The extent of infectious SARS-CoV-2 shedding in an Argentinean cohort

Autores
Blanco, Sebastian; Aguilar, Juan Javier; Konigheim, Brenda Salome; Diaz, Luis Adrian; Spinsanti, Lorena Ivana; Beranek, Mauricio Daniel; Collino, César; Diaz, Miguel; Barbás, María Gabriela; Gallego, Sandra Veronica
Año de publicación
2021
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Background To analyze the infectious extent of severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) in different settings where prevention strategies are critical to limit infection spread, we evaluated SARS-COV-2 viability to guide public health policies regarding isolation criteria and infection control. Methods We attempted viral isolation in 82 nasopharyngeal swabs from 72 patients with confirmed SARS-COV-2 infection. Study population was divided into four groups: (i) Patients during the first week of symptoms; (ii) Patients with prolonged positive PCR; (iii) Healthcare workers from a hospital participating of an outbreak investigation, with SARS-COV-2 infection confirmed by reverse transcriptase polymerase chain reaction (RT-PCR) and (iv) Recipients of convalescent immune plasma (CIP). Vero Cl76 cell-line (ATCC CRL-587) was used in assays for virus isolation. Plasma samples of CIP recipients were also tested with plaque-reduction neutralization test. Results We obtained infectious SARS-COV-2 isolates from 15/84 nasopharyngeal swabs. The virus could not be isolated from upper respiratory tract samples collected 10-day after onset of symptoms (AOS) in patients with mild moderate disease. Conclusion The knowledge of the extent of SARS-CoV-2 infectivity AOS is relevant for effective prevention measures. This allows to discuss criteria for end isolation despite persistence of positive PCR and improve timing for hospital discharge with consequent availability of critical beds.
Fil: Blanco, Sebastian. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología Dr. J. M. Vanella; Argentina
Fil: Aguilar, Juan Javier. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología Dr. J. M. Vanella; Argentina
Fil: Konigheim, Brenda Salome. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología Dr. J. M. Vanella; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina
Fil: Diaz, Luis Adrian. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología Dr. J. M. Vanella; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina
Fil: Spinsanti, Lorena Ivana. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología Dr. J. M. Vanella; Argentina
Fil: Beranek, Mauricio Daniel. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología Dr. J. M. Vanella; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina
Fil: Collino, César. Hospital Público Descentralizado Dr. Guillermo Rawson.; Argentina
Fil: Diaz, Miguel. Ministerio de Salud de la Provincia de Córdoba; Argentina
Fil: Barbás, María Gabriela. Hospital Público Descentralizado Dr. Guillermo Rawson.; Argentina
Fil: Gallego, Sandra Veronica. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología Dr. J. M. Vanella; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina
Materia
COVID-19
INFECTIVITY
ISOLATION
PUBLIC HEALTH
SARS-COV-2
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/152192

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network_name_str CONICET Digital (CONICET)
spelling The extent of infectious SARS-CoV-2 shedding in an Argentinean cohortBlanco, SebastianAguilar, Juan JavierKonigheim, Brenda SalomeDiaz, Luis AdrianSpinsanti, Lorena IvanaBeranek, Mauricio DanielCollino, CésarDiaz, MiguelBarbás, María GabrielaGallego, Sandra VeronicaCOVID-19INFECTIVITYISOLATIONPUBLIC HEALTHSARS-COV-2https://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Background To analyze the infectious extent of severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) in different settings where prevention strategies are critical to limit infection spread, we evaluated SARS-COV-2 viability to guide public health policies regarding isolation criteria and infection control. Methods We attempted viral isolation in 82 nasopharyngeal swabs from 72 patients with confirmed SARS-COV-2 infection. Study population was divided into four groups: (i) Patients during the first week of symptoms; (ii) Patients with prolonged positive PCR; (iii) Healthcare workers from a hospital participating of an outbreak investigation, with SARS-COV-2 infection confirmed by reverse transcriptase polymerase chain reaction (RT-PCR) and (iv) Recipients of convalescent immune plasma (CIP). Vero Cl76 cell-line (ATCC CRL-587) was used in assays for virus isolation. Plasma samples of CIP recipients were also tested with plaque-reduction neutralization test. Results We obtained infectious SARS-COV-2 isolates from 15/84 nasopharyngeal swabs. The virus could not be isolated from upper respiratory tract samples collected 10-day after onset of symptoms (AOS) in patients with mild moderate disease. Conclusion The knowledge of the extent of SARS-CoV-2 infectivity AOS is relevant for effective prevention measures. This allows to discuss criteria for end isolation despite persistence of positive PCR and improve timing for hospital discharge with consequent availability of critical beds.Fil: Blanco, Sebastian. