The Mitochondrial Interplay of Ubiquinol and Nitric Oxide in Endotoxemia
- Autores
- Lisdero, Constanza L.; Carreras, Maria Cecilia; Meulemans, Alain; Melani, Mariana; Aubier, Michel; Boczkowski, Jorge; Poderoso, Juan José
- Año de publicación
- 2004
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- This chapter focuses on role of ubiquinol (UQ) and nitric oxide in endotoxemia. UQ is endogenously synthesized in every organ in a specific pathway branched from cholesterol biosynthesis. Organs have different ubiquinol content depending on the activity of the biosynthetic pathway. In addition to its role as electron carrier in the mitochondrial respiratory chain, UQ exhibits prooxidant and antioxidant properties. The chapter provides the methodological bases that support the relation between UQ content, mitochondrial NO steady-state concentration, and peroxynitrite-mediated mitochondrial damage in representative organs. The chapter also focuses on the contribution of mtNOS to peroxynitrite formation in mitochondria. The chapter presents an experimental model, elaborating endotoxemic animals and sample preparation, and homogenate and mitochondrial preparations. Sources of NO in endotoxemia are also analyzed in the chapter. The chapter discusses the measurement of NOS expression and activity and analyzes the role of ubiquinol in endotoxemia. The endotoxemic mitochondrial damage is also analyzed in the chapter. The chapter elaborates the ubiquinone content and NO-induced hydrogen peroxide production by mitochondria..
Fil: Lisdero, Constanza L.. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Carreras, Maria Cecilia. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Inmunología, Genética y Metabolismo. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Inmunología, Genética y Metabolismo; Argentina
Fil: Meulemans, Alain. Universite de Paris; Francia
Fil: Melani, Mariana. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
Fil: Aubier, Michel. Universite de Paris; Francia
Fil: Boczkowski, Jorge. Universite de Paris; Francia
Fil: Poderoso, Juan José. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Inmunología, Genética y Metabolismo. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Inmunología, Genética y Metabolismo; Argentina - Materia
-
ubiquinol
nitric oxide
endotoxemia
mitochondria - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/118443
Ver los metadatos del registro completo
id |
CONICETDig_47ed628adbeb4a5e1ac9b7be9b7a9024 |
---|---|
oai_identifier_str |
oai:ri.conicet.gov.ar:11336/118443 |
network_acronym_str |
CONICETDig |
repository_id_str |
3498 |
network_name_str |
CONICET Digital (CONICET) |
spelling |
The Mitochondrial Interplay of Ubiquinol and Nitric Oxide in EndotoxemiaLisdero, Constanza L.Carreras, Maria CeciliaMeulemans, AlainMelani, MarianaAubier, MichelBoczkowski, JorgePoderoso, Juan Joséubiquinolnitric oxideendotoxemiamitochondriahttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3This chapter focuses on role of ubiquinol (UQ) and nitric oxide in endotoxemia. UQ is endogenously synthesized in every organ in a specific pathway branched from cholesterol biosynthesis. Organs have different ubiquinol content depending on the activity of the biosynthetic pathway. In addition to its role as electron carrier in the mitochondrial respiratory chain, UQ exhibits prooxidant and antioxidant properties. The chapter provides the methodological bases that support the relation between UQ content, mitochondrial NO steady-state concentration, and peroxynitrite-mediated mitochondrial damage in representative organs. The chapter also focuses on the contribution of mtNOS to peroxynitrite formation in mitochondria. The chapter presents an experimental model, elaborating endotoxemic animals and sample preparation, and homogenate and mitochondrial preparations. Sources of NO in endotoxemia are also analyzed in the chapter. The chapter discusses the measurement of NOS expression and activity and analyzes the role of ubiquinol in endotoxemia. The endotoxemic mitochondrial damage is also analyzed in the chapter. The chapter elaborates the ubiquinone content and NO-induced hydrogen peroxide production by mitochondria..Fil: Lisdero, Constanza L.. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; ArgentinaFil: Carreras, Maria Cecilia. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Inmunología, Genética y Metabolismo. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Inmunología, Genética y Metabolismo; ArgentinaFil: Meulemans, Alain. Universite de Paris; FranciaFil: Melani, Mariana. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; ArgentinaFil: Aubier, Michel. Universite de Paris; FranciaFil: Boczkowski, Jorge. Universite de Paris; FranciaFil: Poderoso, Juan José. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Inmunología, Genética y Metabolismo. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Inmunología, Genética y Metabolismo; ArgentinaElsevier Academic Press Inc2004-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/118443Lisdero, Constanza L.; Carreras, Maria Cecilia; Meulemans, Alain; Melani, Mariana; Aubier, Michel; et al.; The Mitochondrial Interplay of Ubiquinol and Nitric Oxide in Endotoxemia; Elsevier Academic Press Inc; Methods In Enzymology.; 382; 12-2004; 67-810076-6879CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/S0076-6879(04)82004-4info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:19:38Zoai:ri.conicet.gov.ar:11336/118443instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:19:38.706CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
The Mitochondrial Interplay of Ubiquinol and Nitric Oxide in Endotoxemia |
title |
