Lack of head sparing following third-trimester caloric restriction among Tanzanian Maasai

Autores
Powell, Christopher D.; Wilson, Warren M.; Olesaningo, Godwin; Manyama, Mange; Jamniczky, Heather; Spritz, Richard; Cross, James C.; Lukowiak, Kenneth; Hallgrimsson, Benedikt; Gonzalez, Paula Natalia
Año de publicación
2020
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The reduction of food intake during pregnancy is part of many cultural and religious traditions around the world. The impact of such practices on fetal growth and development are poorly understood. Here, we examined the patterns of diet intake among Maasai pregnant women and assessed their effect on newborn morphometrics. We recruited 141 mother-infant pairs from Ngorongoro Conservation Area (NCA) in Northern Tanzania and quantified dietary intake and changes in maternal diet during pregnancy. We obtained measurements of body weight (BW) and head circumference (HC) at birth. We found that Maasai women significantly reduced their dietary intake during the third trimester, going from an average of 1601 kcal/day during the first two trimesters to 799 kcal/day in the final trimester. The greatest proportion of nutrient reduction was in carbohydrates. Overall, 40% of HC Z-scores of the NCA sample were more than 2 standard deviations below the WHO standard. Nearly a third of neonates classify as low birth weight (< 2500g). HC was smaller relative to BW in this cohort than predicted using the WHO standard. This contrasts markedly to a Tanzanian birth cohort obtained at the same time in an urban context in which only 12% of infants exhibited low weight, only two individuals had HC Z-scores < 2 and HC’s relative to birth weight were larger than predicted using the WHO standards. The surprising lack of head sparing in the NCA cohort suggests that the impact of third trimester malnutrition bears further investigation in both animal models and human populations, especially as low HC is negatively associated with long term health outcomes.
Fil: Powell, Christopher D.. University of Calgary; Canadá
Fil: Wilson, Warren M.. University of Calgary; Canadá
Fil: Olesaningo, Godwin. Endulen Hospital; Tanzania
Fil: Manyama, Mange. Catholic University of Health and Allied Sciences; Tanzania. Weill Cornell Medicine; Qatar
Fil: Jamniczky, Heather. University of Calgary; Canadá
Fil: Spritz, Richard. University Of Colorado. School Of Medicine.; Estados Unidos
Fil: Cross, James C.. University of Calgary; Canadá
Fil: Lukowiak, Kenneth. University of Calgary; Canadá
Fil: Hallgrimsson, Benedikt. University of Calgary; Canadá
Fil: Gonzalez, Paula Natalia. Universidad Nacional Arturo Jauretche. Unidad Ejecutora de Estudios en Neurociencias y Sistemas Complejos. Provincia de Buenos Aires. Ministerio de Salud. Hospital Alta Complejidad en Red El Cruce Dr. Néstor Carlos Kirchner Samic. Unidad Ejecutora de Estudios en Neurociencias y Sistemas Complejos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Unidad Ejecutora de Estudios en Neurociencias y Sistemas Complejos; Argentina
Materia
BRAIN GROWTH
MALNUTRITION
TANZANIA
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/181531
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/181531
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Lack of head sparing following third-trimester caloric restriction among Tanzanian MaasaiPowell, Christopher D.Wilson, Warren M.Olesaningo, GodwinManyama, MangeJamniczky, HeatherSpritz, RichardCross, James C.Lukowiak, KennethHallgrimsson, BenediktGonzalez, Paula NataliaBRAIN GROWTHMALNUTRITIONTANZANIAhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1The reduction of food intake during pregnancy is part of many cultural and religious traditions around the world. The impact of such practices on fetal growth and development are poorly understood. Here, we examined the patterns of diet intake among Maasai pregnant women and assessed their effect on newborn morphometrics. We recruited 141 mother-infant pairs from Ngorongoro Conservation Area (NCA) in Northern Tanzania and quantified dietary intake and changes in maternal diet during pregnancy. We obtained measurements of body weight (BW) and head circumference (HC) at birth. We found that