Optimized EDXRF system for simultaneous detection of gold and silver nanoparticles in tumor phantom

Autores
Santibáñez, M.; Saavedra, R.; Vedelago, José Alberto; Malano, Francisco Mauricio; Valente, Mauro Andres
Año de publicación
2019
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
An energy-dispersive X-ray fluorescence system (EDXRF) was optimized for simultaneous detection of gold and silver nanoparticles inside water-equivalent phantoms applied to theranostics. The optimization process was carried out in order to maximize the fluorescence detection, keeping dose levels as low as possible. Gold and silver fluorescent emissions were simultaneously detected emerging from phantom's volume, allowing the future development of multi-parametric imaging associated to specific tumor characteristics. For fluorescence detection, gold LIII-edge and silver K-edge emission lines were used, exited with a conventional X-ray source with a tungsten target. Several combinations of filters of different thickness were used to hardening the Bremsstrahlung spectrum, thus producing energetically narrow beams with central energy according to both excitation edges. In the case of gold, incident spectrum was optimized by means of strontium (Sr) and yttrium (Y) filters to relatively incrementing photons capable of exciting gold LIII-edge, while silver K-edge excitation was improved using a tin (Sn) filter. Filtering combinations made of 212.0 μm Sr with 94.5 μm Sn, and 130.2 μm Y with 94.5 μm Sn maximized fluorescence detection sensitivity and minimized delivered dose, resulting in doses 2.24 and 2.36 times lower than individual gold or silver fluorescent detection. Furthermore, when dual gold and silver fluorescent detection was performed, the minimum detectable concentration was lower than single element detection: 0.042 ± 0.002 mg/mL of Au and 0.024 ± 0.005 mg/mL of Ag in dual detection against 0.058 ± 0.003 mg/mL of Au and 0.124 ± 0.007 mg/mL of Ag when measured independently.
Fil: Santibáñez, M.. Universidad de La Frontera; Chile
Fil: Saavedra, R.. Universidad de La Frontera; Chile
Fil: Vedelago, José Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; Argentina
Fil: Malano, Francisco Mauricio. Universidad de La Frontera; Chile
Fil: Valente, Mauro Andres. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; Argentina. Universidad de La Frontera; Chile
Materia
GOLD NANOPARTICLES
IN VIVO EDXRF
SILVER NANOPARTICLES
TARGETING RADIOTHERAPY
TUMOR BIOMARKERS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/124385
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/124385
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Optimized EDXRF system for simultaneous detection of gold and silver nanoparticles in tumor phantomSantibáñez, M.Saavedra, R.Vedelago, José AlbertoMalano, Francisco MauricioValente, Mauro AndresGOLD NANOPARTICLESIN VIVO EDXRFSILVER NANOPARTICLESTARGETING RADIOTHERAPYTUMOR BIOMARKERShttps://purl.org/becyt/ford/1.3https://purl.org/becyt/ford/1An energy-dispersive X-ray fluorescence system (EDXRF) was optimized for simultaneous detection of gold and silver nanoparticles inside water-equivalent phantoms applied to theranostics. The optimization process was carried out in order to maximize the fluorescence detection, keeping dose levels as low as possible. Gold and silver fluorescent emissions were simultaneously detected emerging from phantom's volume, allowing the future development of multi-parametric imaging associated to specific tumor characteristics. For fluorescence detection, gold LIII-edge and silver K-edge emission lines were used, exited with a conventional X-ray source with a tungsten target. Several combinations of filters of different thickness were used to hardening the Bremsstrahlung spectrum, thus producing energetically narrow beams with central energy according to both excitation edges. In the case of gold, incident spectrum was optimized by means of strontium (Sr) and yttrium (Y) filters to relatively incrementing photons capable of exciting gold LIII-edge, while silver K-edge excitation was improved using a tin (Sn) filter. Filtering combinations made of 212.0 μm Sr with 94.5 μm Sn, and 130.2 μm Y with 94.5 μm Sn maximized fluorescence detection sensitivity and minimized delivered dose, resulting in doses 2.24 and 2.36 times lower than individual gold or silver fluorescent detection. Furthermore, when dual gold and silver fluorescent detection was performed, the minimum detectable concentration was lower than single element detection: 0.042 ± 0.002 mg/mL of Au and 0.024 ± 0.005 mg/mL of Ag in dual detection against 0.058 ± 0.003 mg/mL of Au and 0.124 ± 0.007 mg/mL of Ag when measured independently.Fil: Santibáñez, M.. Universidad de La Frontera; ChileFil: Saavedra, R.. Universidad de La Frontera; ChileFil: Vedelago, José Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; ArgentinaFil: Malano, Francisco Mauricio. Universidad de La Frontera; ChileFil: Valente, Mauro Andres. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; Argentina. Universidad de La Frontera; ChilePergamon-Elsevier Science Ltd2019-12-24info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/124385Santibáñez, M.; Saavedra, R.; Vedelago, José Alberto; Malano, Francisco Mauricio; Valente, Mauro Andres; Optimized EDXRF system for simultaneous detection of gold and silver nanoparticles in tumor phantom; Pergamon-Elsevier Science Ltd; Radiation Physics and Chemistry (Oxford); 165; 24-12-2019; 1-20; 1084150969-806XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.radphyschem.2019.108415info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0969806X19303408info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:01:56Zoai:ri.conicet.gov.ar:11336/124385instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:01:56.921CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Optimized EDXRF system for simultaneous detection of gold and silver nanoparticles in tumor phantom
title Optimized EDXRF system for simultaneous detection of gold and silver nanoparticles in tumor phantom
spellingShingle Optimized EDXRF system for simultaneous detection of gold and silver nanoparticles in tumor phantom
Santibáñez, M.
GOLD NANOPARTICLES
IN VIVO EDXRF
SILVER NANOPARTICLES
TARGETING RADIOTHERAPY
TUMOR BIOMARKERS
title_short Optimized EDXRF system for simultaneous detection of gold and silver nanoparticles in tumor phantom
title_full Optimized EDXRF system for simultaneous detection of gold and silver nanoparticles in tumor phantom
title_fullStr Optimized EDXRF system for simultaneous detection of gold and silver nanoparticles in tumor phantom
title_full_unstemmed Optimized EDXRF system for simultaneous detection of gold and silver nanoparticles in tumor phantom
title_sort Optimized EDXRF system for simultaneous detection of gold and silver nanoparticles in tumor phantom
dc.creator.none.fl_str_mv Santibáñez, M.
Saavedra, R.
Vedelago, José Alberto
Malano, Francisco Mauricio
Valente, Mauro Andres
author Santibáñez, M.
author_facet Santibáñez, M.
Saavedra, R.
Vedelago, José Alberto
Malano, Francisco Mauricio
Valente, Mauro Andres
author_role author
author2 Saavedra, R.
Vedelago, José Alberto
Malano, Francisco Mauricio
Valente, Mauro Andres
author2_role author
author
author
author
dc.subject.none.fl_str_mv GOLD NANOPARTICLES
IN VIVO EDXRF
SILVER NANOPARTICLES
TARGETING RADIOTHERAPY
TUMOR BIOMARKERS
topic GOLD NANOPARTICLES
IN VIVO EDXRF
SILVER NANOPARTICLES
TARGETING RADIOTHERAPY
TUMOR BIOMARKERS
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.3
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv An energy-dispersive X-ray fluorescence system (EDXRF) was optimized for simultaneous detection of gold and silver nanoparticles inside water-equivalent phantoms applied to theranostics. The optimization process was carried out in order to maximize the fluorescence detection, keeping dose levels as low as possible. Gold and silver fluorescent emissions were simultaneously detected emerging from phantom's volume, allowing the future development of multi-parametric imaging associated to specific tumor characteristics. For fluorescence detection, gold LIII-edge and silver K-edge emission lines were used, exited with a conventional X-ray source with a tungsten target. Several combinations of filters of different thickness were used to hardening the Bremsstrahlung spectrum, thus producing energetically narrow beams with central energy according to both excitation edges. In the case of gold, incident spectrum was optimized by means of strontium (Sr) and yttrium (Y) filters to relatively incrementing photons capable of exciting gold LIII-edge, while silver K-edge excitation was improved using a tin (Sn) filter. Filtering combinations made of 212.0 μm Sr with 94.5 μm Sn, and 130.2 μm Y with 94.5 μm Sn maximized fluorescence detection sensitivity and minimized delivered dose, resulting in doses 2.24 and 2.36 times lower than individual gold or silver fluorescent detection. Furthermore, when dual gold and silver fluorescent detection was performed, the minimum detectable concentration was lower than single element detection: 0.042 ± 0.002 mg/mL of Au and 0.024 ± 0.005 mg/mL of Ag in dual detection against 0.058 ± 0.003 mg/mL of Au and 0.124 ± 0.007 mg/mL of Ag when measured independently.
