Determination of Cell Proliferation and Apoptosis in Placentas of Chronically Stressed Rats
- Autores
- Cots, Debora Soledad; Rolando, Alicia Nelida; Mugnaini, Maria Teresa; Soñez, Carlos Alberto; Bozzo, Aida Andrea; Borghi, Damiana; Gauana, Hector Fernando; Romanini, María Cristina
- Año de publicación
- 2013
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Chronic stress during gestation can alter several mechanisms that maintain homeostasis in the placenta. The aim of this study was to determine both effects of chronic stress on the apoptotic and cell proliferation processes in placentas of rats, during the second half of pregnancy and the immunolocalization of apoptotic and proliferating marked nuclei in the different placental zones. Stress by immobilization was applied to rats from the 4th day of pregnancy until their sacrifice on days 12, 17 or 21. Placental sections were immunolabeled with anti-BrdU and TUNEL. The apoptotic index did not present significant differences between control and stress groups. The gestational day influenced significantly on the apoptotic index, which showed a significant decrease on day 17 of gestation and significant increase on day 21. The proliferating index presented significant differences between gestational stages studied, which showed a significant increase at day 17 and then a significant decrease at day 21. Moreover, the stress treatment applied highly influenced on the proliferation index. In conclusion, chronic stress by immobilization did not produce effects on apoptotic process. However it produces an increase in cellular proliferation index in the three gestation days analyzed, which could generate a deleterious environment for the fetus development
Fil: Cots, Debora Soledad. Universidad Nacional de Rio Cuarto. Facultad de Agronomia y Veterinaria. Departamento de Anatomia Animal. Laboratorio de Biología Cecular y Embriologia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina
Fil: Rolando, Alicia Nelida. Universidad Nacional de Rio Cuarto. Facultad de Agronomia y Veterinaria. Departamento de Anatomia Animal. Laboratorio de Biología Cecular y Embriologia; Argentina
Fil: Mugnaini, Maria Teresa. Universidad Nacional de Rio Cuarto. Facultad de Agronomia y Veterinaria. Departamento de Anatomia Animal. Laboratorio de Biología Cecular y Embriologia; Argentina
Fil: Soñez, Carlos Alberto. Universidad Nacional de Rio Cuarto. Facultad de Agronomia y Veterinaria. Departamento de Anatomia Animal. Laboratorio de Biología Cecular y Embriologia; Argentina
Fil: Bozzo, Aida Andrea. Universidad Nacional de Rio Cuarto. Facultad de Agronomia y Veterinaria. Departamento de Anatomia Animal. Laboratorio de Biología Cecular y Embriologia; Argentina
Fil: Borghi, Damiana. Universidad Nacional de Rio Cuarto. Facultad de Agronomia y Veterinaria. Departamento de Anatomia Animal. Laboratorio de Biología Cecular y Embriologia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina
Fil: Gauana, Hector Fernando. Universidad Nacional de Rio Cuarto. Facultad de Agronomia y Veterinaria. Departamento de Anatomia Animal. Laboratorio de Biología Cecular y Embriologia; Argentina
Fil: Romanini, María Cristina. Universidad Nacional de Rio Cuarto. Facultad de Agronomia y Veterinaria. Departamento de Anatomia Animal. Laboratorio de Biología Cecular y Embriologia; Argentina - Materia
-
CHRONIC STRESS
APOPTOSIS
CELL PROLIFERATION
PLACENTA - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/180724
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Determination of Cell Proliferation and Apoptosis in Placentas of Chronically Stressed RatsCots, Debora SoledadRolando, Alicia NelidaMugnaini, Maria TeresaSoñez, Carlos AlbertoBozzo, Aida AndreaBorghi, DamianaGauana, Hector FernandoRomanini, María CristinaCHRONIC STRESSAPOPTOSISCELL PROLIFERATIONPLACENTAhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Chronic stress during gestation can alter several mechanisms that maintain homeostasis in the placenta. The aim of this study was to determine both effects of chronic stress on the apoptotic and cell proliferation processes in placentas of rats, during the second half of pregnancy and the immunolocalization of apoptotic and proliferating marked nuclei in the different placental zones. Stress by immobilization was applied to rats from the 4th day of pregnancy until their sacrifice on days 12, 17 or 21. Placental sections were immunolabeled with anti-BrdU and TUNEL. The apoptotic index did not present significant differences between control and stress groups. The gestational day influenced significantly on the apoptotic index, which showed a significant decrease on day 17 of gestation and significant increase on day 21. The proliferating index presented significant differences between gestational stages studied, which showed a significant increase at day 17 and then a significant decrease at day 21. Moreover, the stress treatment applied highly influenced on the proliferation index. In conclusion, chronic stress by immobilization did not produce effects on apoptotic process. However