Do We Need a New Hypothesis for KATP Closure in β-Cells? Distinguishing the Baby From the Bathwater

Autores
Satin, Leslie Sherwin; Corradi, Jeremias; Sherman, Arthur Stewart
Año de publicación
2024
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Let us first start where we all agree: KATP channels are the main conductance of the resting pancreatic b-cell, and their closure by changes in the ATP-to-ADP ratio is the triggering mechanism used by glucose to increase Ca21 flux into the b-cell (1–3). When Cook and Hales (4) and Ashcroft et al. (5) discovered the KATP channel and showed it was closed by glucose metabolism, the source of the ATP that closed the channel was not stipulated. In fact, we struggled to find the first references to the term consensus model or canonical model in the literature. This is not mere semantics, as it seems most parsimonious to us that both glycolytic and mitochondrially derived ATP should be capable of closing the channel. As Merrins and Kibbey (6) argue in their Counterpoint article in this issue of Diabetes, it is difficult to separate glycolysis from oxidative phosphorylation (OXPHOS) because they are tightly linked: inhibiting glycolysis will also affect mitochondria by depriving them of pyruvate
Fil: Satin, Leslie Sherwin. University of Michigan; Estados Unidos
Fil: Corradi, Jeremias. University of Michigan; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina
Fil: Sherman, Arthur Stewart. National Institutes of Health; Estados Unidos
Materia
DIABETES
BETA CELL
PATCH-CLAMP
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/239700
Acceder
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spelling Do We Need a New Hypothesis for KATP Closure in β-Cells? Distinguishing the Baby From the BathwaterSatin, Leslie SherwinCorradi, JeremiasSherman, Arthur StewartDIABETESBETA CELLPATCH-CLAMPhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Let us first start where we all agree: KATP channels are the main conductance of the resting pancreatic b-cell, and their closure by changes in the ATP-to-ADP ratio is the triggering mechanism used by glucose to increase Ca21 flux into the b-cell (1–3). When Cook and Hales (4) and Ashcroft et al. (5) discovered the KATP channel and showed it was closed by glucose metabolism, the source of the ATP that closed the channel was not stipulated. In fact, we struggled to find the first references to the term consensus model or canonical model in the literature. This is not mere semantics, as it seems most parsimonious to us that both glycolytic and mitochondrially derived ATP should be capable of closing the channel. As Merrins and Kibbey (6) argue in their Counterpoint article in this issue of Diabetes, it is difficult to separate glycolysis from oxidative phosphorylation (OXPHOS) because they are tightly linked: inhibiting glycolysis will also affect mitochondria by depriving them of pyruvateFil: Satin, Leslie Sherwin. University of Michigan; Estados UnidosFil: Corradi, Jeremias. University of Michigan; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; ArgentinaFil: Sherman, Arthur Stewart. National Institutes of Health; Estados UnidosAmerican Diabetes Association2024-04-19info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/239700Satin, Leslie Sherwin; Corradi, Jeremias; Sherman, Arthur Stewart; Do We Need a New Hypothesis for KATP Closure in β-Cells? Distinguishing the Baby From the Bathwater; American Diabetes Association; Diabetes; 73; 6; 19-4-2024; 844-8480012-17971939-327XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://diabetesjournals.org/diabetes/article/73/6/844/154509/Do-We-Need-a-New-Hypothesis-for-KATP-Closure-ininfo:eu-repo/semantics/altIdentifier/doi/10.2337/db24-0131info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T12:22:17Zoai:ri.conicet.gov.ar:11336/239700instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 12:22:17.498CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Do We Need a New Hypothesis for KATP Closure in β-Cells? Distinguishing the Baby From the Bathwater
title Do We Need a New Hypothesis for KATP Closure in β-Cells? Distinguishing the Baby From the Bathwater
spellingShingle Do We Need a New Hypothesis for KATP Closure in β-Cells? Distinguishing the Baby From the Bathwater
Satin, Leslie Sherwin
DIABETES
BETA CELL
PATCH-CLAMP
