Elastomeric Protein Bioactive Eutectogels for Topical Drug Delivery

Autores
Picchio, Matías Luis; Orellano, María Soledad; Motta, Maria Angela; Huck Iriart, Cristián; Sánchez deAlcázar, Daniel; López Domene, Rocío; Martín-García, Beatriz; Larrañaga, Aitor; Beloqui, Ana; Mecerreyes, David; Calderón, Marcelo
Año de publicación
2024
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Therapeutic deep eutectic solvents (THEDES) are an emerging family of eutectic mixtures gaining increasing interest in the biomedical space. The immobilization of THEDES into polymer networks allows bioactive eutectogels to expand their application scope to topical drug delivery. Herein, this work presents the first set of elastomeric eutectogels constructed by supporting a therapeutic eutectic system with skin permeation ability in a protein scaffold dynamically crosslinked by a natural polyphenol. In this ionic eutectic, gelatin undergoes gelation through an unexpected mechanism in striking contrast with classical hydrogels, which is herein thoroughly studied. Interestingly, the polyphenol controls the conformation of the protein structure, enabling tuning up the mechanical and viscoelastic behavior of the dynamic eutectogel networks from elastic to hyperelastic. The resultant protein eutectogels exhibit strain-hardening behavior, thermoreversible gel-to-sol transition, and excellent adhesive performance. Furthermore, these versatile materials retain the bioactivity of the liquid THEDES and favor skin occlusion, assisting the delivery of both hydrophilic and hydrophobic substances in ex vivo porcine skin in a time-dependent penetration process. These ultrastretchable eutectogels show new interplays between protein scaffolds and eutectic mixtures, paving the way for innovative therapeutic soft materials.
Fil: Picchio, Matías Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina
Fil: Orellano, María Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad del País Vasco; España
Fil: Motta, Maria Angela. Universidad del País Vasco; España
Fil: Huck Iriart, Cristián. Universidad del País Vasco; España. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Sánchez deAlcázar, Daniel. Universidad Nacional de San Martín; Argentina
Fil: López Domene, Rocío. No especifíca;
Fil: Martín-García, Beatriz. Universidad del País Vasco; España
Fil: Larrañaga, Aitor. No especifíca;
Fil: Beloqui, Ana. Universidad del País Vasco; España
Fil: Mecerreyes, David. No especifíca;
Fil: Calderón, Marcelo. No especifíca;
Materia
CHOLINE GERANATE
EUTECTOGELS
PROTEIN ELASTOMERS
THERAPEUTIC DEEP EUTECTIC SOLVENTS
TOPICAL DRUG DELIVERY
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/239013
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/239013
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Elastomeric Protein Bioactive Eutectogels for Topical Drug DeliveryPicchio, Matías LuisOrellano, María SoledadMotta, Maria AngelaHuck Iriart, CristiánSánchez deAlcázar, DanielLópez Domene, RocíoMartín-García, BeatrizLarrañaga, AitorBeloqui, AnaMecerreyes, DavidCalderón, MarceloCHOLINE GERANATEEUTECTOGELSPROTEIN ELASTOMERSTHERAPEUTIC DEEP EUTECTIC SOLVENTSTOPICAL DRUG DELIVERYhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1Therapeutic deep eutectic solvents (THEDES) are an emerging family of eutectic mixtures gaining increasing interest in the biomedical space. The immobilization of THEDES into polymer networks allows bioactive eutectogels to expand their application scope to topical drug delivery. Herein, this work presents the first set of elastomeric eutectogels constructed by supporting a therapeutic eutectic system with skin permeation ability in a protein scaffold dynamically crosslinked by a natural polyphenol. In this ionic eutectic, gelatin undergoes gelation through an unexpected mechanism in striking contrast with classical hydrogels, which is herein thoroughly studied. Interestingly, the polyphenol controls the conformation of the protein structure, enabling tuning up the mechanical and viscoelastic behavior of the dynamic eutectogel networks from elastic to hyperelastic. The resultant protein eutectogels exhibit strain-hardening behavior, thermoreversible gel-to-sol transition, and excellent adhesive performance. Furthermore, these versatile materials retain the bioactivity of the liquid THEDES and favor skin occlusion, assisting the delivery of both hydrophilic and hydrophobic substances in ex vivo porcine skin in a time-dependent penetration process. These ultrastretchable eutectogels show new interplays between protein scaffolds and eutectic mixtures, paving the way for innovative therapeutic soft materials.Fil: Picchio, Matías Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; ArgentinaFil: Orellano, María Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad del País Vasco; EspañaFil: Motta, Maria Angela. Universidad del País Vasco; EspañaFil: Huck Iriart, Cristián. Universidad del País Vasco; España. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Sánchez deAlcázar, Daniel. Universidad Nacional de San Martín; ArgentinaFil: López Domene, Rocío. No especifíca;Fil: Martín-García, Beatriz. Universidad del País Vasco; EspañaFil: Larrañaga, Aitor. No especifíca;Fil: Beloqui, Ana. Universidad del País Vasco; EspañaFil: Mecerreyes, David. No especifíca;Fil: Calderón, Marcelo. No especifíca;Wiley VCH Verlag2024-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/239013Picchio, Matías Luis; Orellano, María Soledad; Motta, Maria Angela; Huck Iriart, Cristián; Sánchez deAlcázar, Daniel; et al.; Elastomeric Protein Bioactive Eutectogels for Topical Drug Delivery; Wiley VCH Verlag; Advanced Functional Materials; 34; 18; 1-2024; 1-101616-301XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/full/10.1002/adfm.202313747info:eu-repo/semantics/altIdentifier/doi/10.1002/adfm.202313747info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:09:06Zoai:ri.conicet.gov.ar:11336/239013instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:09:06.412CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Elastomeric Protein Bioactive Eutectogels for Topical Drug Delivery
title Elastomeric Protein Bioactive Eutectogels for Topical Drug Delivery
spellingShingle Elastomeric Protein Bioactive Eutectogels for Topical Drug Delivery
Picchio, Matías Luis
CHOLINE GERANATE
EUTECTOGELS
PROTEIN ELASTOMERS
THERAPEUTIC DEEP EUTECTIC SOLVENTS
TOPICAL DRUG DELIVERY
title_short Elastomeric Protein Bioactive Eutectogels for Topical Drug Delivery
title_full Elastomeric Protein Bioactive Eutectogels for Topical Drug Delivery
title_fullStr Elastomeric Protein Bioactive Eutectogels for Topical Drug Delivery
title_full_unstemmed Elastomeric Protein Bioactive Eutectogels for Topical Drug Delivery
title_sort Elastomeric Protein Bioactive Eutectogels for Topical Drug Delivery
dc.creator.none.fl_str_mv Picchio, Matías Luis
Orellano, María Soledad
Motta, Maria Angela
Huck Iriart, Cristián
Sánchez deAlcázar, Daniel
López Domene, Rocío
Martín-García, Beatriz
Larrañaga, Aitor
Beloqui, Ana
Mecerreyes, David
Calderón, Marcelo
author Picchio, Matías Luis
author_facet Picchio, Matías Luis
Orellano, María Soledad
Motta, Maria Angela
Huck Iriart, Cristián
Sánchez deAlcázar, Daniel
López Domene, Rocío
Martín-García, Beatriz
Larrañaga, Aitor
Beloqui, Ana
Mecerreyes, David
Calderón, Marcelo
author_role author
author2 Orellano, María Soledad
Motta, Maria Angela
Huck Iriart, Cristián
Sánchez deAlcázar, Daniel
López Domene, Rocío
Martín-García, Beatriz
Larrañaga, Aitor
Beloqui, Ana
Mecerreyes, David
Calderón, Marcelo
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv CHOLINE GERANATE
EUTECTOGELS
PROTEIN ELASTOMERS
THERAPEUTIC DEEP EUTECTIC SOLVENTS
TOPICAL DRUG DELIVERY
topic CHOLINE GERANATE
EUTECTOGELS
PROTEIN ELASTOMERS
THERAPEUTIC DEEP EUTECTIC SOLVENTS
TOPICAL DRUG DELIVERY
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Therapeutic deep eutectic solvents (THEDES) are an emerging family of eutectic mixtures gaining increasing interest in the biomedical space. The immobilization of THEDES into polymer networks allows bioactive eutectogels to expand their application scope to topical drug delivery. Herein, this work presents the first set of elastomeric eutectogels constructed by supporting a therapeutic eutectic system with skin permeation ability in a protein scaffold dynamically crosslinked by a natural polyphenol. In this ionic eutectic, gelatin undergoes gelation through an unexpected mechanism in striking contrast with classical hydrogels, which is herein thoroughly studied. Interestingly, the polyphenol controls the conformation of the protein structure, enabling tuning up the mechanical and viscoelastic behavior of the dynamic eutectogel networks from elastic to hyperelastic. The resultant protein eutectogels exhibit strain-hardening behavior, thermoreversible gel-to-sol transition, and excellent adhesive performance. Furthermore, these versatile materials retain the bioactivity of the liquid THEDES and favor skin occlusion, assisting the delivery of both hydrophilic and hydrophobic substances in ex vivo porcine skin in a time-dependent penetration process. These ultrastretchable eutectogels show new interplays between protein scaffolds and eutectic mixtures, paving the way for innovative therapeutic soft materials.
