Clinical and microbiological characteristics of bacterial infections in patients with cirrhosis. A prospective cohort study from Argentina and Uruguay
- Autores
- Vazquez, Carolina; Gutierrez-Acevedo, María Nelly; Barbero, Sabrina; Notari, Lorena del Carmen; Agozino, Marina; Fernandez, José Luis; Anders, María Margarita; Grigera, Nadia Lorena; Antinucci, Florencia; Orozco Ganem, Orlando Nicolas Federico; Murga, María Dolores; Perez, María Daniela; Palazzo, Ana Gracia; Rejtman, Liria Martinez; Duarte, Ivonne Giselle; Vorobioff, Julio Daniel; Trevizan, Victoria; Bulaty, Sofía; Bessone, Fernando; Valverde, Marcelo; Elizondo, Martín; Borzi, Silvia Mabel; Stieben, Teodoro Eduardo; Masola, Adriano Carlos; Tomatis, Jesica; Pages, Josefina; Tevez, Silvina; Gadano, Adrián Carlos; Giunta, Diego Hernan; Marciano, Sebastián
- Año de publicación
- 2023
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Introduction and Objectives: there is insufficient data regarding bacterial infections in patients with cirrhosis to support recommendations for empiric antibiotic treatments, particularly in Latin America. This study aimed to evaluate bacterial infection's clinical impact and microbiological characteristics, intending to serve as a platform to revise current practices. Materials and Methods: multicenter prospective cohort study of patients with cirrhosis and bacterial infections from Argentina and Uruguay. Patient and infection-related information were collected, focusing on microbiology, antibiotic susceptibility patterns, and outcomes. Results: 472 patients were included. Spontaneous bacterial infections and urinary tract infections (UTIs) were registered in 187 (39.6%) and 116 (24.6%) patients, respectively, representing the most common infections. Of the 256 culture-positive infections, 103 (40.2%) were caused by multidrug-resistant organisms (reaching 50% for UTI), and 181 (70.7%) received adequate initial antibiotic treatment. The coverage of cefepime and ceftriaxone was over 70% for the empirical treatment of community-acquired spontaneous infections, but ceftazidime´s coverage was only 40%. For all UTI cases and for healthcare-associated or nosocomial spontaneous bacterial infections, the lower-spectrum antibiotics that covered at least 70% of the isolations were imipenem and meropenem. During hospitalization, a second bacterial infection was diagnosed in 9.8% of patients, 23.9% required at least one organ support, and 19.5% died. Conclusions: short-term mortality of bacterial infections in patients with cirrhosis is very high, and a high percentage were caused by multidrug-resistant organisms, particularly in UTIs. The information provided might serve to adapt recommendations, particularly related to empirical antibiotic treatment in Argentina and Uruguay. The study was registered in Clinical Trials (NCT03919032).
Fil: Vazquez, Carolina. Hospital Italiano; Argentina
Fil: Gutierrez-Acevedo, María Nelly. Hospital 4 de Junio; Argentina
Fil: Barbero, Sabrina. Complejo Medico Policial Bartolome Churruca Andres Visca; Argentina
Fil: Notari, Lorena del Carmen. Complejo Medico Policial Bartolome Churruca Andres Visca; Argentina
Fil: Agozino, Marina. Sanatorio Guemes; Argentina
Fil: Fernandez, José Luis. Sanatorio Guemes; Argentina
Fil: Anders, María Margarita. Hospital Alemán; Argentina
Fil: Grigera, Nadia Lorena. Hospital Aleman; Argentina
Fil: Antinucci, Florencia. Hospital Alemán; Argentina
Fil: Orozco Ganem, Orlando Nicolas Federico. Hospital Alemán; Argentina
Fil: Murga, María Dolores. Hospital A. C. Padilla; Argentina
Fil: Perez, María Daniela. Hospital A. C. Padilla; Argentina
Fil: Palazzo, Ana Gracia. Hospital A. C. Padilla; Argentina
Fil: Rejtman, Liria Martinez. Hospital Teodoro J. Schestakow; Argentina
Fil: Duarte, Ivonne Giselle. Hospital 4 de Junio; Argentina
Fil: Vorobioff, Julio Daniel. Hospital Provincial del Centenario; Argentina
Fil: Trevizan, Victoria. Hospital Provincial del Centenario; Argentina
Fil: Bulaty, Sofía. Hospital Provincial del Centenario; Argentina
Fil: Bessone, Fernando. Hospital Provincial del Centenario; Argentina
Fil: Valverde, Marcelo. Hospital de Clinicas Dr. Manuel Quintela; Uruguay
Fil: Elizondo, Martín. Hospital de Clinicas Dr. Manuel Quintela; Uruguay
Fil: Borzi, Silvia Mabel. Hospital Prof. Rodolfo Rossi; Argentina
Fil: Stieben, Teodoro Eduardo. Provincia de Entre Rios. Hospital San Martin; Argentina
Fil: Masola, Adriano Carlos. Provincia de Entre Rios. Hospital San Martin; Argentina
Fil: Tomatis, Jesica. Hospital Privado de Rosario; Argentina
Fil: Pages, Josefina. Universidad Austral; Argentina
Fil: Tevez, Silvina. Sanatorio Guemes; Argentina