Fil: Santibáñez, M.. Universidad de La Frontera; Chile
Fil: Saavedra, R.. Universidad de La Frontera; Chile
Fil: Vedelago, José Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; Argentina
Fil: Malano, Francisco Mauricio. Universidad de La Frontera; Chile
Fil: Valente, Mauro Andres. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; Argentina. Universidad de La Frontera; Chile
description An energy-dispersive X-ray fluorescence system (EDXRF) was optimized for simultaneous detection of gold and silver nanoparticles inside water-equivalent phantoms applied to theranostics. The optimization process was carried out in order to maximize the fluorescence detection, keeping dose levels as low as possible. Gold and silver fluorescent emissions were simultaneously detected emerging from phantom's volume, allowing the future development of multi-parametric imaging associated to specific tumor characteristics. For fluorescence detection, gold LIII-edge and silver K-edge emission lines were used, exited with a conventional X-ray source with a tungsten target. Several combinations of filters of different thickness were used to hardening the Bremsstrahlung spectrum, thus producing energetically narrow beams with central energy according to both excitation edges. In the case of gold, incident spectrum was optimized by means of strontium (Sr) and yttrium (Y) filters to relatively incrementing photons capable of exciting gold LIII-edge, while silver K-edge excitation was improved using a tin (Sn) filter. Filtering combinations made of 212.0 μm Sr with 94.5 μm Sn, and 130.2 μm Y with 94.5 μm Sn maximized fluorescence detection sensitivity and minimized delivered dose, resulting in doses 2.24 and 2.36 times lower than individual gold or silver fluorescent detection. Furthermore, when dual gold and silver fluorescent detection was performed, the minimum detectable concentration was lower than single element detection: 0.042 ± 0.002 mg/mL of Au and 0.024 ± 0.005 mg/mL of Ag in dual detection against 0.058 ± 0.003 mg/mL of Au and 0.124 ± 0.007 mg/mL of Ag when measured independently.
publishDate 2019
dc.date.none.fl_str_mv 2019-12-24
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/124385
Santibáñez, M.; Saavedra, R.; Vedelago, José Alberto; Malano, Francisco Mauricio; Valente, Mauro Andres; Optimized EDXRF system for simultaneous detection of gold and silver nanoparticles in tumor phantom; Pergamon-Elsevier Science Ltd; Radiation Physics and Chemistry (Oxford); 165; 24-12-2019; 1-20; 108415
0969-806X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/124385
identifier_str_mv Santibáñez, M.; Saavedra, R.; Vedelago, José Alberto; Malano, Francisco Mauricio; Valente, Mauro Andres; Optimized EDXRF system for simultaneous detection of gold and silver nanoparticles in tumor phantom; Pergamon-Elsevier Science Ltd; Radiation Physics and Chemistry (Oxford); 165; 24-12-2019; 1-20; 108415
0969-806X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.radphyschem.2019.108415
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0969806X19303408
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Pergamon-Elsevier Science Ltd
publisher.none.fl_str_mv Pergamon-Elsevier Science Ltd
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.22299

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