Maasai women significantly reduced their dietary intake during the third trimester, going from an average of 1601 kcal/day during the first two trimesters to 799 kcal/day in the final trimester. The greatest proportion of nutrient reduction was in carbohydrates. Overall, 40% of HC Z-scores of the NCA sample were more than 2 standard deviations below the WHO standard. Nearly a third of neonates classify as low birth weight (< 2500g). HC was smaller relative to BW in this cohort than predicted using the WHO standard. This contrasts markedly to a Tanzanian birth cohort obtained at the same time in an urban context in which only 12% of infants exhibited low weight, only two individuals had HC Z-scores < 2 and HC’s relative to birth weight were larger than predicted using the WHO standards. The surprising lack of head sparing in the NCA cohort suggests that the impact of third trimester malnutrition bears further investigation in both animal models and human populations, especially as low HC is negatively associated with long term health outcomes.Fil: Powell, Christopher D.. University of Calgary; CanadáFil: Wilson, Warren M.. University of Calgary; CanadáFil: Olesaningo, Godwin. Endulen Hospital; TanzaniaFil: Manyama, Mange. Catholic University of Health and Allied Sciences; Tanzania. Weill Cornell Medicine; QatarFil: Jamniczky, Heather. University of Calgary; CanadáFil: Spritz, Richard. University Of Colorado. School Of Medicine.; Estados UnidosFil: Cross, James C.. University of Calgary; CanadáFil: Lukowiak, Kenneth. University of Calgary; CanadáFil: Hallgrimsson, Benedikt. University of Calgary; CanadáFil: Gonzalez, Paula Natalia. Universidad Nacional Arturo Jauretche. Unidad Ejecutora de Estudios en Neurociencias y Sistemas Complejos. Provincia de Buenos Aires. Ministerio de Salud. Hospital Alta Complejidad en Red El Cruce Dr. Néstor Carlos Kirchner Samic. Unidad Ejecutora de Estudios en Neurociencias y Sistemas Complejos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Unidad Ejecutora de Estudios en Neurociencias y Sistemas Complejos; ArgentinaPublic Library of Science2020-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/181531Powell, Christopher D.; Wilson, Warren M.; Olesaningo, Godwin; Manyama, Mange; Jamniczky, Heather; et al.; Lack of head sparing following third-trimester caloric restriction among Tanzanian Maasai; Public Library of Science; Plos One; 15; 9; 9-2020; 1-171932-6203CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0237700info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pone.0237700info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:28:45Zoai:ri.conicet.gov.ar:11336/181531instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:28:45.973CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Lack of head sparing following third-trimester caloric restriction among Tanzanian Maasai
title Lack of head sparing following third-trimester caloric restriction among Tanzanian Maasai
spellingShingle Lack of head sparing following third-trimester caloric restriction among Tanzanian Maasai
Powell, Christopher D.
BRAIN GROWTH
MALNUTRITION
TANZANIA
title_short Lack of head sparing following third-trimester caloric restriction among Tanzanian Maasai
title_full Lack of head sparing following third-trimester caloric restriction among Tanzanian Maasai
title_fullStr Lack of head sparing following third-trimester caloric restriction among Tanzanian Maasai
title_full_unstemmed Lack of head sparing following third-trimester caloric restriction among Tanzanian Maasai
title_sort Lack of head sparing following third-trimester caloric restriction among Tanzanian Maasai
dc.creator.none.fl_str_mv Powell, Christopher D.
Wilson, Warren M.
Olesaningo, Godwin
Manyama, Mange
Jamniczky, Heather
Spritz, Richard
Cross, James C.
Lukowiak, Kenneth
Hallgrimsson, Benedikt
Gonzalez, Paula Natalia
author Powell, Christopher D.
author_facet Powell, Christopher D.
Wilson, Warren M.
Olesaningo, Godwin
Manyama, Mange
Jamniczky, Heather
Spritz, Richard
Cross, James C.
Lukowiak, Kenneth
Hallgrimsson, Benedikt
Gonzalez, Paula Natalia
author_role author
author2 Wilson, Warren M.
Olesaningo, Godwin
Manyama, Mange
Jamniczky, Heather
Spritz, Richard
Cross, James C.
