The activity of azithromycin against Leishmania (Viannia) braziliensisand Leishmania (Leishmania) amazonensis in the golden hamster model

Autores
Sinagra, Angel; Luna, María Concepción; Abraham, David; Riarte, Adelina; Krolewiecki, Alejandro J.; Iannella, María del Carmen
Año de publicación
2007
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Fil: Sinagra, Angel. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina.
Fil: Luna, Concepción. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina.
Fil: Abraham, David. Thomas Jefferson University. Department of Microbiology and Immunology; Estados Unidos.
Fil: Riarte, Adelina. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología Dr. Mario Fatala Chaben; Argentina.
Fil: Iannella, María del Carmen. Universidad de Buenos Aires. Departamento de Matemática; Argentina.
Fil: Krolewiecki, Alejandro J. Fundación Huésped. Área de Investigaciones Clínicas; Argentina.
New therapeutic alternatives against leishmaniasis remain a priority. The activity of azithromycin against Leishmania(Leishmania) major has been previously demonstrated. Different responses among species of Leishmaniamake species-specific drug screening necessary. The activity of azithromycin against Leishmania (Viannia) braziliensisand Leishmania (Leishmania) amazonensiswas evaluated in golden hamsters infected through footpad injections of metacyclic promastigotes, and compared with untreated controls and animals treated with meglumine antimoniate. Footpad thickness, lesion cultures and dissemination sites were analyzed. Treatment of golden hamsters with oral azithromycin at 450mg/kg had no activity against infections with Leishmania (Leishmania) amazonensis. For infections due to Leishmania (Viannia) braziliensis, azithromycin demonstrated significant activity relative to untreated controls, but inferior to meglumine antimoniate, for controlling lesion size. Neither drug was able to totally eliminate parasites from the lesions. It was concluded that azithromycin has activity against Leishmania (Viannia) braziliensisbut not against Leishmania (Leishmania) amazonensisin this model.
Fuente
Revista da Sociedade Brasileira de Medicina Tropical 2007; 40(6): 627–630
Materia
Leishmania braziliensis
Leishmania
Mesocricetus
Azitromicina
Nivel de accesibilidad
acceso abierto
Condiciones de uso
Repositorio
Sistema de Gestión del Conocimiento ANLIS MALBRÁN
Institución
Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"
OAI Identificador
oai:sgc.anlis.gob.ar:123456789/232

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network_name_str Sistema de Gestión del Conocimiento ANLIS MALBRÁN
spelling The activity of azithromycin against Leishmania (Viannia) braziliensisand Leishmania (Leishmania) amazonensis in the golden hamster modelA atividade da azitromicina contra a Leishmania (Viannia) braziliensise a Leishmania (Leishmania) amazonensis no modelogolden hamsterSinagra, AngelLuna, María ConcepciónAbraham, DavidRiarte, AdelinaKrolewiecki, Alejandro J.Iannella, María del CarmenLeishmania braziliensisLeishmaniaMesocricetusAzitromicinaFil: Sinagra, Angel. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina.Fil: Luna, Concepción. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina.Fil: Abraham, David. Thomas Jefferson University. Department of Microbiology and Immunology; Estados Unidos.Fil: Riarte, Adelina. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología Dr. Mario Fatala Chaben; Argentina.Fil: Iannella, María del Carmen. Universidad de Buenos Aires. Departamento de Matemática; Argentina.Fil: Krolewiecki, Alejandro J. Fundación Huésped. Área de Investigaciones Clínicas; Argentina.New therapeutic alternatives against leishmaniasis remain a priority. The activity of azithromycin against Leishmania(Leishmania) major has been previously demonstrated. Different responses among species of Leishmaniamake species-specific drug screening necessary. The activity of azithromycin against Leishmania (Viannia) braziliensisand Leishmania (Leishmania) amazonensiswas evaluated in golden hamsters infected through footpad injections of metacyclic promastigotes, and compared with untreated controls and animals treated with meglumine antimoniate. Footpad thickness, lesion cultures and dissemination sites were analyzed. Treatment of golden hamsters with oral azithromycin at 450mg/kg had no activity against infections with Leishmania (Leishmania) amazonensis. For infections due to Leishmania (Viannia) braziliensis, azithromycin demonstrated significant activity relative to untreated controls, but inferior to meglumine antimoniate, for controlling lesion size. Neither drug was able to totally eliminate parasites from the lesions. It was concluded that azithromycin has activity against Leishmania (Viannia) braziliensisbut not against Leishmania (Leishmania) amazonensisin this model.2007info:ar-repo/semantics/articuloinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdf0037-8682http://www.scielo.br/pdf/rsbmt/v40n6/a05v40n6.pdfhttp://sgc.anlis.gob.ar/handle/123456789/232Revista da Sociedade Brasileira de Medicina Tropical 2007; 40(6): 627–630reponame:Sistema de Gestión del Conocimiento ANLIS MALBRÁNinstname:Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"instacron:ANLISenginfo:eu-repo/semantics/openAccess2025-09-04T11:15:31Zoai:sgc.anlis.gob.ar:123456789/232Institucionalhttp://sgc.anlis.gob.ar/Organismo científico-tecnológicoNo correspondehttp://sgc.anlis.gob.ar/oai/biblioteca@anlis.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:a2025-09-04 11:15:32.035Sistema de Gestión del Conocimiento ANLIS MALBRÁN - Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"false
