Epidemiology and risk factors of asthma-chronic obstructive pulmonary disease overlap in low- and middle-income countries
- Autores
- Morgan, Brooks W.; Grigsby, Matthew R.; Siddharthan, Trishul; Chowdhury, Muhammad; Rubinstein, Adolfo Luis; Gutierrez, Laura; Irazola, Vilma; Miranda, J. Jaime; Bernabe-Ortiz, Antonio; Alam, Dewan; Wise, Robert A.; Checkley, William
- Año de publicación
- 2019
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Background: Asthma-chronic obstructive pulmonary disease (COPD) overlap (ACO) represents the confluence of bronchial airway hyperreactivity and chronic airflow limitation and has been described as leading to worse lung function and quality of life than found with either singular disease process. Objective: We aimed to describe the prevalence and risk factors for ACO among adults across 6 low- and middle-income countries (LMICs). Methods: We compiled cross-sectional data for 11,923 participants aged 35 to 92 years from 4 population-based studies in 12 settings. We defined COPD as postbronchodilator FEV 1 /forced vital capacity ratio below the lower limit of normal, asthma as wheeze or medication use in 12 months or self-reported physician diagnosis, and ACO as having both. Results: The prevalence of ACO was 3.8% (0% in rural Puno, Peru, to 7.8% in Matlab, Bangladesh). The odds of having ACO were higher with household exposure to biomass fuel smoke (odds ratio [OR], 1.48; 95% CI, 0.98-2.23), smoking tobacco (OR, 1.28 per 10 pack-years; 95% CI, 1.22-1.34), and having primary or less education (OR, 1.35; 95% CI, 1.07-1.70) as compared to nonobstructed nonasthma individuals. ACO was associated with severe obstruction (FEV 1 %, <50; 31.6% of ACO vs 10.9% of COPD alone) and severe spirometric deficits compared with participants with asthma (−1.61 z scores FEV 1 ; 95% CI, −1.48 to −1.75) or COPD alone (−0.94 z scores; 95% CI, −0.78 to −1.10). Conclusions: ACO may be as prevalent and more severe in LMICs than has been reported in high-income settings. Exposure to biomass fuel smoke may be an overlooked risk factor, and we favor diagnostic criteria for ACO that include environmental exposures common to LMICs.
Fil: Morgan, Brooks W.. University Johns Hopkins; Estados Unidos
Fil: Grigsby, Matthew R.. University Johns Hopkins; Estados Unidos
Fil: Siddharthan, Trishul. University Johns Hopkins; Estados Unidos
Fil: Chowdhury, Muhammad. International Centre For Diarrhoeal Disease Research ; Bangladesh
Fil: Rubinstein, Adolfo Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; Argentina
Fil: Gutierrez, Laura. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Irazola, Vilma. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; Argentina
Fil: Miranda, J. Jaime. Universidad Peruana Cayetano Heredia; Perú
Fil: Bernabe-Ortiz, Antonio. Universidad Peruana Cayetano Heredia; Perú
Fil: Alam, Dewan. University of York; Reino Unido
Fil: Wise, Robert A.. University Johns Hopkins; Estados Unidos
Fil: Checkley, William. University Johns Hopkins; Estados Unidos - Materia
-
ACO
ASTHMA
ASTHMA-COPD OVERLAP
CHRONIC OBSTRUCTIVE PULMONARY DISEASE
COPD
EPIDEMIOLOGY
HEALTH OUTCOMES
OVERLAP
POPULATION-BASED
RISK FACTORS
SPIROMETRY - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/147465
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Epidemiology and risk factors of asthma-chronic obstructive pulmonary disease overlap in low- and middle-income countriesMorgan, Brooks W.Grigsby, Matthew R.Siddharthan, TrishulChowdhury, MuhammadRubinstein, Adolfo LuisGutierrez, LauraIrazola, VilmaMiranda, J. JaimeBernabe-Ortiz, AntonioAlam, DewanWise, Robert A.Checkley, WilliamACOASTHMAASTHMA-COPD OVERLAPCHRONIC OBSTRUCTIVE PULMONARY DISEASECOPDEPIDEMIOLOGYHEALTH OUTCOMESOVERLAPPOPULATION-BASEDRISK FACTORSSPIROMETRYhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Background: Asthma-chronic obstructive pulmonary disease (COPD) overlap (ACO) represents the confluence of bronchial airway hyperreactivity and chronic airflow limitation and has been described as leading to worse lung function and quality of life than found with either singular disease process. Objective: We aimed to describe the prevalence and risk factors for ACO among adults across 6 low- and middle-income countries (LMICs). Methods: We compiled cross-sectional data for 11,923 participants aged 35 to 92 years from 4 population-based studies in 12 settings. We defined COPD as postbronchodilator FEV 1 /forced vital capacity ratio below the lower limit of normal, asthma as wheeze or medication use in 12 months or self-reported physician diagnosis, and ACO as having both. Results: The prevalence of ACO was 3.8% (0% in rural Puno, Peru, to 7.8% in Matlab, Bangladesh). The odds of having ACO were higher with household exposure to biomass fuel smoke (odds ratio [OR], 1.48; 95% CI, 0.98-2.23), smoking tobacco (OR, 1.28 per 10 pack-years; 95% CI, 1.22-1.34), and having primary or less education (OR, 1.35; 95% CI, 1.07-1.70) as compared to nonobstructed nonasthma individuals. ACO was associated with severe obstruction (FEV 1 %, <50; 31.6% of ACO vs 10.9% of COPD alone) and severe spirometric deficits compared with participants with asthma (−1.61 z scores FEV 1 ; 95% CI, −1.48 to −1.75) or COPD alone (−0.94 z scores; 95% CI, −0.78 to −1.10). Conclusions: ACO may be as prevalent and more severe in LMICs than has been reported in high-income settings. Exposure to biomass fuel smoke may be an overlooked risk factor, and we favor diagnostic criteria for ACO that include environmental exposures common to LMICs.Fil: Morgan, Brooks W.. University Johns Hopkins; Estados UnidosFil: Grigsby, Matthew R.. University Johns Hopkins; Estados UnidosFil: Siddharthan, Trishul. University Johns Hopkins; Estados UnidosFil: Chowdhury, Muhammad. International Centre For Diarrhoeal Disease Research ; BangladeshFil: Rubinstein, Adolfo Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; ArgentinaFil: Gutierrez, Laura. Instituto de Efectividad Clínica y Sanitaria; ArgentinaFil: Irazola, Vilma. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; ArgentinaFil: Miranda, J. Jaime. Universidad Peruana Cayetano Heredia; PerúFil: Bernabe-Ortiz, Antonio. Universidad Peruana Cayetano Heredia; PerúFil: Alam, Dewan. University of York; Reino UnidoFil: Wise, Robert A.. University Johns Hopkins; Estados UnidosFil: Checkley, William. University Johns Hopkins; Estados UnidosMosby-Elsevier2019-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/147465Morgan, Brooks W.; Grigsby, Matthew R.; Siddharthan, Trishul; Chowdhury, Muhammad; Rubinstein, Adolfo Luis; et al.; Epidemiology and risk factors of asthma-chronic obstructive pulmonary disease overlap in low- and middle-income countries; Mosby-Elsevier; Journal of Allergy and Clinical Immunology; 143; 4; 4-2019; 1598-16060091-6749CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S0091674918313629info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jaci.2018.06.052info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:00:55Zoai:ri.conicet.gov.ar:11336/147465instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:00:55.854CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Epidemiology and risk factors of asthma-chronic obstructive pulmonary disease overlap in low- and middle-income countries |
title |
Epidemiology and risk factors of asthma-chronic obstructive pulmonary disease overlap in low- and middle-income countries |
spellingShingle |
Epidemiology and risk factors of asthma-chronic obstructive pulmonary disease overlap in low- and middle-income countries Morgan, Brooks W. ACO ASTHMA ASTHMA-COPD OVERLAP CHRONIC OBSTRUCTIVE PULMONARY DISEASE COPD EPIDEMIOLOGY HEALTH OUTCOMES OVERLAP POPULATION-BASED RISK FACTORS SPIROMETRY |