Lukowiak, Kenneth
Hallgrimsson, Benedikt
Gonzalez, Paula Natalia
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv BRAIN GROWTH
MALNUTRITION
TANZANIA
topic BRAIN GROWTH
MALNUTRITION
TANZANIA
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The reduction of food intake during pregnancy is part of many cultural and religious traditions around the world. The impact of such practices on fetal growth and development are poorly understood. Here, we examined the patterns of diet intake among Maasai pregnant women and assessed their effect on newborn morphometrics. We recruited 141 mother-infant pairs from Ngorongoro Conservation Area (NCA) in Northern Tanzania and quantified dietary intake and changes in maternal diet during pregnancy. We obtained measurements of body weight (BW) and head circumference (HC) at birth. We found that Maasai women significantly reduced their dietary intake during the third trimester, going from an average of 1601 kcal/day during the first two trimesters to 799 kcal/day in the final trimester. The greatest proportion of nutrient reduction was in carbohydrates. Overall, 40% of HC Z-scores of the NCA sample were more than 2 standard deviations below the WHO standard. Nearly a third of neonates classify as low birth weight (< 2500g). HC was smaller relative to BW in this cohort than predicted using the WHO standard. This contrasts markedly to a Tanzanian birth cohort obtained at the same time in an urban context in which only 12% of infants exhibited low weight, only two individuals had HC Z-scores < 2 and HC’s relative to birth weight were larger than predicted using the WHO standards. The surprising lack of head sparing in the NCA cohort suggests that the impact of third trimester malnutrition bears further investigation in both animal models and human populations, especially as low HC is negatively associated with long term health outcomes.
Fil: Powell, Christopher D.. University of Calgary; Canadá
Fil: Wilson, Warren M.. University of Calgary; Canadá
Fil: Olesaningo, Godwin. Endulen Hospital; Tanzania
Fil: Manyama, Mange. Catholic University of Health and Allied Sciences; Tanzania. Weill Cornell Medicine; Qatar
Fil: Jamniczky, Heather. University of Calgary; Canadá
Fil: Spritz, Richard. University Of Colorado. School Of Medicine.; Estados Unidos
Fil: Cross, James C.. University of Calgary; Canadá
Fil: Lukowiak, Kenneth. University of Calgary; Canadá
Fil: Hallgrimsson, Benedikt. University of Calgary; Canadá
Fil: Gonzalez, Paula Natalia. Universidad Nacional Arturo Jauretche. Unidad Ejecutora de Estudios en Neurociencias y Sistemas Complejos. Provincia de Buenos Aires. Ministerio de Salud. Hospital Alta Complejidad en Red El Cruce Dr. Néstor Carlos Kirchner Samic. Unidad Ejecutora de Estudios en Neurociencias y Sistemas Complejos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Unidad Ejecutora de Estudios en Neurociencias y Sistemas Complejos; Argentina
description The reduction of food intake during pregnancy is part of many cultural and religious traditions around the world. The impact of such practices on fetal growth and development are poorly understood. Here, we examined the patterns of diet intake among Maasai pregnant women and assessed their effect on newborn morphometrics. We recruited 141 mother-infant pairs from Ngorongoro Conservation Area (NCA) in Northern Tanzania and quantified dietary intake and changes in maternal diet during pregnancy. We obtained measurements of body weight (BW) and head circumference (HC) at birth. We found that Maasai women significantly reduced their dietary intake during the third trimester, going from an average of 1601 kcal/day during the first two trimesters to 799 kcal/day in the final trimester. The greatest proportion of nutrient reduction was in carbohydrates. Overall, 40% of HC Z-scores of the NCA sample were more than 2 standard deviations below the WHO standard. Nearly a third of neonates classify as low birth weight (< 2500g). HC was smaller relative to BW in this cohort than predicted using the WHO standard. This contrasts markedly to a Tanzanian birth cohort obtained at the same time in an urban context in which only 12% of infants exhibited low weight, only two individuals had HC Z-scores < 2 and HC’s relative to birth weight were larger than predicted using the WHO standards. The surprising lack of head sparing in the NCA cohort suggests that the impact of third trimester malnutrition bears further investigation in both animal models and human populations, especially as low HC is negatively associated with long term health outcomes.
publishDate 2020
dc.date.none.fl_str_mv 2020-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/181531
Powell, Christopher D.; Wilson, Warren M.; Olesaningo, Godwin; Manyama, Mange; Jamniczky, Heather; et al.; Lack of head sparing following third-trimester caloric restriction among Tanzanian Maasai; Public Library of Science; Plos One; 15; 9; 9-2020; 1-17
1932-6203
CONICET Digital
CONICET
url http://hdl.handle.net/11336/181531
identifier_str_mv Powell, Christopher D.; Wilson, Warren M.; Olesaningo, Godwin; Manyama, Mange; Jamniczky, Heather; et al.; Lack of head sparing following third-trimester caloric restriction among Tanzanian Maasai; Public Library of Science; Plos One; 15; 9; 9-2020; 1-17
1932-6203
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0237700
info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pone.0237700
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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