (5.8 ± 0.4) × 104 CAZ (μA M −1 ) sensitivity and 4.44 × 10−7 M limit of detection are obtained. Also, this technique can be used without sample pretreatment and presents good reproducibility. The procedure was applied to the determination of the content of AZ in commercial tablets, to study the intrinsic dissolution rate of compacts of AZ dihydrate, and to determine the AZ release from a AZ hydrogel and carbomer. The method was statistically analyzed and proves to be reliable and robust. However, more remarkable is that FIA-AM technique presents better sensitivity and high sampling rate.
Fil: Pfaffen, Maria Valeria del Valle. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; Argentina
Fil: Faudone, Sonia Nerina. Provincia de Córdoba. Ministerio de Ciencia y Técnica. Centro de Excelencia En Productos y Procesos de Córdoba; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Sperandeo, Norma Rebeca. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Cuffini, Silvia Lucia. Provincia de Córdoba. Ministerio de Ciencia y Técnica. Centro de Excelencia En Productos y Procesos de Córdoba; Argentina. Universidade Federal Da Santa Catarina; Brasil. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Ortiz, Patricia Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; Argentina
Materia
Azitromicina
Analisi por Inyeccion En Flujo
Amperometria
Muestras Farmaceuticas
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/25173
Acceder
id CONICETDig_4eefb4b81aae8776734488cd4cb89933
oai_identifier_str oai:ri.conicet.gov.ar:11336/25173
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Determination of Azithromycin by an alternative FIA amperometric method for different pharmaceutical applicationsPfaffen, Maria Valeria del ValleFaudone, Sonia NerinaSperandeo, Norma RebecaCuffini, Silvia LuciaOrtiz, Patricia InesAzitromicinaAnalisi por Inyeccion En FlujoAmperometriaMuestras Farmaceuticashttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1This work presents a fast and reliable electroanalytical procedure for the quantification of azithromycin (AZ) in different systems that couples flow injection analysis and amperometric detection (FIA-AM). The quantification was performed at a working potential of 1.20 V (vs Ag/AgCl/NaCl (3 M)) in 0.05 M phosphate buffer at a flow rate of 1.0 mL min−1 . Under these conditions a 1.00 × 10−6 −1.50 × 10−5 M linear range, (5.8 ± 0.4) × 104 CAZ (μA M −1 ) sensitivity and 4.44 × 10−7 M limit of detection are obtained. Also, this technique can be used without sample pretreatment and presents good reproducibility. The procedure was applied to the determination of the content of AZ in commercial tablets, to study the intrinsic dissolution rate of compacts of AZ dihydrate, and to determine the AZ release from a AZ hydrogel and carbomer. The method was statistically analyzed and proves to be reliable and robust. However, more remarkable is that FIA-AM technique presents better sensitivity and high sampling rate.Fil: Pfaffen, Maria Valeria del Valle. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; ArgentinaFil: Faudone, Sonia Nerina. Provincia de Córdoba. Ministerio de Ciencia y Técnica. Centro de Excelencia En Productos y Procesos de Córdoba; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Sperandeo, Norma Rebeca. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Cuffini, Silvia Lucia. Provincia de Córdoba. Ministerio de Ciencia y Técnica. Centro de Excelencia En Productos y Procesos de Córdoba; Argentina. Universidade Federal Da Santa Catarina; Brasil. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Ortiz, Patricia Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; ArgentinaAmerican Chemical Society2013-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/25173Pfaffen, Maria Valeria del Valle; Faudone, Sonia Nerina; Sperandeo, Norma Rebeca; Cuffini, Silvia Lucia; Ortiz, Patricia Ines; Determination of Azithromycin by an alternative FIA amperometric method for different pharmaceutical applications; American Chemical Society; Industrial & Engineering Chemical Research; 52; 14; 3-2013; 4973-49770888-5885CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1021/ie3027845info:eu-repo/semantics/altIdentifier/url/http://pubs.acs.org/doi/abs/10.1021/ie3027845info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2026-05-13T11:20:28Zoai:ri.conicet.gov.ar:11336/25173instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982026-05-13 11:20:28.9CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Determination of Azithromycin by an alternative FIA amperometric method for different pharmaceutical applications
title Determination of Azithromycin by an alternative FIA amperometric method for different pharmaceutical applications
spellingShingle Determination of Azithromycin by an alternative FIA amperometric method for different pharmaceutical applications
Pfaffen, Maria Valeria del Valle
Azitromicina
Analisi por Inyeccion En Flujo
Amperometria
Muestras Farmaceuticas
title_short Determination of Azithromycin by an alternative FIA amperometric method for different pharmaceutical applications
title_full Determination of Azithromycin by an alternative FIA amperometric method for different pharmaceutical applications