Fil: Picchio, Matías Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina
Fil: Orellano, María Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad del País Vasco; España
Fil: Motta, Maria Angela. Universidad del País Vasco; España
Fil: Huck Iriart, Cristián. Universidad del País Vasco; España. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Sánchez deAlcázar, Daniel. Universidad Nacional de San Martín; Argentina
Fil: López Domene, Rocío. No especifíca;
Fil: Martín-García, Beatriz. Universidad del País Vasco; España
Fil: Larrañaga, Aitor. No especifíca;
Fil: Beloqui, Ana. Universidad del País Vasco; España
Fil: Mecerreyes, David. No especifíca;
Fil: Calderón, Marcelo. No especifíca;
description Therapeutic deep eutectic solvents (THEDES) are an emerging family of eutectic mixtures gaining increasing interest in the biomedical space. The immobilization of THEDES into polymer networks allows bioactive eutectogels to expand their application scope to topical drug delivery. Herein, this work presents the first set of elastomeric eutectogels constructed by supporting a therapeutic eutectic system with skin permeation ability in a protein scaffold dynamically crosslinked by a natural polyphenol. In this ionic eutectic, gelatin undergoes gelation through an unexpected mechanism in striking contrast with classical hydrogels, which is herein thoroughly studied. Interestingly, the polyphenol controls the conformation of the protein structure, enabling tuning up the mechanical and viscoelastic behavior of the dynamic eutectogel networks from elastic to hyperelastic. The resultant protein eutectogels exhibit strain-hardening behavior, thermoreversible gel-to-sol transition, and excellent adhesive performance. Furthermore, these versatile materials retain the bioactivity of the liquid THEDES and favor skin occlusion, assisting the delivery of both hydrophilic and hydrophobic substances in ex vivo porcine skin in a time-dependent penetration process. These ultrastretchable eutectogels show new interplays between protein scaffolds and eutectic mixtures, paving the way for innovative therapeutic soft materials.
publishDate 2024
dc.date.none.fl_str_mv 2024-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/239013
Picchio, Matías Luis; Orellano, María Soledad; Motta, Maria Angela; Huck Iriart, Cristián; Sánchez deAlcázar, Daniel; et al.; Elastomeric Protein Bioactive Eutectogels for Topical Drug Delivery; Wiley VCH Verlag; Advanced Functional Materials; 34; 18; 1-2024; 1-10
1616-301X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/239013
identifier_str_mv Picchio, Matías Luis; Orellano, María Soledad; Motta, Maria Angela; Huck Iriart, Cristián; Sánchez deAlcázar, Daniel; et al.; Elastomeric Protein Bioactive Eutectogels for Topical Drug Delivery; Wiley VCH Verlag; Advanced Functional Materials; 34; 18; 1-2024; 1-10
1616-301X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/full/10.1002/adfm.202313747
info:eu-repo/semantics/altIdentifier/doi/10.1002/adfm.202313747
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley VCH Verlag
publisher.none.fl_str_mv Wiley VCH Verlag
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.885934

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