dc.title.none.fl_str_mv The activity of azithromycin against Leishmania (Viannia) braziliensisand Leishmania (Leishmania) amazonensis in the golden hamster model
A atividade da azitromicina contra a Leishmania (Viannia) braziliensise a Leishmania (Leishmania) amazonensis no modelogolden hamster
title The activity of azithromycin against Leishmania (Viannia) braziliensisand Leishmania (Leishmania) amazonensis in the golden hamster model
spellingShingle The activity of azithromycin against Leishmania (Viannia) braziliensisand Leishmania (Leishmania) amazonensis in the golden hamster model
Sinagra, Angel
Leishmania braziliensis
Leishmania
Mesocricetus
Azitromicina
title_short The activity of azithromycin against Leishmania (Viannia) braziliensisand Leishmania (Leishmania) amazonensis in the golden hamster model
title_full The activity of azithromycin against Leishmania (Viannia) braziliensisand Leishmania (Leishmania) amazonensis in the golden hamster model
title_fullStr The activity of azithromycin against Leishmania (Viannia) braziliensisand Leishmania (Leishmania) amazonensis in the golden hamster model
title_full_unstemmed The activity of azithromycin against Leishmania (Viannia) braziliensisand Leishmania (Leishmania) amazonensis in the golden hamster model
title_sort The activity of azithromycin against Leishmania (Viannia) braziliensisand Leishmania (Leishmania) amazonensis in the golden hamster model
dc.creator.none.fl_str_mv Sinagra, Angel
Luna, María Concepción
Abraham, David
Riarte, Adelina
Krolewiecki, Alejandro J.
Iannella, María del Carmen
author Sinagra, Angel
author_facet Sinagra, Angel
Luna, María Concepción
Abraham, David
Riarte, Adelina
Krolewiecki, Alejandro J.
Iannella, María del Carmen
author_role author
author2 Luna, María Concepción
Abraham, David
Riarte, Adelina
Krolewiecki, Alejandro J.
Iannella, María del Carmen
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Leishmania braziliensis
Leishmania
Mesocricetus
Azitromicina
topic Leishmania braziliensis
Leishmania
Mesocricetus
Azitromicina
dc.description.none.fl_txt_mv Fil: Sinagra, Angel. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina.
Fil: Luna, Concepción. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina.
Fil: Abraham, David. Thomas Jefferson University. Department of Microbiology and Immunology; Estados Unidos.
Fil: Riarte, Adelina. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología Dr. Mario Fatala Chaben; Argentina.
Fil: Iannella, María del Carmen. Universidad de Buenos Aires. Departamento de Matemática; Argentina.
Fil: Krolewiecki, Alejandro J. Fundación Huésped. Área de Investigaciones Clínicas; Argentina.
New therapeutic alternatives against leishmaniasis remain a priority. The activity of azithromycin against Leishmania(Leishmania) major has been previously demonstrated. Different responses among species of Leishmaniamake species-specific drug screening necessary. The activity of azithromycin against Leishmania (Viannia) braziliensisand Leishmania (Leishmania) amazonensiswas evaluated in golden hamsters infected through footpad injections of metacyclic promastigotes, and compared with untreated controls and animals treated with meglumine antimoniate. Footpad thickness, lesion cultures and dissemination sites were analyzed. Treatment of golden hamsters with oral azithromycin at 450mg/kg had no activity against infections with Leishmania (Leishmania) amazonensis. For infections due to Leishmania (Viannia) braziliensis, azithromycin demonstrated significant activity relative to untreated controls, but inferior to meglumine antimoniate, for controlling lesion size. Neither drug was able to totally eliminate parasites from the lesions. It was concluded that azithromycin has activity against Leishmania (Viannia) braziliensisbut not against Leishmania (Leishmania) amazonensisin this model.
description Fil: Sinagra, Angel. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina.
publishDate 2007
dc.date.none.fl_str_mv 2007
dc.type.none.fl_str_mv info:ar-repo/semantics/articulo
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv 0037-8682
http://www.scielo.br/pdf/rsbmt/v40n6/a05v40n6.pdf
http://sgc.anlis.gob.ar/handle/123456789/232
identifier_str_mv 0037-8682
url http://www.scielo.br/pdf/rsbmt/v40n6/a05v40n6.pdf
http://sgc.anlis.gob.ar/handle/123456789/232
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv Revista da Sociedade Brasileira de Medicina Tropical 2007; 40(6): 627–630
reponame:Sistema de Gestión del Conocimiento ANLIS MALBRÁN
instname:Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"
instacron:ANLIS
reponame_str Sistema de Gestión del Conocimiento ANLIS MALBRÁN
collection Sistema de Gestión del Conocimiento ANLIS MALBRÁN
instname_str Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"
instacron_str ANLIS
institution ANLIS
repository.name.fl_str_mv Sistema de Gestión del Conocimiento ANLIS MALBRÁN - Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"
repository.mail.fl_str_mv biblioteca@anlis.gov.ar
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