title_fullStr Determination of Azithromycin by an alternative FIA amperometric method for different pharmaceutical applications
title_full_unstemmed Determination of Azithromycin by an alternative FIA amperometric method for different pharmaceutical applications
title_sort Determination of Azithromycin by an alternative FIA amperometric method for different pharmaceutical applications
dc.creator.none.fl_str_mv Pfaffen, Maria Valeria del Valle
Faudone, Sonia Nerina
Sperandeo, Norma Rebeca
Cuffini, Silvia Lucia
Ortiz, Patricia Ines
author Pfaffen, Maria Valeria del Valle
author_facet Pfaffen, Maria Valeria del Valle
Faudone, Sonia Nerina
Sperandeo, Norma Rebeca
Cuffini, Silvia Lucia
Ortiz, Patricia Ines
author_role author
author2 Faudone, Sonia Nerina
Sperandeo, Norma Rebeca
Cuffini, Silvia Lucia
Ortiz, Patricia Ines
author2_role author
author
author
author
dc.subject.none.fl_str_mv Azitromicina
Analisi por Inyeccion En Flujo
Amperometria
Muestras Farmaceuticas
topic Azitromicina
Analisi por Inyeccion En Flujo
Amperometria
Muestras Farmaceuticas
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv This work presents a fast and reliable electroanalytical procedure for the quantification of azithromycin (AZ) in different systems that couples flow injection analysis and amperometric detection (FIA-AM). The quantification was performed at a working potential of 1.20 V (vs Ag/AgCl/NaCl (3 M)) in 0.05 M phosphate buffer at a flow rate of 1.0 mL min−1 . Under these conditions a 1.00 × 10−6 −1.50 × 10−5 M linear range, (5.8 ± 0.4) × 104 CAZ (μA M −1 ) sensitivity and 4.44 × 10−7 M limit of detection are obtained. Also, this technique can be used without sample pretreatment and presents good reproducibility. The procedure was applied to the determination of the content of AZ in commercial tablets, to study the intrinsic dissolution rate of compacts of AZ dihydrate, and to determine the AZ release from a AZ hydrogel and carbomer. The method was statistically analyzed and proves to be reliable and robust. However, more remarkable is that FIA-AM technique presents better sensitivity and high sampling rate.
Fil: Pfaffen, Maria Valeria del Valle. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; Argentina
Fil: Faudone, Sonia Nerina. Provincia de Córdoba. Ministerio de Ciencia y Técnica. Centro de Excelencia En Productos y Procesos de Córdoba; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Sperandeo, Norma Rebeca. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Cuffini, Silvia Lucia. Provincia de Córdoba. Ministerio de Ciencia y Técnica. Centro de Excelencia En Productos y Procesos de Córdoba; Argentina. Universidade Federal Da Santa Catarina; Brasil. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Ortiz, Patricia Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; Argentina
description This work presents a fast and reliable electroanalytical procedure for the quantification of azithromycin (AZ) in different systems that couples flow injection analysis and amperometric detection (FIA-AM). The quantification was performed at a working potential of 1.20 V (vs Ag/AgCl/NaCl (3 M)) in 0.05 M phosphate buffer at a flow rate of 1.0 mL min−1 . Under these conditions a 1.00 × 10−6 −1.50 × 10−5 M linear range, (5.8 ± 0.4) × 104 CAZ (μA M −1 ) sensitivity and 4.44 × 10−7 M limit of detection are obtained. Also, this technique can be used without sample pretreatment and presents good reproducibility. The procedure was applied to the determination of the content of AZ in commercial tablets, to study the intrinsic dissolution rate of compacts of AZ dihydrate, and to determine the AZ release from a AZ hydrogel and carbomer. The method was statistically analyzed and proves to be reliable and robust. However, more remarkable is that FIA-AM technique presents better sensitivity and high sampling rate.
publishDate 2013
dc.date.none.fl_str_mv 2013-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/25173
Pfaffen, Maria Valeria del Valle; Faudone, Sonia Nerina; Sperandeo, Norma Rebeca; Cuffini, Silvia Lucia; Ortiz, Patricia Ines; Determination of Azithromycin by an alternative FIA amperometric method for different pharmaceutical applications; American Chemical Society; Industrial & Engineering Chemical Research; 52; 14; 3-2013; 4973-4977
0888-5885
CONICET Digital
CONICET
url http://hdl.handle.net/11336/25173
identifier_str_mv Pfaffen, Maria Valeria del Valle; Faudone, Sonia Nerina; Sperandeo, Norma Rebeca; Cuffini, Silvia Lucia; Ortiz, Patricia Ines; Determination of Azithromycin by an alternative FIA amperometric method for different pharmaceutical applications; American Chemical Society; Industrial & Engineering Chemical Research; 52; 14; 3-2013; 4973-4977
0888-5885
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1021/ie3027845
info:eu-repo/semantics/altIdentifier/url/http://pubs.acs.org/doi/abs/10.1021/ie3027845
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv American Chemical Society
publisher.none.fl_str_mv American Chemical Society
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1865200802208940032
score 13.115601

Publicaciones similares