Penicillium commune metabolic profile as a promising source of antipathogenic natural products

Autores
Diblasi, Lorena; Arrighi, Carlos Federico; Silva, Julio; Bardon, Alicia del Valle; Cartagena, Elena
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Penicillium is an important genus of ascomycetous fungi in the environment and in food and drug production. This paper aims to investigate statins and antipathogenic natural products from a Penicillium commune environmental isolate. Fractions (F1, F2, F3 and F4) were obtained from an ethyl acetate extract. Direct insertion probe/electron ionisation/ion trap detection mass spectrometry (MS and MS/MS) identified lovastatin (1) in F1, while GC-MS showed that 3-isobutylhexahydropyrrolo[1,2-a]pyrazine-1,4-dione (2) was the main constituent of F2 (49.34%). F4 presented 3 (16.38%) as an analogue of 2 and their known structures were similar to that of an autoinducer-signal. F1 produced a significant decrease in the Pseudomonas aeruginosa biofilms, which is the main cause of bacterial pathogenicity. F2 and F4 were effective against Staphylococcus aureus biofilms, but when F2 was associated with oxacillin, it showed an important activity against both bacteria. These novel results suggest that P. commune INTA1 is a new source of promising antipathogenic products.
Fil: Diblasi, Lorena. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química Orgánica; Argentina
Fil: Arrighi, Carlos Federico. Laboratorio LISA; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Silva, Julio. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; Argentina
Fil: Bardon, Alicia del Valle. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química Orgánica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tucumán. Instituto de Química del Noroeste. Grupo Vinculado Unse-inquinoa; Argentina. Laboratorio LISA; Argentina
Fil: Cartagena, Elena. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química Orgánica; Argentina
Materia
Penicillium Commune Metabolic Profile
Dip/Ei/Itd Mass Spectrometry (Ms And Ms/Ms)
Gc-Ms Analysis
Lovastatin
Pyrrolopyrazines
Biofilms
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/12480
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/12480
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Penicillium commune metabolic profile as a promising source of antipathogenic natural productsDiblasi, LorenaArrighi, Carlos FedericoSilva, JulioBardon, Alicia del ValleCartagena, ElenaPenicillium Commune Metabolic ProfileDip/Ei/Itd Mass Spectrometry (Ms And Ms/Ms)Gc-Ms AnalysisLovastatinPyrrolopyrazinesBiofilmshttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1https://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1https://purl.org/becyt/ford/3.4https://purl.org/becyt/ford/3Penicillium is an important genus of ascomycetous fungi in the environment and in food and drug production. This paper aims to investigate statins and antipathogenic natural products from a Penicillium commune environmental isolate. Fractions (F1, F2, F3 and F4) were obtained from an ethyl acetate extract. Direct insertion probe/electron ionisation/ion trap detection mass spectrometry (MS and MS/MS) identified lovastatin (1) in F1, while GC-MS showed that 3-isobutylhexahydropyrrolo[1,2-a]pyrazine-1,4-dione (2) was the main constituent of F2 (49.34%). F4 presented 3 (16.38%) as an analogue of 2 and their known structures were similar to that of an autoinducer-signal. F1 produced a significant decrease in the Pseudomonas aeruginosa biofilms, which is the main cause of bacterial pathogenicity. F2 and F4 were effective against Staphylococcus aureus biofilms, but when F2 was associated with oxacillin, it showed an important activity against both bacteria. These novel results suggest that P. commune INTA1 is a new source of promising antipathogenic products.Fil: Diblasi, Lorena. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química Orgánica; ArgentinaFil: Arrighi, Carlos Federico. Laboratorio LISA; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Silva, Julio. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; ArgentinaFil: Bardon, Alicia del Valle. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química Orgánica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tucumán. Instituto de Química del Noroeste. Grupo Vinculado Unse-inquinoa; Argentina. Laboratorio LISA; ArgentinaFil: Cartagena, Elena. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química Orgánica; ArgentinaTaylor & Francis Ltd2015info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/12480Diblasi, Lorena; Arrighi, Carlos Federico; Silva, Julio; Bardon, Alicia del Valle; Cartagena, Elena; Penicillium commune metabolic profile as a promising source of antipathogenic natural products; Taylor & Francis Ltd; Natural Product Research; 29; 23; 2015; 2181-21871478-64191478-6427enginfo:eu-repo/semantics/altIdentifier/doi/10.1080/14786419.2015.1007457info:eu-repo/semantics/altIdentifier/url/http://www.tandfonline.com/doi/full/10.1080/14786419.2015.1007457info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:36:35Zoai:ri.conicet.gov.ar:11336/12480instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:36:35.38CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Penicillium commune metabolic profile as a promising source of antipathogenic natural products
title Penicillium commune metabolic profile as a promising source of antipathogenic natural products
spellingShingle Penicillium commune metabolic profile as a promising source of antipathogenic natural products
