Clinical, Ovulatory and Histological Effect of a Postnatal Testosterone Treatment in Female Dogs

Autores
Marchetti, Cynthia Dayana; Grisolia Romero, Mariela Eugenia; Priotto, Marcelo Adrián; Faya, Marcela Inés; Gobello, María Cristina
Año de publicación
2024
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
It has been described in some female mammalian species that postnatal androgenizationcauses reproductive structural and functional abnormalities. The objective of this study was todescribe the clinical, ovulatory and genital effects of postnatal androgens in female dogs. Tennewborn female crossbred puppies were randomly assigned to: testosterone enanthate 18 mg/100g sc (TE; n = 5) or placebo sc (PL; n = 5). The puppies were physically followed up until pubertywhen ovulation was tested by serum progesterone. Then, ovariohysterectomies were performed, and genital tracts were grossly and histomorphometrically examined. At puberty, all the females had normal estrous behavior and ovulated without age and body weight differences. All TE puppiespresented mild clitoris enlargement. Gross and microscopical ovarian examination did not revealdifferences. Conversely, the endometrial area occupied by uterine glands as well as the height of the glandular and luminal epithelium were higher in the TE than in the PL group (<0.01). The height of the endometrium and myometrial thickness did not differ between groups. It was concluded that a supraphysiological postnatal dose of testosterone did not affect ovulatory capacity, nor did it provoke gonadal histological alterations, although it caused an increased area of endometrial glands and a higher uterine epithelium.
Fil: Marchetti, Cynthia Dayana. Universidad Católica de Córdoba. Instituto de Investigaciones en Recursos Naturales y Sustentabilidad José Sanchez Labrador S. J. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Recursos Naturales y Sustentabilidad José Sanchez Labrador S. J.; Argentina
Fil: Grisolia Romero, Mariela Eugenia. Universidad Católica de Córdoba. Instituto de Investigaciones en Recursos Naturales y Sustentabilidad José Sanchez Labrador S. J. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Recursos Naturales y Sustentabilidad José Sanchez Labrador S. J.; Argentina
Fil: Priotto, Marcelo Adrián. Universidad Católica de Córdoba. Facultad de Ciencias Agropecuarias; Argentina
Fil: Faya, Marcela Inés. Universidad Católica de Córdoba. Instituto de Investigaciones en Recursos Naturales y Sustentabilidad José Sanchez Labrador S. J. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Recursos Naturales y Sustentabilidad José Sanchez Labrador S. J.; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Gobello, María Cristina. Universidad Nacional de la Plata. Facultad de Cs.veterinarias. Centro de Fisiologia Reproductiva y Metodos Complementarios de Diagnostico.; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
CANINE
ANDROGEN
NEONATAL
UTERUS
OVARY
BITCH
CONTRACEPTION
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/260208
Acceder
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repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Clinical, Ovulatory and Histological Effect of a Postnatal Testosterone Treatment in Female DogsMarchetti, Cynthia DayanaGrisolia Romero, Mariela EugeniaPriotto, Marcelo AdriánFaya, Marcela InésGobello, María CristinaCANINEANDROGENNEONATALUTERUSOVARYBITCHCONTRACEPTIONhttps://purl.org/becyt/ford/4.3https://purl.org/becyt/ford/4It has been described in some female mammalian species that postnatal androgenizationcauses reproductive structural and functional abnormalities. The objective of this study was todescribe the clinical, ovulatory and genital effects of postnatal androgens in female dogs. Tennewborn female crossbred puppies were randomly assigned to: testosterone enanthate 18 mg/100g sc (TE; n = 5) or placebo sc (PL; n = 5). The puppies were physically followed up until pubertywhen ovulation was tested by serum progesterone. Then, ovariohysterectomies were performed, and genital tracts were grossly and histomorphometrically examined. At puberty, all the females had normal estrous behavior and ovulated without age and body weight differences. All TE puppiespresented mild clitoris enlargement. Gross and microscopical ovarian examination did not revealdifferences. Conversely, the endometrial area occupied by uterine glands as well as the height of the glandular and luminal epithelium were higher in the TE than in the PL group (<0.01). The height of the endometrium and myometrial thickness did not differ between groups. It was concluded that a supraphysiological postnatal dose of testosterone did not affect ovulatory capacity, nor did it provoke gonadal histological alterations, although it caused an increased area of endometrial glands and a higher uterine epithelium.Fil: Marchetti, Cynthia Dayana. Universidad Católica de Córdoba. Instituto de Investigaciones en Recursos Naturales y Sustentabilidad José Sanchez Labrador S. J. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Recursos Naturales y Sustentabilidad José Sanchez Labrador S. J.; ArgentinaFil: Grisolia Romero, Mariela Eugenia. Universidad Católica de Córdoba. Instituto de Investigaciones en Recursos Naturales y Sustentabilidad José Sanchez Labrador S. J. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Recursos Naturales y Sustentabilidad José Sanchez Labrador S. J.; ArgentinaFil: Priotto, Marcelo Adrián. Universidad Católica de Córdoba. Facultad de Ciencias Agropecuarias; ArgentinaFil: Faya, Marcela Inés. Universidad Católica de Córdoba. Instituto de Investigaciones en Recursos Naturales y Sustentabilidad José Sanchez Labrador S. J. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Recursos Naturales y Sustentabilidad José Sanchez Labrador S. J.; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Gobello, María Cristina. Universidad Nacional de la Plata. Facultad de Cs.veterinarias. Centro de Fisiologia Reproductiva y Metodos Complementarios de Diagnostico.; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaMultidisciplinary Digital Publishing Institute2024-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/260208Marchetti, Cynthia Dayana; Grisolia Romero, Mariela Eugenia; Priotto, Marcelo Adrián; Faya, Marcela Inés; Gobello, María Cristina; Clinical, Ovulatory and Histological Effect of a Postnatal Testosterone Treatment in Female Dogs; Multidisciplinary Digital Publishing Institute; Animals; 14; 7; 3-2024; 1-92076-2615CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2076-2615/14/7/1049info:eu-repo/semantics/altIdentifier/doi/10.3390/ani14071049info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:44:51Zoai:ri.conicet.gov.ar:11336/260208instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:44:52.114CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Clinical, Ovulatory and Histological Effect of a Postnatal Testosterone Treatment in Female Dogs
title Clinical, Ovulatory and Histological Effect of a Postnatal Testosterone Treatment in Female Dogs
spellingShingle Clinical, Ovulatory and Histological Effect of a Postnatal Testosterone Treatment in Female Dogs
Marchetti, Cynthia Dayana
CANINE
ANDROGEN
NEONATAL
UTERUS
OVARY
BITCH
CONTRACEPTION
title_short Clinical, Ovulatory and Histological Effect of a Postnatal Testosterone Treatment in Female Dogs
title_full Clinical, Ovulatory and Histological Effect of a Postnatal Testosterone Treatment in Female Dogs
title_fullStr Clinical, Ovulatory and Histological Effect of a Postnatal Testosterone Treatment in Female Dogs
title_full_unstemmed Clinical, Ovulatory and Histological Effect of a Postnatal Testosterone Treatment in Female Dogs
title_sort Clinical, Ovulatory and Histological Effect of a Postnatal Testosterone Treatment in Female Dogs
dc.creator.none.fl_str_mv Marchetti, Cynthia Dayana
Grisolia Romero, Mariela Eugenia
Priotto, Marcelo Adrián
Faya, Marcela Inés
Gobello, María Cristina
author Marchetti, Cynthia Dayana
author_facet Marchetti, Cynthia Dayana
Grisolia Romero, Mariela Eugenia
Priotto, Marcelo Adrián
Faya, Marcela Inés
Gobello, María Cristina
author_role author
author2 Grisolia Romero, Mariela Eugenia
Priotto, Marcelo Adrián
Faya, Marcela Inés
Gobello, María Cristina
author2_role author
author
author
author
dc.subject.none.fl_str_mv CANINE
ANDROGEN
NEONATAL
UTERUS
OVARY
BITCH
CONTRACEPTION
topic CANINE
ANDROGEN
NEONATAL
UTERUS
OVARY
BITCH
CONTRACEPTION
purl_subject.fl_str_mv https://purl.org/becyt/ford/4.3
https://purl.org/becyt/ford/4
dc.description.none.fl_txt_mv It has been described in some female mammalian species that postnatal androgenizationcauses reproductive structural and functional abnormalities. The objective of this study was todescribe the clinical, ovulatory and genital effects of postnatal androgens in female dogs. Tennewborn female crossbred puppies were randomly assigned to: testosterone enanthate 18 mg/100g sc (TE; n = 5) or placebo sc (PL; n = 5). The puppies were physically followed up until pubertywhen ovulation was tested by serum progesterone. Then, ovariohysterectomies were performed, and genital tracts were grossly and histomorphometrically examined. At puberty, all the females had normal estrous behavior and ovulated without age and body weight differences. All TE puppiespresented mild clitoris enlargement. Gross and microscopical ovarian examination did not revealdifferences. Conversely, the endometrial area occupied by uterine glands as well as the height of the glandular and luminal epithelium were higher in the TE than in the PL group (<0.01). The height of the endometrium and myometrial thickness did not differ between groups. It was concluded that a supraphysiological postnatal dose of testosterone did not affect ovulatory capacity, nor did it provoke gonadal histological alterations, although it caused an increased area of endometrial glands and a higher uterine epithelium.
