Do We Need a New Hypothesis for KATP Closure in β-Cells? Distinguishing the Baby From the Bathwater
- Autores
- Satin, Leslie Sherwin; Corradi, Jeremias; Sherman, Arthur Stewart
- Año de publicación
- 2024
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Let us first start where we all agree: KATP channels are the main conductance of the resting pancreatic b-cell, and their closure by changes in the ATP-to-ADP ratio is the triggering mechanism used by glucose to increase Ca21 flux into the b-cell (1–3). When Cook and Hales (4) and Ashcroft et al. (5) discovered the KATP channel and showed it was closed by glucose metabolism, the source of the ATP that closed the channel was not stipulated. In fact, we struggled to find the first references to the term consensus model or canonical model in the literature. This is not mere semantics, as it seems most parsimonious to us that both glycolytic and mitochondrially derived ATP should be capable of closing the channel. As Merrins and Kibbey (6) argue in their Counterpoint article in this issue of Diabetes, it is difficult to separate glycolysis from oxidative phosphorylation (OXPHOS) because they are tightly linked: inhibiting glycolysis will also affect mitochondria by depriving them of pyruvate
Fil: Satin, Leslie Sherwin. University of Michigan; Estados Unidos
Fil: Corradi, Jeremias. University of Michigan; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina
Fil: Sherman, Arthur Stewart. National Institutes of Health; Estados Unidos - Materia
-
DIABETES
BETA CELL
PATCH-CLAMP - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/239700
Ver los metadatos del registro completo
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Do We Need a New Hypothesis for KATP Closure in β-Cells? Distinguishing the Baby From the BathwaterSatin, Leslie SherwinCorradi, JeremiasSherman, Arthur StewartDIABETESBETA CELLPATCH-CLAMPhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Let us first start where we all agree: KATP channels are the main conductance of the resting pancreatic b-cell, and their closure by changes in the ATP-to-ADP ratio is the triggering mechanism used by glucose to increase Ca21 flux into the b-cell (1–3). When Cook and Hales (4) and Ashcroft et al. (5) discovered the KATP channel and showed it was closed by glucose metabolism, the source of the ATP that closed the channel was not stipulated. In fact, we struggled to find the first references to the term consensus model or canonical model in the literature. This is not mere semantics, as it seems most parsimonious to us that both glycolytic and mitochondrially derived ATP should be capable of closing the channel. As Merrins and Kibbey (6) argue in their Counterpoint article in this issue of Diabetes, it is difficult to separate glycolysis from oxidative phosphorylation (OXPHOS) because they are tightly linked: inhibiting glycolysis will also affect mitochondria by depriving them of pyruvateFil: Satin, Leslie Sherwin. University of Michigan; Estados UnidosFil: Corradi, Jeremias. University of Michigan; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; ArgentinaFil: Sherman, Arthur Stewart. National Institutes of Health; Estados UnidosAmerican Diabetes Association2024-04-19info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/239700Satin, Leslie Sherwin; Corradi, Jeremias; Sherman, Arthur Stewart; Do We Need a New Hypothesis for KATP Closure in β-Cells? Distinguishing the Baby From the Bathwater; American Diabetes Association; Diabetes; 73; 6; 19-4-2024; 844-8480012-17971939-327XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://diabetesjournals.org/diabetes/article/73/6/844/154509/Do-We-Need-a-New-Hypothesis-for-KATP-Closure-ininfo:eu-repo/semantics/altIdentifier/doi/10.2337/db24-0131info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:47:48Zoai:ri.conicet.gov.ar:11336/239700instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:47:49.215CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Do We Need a New Hypothesis for KATP Closure in β-Cells? Distinguishing the Baby From the Bathwater |
title |
Do We Need a New Hypothesis for KATP Closure in β-Cells? Distinguishing the Baby From the Bathwater |
spellingShingle |
Do We Need a New Hypothesis for KATP Closure in β-Cells? Distinguishing the Baby From the Bathwater Satin, Leslie Sherwin DIABETES BETA CELL PATCH-CLAMP |
title_short |
Do We Need a New Hypothesis for KATP Closure in β-Cells? Distinguishing the Baby From the Bathwater |
title_full |
Do We Need a New Hypothesis for KATP Closure in β-Cells? Distinguishing the Baby From the Bathwater |
