Evaluation of EDXRF configurations to improve the limit of detection and exposure for in vivo quantification of gadolinium in tumor tissue

Autores
Santibáñez, M.; Vásquez, M.; Figueroa, R. G.; Valente, Mauro Andres
Año de publicación
2016
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
In this paper the configuration of an Energy Dispersive X-Ray Fluorescence (EDXRF) system optimized for in vivo quantification of gadolinium in tumor tissue was studied. The system was configured using XMI-MSIM software designed to predict the XRF spectral response using Monte Carlo simulations. The studied setup is comprised of an X-ray tube, tuned to different voltages, and a copper filter system configured with variable thickness, which emits a spectrally narrow beam centered on the specific excitation energy. The values for the central energy excitation and the spectral width were adjusted to optimize the system, using like figures of merit: minimization of the limit of detection, measurement uncertainty and radiation exposure. These values were obtained in two stages. The first was successive simulations of incident spectra with central energy in the range of 50-70keV. The second was comprised of simulations with incident spectra of different widths (8-29keV), all with the same determined central energy, evaluating the limit of detection depending on the exposure. This made it possible to find the best balance between system sensitivity and the delivered dose. The obtained results were compared with those produced by radioactive sources of 241Am whose activity was set to produce the same exposure as the proposed setup. To evaluate the feasibility of in vivo quantification, a set of tumor phantoms of 1-6cm3 at different depths and labeled with a gadolinium concentration of 250ppm was evaluated. From the resulting spectrum, calibration curves were obtained in function of the size and depth of the tumor, allowing for the evaluation of the potential of the methodology.
Fil: Santibáñez, M.. Universidad de La Frontera; Chile
Fil: Vásquez, M.. Universidad de La Frontera; Chile
Fil: Figueroa, R. G.. Universidad de La Frontera; Chile
Fil: Valente, Mauro Andres. Universidad de La Frontera; Chile. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina
Materia
GADOLINIUM
IN VIVO EDXRF
XMI-MSIM
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/71548
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Evaluation of EDXRF configurations to improve the limit of detection and exposure for in vivo quantification of gadolinium in tumor tissueSantibáñez, M.Vásquez, M.Figueroa, R. G.Valente, Mauro AndresGADOLINIUMIN VIVO EDXRFXMI-MSIMhttps://purl.org/becyt/ford/1.3https://purl.org/becyt/ford/1In this paper the configuration of an Energy Dispersive X-Ray Fluorescence (EDXRF) system optimized for in vivo quantification of gadolinium in tumor tissue was studied. The system was configured using XMI-MSIM software designed to predict the XRF spectral response using Monte Carlo simulations. The studied setup is comprised of an X-ray tube, tuned to different voltages, and a copper filter system configured with variable thickness, which emits a spectrally narrow beam centered on the specific excitation energy. The values for the central energy excitation and the spectral width were adjusted to optimize the system, using like figures of merit: minimization of the limit of detection, measurement uncertainty and radiation exposure. These values were obtained in two stages. The first was successive simulations of incident spectra with central energy in the range of 50-70keV. The second was comprised of simulations with incident spectra of different widths (8-29keV), all with the same determined central energy, evaluating the limit of detection depending on the exposure. This made it possible to find the best balance between system sensitivity and the delivered dose. The obtained results were compared with those produced by radioactive sources of 241Am whose activity was set to produce the same exposure as the proposed setup. To evaluate the feasibility of in vivo quantification, a set of tumor phantoms of 1-6cm3 at different depths and labeled with a gadolinium concentration of 250ppm was evaluated. From the resulting spectrum, calibration curves were obtained in function of the size and depth of the tumor, allowing for the evaluation of the potential of the methodology.Fil: Santibáñez, M.. Universidad de La Frontera; ChileFil: Vásquez, M.. Universidad de La Frontera; ChileFil: Figueroa, R. G.. Universidad de La Frontera; ChileFil: Valente, Mauro Andres. Universidad de La Frontera; Chile. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; ArgentinaPergamon-Elsevier Science Ltd2016-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/71548Santibáñez, M.; Vásquez, M.; Figueroa, R. G.; Valente, Mauro Andres; Evaluation of EDXRF configurations to improve the limit of detection and exposure for in vivo quantification of gadolinium in tumor tissue; Pergamon-Elsevier Science Ltd; Radiation Physics and Chemistry (Oxford); 122; 5-2016; 28-340969-806XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.radphyschem.2016.01.015info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0969806X16300159info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:45:10Zoai:ri.conicet.gov.ar:11336/71548instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:45:11.015CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Evaluation of EDXRF configurations to improve the limit of detection and exposure for in vivo quantification of gadolinium in tumor tissue
title Evaluation of EDXRF configurations to improve the limit of detection and exposure for in vivo quantification of gadolinium in tumor tissue
spellingShingle Evaluation of EDXRF configurations to improve the limit of detection and exposure for in vivo quantification of gadolinium in tumor tissue
Santibáñez, M.
