Paracrine/autocrine control of female reproduction

Autores
Reis, M. F.; Cobellis, L.; Luisi, S.; Driul, L.; Florio, P.; Faletti, Alicia Graciela; Petraglia, F.
Año de publicación
2000
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Neuropeptides, growth factors and cytokines are expressed in reproductive organs and tissues, where they interact with afferent endocrine messages to modulate cell proliferation and differentiation, local hormone secretion and vascular function. These events regulate complex processes such as gonadotropin pulsatility, ovulation, implantation and parturition. During reproductive life, a number of neuropeptides produced within the hypothalamus play a modulatory role in the control of gonadotropin-releasing hormone (GnRH) release, hence characterizing a hypothalamic paracrine system. The pituitary gland is a source and target of inhibin-related proteins, and these typical 'gonadal' products, once secreted by the pituitary cells, acquire the function of paracrine modulators of follide-stimulating hormone (FSH) secretion. In the ovary, the effect of gonadotropins is locally modulated by growth factors acting in an autocrine/paracrine manner, although their precise role in folliculogenesis remains uncertain. Numerous local factors are involved in the control of endometrial growth, differentiation, receptivity and menstruation. Alterations in the paracrine endometrial system may underlie pathological processes such as infertility or endometrial neoplasia. The human placenta and its related membranes produce cytokines, hormones and growth factors that participate in the control of gestational development as well as in the maternal-fetal adaptation to gestational diseases. There is increasing evidence that paracrine signaling plays a fundamental role in all spheres of female reproductive function, and future research will concentrate on clarifying which of these local mechanisms play a decisive role in both physiology and disease, thus giving rise to new therapeutic strategies.
Fil: Reis, M. F.. Università degli Studi di Siena; Italia
Fil: Cobellis, L.. Università degli Studi di Siena; Italia
Fil: Luisi, S.. Università degli Studi di Siena; Italia
Fil: Driul, L.. Università degli Studi di Siena; Italia
Fil: Florio, P.. Università degli Studi di Siena; Italia
Fil: Faletti, Alicia Graciela. Università degli Studi di Siena; Italia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; Argentina
Fil: Petraglia, F.. Università degli Studi di Siena; Italia
Materia
Cytokines
Growth Factors
Neuropeptides
Ovary
Paracrine
Pituitary
Placenta
Uterus
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/39198
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/39198
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Paracrine/autocrine control of female reproductionReis, M. F.Cobellis, L.Luisi, S.Driul, L.Florio, P.Faletti, Alicia GracielaPetraglia, F.CytokinesGrowth FactorsNeuropeptidesOvaryParacrinePituitaryPlacentaUterushttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Neuropeptides, growth factors and cytokines are expressed in reproductive organs and tissues, where they interact with afferent endocrine messages to modulate cell proliferation and differentiation, local hormone secretion and vascular function. These events regulate complex processes such as gonadotropin pulsatility, ovulation, implantation and parturition. During reproductive life, a number of neuropeptides produced within the hypothalamus play a modulatory role in the control of gonadotropin-releasing hormone (GnRH) release, hence characterizing a hypothalamic paracrine system. The pituitary gland is a source and target of inhibin-related proteins, and these typical 'gonadal' products, once secreted by the pituitary cells, acquire the function of paracrine modulators of follide-stimulating hormone (FSH) secretion. In the ovary, the effect of gonadotropins is locally modulated by growth factors acting in an autocrine/paracrine manner, although their precise role in folliculogenesis remains uncertain. Numerous local factors are involved in the control of endometrial growth, differentiation, receptivity and menstruation. Alterations in the paracrine endometrial system may underlie pathological processes such as infertility or endometrial neoplasia. The human placenta and its related membranes produce cytokines, hormones and growth factors that participate in the control of gestational development as well as in the maternal-fetal adaptation to gestational diseases. There is increasing evidence that paracrine signaling plays a fundamental role in all spheres of female reproductive function, and future research will concentrate on clarifying which of these local mechanisms play a decisive role in both physiology and disease, thus giving rise to new therapeutic strategies.Fil: Reis, M. F.. Università degli Studi di Siena; ItaliaFil: Cobellis, L.. Università degli Studi di Siena; ItaliaFil: Luisi, S.. Università degli Studi di Siena; ItaliaFil: Driul, L.. Università degli Studi di Siena; ItaliaFil: Florio, P.. Università degli Studi di Siena; ItaliaFil: Faletti, Alicia Graciela. Università degli Studi di Siena; Italia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; ArgentinaFil: Petraglia, F.. Università degli Studi di Siena; ItaliaInforma Healthcare2000-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/39198Reis, M. F.; Cobellis, L.; Luisi, S.; Driul, L.; Florio, P.; et al.; Paracrine/autocrine control of female reproduction; Informa Healthcare; Gynecological Endocrinology; 14; 6; 12-2000; 464-4750951-3590CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/abs/10.3109/09513590009167720info:eu-repo/semantics/altIdentifier/doi/10.3109/09513590009167720info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-29T12:10:11Zoai:ri.conicet.gov.ar:11336/39198instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-29 12:10:12.126CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Paracrine/autocrine control of female reproduction
title Paracrine/autocrine control of female reproduction
spellingShingle Paracrine/autocrine control of female reproduction
Reis, M. F.