title_fullStr |
Do We Need a New Hypothesis for KATP Closure in β-Cells? Distinguishing the Baby From the Bathwater |
title_full_unstemmed |
Do We Need a New Hypothesis for KATP Closure in β-Cells? Distinguishing the Baby From the Bathwater |
title_sort |
Do We Need a New Hypothesis for KATP Closure in β-Cells? Distinguishing the Baby From the Bathwater |
dc.creator.none.fl_str_mv |
Satin, Leslie Sherwin Corradi, Jeremias Sherman, Arthur Stewart |
author |
Satin, Leslie Sherwin |
author_facet |
Satin, Leslie Sherwin Corradi, Jeremias Sherman, Arthur Stewart |
author_role |
author |
author2 |
Corradi, Jeremias Sherman, Arthur Stewart |
author2_role |
author author |
dc.subject.none.fl_str_mv |
DIABETES BETA CELL PATCH-CLAMP |
topic |
DIABETES BETA CELL PATCH-CLAMP |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 |
dc.description.none.fl_txt_mv |
Let us first start where we all agree: KATP channels are the main conductance of the resting pancreatic b-cell, and their closure by changes in the ATP-to-ADP ratio is the triggering mechanism used by glucose to increase Ca21 flux into the b-cell (1–3). When Cook and Hales (4) and Ashcroft et al. (5) discovered the KATP channel and showed it was closed by glucose metabolism, the source of the ATP that closed the channel was not stipulated. In fact, we struggled to find the first references to the term consensus model or canonical model in the literature. This is not mere semantics, as it seems most parsimonious to us that both glycolytic and mitochondrially derived ATP should be capable of closing the channel. As Merrins and Kibbey (6) argue in their Counterpoint article in this issue of Diabetes, it is difficult to separate glycolysis from oxidative phosphorylation (OXPHOS) because they are tightly linked: inhibiting glycolysis will also affect mitochondria by depriving them of pyruvate Fil: Satin, Leslie Sherwin. University of Michigan; Estados Unidos Fil: Corradi, Jeremias. University of Michigan; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina Fil: Sherman, Arthur Stewart. National Institutes of Health; Estados Unidos |
description |
Let us first start where we all agree: KATP channels are the main conductance of the resting pancreatic b-cell, and their closure by changes in the ATP-to-ADP ratio is the triggering mechanism used by glucose to increase Ca21 flux into the b-cell (1–3). When Cook and Hales (4) and Ashcroft et al. (5) discovered the KATP channel and showed it was closed by glucose metabolism, the source of the ATP that closed the channel was not stipulated. In fact, we struggled to find the first references to the term consensus model or canonical model in the literature. This is not mere semantics, as it seems most parsimonious to us that both glycolytic and mitochondrially derived ATP should be capable of closing the channel. As Merrins and Kibbey (6) argue in their Counterpoint article in this issue of Diabetes, it is difficult to separate glycolysis from oxidative phosphorylation (OXPHOS) because they are tightly linked: inhibiting glycolysis will also affect mitochondria by depriving them of pyruvate |
publishDate |
2024 |
dc.date.none.fl_str_mv |
2024-04-19 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/239700 Satin, Leslie Sherwin; Corradi, Jeremias; Sherman, Arthur Stewart; Do We Need a New Hypothesis for KATP Closure in β-Cells? Distinguishing the Baby From the Bathwater; American Diabetes Association; Diabetes; 73; 6; 19-4-2024; 844-848 0012-1797 1939-327X CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/239700 |
identifier_str_mv |
Satin, Leslie Sherwin; Corradi, Jeremias; Sherman, Arthur Stewart; Do We Need a New Hypothesis for KATP Closure in β-Cells? Distinguishing the Baby From the Bathwater; American Diabetes Association; Diabetes; 73; 6; 19-4-2024; 844-848 0012-1797 1939-327X CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://diabetesjournals.org/diabetes/article/73/6/844/154509/Do-We-Need-a-New-Hypothesis-for-KATP-Closure-in info:eu-repo/semantics/altIdentifier/doi/10.2337/db24-0131 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
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application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
American Diabetes Association |
publisher.none.fl_str_mv |
American Diabetes Association |
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reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
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Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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