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología Dr. J. M. Vanella; ArgentinaFil: Aguilar, Juan Javier. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología Dr. J. M. Vanella; ArgentinaFil: Konigheim, Brenda Salome. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología Dr. J. M. Vanella; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; ArgentinaFil: Diaz, Luis Adrian. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología Dr. J. M. Vanella; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; ArgentinaFil: Spinsanti, Lorena Ivana. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología Dr. J. M. Vanella; ArgentinaFil: Beranek, Mauricio Daniel. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología Dr. J. M. Vanella; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; ArgentinaFil: Collino, César. Hospital Público Descentralizado Dr. Guillermo Rawson.; ArgentinaFil: Diaz, Miguel. Ministerio de Salud de la Provincia de Córdoba; ArgentinaFil: Barbás, María Gabriela. Hospital Público Descentralizado Dr. Guillermo Rawson.; ArgentinaFil: Gallego, Sandra Veronica. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología Dr. J. M. Vanella; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; ArgentinaOxford University Press2021-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/152192Blanco, Sebastian; Aguilar, Juan Javier; Konigheim, Brenda Salome; Diaz, Luis Adrian; Spinsanti, Lorena Ivana; et al.; The extent of infectious SARS-CoV-2 shedding in an Argentinean cohort; Oxford University Press; Journal Of Public Health; 43; 3; 9-2021; E482-E4861741-3842CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/jpubhealth/advance-article/doi/10.1093/pubmed/fdab145/6272006info:eu-repo/semantics/altIdentifier/doi/10.1093/pubmed/fdab145info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:20:55Zoai:ri.conicet.gov.ar:11336/152192instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:20:55.637CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv The extent of infectious SARS-CoV-2 shedding in an Argentinean cohort
title The extent of infectious SARS-CoV-2 shedding in an Argentinean cohort
spellingShingle The extent of infectious SARS-CoV-2 shedding in an Argentinean cohort
Blanco, Sebastian
COVID-19
INFECTIVITY
ISOLATION
PUBLIC HEALTH
SARS-COV-2
title_short The extent of infectious SARS-CoV-2 shedding in an Argentinean cohort
title_full The extent of infectious SARS-CoV-2 shedding in an Argentinean cohort
title_fullStr The extent of infectious SARS-CoV-2 shedding in an Argentinean cohort
title_full_unstemmed The extent of infectious SARS-CoV-2 shedding in an Argentinean cohort
title_sort The extent of infectious SARS-CoV-2 shedding in an Argentinean cohort
dc.creator.none.fl_str_mv Blanco, Sebastian
Aguilar, Juan Javier
Konigheim, Brenda Salome
Diaz, Luis Adrian
Spinsanti, Lorena Ivana
Beranek, Mauricio Daniel
Collino, César
Diaz, Miguel
Barbás, María Gabriela
Gallego, Sandra Veronica
author Blanco, Sebastian
author_facet Blanco, Sebastian
Aguilar, Juan Javier
Konigheim, Brenda Salome
Diaz, Luis Adrian
Spinsanti, Lorena Ivana
Beranek, Mauricio Daniel
Collino, César
Diaz, Miguel
Barbás, María Gabriela
Gallego, Sandra Veronica
author_role author
author2 Aguilar, Juan Javier
Konigheim, Brenda Salome
Diaz, Luis Adrian
Spinsanti, Lorena Ivana
Beranek, Mauricio Daniel
Collino, César
Diaz, Miguel
Barbás, María Gabriela
Gallego, Sandra Veronica
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv COVID-19
INFECTIVITY
ISOLATION
PUBLIC HEALTH
SARS-COV-2
topic COVID-19
INFECTIVITY
ISOLATION
PUBLIC HEALTH
SARS-COV-2
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Background To analyze the infectious extent of severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) in different settings where prevention strategies are critical to limit infection spread, we evaluated SARS-COV-2 viability to guide public health policies regarding isolation criteria and infection control. Methods We attempted viral isolation in 82 nasopharyngeal swabs from 72 patients with confirmed SARS-COV-2 infection. Study population was divided into four groups: (i) Patients during the first week of symptoms; (ii) Patients with prolonged positive PCR; (iii) Healthcare workers from a hospital participating of an outbreak investigation, with SARS-COV-2 infection confirmed by reverse transcriptase polymerase chain reaction (RT-PCR) and (iv) Recipients of convalescent immune plasma (CIP). Vero Cl76 cell-line (ATCC CRL-587) was used in assays for virus isolation. Plasma samples of CIP recipients were also tested with plaque-reduction neutralization test. Results We obtained infectious SARS-COV-2 isolates from 15/84 nasopharyngeal swabs. The virus could not be isolated from upper respiratory tract samples collected 10-day after onset of symptoms (AOS) in patients with mild moderate disease. Conclusion The knowledge of the extent of SARS-CoV-2 infectivity AOS is relevant for effective prevention measures. This allows to discuss criteria for end isolation despite persistence of positive PCR and improve timing for hospital discharge with consequent availability of critical beds.