Diblasi, Lorena
Penicillium Commune Metabolic Profile
Dip/Ei/Itd Mass Spectrometry (Ms And Ms/Ms)
Gc-Ms Analysis
Lovastatin
Pyrrolopyrazines
Biofilms
title_short Penicillium commune metabolic profile as a promising source of antipathogenic natural products
title_full Penicillium commune metabolic profile as a promising source of antipathogenic natural products
title_fullStr Penicillium commune metabolic profile as a promising source of antipathogenic natural products
title_full_unstemmed Penicillium commune metabolic profile as a promising source of antipathogenic natural products
title_sort Penicillium commune metabolic profile as a promising source of antipathogenic natural products
dc.creator.none.fl_str_mv Diblasi, Lorena
Arrighi, Carlos Federico
Silva, Julio
Bardon, Alicia del Valle
Cartagena, Elena
author Diblasi, Lorena
author_facet Diblasi, Lorena
Arrighi, Carlos Federico
Silva, Julio
Bardon, Alicia del Valle
Cartagena, Elena
author_role author
author2 Arrighi, Carlos Federico
Silva, Julio
Bardon, Alicia del Valle
Cartagena, Elena
author2_role author
author
author
author
dc.subject.none.fl_str_mv Penicillium Commune Metabolic Profile
Dip/Ei/Itd Mass Spectrometry (Ms And Ms/Ms)
Gc-Ms Analysis
Lovastatin
Pyrrolopyrazines
Biofilms
topic Penicillium Commune Metabolic Profile
Dip/Ei/Itd Mass Spectrometry (Ms And Ms/Ms)
Gc-Ms Analysis
Lovastatin
Pyrrolopyrazines
Biofilms
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
https://purl.org/becyt/ford/3.4
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Penicillium is an important genus of ascomycetous fungi in the environment and in food and drug production. This paper aims to investigate statins and antipathogenic natural products from a Penicillium commune environmental isolate. Fractions (F1, F2, F3 and F4) were obtained from an ethyl acetate extract. Direct insertion probe/electron ionisation/ion trap detection mass spectrometry (MS and MS/MS) identified lovastatin (1) in F1, while GC-MS showed that 3-isobutylhexahydropyrrolo[1,2-a]pyrazine-1,4-dione (2) was the main constituent of F2 (49.34%). F4 presented 3 (16.38%) as an analogue of 2 and their known structures were similar to that of an autoinducer-signal. F1 produced a significant decrease in the Pseudomonas aeruginosa biofilms, which is the main cause of bacterial pathogenicity. F2 and F4 were effective against Staphylococcus aureus biofilms, but when F2 was associated with oxacillin, it showed an important activity against both bacteria. These novel results suggest that P. commune INTA1 is a new source of promising antipathogenic products.
Fil: Diblasi, Lorena. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química Orgánica; Argentina
Fil: Arrighi, Carlos Federico. Laboratorio LISA; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Silva, Julio. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; Argentina
Fil: Bardon, Alicia del Valle. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química Orgánica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tucumán. Instituto de Química del Noroeste. Grupo Vinculado Unse-inquinoa; Argentina. Laboratorio LISA; Argentina
Fil: Cartagena, Elena. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química Orgánica; Argentina
description Penicillium is an important genus of ascomycetous fungi in the environment and in food and drug production. This paper aims to investigate statins and antipathogenic natural products from a Penicillium commune environmental isolate. Fractions (F1, F2, F3 and F4) were obtained from an ethyl acetate extract. Direct insertion probe/electron ionisation/ion trap detection mass spectrometry (MS and MS/MS) identified lovastatin (1) in F1, while GC-MS showed that 3-isobutylhexahydropyrrolo[1,2-a]pyrazine-1,4-dione (2) was the main constituent of F2 (49.34%). F4 presented 3 (16.38%) as an analogue of 2 and their known structures were similar to that of an autoinducer-signal. F1 produced a significant decrease in the Pseudomonas aeruginosa biofilms, which is the main cause of bacterial pathogenicity. F2 and F4 were effective against Staphylococcus aureus biofilms, but when F2 was associated with oxacillin, it showed an important activity against both bacteria. These novel results suggest that P. commune INTA1 is a new source of promising antipathogenic products.
publishDate 2015
dc.date.none.fl_str_mv 2015
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/12480
Diblasi, Lorena; Arrighi, Carlos Federico; Silva, Julio; Bardon, Alicia del Valle; Cartagena, Elena; Penicillium commune metabolic profile as a promising source of antipathogenic natural products; Taylor & Francis Ltd; Natural Product Research; 29; 23; 2015; 2181-2187
1478-6419
1478-6427
url http://hdl.handle.net/11336/12480
identifier_str_mv Diblasi, Lorena; Arrighi, Carlos Federico; Silva, Julio; Bardon, Alicia del Valle; Cartagena, Elena; Penicillium commune metabolic profile as a promising source of antipathogenic natural products; Taylor & Francis Ltd; Natural Product Research; 29; 23; 2015; 2181-2187
1478-6419
1478-6427
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1080/14786419.2015.1007457
info:eu-repo/semantics/altIdentifier/url/http://www.tandfonline.com/doi/full/10.1080/14786419.2015.1007457
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Taylor & Francis Ltd
publisher.none.fl_str_mv Taylor & Francis Ltd
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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