The Mitochondrial Interplay of Ubiquinol and Nitric Oxide in Endotoxemia |
spellingShingle |
The Mitochondrial Interplay of Ubiquinol and Nitric Oxide in Endotoxemia Lisdero, Constanza L. ubiquinol nitric oxide endotoxemia mitochondria |
title_short |
The Mitochondrial Interplay of Ubiquinol and Nitric Oxide in Endotoxemia |
title_full |
The Mitochondrial Interplay of Ubiquinol and Nitric Oxide in Endotoxemia |
title_fullStr |
The Mitochondrial Interplay of Ubiquinol and Nitric Oxide in Endotoxemia |
title_full_unstemmed |
The Mitochondrial Interplay of Ubiquinol and Nitric Oxide in Endotoxemia |
title_sort |
The Mitochondrial Interplay of Ubiquinol and Nitric Oxide in Endotoxemia |
dc.creator.none.fl_str_mv |
Lisdero, Constanza L. Carreras, Maria Cecilia Meulemans, Alain Melani, Mariana Aubier, Michel Boczkowski, Jorge Poderoso, Juan José |
author |
Lisdero, Constanza L. |
author_facet |
Lisdero, Constanza L. Carreras, Maria Cecilia Meulemans, Alain Melani, Mariana Aubier, Michel Boczkowski, Jorge Poderoso, Juan José |
author_role |
author |
author2 |
Carreras, Maria Cecilia Meulemans, Alain Melani, Mariana Aubier, Michel Boczkowski, Jorge Poderoso, Juan José |
author2_role |
author author author author author author |
dc.subject.none.fl_str_mv |
ubiquinol nitric oxide endotoxemia mitochondria |
topic |
ubiquinol nitric oxide endotoxemia mitochondria |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.3 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
This chapter focuses on role of ubiquinol (UQ) and nitric oxide in endotoxemia. UQ is endogenously synthesized in every organ in a specific pathway branched from cholesterol biosynthesis. Organs have different ubiquinol content depending on the activity of the biosynthetic pathway. In addition to its role as electron carrier in the mitochondrial respiratory chain, UQ exhibits prooxidant and antioxidant properties. The chapter provides the methodological bases that support the relation between UQ content, mitochondrial NO steady-state concentration, and peroxynitrite-mediated mitochondrial damage in representative organs. The chapter also focuses on the contribution of mtNOS to peroxynitrite formation in mitochondria. The chapter presents an experimental model, elaborating endotoxemic animals and sample preparation, and homogenate and mitochondrial preparations. Sources of NO in endotoxemia are also analyzed in the chapter. The chapter discusses the measurement of NOS expression and activity and analyzes the role of ubiquinol in endotoxemia. The endotoxemic mitochondrial damage is also analyzed in the chapter. The chapter elaborates the ubiquinone content and NO-induced hydrogen peroxide production by mitochondria.. Fil: Lisdero, Constanza L.. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina Fil: Carreras, Maria Cecilia. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Inmunología, Genética y Metabolismo. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Inmunología, Genética y Metabolismo; Argentina Fil: Meulemans, Alain. Universite de Paris; Francia Fil: Melani, Mariana. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina Fil: Aubier, Michel. Universite de Paris; Francia Fil: Boczkowski, Jorge. Universite de Paris; Francia Fil: Poderoso, Juan José. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Inmunología, Genética y Metabolismo. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Inmunología, Genética y Metabolismo; Argentina |
description |
This chapter focuses on role of ubiquinol (UQ) and nitric oxide in endotoxemia. UQ is endogenously synthesized in every organ in a specific pathway branched from cholesterol biosynthesis. Organs have different ubiquinol content depending on the activity of the biosynthetic pathway. In addition to its role as electron carrier in the mitochondrial respiratory chain, UQ exhibits prooxidant and antioxidant properties. The chapter provides the methodological bases that support the relation between UQ content, mitochondrial NO steady-state concentration, and peroxynitrite-mediated mitochondrial damage in representative organs. The chapter also focuses on the contribution of mtNOS to peroxynitrite formation in mitochondria. The chapter presents an experimental model, elaborating endotoxemic animals and sample preparation, and homogenate and mitochondrial preparations. Sources of NO in endotoxemia are also analyzed in the chapter. The chapter discusses the measurement of NOS expression and activity and analyzes the role of ubiquinol in endotoxemia. The endotoxemic mitochondrial damage is also analyzed in the chapter. The chapter elaborates the ubiquinone content and NO-induced hydrogen peroxide production by mitochondria.. |
publishDate |
2004 |
dc.date.none.fl_str_mv |
2004-12 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/118443 Lisdero, Constanza L.; Carreras, Maria Cecilia; Meulemans, Alain; Melani, Mariana; Aubier, Michel; et al.; The Mitochondrial Interplay of Ubiquinol and Nitric Oxide in Endotoxemia; Elsevier Academic Press Inc; Methods In Enzymology.; 382; 12-2004; 67-81 0076-6879 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/118443 |
identifier_str_mv |
Lisdero, Constanza L.; Carreras, Maria Cecilia; Meulemans, Alain; Melani, Mariana; Aubier, Michel; et al.; The Mitochondrial Interplay of Ubiquinol and Nitric Oxide in Endotoxemia; Elsevier Academic Press Inc; Methods In Enzymology.; 382; 12-2004; 67-81 0076-6879 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.1016/S0076-6879(04)82004-4 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier Academic Press Inc |
publisher.none.fl_str_mv |
Elsevier Academic Press Inc |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
_version_ |
1844614169270157312 |
score |
13.070432 |