Cytokines
Growth Factors
Neuropeptides
Ovary
Paracrine
Pituitary
Placenta
Uterus
title_short Paracrine/autocrine control of female reproduction
title_full Paracrine/autocrine control of female reproduction
title_fullStr Paracrine/autocrine control of female reproduction
title_full_unstemmed Paracrine/autocrine control of female reproduction
title_sort Paracrine/autocrine control of female reproduction
dc.creator.none.fl_str_mv Reis, M. F.
Cobellis, L.
Luisi, S.
Driul, L.
Florio, P.
Faletti, Alicia Graciela
Petraglia, F.
author Reis, M. F.
author_facet Reis, M. F.
Cobellis, L.
Luisi, S.
Driul, L.
Florio, P.
Faletti, Alicia Graciela
Petraglia, F.
author_role author
author2 Cobellis, L.
Luisi, S.
Driul, L.
Florio, P.
Faletti, Alicia Graciela
Petraglia, F.
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Cytokines
Growth Factors
Neuropeptides
Ovary
Paracrine
Pituitary
Placenta
Uterus
topic Cytokines
Growth Factors
Neuropeptides
Ovary
Paracrine
Pituitary
Placenta
Uterus
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Neuropeptides, growth factors and cytokines are expressed in reproductive organs and tissues, where they interact with afferent endocrine messages to modulate cell proliferation and differentiation, local hormone secretion and vascular function. These events regulate complex processes such as gonadotropin pulsatility, ovulation, implantation and parturition. During reproductive life, a number of neuropeptides produced within the hypothalamus play a modulatory role in the control of gonadotropin-releasing hormone (GnRH) release, hence characterizing a hypothalamic paracrine system. The pituitary gland is a source and target of inhibin-related proteins, and these typical 'gonadal' products, once secreted by the pituitary cells, acquire the function of paracrine modulators of follide-stimulating hormone (FSH) secretion. In the ovary, the effect of gonadotropins is locally modulated by growth factors acting in an autocrine/paracrine manner, although their precise role in folliculogenesis remains uncertain. Numerous local factors are involved in the control of endometrial growth, differentiation, receptivity and menstruation. Alterations in the paracrine endometrial system may underlie pathological processes such as infertility or endometrial neoplasia. The human placenta and its related membranes produce cytokines, hormones and growth factors that participate in the control of gestational development as well as in the maternal-fetal adaptation to gestational diseases. There is increasing evidence that paracrine signaling plays a fundamental role in all spheres of female reproductive function, and future research will concentrate on clarifying which of these local mechanisms play a decisive role in both physiology and disease, thus giving rise to new therapeutic strategies.
Fil: Reis, M. F.. Università degli Studi di Siena; Italia
Fil: Cobellis, L.. Università degli Studi di Siena; Italia
Fil: Luisi, S.. Università degli Studi di Siena; Italia
Fil: Driul, L.. Università degli Studi di Siena; Italia
Fil: Florio, P.. Università degli Studi di Siena; Italia
Fil: Faletti, Alicia Graciela. Università degli Studi di Siena; Italia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; Argentina
Fil: Petraglia, F.. Università degli Studi di Siena; Italia
description Neuropeptides, growth factors and cytokines are expressed in reproductive organs and tissues, where they interact with afferent endocrine messages to modulate cell proliferation and differentiation, local hormone secretion and vascular function. These events regulate complex processes such as gonadotropin pulsatility, ovulation, implantation and parturition. During reproductive life, a number of neuropeptides produced within the hypothalamus play a modulatory role in the control of gonadotropin-releasing hormone (GnRH) release, hence characterizing a hypothalamic paracrine system. The pituitary gland is a source and target of inhibin-related proteins, and these typical 'gonadal' products, once secreted by the pituitary cells, acquire the function of paracrine modulators of follide-stimulating hormone (FSH) secretion. In the ovary, the effect of gonadotropins is locally modulated by growth factors acting in an autocrine/paracrine manner, although their precise role in folliculogenesis remains uncertain. Numerous local factors are involved in the control of endometrial growth, differentiation, receptivity and menstruation. Alterations in the paracrine endometrial system may underlie pathological processes such as infertility or endometrial neoplasia. The human placenta and its related membranes produce cytokines, hormones and growth factors that participate in the control of gestational development as well as in the maternal-fetal adaptation to gestational diseases. There is increasing evidence that paracrine signaling plays a fundamental role in all spheres of female reproductive function, and future research will concentrate on clarifying which of these local mechanisms play a decisive role in both physiology and disease, thus giving rise to new therapeutic strategies.
publishDate 2000
dc.date.none.fl_str_mv 2000-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/39198
Reis, M. F.; Cobellis, L.; Luisi, S.; Driul, L.; Florio, P.; et al.; Paracrine/autocrine control of female reproduction; Informa Healthcare; Gynecological Endocrinology; 14; 6; 12-2000; 464-475
0951-3590
CONICET Digital
CONICET
url http://hdl.handle.net/11336/39198
identifier_str_mv Reis, M. F.; Cobellis, L.; Luisi, S.; Driul, L.; Florio, P.; et al.; Paracrine/autocrine control of female reproduction; Informa Healthcare; Gynecological Endocrinology; 14; 6; 12-2000; 464-475
0951-3590
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/abs/10.3109/09513590009167720
info:eu-repo/semantics/altIdentifier/doi/10.3109/09513590009167720
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Informa Healthcare
publisher.none.fl_str_mv Informa Healthcare
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.10058

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