title_short |
Epidemiology and risk factors of asthma-chronic obstructive pulmonary disease overlap in low- and middle-income countries |
title_full |
Epidemiology and risk factors of asthma-chronic obstructive pulmonary disease overlap in low- and middle-income countries |
title_fullStr |
Epidemiology and risk factors of asthma-chronic obstructive pulmonary disease overlap in low- and middle-income countries |
title_full_unstemmed |
Epidemiology and risk factors of asthma-chronic obstructive pulmonary disease overlap in low- and middle-income countries |
title_sort |
Epidemiology and risk factors of asthma-chronic obstructive pulmonary disease overlap in low- and middle-income countries |
dc.creator.none.fl_str_mv |
Morgan, Brooks W. Grigsby, Matthew R. Siddharthan, Trishul Chowdhury, Muhammad Rubinstein, Adolfo Luis Gutierrez, Laura Irazola, Vilma Miranda, J. Jaime Bernabe-Ortiz, Antonio Alam, Dewan Wise, Robert A. Checkley, William |
author |
Morgan, Brooks W. |
author_facet |
Morgan, Brooks W. Grigsby, Matthew R. Siddharthan, Trishul Chowdhury, Muhammad Rubinstein, Adolfo Luis Gutierrez, Laura Irazola, Vilma Miranda, J. Jaime Bernabe-Ortiz, Antonio Alam, Dewan Wise, Robert A. Checkley, William |
author_role |
author |
author2 |
Grigsby, Matthew R. Siddharthan, Trishul Chowdhury, Muhammad Rubinstein, Adolfo Luis Gutierrez, Laura Irazola, Vilma Miranda, J. Jaime Bernabe-Ortiz, Antonio Alam, Dewan Wise, Robert A. Checkley, William |
author2_role |
author author author author author author author author author author author |
dc.subject.none.fl_str_mv |
ACO ASTHMA ASTHMA-COPD OVERLAP CHRONIC OBSTRUCTIVE PULMONARY DISEASE COPD EPIDEMIOLOGY HEALTH OUTCOMES OVERLAP POPULATION-BASED RISK FACTORS SPIROMETRY |
topic |
ACO ASTHMA ASTHMA-COPD OVERLAP CHRONIC OBSTRUCTIVE PULMONARY DISEASE COPD EPIDEMIOLOGY HEALTH OUTCOMES OVERLAP POPULATION-BASED RISK FACTORS SPIROMETRY |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.3 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
Background: Asthma-chronic obstructive pulmonary disease (COPD) overlap (ACO) represents the confluence of bronchial airway hyperreactivity and chronic airflow limitation and has been described as leading to worse lung function and quality of life than found with either singular disease process. Objective: We aimed to describe the prevalence and risk factors for ACO among adults across 6 low- and middle-income countries (LMICs). Methods: We compiled cross-sectional data for 11,923 participants aged 35 to 92 years from 4 population-based studies in 12 settings. We defined COPD as postbronchodilator FEV 1 /forced vital capacity ratio below the lower limit of normal, asthma as wheeze or medication use in 12 months or self-reported physician diagnosis, and ACO as having both. Results: The prevalence of ACO was 3.8% (0% in rural Puno, Peru, to 7.8% in Matlab, Bangladesh). The odds of having ACO were higher with household exposure to biomass fuel smoke (odds ratio [OR], 1.48; 95% CI, 0.98-2.23), smoking tobacco (OR, 1.28 per 10 pack-years; 95% CI, 1.22-1.34), and having primary or less education (OR, 1.35; 95% CI, 1.07-1.70) as compared to nonobstructed nonasthma individuals. ACO was associated with severe obstruction (FEV 1 %, <50; 31.6% of ACO vs 10.9% of COPD alone) and severe spirometric deficits compared with participants with asthma (−1.61 z scores FEV 1 ; 95% CI, −1.48 to −1.75) or COPD alone (−0.94 z scores; 95% CI, −0.78 to −1.10). Conclusions: ACO may be as prevalent and more severe in LMICs than has been reported in high-income settings. Exposure to biomass fuel smoke may be an overlooked risk factor, and we favor diagnostic criteria for ACO that include environmental exposures common to LMICs. Fil: Morgan, Brooks W.. University Johns Hopkins; Estados Unidos Fil: Grigsby, Matthew R.. University Johns Hopkins; Estados Unidos Fil: Siddharthan, Trishul. University Johns Hopkins; Estados Unidos Fil: Chowdhury, Muhammad. International Centre For Diarrhoeal Disease Research ; Bangladesh Fil: Rubinstein, Adolfo Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; Argentina Fil: Gutierrez, Laura. Instituto de Efectividad Clínica y Sanitaria; Argentina Fil: Irazola, Vilma. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; Argentina Fil: Miranda, J. Jaime. Universidad Peruana Cayetano Heredia; Perú Fil: Bernabe-Ortiz, Antonio. Universidad Peruana Cayetano Heredia; Perú Fil: Alam, Dewan. University of York; Reino Unido Fil: Wise, Robert A.. University Johns Hopkins; Estados Unidos Fil: Checkley, William. University Johns Hopkins; Estados Unidos |
description |
Background: Asthma-chronic obstructive pulmonary disease (COPD) overlap (ACO) represents the confluence of bronchial airway hyperreactivity and chronic airflow limitation and has been described as leading to worse lung function and quality of life than found with either singular disease process. Objective: We aimed to describe the prevalence and risk factors for ACO among adults across 6 low- and middle-income countries (LMICs). Methods: We compiled cross-sectional data for 11,923 participants aged 35 to 92 years from 4 population-based studies in 12 settings. We defined COPD as postbronchodilator FEV 1 /forced vital capacity ratio below the lower limit of normal, asthma as wheeze or medication use in 12 months or self-reported physician diagnosis, and ACO as having both. Results: The prevalence of ACO was 3.8% (0% in rural Puno, Peru, to 7.8% in Matlab, Bangladesh). The odds of having ACO were higher with household exposure to biomass fuel smoke (odds ratio [OR], 1.48; 95% CI, 0.98-2.23), smoking tobacco (OR, 1.28 per 10 pack-years; 95% CI, 1.22-1.34), and having primary or less education (OR, 1.35; 95% CI, 1.07-1.70) as compared to nonobstructed nonasthma individuals. ACO was associated with severe obstruction (FEV 1 %, <50; 31.6% of ACO vs 10.9% of COPD alone) and severe spirometric deficits compared with participants with asthma (−1.61 z scores FEV 1 ; 95% CI, −1.48 to −1.75) or COPD alone (−0.94 z scores; 95% CI, −0.78 to −1.10). Conclusions: ACO may be as prevalent and more severe in LMICs than has been reported in high-income settings. Exposure to biomass fuel smoke may be an overlooked risk factor, and we favor diagnostic criteria for ACO that include environmental exposures common to LMICs. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-04 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/147465 Morgan, Brooks W.; Grigsby, Matthew R.; Siddharthan, Trishul; Chowdhury, Muhammad; Rubinstein, Adolfo Luis; et al.; Epidemiology and risk factors of asthma-chronic obstructive pulmonary disease overlap in low- and middle-income countries; Mosby-Elsevier; Journal of Allergy and Clinical Immunology; 143; 4; 4-2019; 1598-1606 0091-6749 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/147465 |
identifier_str_mv |
Morgan, Brooks W.; Grigsby, Matthew R.; Siddharthan, Trishul; Chowdhury, Muhammad; Rubinstein, Adolfo Luis; et al.; Epidemiology and risk factors of asthma-chronic obstructive pulmonary disease overlap in low- and middle-income countries; Mosby-Elsevier; Journal of Allergy and Clinical Immunology; 143; 4; 4-2019; 1598-1606 0091-6749 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S0091674918313629 info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jaci.2018.06.052 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Mosby-Elsevier |
publisher.none.fl_str_mv |
Mosby-Elsevier |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1844613796418551808 |
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13.070432 |