title_short Do We Need a New Hypothesis for KATP Closure in β-Cells? Distinguishing the Baby From the Bathwater
title_full Do We Need a New Hypothesis for KATP Closure in β-Cells? Distinguishing the Baby From the Bathwater
title_fullStr Do We Need a New Hypothesis for KATP Closure in β-Cells? Distinguishing the Baby From the Bathwater
title_full_unstemmed Do We Need a New Hypothesis for KATP Closure in β-Cells? Distinguishing the Baby From the Bathwater
title_sort Do We Need a New Hypothesis for KATP Closure in β-Cells? Distinguishing the Baby From the Bathwater
dc.creator.none.fl_str_mv Satin, Leslie Sherwin
Corradi, Jeremias
Sherman, Arthur Stewart
author Satin, Leslie Sherwin
author_facet Satin, Leslie Sherwin
Corradi, Jeremias
Sherman, Arthur Stewart
author_role author
author2 Corradi, Jeremias
Sherman, Arthur Stewart
author2_role author
author
dc.subject.none.fl_str_mv DIABETES
BETA CELL
PATCH-CLAMP
topic DIABETES
BETA CELL
PATCH-CLAMP
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Let us first start where we all agree: KATP channels are the main conductance of the resting pancreatic b-cell, and their closure by changes in the ATP-to-ADP ratio is the triggering mechanism used by glucose to increase Ca21 flux into the b-cell (1–3). When Cook and Hales (4) and Ashcroft et al. (5) discovered the KATP channel and showed it was closed by glucose metabolism, the source of the ATP that closed the channel was not stipulated. In fact, we struggled to find the first references to the term consensus model or canonical model in the literature. This is not mere semantics, as it seems most parsimonious to us that both glycolytic and mitochondrially derived ATP should be capable of closing the channel. As Merrins and Kibbey (6) argue in their Counterpoint article in this issue of Diabetes, it is difficult to separate glycolysis from oxidative phosphorylation (OXPHOS) because they are tightly linked: inhibiting glycolysis will also affect mitochondria by depriving them of pyruvate
Fil: Satin, Leslie Sherwin. University of Michigan; Estados Unidos
Fil: Corradi, Jeremias. University of Michigan; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina
Fil: Sherman, Arthur Stewart. National Institutes of Health; Estados Unidos
description Let us first start where we all agree: KATP channels are the main conductance of the resting pancreatic b-cell, and their closure by changes in the ATP-to-ADP ratio is the triggering mechanism used by glucose to increase Ca21 flux into the b-cell (1–3). When Cook and Hales (4) and Ashcroft et al. (5) discovered the KATP channel and showed it was closed by glucose metabolism, the source of the ATP that closed the channel was not stipulated. In fact, we struggled to find the first references to the term consensus model or canonical model in the literature. This is not mere semantics, as it seems most parsimonious to us that both glycolytic and mitochondrially derived ATP should be capable of closing the channel. As Merrins and Kibbey (6) argue in their Counterpoint article in this issue of Diabetes, it is difficult to separate glycolysis from oxidative phosphorylation (OXPHOS) because they are tightly linked: inhibiting glycolysis will also affect mitochondria by depriving them of pyruvate
publishDate 2024
dc.date.none.fl_str_mv 2024-04-19
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/239700
Satin, Leslie Sherwin; Corradi, Jeremias; Sherman, Arthur Stewart; Do We Need a New Hypothesis for KATP Closure in β-Cells? Distinguishing the Baby From the Bathwater; American Diabetes Association; Diabetes; 73; 6; 19-4-2024; 844-848
0012-1797
1939-327X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/239700
identifier_str_mv Satin, Leslie Sherwin; Corradi, Jeremias; Sherman, Arthur Stewart; Do We Need a New Hypothesis for KATP Closure in β-Cells? Distinguishing the Baby From the Bathwater; American Diabetes Association; Diabetes; 73; 6; 19-4-2024; 844-848
0012-1797
1939-327X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://diabetesjournals.org/diabetes/article/73/6/844/154509/Do-We-Need-a-New-Hypothesis-for-KATP-Closure-in
info:eu-repo/semantics/altIdentifier/doi/10.2337/db24-0131
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv American Diabetes Association
publisher.none.fl_str_mv American Diabetes Association
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.982451

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