it produces an increase in cellular proliferation index in the three gestation days analyzed, which could generate a deleterious environment for the fetus developmentFil: Cots, Debora Soledad. Universidad Nacional de Rio Cuarto. Facultad de Agronomia y Veterinaria. Departamento de Anatomia Animal. Laboratorio de Biología Cecular y Embriologia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; ArgentinaFil: Rolando, Alicia Nelida. Universidad Nacional de Rio Cuarto. Facultad de Agronomia y Veterinaria. Departamento de Anatomia Animal. Laboratorio de Biología Cecular y Embriologia; ArgentinaFil: Mugnaini, Maria Teresa. Universidad Nacional de Rio Cuarto. Facultad de Agronomia y Veterinaria. Departamento de Anatomia Animal. Laboratorio de Biología Cecular y Embriologia; ArgentinaFil: Soñez, Carlos Alberto. Universidad Nacional de Rio Cuarto. Facultad de Agronomia y Veterinaria. Departamento de Anatomia Animal. Laboratorio de Biología Cecular y Embriologia; ArgentinaFil: Bozzo, Aida Andrea. Universidad Nacional de Rio Cuarto. Facultad de Agronomia y Veterinaria. Departamento de Anatomia Animal. Laboratorio de Biología Cecular y Embriologia; ArgentinaFil: Borghi, Damiana. Universidad Nacional de Rio Cuarto. Facultad de Agronomia y Veterinaria. Departamento de Anatomia Animal. Laboratorio de Biología Cecular y Embriologia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; ArgentinaFil: Gauana, Hector Fernando. Universidad Nacional de Rio Cuarto. Facultad de Agronomia y Veterinaria. Departamento de Anatomia Animal. Laboratorio de Biología Cecular y Embriologia; ArgentinaFil: Romanini, María Cristina. Universidad Nacional de Rio Cuarto. Facultad de Agronomia y Veterinaria. Departamento de Anatomia Animal. Laboratorio de Biología Cecular y Embriologia; ArgentinaOpen Access Scientific Reports2013-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/180724Cots, Debora Soledad; Rolando, Alicia Nelida; Mugnaini, Maria Teresa; Soñez, Carlos Alberto; Bozzo, Aida Andrea; et al.; Determination of Cell Proliferation and Apoptosis in Placentas of Chronically Stressed Rats; Open Access Scientific Reports; Journal of Cytology and Histology; 2; 3; 3-2013; 1-52157-7099CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.4172/scientificreports.664info:eu-repo/semantics/altIdentifier/url/https://www.omicsonline.org/scientific-reports/srep664.phpinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:44:52Zoai:ri.conicet.gov.ar:11336/180724instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:44:53.015CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Determination of Cell Proliferation and Apoptosis in Placentas of Chronically Stressed Rats |
title |
Determination of Cell Proliferation and Apoptosis in Placentas of Chronically Stressed Rats |
spellingShingle |
Determination of Cell Proliferation and Apoptosis in Placentas of Chronically Stressed Rats Cots, Debora Soledad CHRONIC STRESS APOPTOSIS CELL PROLIFERATION PLACENTA |
title_short |
Determination of Cell Proliferation and Apoptosis in Placentas of Chronically Stressed Rats |
title_full |
Determination of Cell Proliferation and Apoptosis in Placentas of Chronically Stressed Rats |
title_fullStr |
Determination of Cell Proliferation and Apoptosis in Placentas of Chronically Stressed Rats |
title_full_unstemmed |
Determination of Cell Proliferation and Apoptosis in Placentas of Chronically Stressed Rats |
title_sort |
Determination of Cell Proliferation and Apoptosis in Placentas of Chronically Stressed Rats |
dc.creator.none.fl_str_mv |
Cots, Debora Soledad Rolando, Alicia Nelida Mugnaini, Maria Teresa Soñez, Carlos Alberto Bozzo, Aida Andrea Borghi, Damiana Gauana, Hector Fernando Romanini, María Cristina |
author |
Cots, Debora Soledad |
author_facet |
Cots, Debora Soledad Rolando, Alicia Nelida Mugnaini, Maria Teresa Soñez, Carlos Alberto Bozzo, Aida Andrea Borghi, Damiana Gauana, Hector Fernando Romanini, María Cristina |
author_role |
author |
author2 |
Rolando, Alicia Nelida Mugnaini, Maria Teresa Soñez, Carlos Alberto Bozzo, Aida Andrea Borghi, Damiana Gauana, Hector Fernando Romanini, María Cristina |
author2_role |
author author author author author author author |
dc.subject.none.fl_str_mv |
CHRONIC STRESS APOPTOSIS CELL PROLIFERATION PLACENTA |
topic |
CHRONIC STRESS APOPTOSIS CELL PROLIFERATION PLACENTA |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 |
dc.description.none.fl_txt_mv |