Fil: Blanco, Sebastian. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología Dr. J. M. Vanella; Argentina
Fil: Aguilar, Juan Javier. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología Dr. J. M. Vanella; Argentina
Fil: Konigheim, Brenda Salome. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología Dr. J. M. Vanella; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina
Fil: Diaz, Luis Adrian. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología Dr. J. M. Vanella; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina
Fil: Spinsanti, Lorena Ivana. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología Dr. J. M. Vanella; Argentina
Fil: Beranek, Mauricio Daniel. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología Dr. J. M. Vanella; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina
Fil: Collino, César. Hospital Público Descentralizado Dr. Guillermo Rawson.; Argentina
Fil: Diaz, Miguel. Ministerio de Salud de la Provincia de Córdoba; Argentina
Fil: Barbás, María Gabriela. Hospital Público Descentralizado Dr. Guillermo Rawson.; Argentina
Fil: Gallego, Sandra Veronica. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología Dr. J. M. Vanella; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina
description Background To analyze the infectious extent of severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) in different settings where prevention strategies are critical to limit infection spread, we evaluated SARS-COV-2 viability to guide public health policies regarding isolation criteria and infection control. Methods We attempted viral isolation in 82 nasopharyngeal swabs from 72 patients with confirmed SARS-COV-2 infection. Study population was divided into four groups: (i) Patients during the first week of symptoms; (ii) Patients with prolonged positive PCR; (iii) Healthcare workers from a hospital participating of an outbreak investigation, with SARS-COV-2 infection confirmed by reverse transcriptase polymerase chain reaction (RT-PCR) and (iv) Recipients of convalescent immune plasma (CIP). Vero Cl76 cell-line (ATCC CRL-587) was used in assays for virus isolation. Plasma samples of CIP recipients were also tested with plaque-reduction neutralization test. Results We obtained infectious SARS-COV-2 isolates from 15/84 nasopharyngeal swabs. The virus could not be isolated from upper respiratory tract samples collected 10-day after onset of symptoms (AOS) in patients with mild moderate disease. Conclusion The knowledge of the extent of SARS-CoV-2 infectivity AOS is relevant for effective prevention measures. This allows to discuss criteria for end isolation despite persistence of positive PCR and improve timing for hospital discharge with consequent availability of critical beds.
publishDate 2021
dc.date.none.fl_str_mv 2021-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/152192
Blanco, Sebastian; Aguilar, Juan Javier; Konigheim, Brenda Salome; Diaz, Luis Adrian; Spinsanti, Lorena Ivana; et al.; The extent of infectious SARS-CoV-2 shedding in an Argentinean cohort; Oxford University Press; Journal Of Public Health; 43; 3; 9-2021; E482-E486
1741-3842
CONICET Digital
CONICET
url http://hdl.handle.net/11336/152192
identifier_str_mv Blanco, Sebastian; Aguilar, Juan Javier; Konigheim, Brenda Salome; Diaz, Luis Adrian; Spinsanti, Lorena Ivana; et al.; The extent of infectious SARS-CoV-2 shedding in an Argentinean cohort; Oxford University Press; Journal Of Public Health; 43; 3; 9-2021; E482-E486
1741-3842
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
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info:eu-repo/semantics/altIdentifier/doi/10.1093/pubmed/fdab145
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https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
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application/pdf
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dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
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instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
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