Fil: Marchetti, Cynthia Dayana. Universidad Católica de Córdoba. Instituto de Investigaciones en Recursos Naturales y Sustentabilidad José Sanchez Labrador S. J. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Recursos Naturales y Sustentabilidad José Sanchez Labrador S. J.; Argentina
Fil: Grisolia Romero, Mariela Eugenia. Universidad Católica de Córdoba. Instituto de Investigaciones en Recursos Naturales y Sustentabilidad José Sanchez Labrador S. J. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Recursos Naturales y Sustentabilidad José Sanchez Labrador S. J.; Argentina
Fil: Priotto, Marcelo Adrián. Universidad Católica de Córdoba. Facultad de Ciencias Agropecuarias; Argentina
Fil: Faya, Marcela Inés. Universidad Católica de Córdoba. Instituto de Investigaciones en Recursos Naturales y Sustentabilidad José Sanchez Labrador S. J. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Recursos Naturales y Sustentabilidad José Sanchez Labrador S. J.; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Gobello, María Cristina. Universidad Nacional de la Plata. Facultad de Cs.veterinarias. Centro de Fisiologia Reproductiva y Metodos Complementarios de Diagnostico.; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description It has been described in some female mammalian species that postnatal androgenizationcauses reproductive structural and functional abnormalities. The objective of this study was todescribe the clinical, ovulatory and genital effects of postnatal androgens in female dogs. Tennewborn female crossbred puppies were randomly assigned to: testosterone enanthate 18 mg/100g sc (TE; n = 5) or placebo sc (PL; n = 5). The puppies were physically followed up until pubertywhen ovulation was tested by serum progesterone. Then, ovariohysterectomies were performed, and genital tracts were grossly and histomorphometrically examined. At puberty, all the females had normal estrous behavior and ovulated without age and body weight differences. All TE puppiespresented mild clitoris enlargement. Gross and microscopical ovarian examination did not revealdifferences. Conversely, the endometrial area occupied by uterine glands as well as the height of the glandular and luminal epithelium were higher in the TE than in the PL group (<0.01). The height of the endometrium and myometrial thickness did not differ between groups. It was concluded that a supraphysiological postnatal dose of testosterone did not affect ovulatory capacity, nor did it provoke gonadal histological alterations, although it caused an increased area of endometrial glands and a higher uterine epithelium.
publishDate 2024
dc.date.none.fl_str_mv 2024-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/260208
Marchetti, Cynthia Dayana; Grisolia Romero, Mariela Eugenia; Priotto, Marcelo Adrián; Faya, Marcela Inés; Gobello, María Cristina; Clinical, Ovulatory and Histological Effect of a Postnatal Testosterone Treatment in Female Dogs; Multidisciplinary Digital Publishing Institute; Animals; 14; 7; 3-2024; 1-9
2076-2615
CONICET Digital
CONICET
url http://hdl.handle.net/11336/260208
identifier_str_mv Marchetti, Cynthia Dayana; Grisolia Romero, Mariela Eugenia; Priotto, Marcelo Adrián; Faya, Marcela Inés; Gobello, María Cristina; Clinical, Ovulatory and Histological Effect of a Postnatal Testosterone Treatment in Female Dogs; Multidisciplinary Digital Publishing Institute; Animals; 14; 7; 3-2024; 1-9
2076-2615
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2076-2615/14/7/1049
info:eu-repo/semantics/altIdentifier/doi/10.3390/ani14071049
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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