Chronic stress during gestation can alter several mechanisms that maintain homeostasis in the placenta. The aim of this study was to determine both effects of chronic stress on the apoptotic and cell proliferation processes in placentas of rats, during the second half of pregnancy and the immunolocalization of apoptotic and proliferating marked nuclei in the different placental zones. Stress by immobilization was applied to rats from the 4th day of pregnancy until their sacrifice on days 12, 17 or 21. Placental sections were immunolabeled with anti-BrdU and TUNEL. The apoptotic index did not present significant differences between control and stress groups. The gestational day influenced significantly on the apoptotic index, which showed a significant decrease on day 17 of gestation and significant increase on day 21. The proliferating index presented significant differences between gestational stages studied, which showed a significant increase at day 17 and then a significant decrease at day 21. Moreover, the stress treatment applied highly influenced on the proliferation index. In conclusion, chronic stress by immobilization did not produce effects on apoptotic process. However it produces an increase in cellular proliferation index in the three gestation days analyzed, which could generate a deleterious environment for the fetus development Fil: Cots, Debora Soledad. Universidad Nacional de Rio Cuarto. Facultad de Agronomia y Veterinaria. Departamento de Anatomia Animal. Laboratorio de Biología Cecular y Embriologia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina Fil: Rolando, Alicia Nelida. Universidad Nacional de Rio Cuarto. Facultad de Agronomia y Veterinaria. Departamento de Anatomia Animal. Laboratorio de Biología Cecular y Embriologia; Argentina Fil: Mugnaini, Maria Teresa. Universidad Nacional de Rio Cuarto. Facultad de Agronomia y Veterinaria. Departamento de Anatomia Animal. Laboratorio de Biología Cecular y Embriologia; Argentina Fil: Soñez, Carlos Alberto. Universidad Nacional de Rio Cuarto. Facultad de Agronomia y Veterinaria. Departamento de Anatomia Animal. Laboratorio de Biología Cecular y Embriologia; Argentina Fil: Bozzo, Aida Andrea. Universidad Nacional de Rio Cuarto. Facultad de Agronomia y Veterinaria. Departamento de Anatomia Animal. Laboratorio de Biología Cecular y Embriologia; Argentina Fil: Borghi, Damiana. Universidad Nacional de Rio Cuarto. Facultad de Agronomia y Veterinaria. Departamento de Anatomia Animal. Laboratorio de Biología Cecular y Embriologia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina Fil: Gauana, Hector Fernando. Universidad Nacional de Rio Cuarto. Facultad de Agronomia y Veterinaria. Departamento de Anatomia Animal. Laboratorio de Biología Cecular y Embriologia; Argentina Fil: Romanini, María Cristina. Universidad Nacional de Rio Cuarto. Facultad de Agronomia y Veterinaria. Departamento de Anatomia Animal. Laboratorio de Biología Cecular y Embriologia; Argentina |
description |
Chronic stress during gestation can alter several mechanisms that maintain homeostasis in the placenta. The aim of this study was to determine both effects of chronic stress on the apoptotic and cell proliferation processes in placentas of rats, during the second half of pregnancy and the immunolocalization of apoptotic and proliferating marked nuclei in the different placental zones. Stress by immobilization was applied to rats from the 4th day of pregnancy until their sacrifice on days 12, 17 or 21. Placental sections were immunolabeled with anti-BrdU and TUNEL. The apoptotic index did not present significant differences between control and stress groups. The gestational day influenced significantly on the apoptotic index, which showed a significant decrease on day 17 of gestation and significant increase on day 21. The proliferating index presented significant differences between gestational stages studied, which showed a significant increase at day 17 and then a significant decrease at day 21. Moreover, the stress treatment applied highly influenced on the proliferation index. In conclusion, chronic stress by immobilization did not produce effects on apoptotic process. However it produces an increase in cellular proliferation index in the three gestation days analyzed, which could generate a deleterious environment for the fetus development |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-03 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/180724 Cots, Debora Soledad; Rolando, Alicia Nelida; Mugnaini, Maria Teresa; Soñez, Carlos Alberto; Bozzo, Aida Andrea; et al.; Determination of Cell Proliferation and Apoptosis in Placentas of Chronically Stressed Rats; Open Access Scientific Reports; Journal of Cytology and Histology; 2; 3; 3-2013; 1-5 2157-7099 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/180724 |
identifier_str_mv |
Cots, Debora Soledad; Rolando, Alicia Nelida; Mugnaini, Maria Teresa; Soñez, Carlos Alberto; Bozzo, Aida Andrea; et al.; Determination of Cell Proliferation and Apoptosis in Placentas of Chronically Stressed Rats; Open Access Scientific Reports; Journal of Cytology and Histology; 2; 3; 3-2013; 1-5 2157-7099 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.4172/scientificreports.664 info:eu-repo/semantics/altIdentifier/url/https://www.omicsonline.org/scientific-reports/srep664.php |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Open Access Scientific Reports |
publisher.none.fl_str_mv |
Open Access Scientific Reports |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
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Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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13.070432 |