GADOLINIUM
IN VIVO EDXRF
XMI-MSIM
title_short Evaluation of EDXRF configurations to improve the limit of detection and exposure for in vivo quantification of gadolinium in tumor tissue
title_full Evaluation of EDXRF configurations to improve the limit of detection and exposure for in vivo quantification of gadolinium in tumor tissue
title_fullStr Evaluation of EDXRF configurations to improve the limit of detection and exposure for in vivo quantification of gadolinium in tumor tissue
title_full_unstemmed Evaluation of EDXRF configurations to improve the limit of detection and exposure for in vivo quantification of gadolinium in tumor tissue
title_sort Evaluation of EDXRF configurations to improve the limit of detection and exposure for in vivo quantification of gadolinium in tumor tissue
dc.creator.none.fl_str_mv Santibáñez, M.
Vásquez, M.
Figueroa, R. G.
Valente, Mauro Andres
author Santibáñez, M.
author_facet Santibáñez, M.
Vásquez, M.
Figueroa, R. G.
Valente, Mauro Andres
author_role author
author2 Vásquez, M.
Figueroa, R. G.
Valente, Mauro Andres
author2_role author
author
author
dc.subject.none.fl_str_mv GADOLINIUM
IN VIVO EDXRF
XMI-MSIM
topic GADOLINIUM
IN VIVO EDXRF
XMI-MSIM
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.3
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv In this paper the configuration of an Energy Dispersive X-Ray Fluorescence (EDXRF) system optimized for in vivo quantification of gadolinium in tumor tissue was studied. The system was configured using XMI-MSIM software designed to predict the XRF spectral response using Monte Carlo simulations. The studied setup is comprised of an X-ray tube, tuned to different voltages, and a copper filter system configured with variable thickness, which emits a spectrally narrow beam centered on the specific excitation energy. The values for the central energy excitation and the spectral width were adjusted to optimize the system, using like figures of merit: minimization of the limit of detection, measurement uncertainty and radiation exposure. These values were obtained in two stages. The first was successive simulations of incident spectra with central energy in the range of 50-70keV. The second was comprised of simulations with incident spectra of different widths (8-29keV), all with the same determined central energy, evaluating the limit of detection depending on the exposure. This made it possible to find the best balance between system sensitivity and the delivered dose. The obtained results were compared with those produced by radioactive sources of 241Am whose activity was set to produce the same exposure as the proposed setup. To evaluate the feasibility of in vivo quantification, a set of tumor phantoms of 1-6cm3 at different depths and labeled with a gadolinium concentration of 250ppm was evaluated. From the resulting spectrum, calibration curves were obtained in function of the size and depth of the tumor, allowing for the evaluation of the potential of the methodology.
Fil: Santibáñez, M.. Universidad de La Frontera; Chile
Fil: Vásquez, M.. Universidad de La Frontera; Chile
Fil: Figueroa, R. G.. Universidad de La Frontera; Chile
Fil: Valente, Mauro Andres. Universidad de La Frontera; Chile. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina
description In this paper the configuration of an Energy Dispersive X-Ray Fluorescence (EDXRF) system optimized for in vivo quantification of gadolinium in tumor tissue was studied. The system was configured using XMI-MSIM software designed to predict the XRF spectral response using Monte Carlo simulations. The studied setup is comprised of an X-ray tube, tuned to different voltages, and a copper filter system configured with variable thickness, which emits a spectrally narrow beam centered on the specific excitation energy. The values for the central energy excitation and the spectral width were adjusted to optimize the system, using like figures of merit: minimization of the limit of detection, measurement uncertainty and radiation exposure. These values were obtained in two stages. The first was successive simulations of incident spectra with central energy in the range of 50-70keV. The second was comprised of simulations with incident spectra of different widths (8-29keV), all with the same determined central energy, evaluating the limit of detection depending on the exposure. This made it possible to find the best balance between system sensitivity and the delivered dose. The obtained results were compared with those produced by radioactive sources of 241Am whose activity was set to produce the same exposure as the proposed setup. To evaluate the feasibility of in vivo quantification, a set of tumor phantoms of 1-6cm3 at different depths and labeled with a gadolinium concentration of 250ppm was evaluated. From the resulting spectrum, calibration curves were obtained in function of the size and depth of the tumor, allowing for the evaluation of the potential of the methodology.
publishDate 2016
dc.date.none.fl_str_mv 2016-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/71548
Santibáñez, M.; Vásquez, M.; Figueroa, R. G.; Valente, Mauro Andres; Evaluation of EDXRF configurations to improve the limit of detection and exposure for in vivo quantification of gadolinium in tumor tissue; Pergamon-Elsevier Science Ltd; Radiation Physics and Chemistry (Oxford); 122; 5-2016; 28-34
0969-806X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/71548
identifier_str_mv Santibáñez, M.; Vásquez, M.; Figueroa, R. G.; Valente, Mauro Andres; Evaluation of EDXRF configurations to improve the limit of detection and exposure for in vivo quantification of gadolinium in tumor tissue; Pergamon-Elsevier Science Ltd; Radiation Physics and Chemistry (Oxford); 122; 5-2016; 28-34
0969-806X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.radphyschem.2016.01.015
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0969806X16300159
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Pergamon-Elsevier Science Ltd
publisher.none.fl_str_mv Pergamon-Elsevier Science Ltd
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.22299

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