The extent of infectious SARS-CoV-2 shedding in an Argentinean cohort
- Autores
- Blanco, Sebastian; Aguilar, Juan Javier; Konigheim, Brenda Salome; Diaz, Luis Adrian; Spinsanti, Lorena Ivana; Beranek, Mauricio Daniel; Collino, César; Diaz, Miguel; Barbás, María Gabriela; Gallego, Sandra Veronica
- Año de publicación
- 2021
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Background To analyze the infectious extent of severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) in different settings where prevention strategies are critical to limit infection spread, we evaluated SARS-COV-2 viability to guide public health policies regarding isolation criteria and infection control. Methods We attempted viral isolation in 82 nasopharyngeal swabs from 72 patients with confirmed SARS-COV-2 infection. Study population was divided into four groups: (i) Patients during the first week of symptoms; (ii) Patients with prolonged positive PCR; (iii) Healthcare workers from a hospital participating of an outbreak investigation, with SARS-COV-2 infection confirmed by reverse transcriptase polymerase chain reaction (RT-PCR) and (iv) Recipients of convalescent immune plasma (CIP). Vero Cl76 cell-line (ATCC CRL-587) was used in assays for virus isolation. Plasma samples of CIP recipients were also tested with plaque-reduction neutralization test. Results We obtained infectious SARS-COV-2 isolates from 15/84 nasopharyngeal swabs. The virus could not be isolated from upper respiratory tract samples collected 10-day after onset of symptoms (AOS) in patients with mild moderate disease. Conclusion The knowledge of the extent of SARS-CoV-2 infectivity AOS is relevant for effective prevention measures. This allows to discuss criteria for end isolation despite persistence of positive PCR and improve timing for hospital discharge with consequent availability of critical beds.
Fil: Blanco, Sebastian. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología Dr. J. M. Vanella; Argentina
Fil: Aguilar, Juan Javier. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología Dr. J. M. Vanella; Argentina
Fil: Konigheim, Brenda Salome. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología Dr. J. M. Vanella; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina
Fil: Diaz, Luis Adrian. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología Dr. J. M. Vanella; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina
Fil: Spinsanti, Lorena Ivana. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología Dr. J. M. Vanella; Argentina
Fil: Beranek, Mauricio Daniel. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología Dr. J. M. Vanella; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina
Fil: Collino, César. Hospital Público Descentralizado Dr. Guillermo Rawson.; Argentina
Fil: Diaz, Miguel. Ministerio de Salud de la Provincia de Córdoba; Argentina
Fil: Barbás, María Gabriela. Hospital Público Descentralizado Dr. Guillermo Rawson.; Argentina
Fil: Gallego, Sandra Veronica. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología Dr. J. M. Vanella; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina - Materia
-
COVID-19
INFECTIVITY
ISOLATION
PUBLIC HEALTH
SARS-COV-2 - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/152192
Ver los metadatos del registro completo
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The extent of infectious SARS-CoV-2 shedding in an Argentinean cohortBlanco, SebastianAguilar, Juan JavierKonigheim, Brenda SalomeDiaz, Luis AdrianSpinsanti, Lorena IvanaBeranek, Mauricio DanielCollino, CésarDiaz, MiguelBarbás, María GabrielaGallego, Sandra VeronicaCOVID-19INFECTIVITYISOLATIONPUBLIC HEALTHSARS-COV-2https://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Background To analyze the infectious extent of severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) in different settings where prevention strategies are critical to limit infection spread, we evaluated SARS-COV-2 viability to guide public health policies regarding isolation criteria and infection control. Methods We attempted viral isolation in 82 nasopharyngeal swabs from 72 patients with confirmed SARS-COV-2 infection. Study population was divided into four groups: (i) Patients during the first week of symptoms; (ii) Patients with prolonged positive PCR; (iii) Healthcare workers from a hospital participating of an outbreak investigation, with SARS-COV-2 infection confirmed by reverse transcriptase polymerase chain reaction (RT-PCR) and (iv) Recipients of convalescent immune plasma (CIP). Vero Cl76 cell-line (ATCC CRL-587) was used in assays for virus isolation. Plasma samples of CIP recipients were also tested with plaque-reduction neutralization test. Results We obtained infectious SARS-COV-2 isolates from 15/84 nasopharyngeal swabs. The virus could not be isolated from upper respiratory tract samples collected 10-day after onset of symptoms (AOS) in patients with mild moderate disease. Conclusion The knowledge of the extent of SARS-CoV-2 infectivity AOS is relevant for effective prevention measures. This allows to discuss criteria for end isolation despite persistence of positive PCR and improve timing for hospital discharge with consequent availability of critical beds.Fil: Blanco, Sebastian. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología Dr. J. M. Vanella; ArgentinaFil: Aguilar, Juan Javier. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología Dr. J. M. Vanella; ArgentinaFil: Konigheim, Brenda Salome. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología Dr. J. M. Vanella; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; ArgentinaFil: Diaz, Luis Adrian. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología Dr. J. M. Vanella; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; ArgentinaFil: Spinsanti, Lorena Ivana. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología Dr. J. M. Vanella; ArgentinaFil: Beranek, Mauricio Daniel. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología Dr. J. M. Vanella; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; ArgentinaFil: Collino, César. Hospital Público Descentralizado Dr. Guillermo Rawson.; ArgentinaFil: Diaz, Miguel. Ministerio de Salud de la Provincia de Córdoba; ArgentinaFil: Barbás, María Gabriela. Hospital Público Descentralizado Dr. Guillermo Rawson.; ArgentinaFil: Gallego, Sandra Veronica. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología Dr. J. M. Vanella; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; ArgentinaOxford University Press2021-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/152192Blanco, Sebastian; Aguilar, Juan Javier; Konigheim, Brenda Salome; Diaz, Luis Adrian; Spinsanti, Lorena Ivana; et al.; The extent of infectious SARS-CoV-2 shedding in an Argentinean cohort; Oxford University Press; Journal Of Public Health; 43; 3; 9-2021; E482-E4861741-3842CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/jpubhealth/advance-article/doi/10.1093/pubmed/fdab145/6272006info:eu-repo/semantics/altIdentifier/doi/10.1093/pubmed/fdab145info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:20:55Zoai:ri.conicet.gov.ar:11336/152192instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:20:55.637CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
The extent of infectious SARS-CoV-2 shedding in an Argentinean cohort |
title |
The extent of infectious SARS-CoV-2 shedding in an Argentinean cohort |
spellingShingle |
The extent of infectious SARS-CoV-2 shedding in an Argentinean cohort Blanco, Sebastian COVID-19 INFECTIVITY ISOLATION PUBLIC HEALTH SARS-COV-2 |
title_short |
The extent of infectious SARS-CoV-2 shedding in an Argentinean cohort |
title_full |
The extent of infectious SARS-CoV-2 shedding in an Argentinean cohort |
title_fullStr |
The extent of infectious SARS-CoV-2 shedding in an Argentinean cohort |
title_full_unstemmed |
The extent of infectious SARS-CoV-2 shedding in an Argentinean cohort |
title_sort |
The extent of infectious SARS-CoV-2 shedding in an Argentinean cohort |
dc.creator.none.fl_str_mv |
Blanco, Sebastian Aguilar, Juan Javier Konigheim, Brenda Salome Diaz, Luis Adrian Spinsanti, Lorena Ivana Beranek, Mauricio Daniel Collino, César Diaz, Miguel Barbás, María Gabriela Gallego, Sandra Veronica |
author |
Blanco, Sebastian |
author_facet |
Blanco, Sebastian Aguilar, Juan Javier Konigheim, Brenda Salome Diaz, Luis Adrian Spinsanti, Lorena Ivana Beranek, Mauricio Daniel Collino, César Diaz, Miguel Barbás, María Gabriela Gallego, Sandra Veronica |
author_role |
author |
author2 |
Aguilar, Juan Javier Konigheim, Brenda Salome Diaz, Luis Adrian Spinsanti, Lorena Ivana Beranek, Mauricio Daniel Collino, César Diaz, Miguel Barbás, María Gabriela Gallego, Sandra Veronica |
author2_role |
author author author author author author author author author |
dc.subject.none.fl_str_mv |
COVID-19 INFECTIVITY ISOLATION PUBLIC HEALTH SARS-COV-2 |
topic |
COVID-19 INFECTIVITY ISOLATION PUBLIC HEALTH SARS-COV-2 |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 |
dc.description.none.fl_txt_mv |
Background To analyze the infectious extent of severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) in different settings where prevention strategies are critical to limit infection spread, we evaluated SARS-COV-2 viability to guide public health policies regarding isolation criteria and infection control. Methods We attempted viral isolation in 82 nasopharyngeal swabs from 72 patients with confirmed SARS-COV-2 infection. Study population was divided into four groups: (i) Patients during the first week of symptoms; (ii) Patients with prolonged positive PCR; (iii) Healthcare workers from a hospital participating of an outbreak investigation, with SARS-COV-2 infection confirmed by reverse transcriptase polymerase chain reaction (RT-PCR) and (iv) Recipients of convalescent immune plasma (CIP). Vero Cl76 cell-line (ATCC CRL-587) was used in assays for virus isolation. Plasma samples of CIP recipients were also tested with plaque-reduction neutralization test. Results We obtained infectious SARS-COV-2 isolates from 15/84 nasopharyngeal swabs. The virus could not be isolated from upper respiratory tract samples collected 10-day after onset of symptoms (AOS) in patients with mild moderate disease. Conclusion The knowledge of the extent of SARS-CoV-2 infectivity AOS is relevant for effective prevention measures. This allows to discuss criteria for end isolation despite persistence of positive PCR and improve timing for hospital discharge with consequent availability of critical beds. Fil: Blanco, Sebastian. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología Dr. J. M. Vanella; Argentina Fil: Aguilar, Juan Javier. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología Dr. J. M. Vanella; Argentina Fil: Konigheim, Brenda Salome. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología Dr. J. M. Vanella; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina Fil: Diaz, Luis Adrian. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología Dr. J. M. Vanella; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina Fil: Spinsanti, Lorena Ivana. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología Dr. J. M. Vanella; Argentina Fil: Beranek, Mauricio Daniel. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología Dr. J. M. Vanella; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina Fil: Collino, César. Hospital Público Descentralizado Dr. Guillermo Rawson.; Argentina Fil: Diaz, Miguel. Ministerio de Salud de la Provincia de Córdoba; Argentina Fil: Barbás, María Gabriela. Hospital Público Descentralizado Dr. Guillermo Rawson.; Argentina Fil: Gallego, Sandra Veronica. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología Dr. J. M. Vanella; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina |
description |
Background To analyze the infectious extent of severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) in different settings where prevention strategies are critical to limit infection spread, we evaluated SARS-COV-2 viability to guide public health policies regarding isolation criteria and infection control. Methods We attempted viral isolation in 82 nasopharyngeal swabs from 72 patients with confirmed SARS-COV-2 infection. Study population was divided into four groups: (i) Patients during the first week of symptoms; (ii) Patients with prolonged positive PCR; (iii) Healthcare workers from a hospital participating of an outbreak investigation, with SARS-COV-2 infection confirmed by reverse transcriptase polymerase chain reaction (RT-PCR) and (iv) Recipients of convalescent immune plasma (CIP). Vero Cl76 cell-line (ATCC CRL-587) was used in assays for virus isolation. Plasma samples of CIP recipients were also tested with plaque-reduction neutralization test. Results We obtained infectious SARS-COV-2 isolates from 15/84 nasopharyngeal swabs. The virus could not be isolated from upper respiratory tract samples collected 10-day after onset of symptoms (AOS) in patients with mild moderate disease. Conclusion The knowledge of the extent of SARS-CoV-2 infectivity AOS is relevant for effective prevention measures. This allows to discuss criteria for end isolation despite persistence of positive PCR and improve timing for hospital discharge with consequent availability of critical beds. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-09 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/152192 Blanco, Sebastian; Aguilar, Juan Javier; Konigheim, Brenda Salome; Diaz, Luis Adrian; Spinsanti, Lorena Ivana; et al.; The extent of infectious SARS-CoV-2 shedding in an Argentinean cohort; Oxford University Press; Journal Of Public Health; 43; 3; 9-2021; E482-E486 1741-3842 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/152192 |
identifier_str_mv |
Blanco, Sebastian; Aguilar, Juan Javier; Konigheim, Brenda Salome; Diaz, Luis Adrian; Spinsanti, Lorena Ivana; et al.; The extent of infectious SARS-CoV-2 shedding in an Argentinean cohort; Oxford University Press; Journal Of Public Health; 43; 3; 9-2021; E482-E486 1741-3842 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/jpubhealth/advance-article/doi/10.1093/pubmed/fdab145/6272006 info:eu-repo/semantics/altIdentifier/doi/10.1093/pubmed/fdab145 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
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openAccess |
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https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
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application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Oxford University Press |
publisher.none.fl_str_mv |
Oxford University Press |
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Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
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dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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