Fil: Gadano, Adrián Carlos. Hospital Italiano; Argentina
Fil: Giunta, Diego Hernan. Hospital Italiano; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Marciano, Sebastián. Hospital Italiano; Argentina - Materia
-
ANTIBIOTICS
ANTIMICROBIAL AGENTS
MULTIDRUG RESISTANCE - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
.jpg)
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/221031
Ver los metadatos del registro completo
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Clinical and microbiological characteristics of bacterial infections in patients with cirrhosis. A prospective cohort study from Argentina and UruguayVazquez, CarolinaGutierrez-Acevedo, María NellyBarbero, SabrinaNotari, Lorena del CarmenAgozino, MarinaFernandez, José LuisAnders, María MargaritaGrigera, Nadia LorenaAntinucci, FlorenciaOrozco Ganem, Orlando Nicolas FedericoMurga, María DoloresPerez, María DanielaPalazzo, Ana GraciaRejtman, Liria MartinezDuarte, Ivonne GiselleVorobioff, Julio DanielTrevizan, VictoriaBulaty, SofíaBessone, FernandoValverde, MarceloElizondo, MartínBorzi, Silvia MabelStieben, Teodoro EduardoMasola, Adriano CarlosTomatis, JesicaPages, JosefinaTevez, SilvinaGadano, Adrián CarlosGiunta, Diego HernanMarciano, SebastiánANTIBIOTICSANTIMICROBIAL AGENTSMULTIDRUG RESISTANCEhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Introduction and Objectives: there is insufficient data regarding bacterial infections in patients with cirrhosis to support recommendations for empiric antibiotic treatments, particularly in Latin America. This study aimed to evaluate bacterial infection's clinical impact and microbiological characteristics, intending to serve as a platform to revise current practices. Materials and Methods: multicenter prospective cohort study of patients with cirrhosis and bacterial infections from Argentina and Uruguay. Patient and infection-related information were collected, focusing on microbiology, antibiotic susceptibility patterns, and outcomes. Results: 472 patients were included. Spontaneous bacterial infections and urinary tract infections (UTIs) were registered in 187 (39.6%) and 116 (24.6%) patients, respectively, representing the most common infections. Of the 256 culture-positive infections, 103 (40.2%) were caused by multidrug-resistant organisms (reaching 50% for UTI), and 181 (70.7%) received adequate initial antibiotic treatment. The coverage of cefepime and ceftriaxone was over 70% for the empirical treatment of community-acquired spontaneous infections, but ceftazidime´s coverage was only 40%. For all UTI cases and for healthcare-associated or nosocomial spontaneous bacterial infections, the lower-spectrum antibiotics that covered at least 70% of the isolations were imipenem and meropenem. During hospitalization, a second bacterial infection was diagnosed in 9.8% of patients, 23.9% required at least one organ support, and 19.5% died. Conclusions: short-term mortality of bacterial infections in patients with cirrhosis is very high, and a high percentage were caused by multidrug-resistant organisms, particularly in UTIs. The information provided might serve to adapt recommendations, particularly related to empirical antibiotic treatment in Argentina and Uruguay. The study was registered in Clinical Trials (NCT03919032).Fil: Vazquez, Carolina. Hospital Italiano; ArgentinaFil: Gutierrez-Acevedo, María Nelly. Hospital 4 de Junio; ArgentinaFil: Barbero, Sabrina. Complejo Medico Policial Bartolome Churruca Andres Visca; ArgentinaFil: Notari, Lorena del Carmen. Complejo Medico Policial Bartolome Churruca Andres Visca; ArgentinaFil: Agozino, Marina. Sanatorio Guemes; ArgentinaFil: Fernandez, José Luis. Sanatorio Guemes; ArgentinaFil: Anders, María Margarita. Hospital Alemán; ArgentinaFil: Grigera, Nadia Lorena. Hospital Aleman; ArgentinaFil: Antinucci, Florencia. Hospital Alemán; ArgentinaFil: Orozco Ganem, Orlando Nicolas Federico. Hospital Alemán; ArgentinaFil: Murga, María Dolores. Hospital A. C. Padilla; ArgentinaFil: Perez, María Daniela. Hospital A. C. Padilla; ArgentinaFil: Palazzo, Ana Gracia. Hospital A. C. Padilla; ArgentinaFil: Rejtman, Liria Martinez. Hospital Teodoro J. Schestakow; ArgentinaFil: Duarte, Ivonne Giselle. Hospital 4 de Junio; ArgentinaFil: Vorobioff, Julio Daniel. Hospital Provincial del Centenario; ArgentinaFil: Trevizan, Victoria. Hospital Provincial del Centenario; ArgentinaFil: Bulaty, Sofía. Hospital Provincial del Centenario; ArgentinaFil: Bessone, Fernando. Hospital Provincial del Centenario; ArgentinaFil: Valverde, Marcelo. Hospital de Clinicas Dr. Manuel Quintela; UruguayFil: Elizondo, Martín. Hospital de Clinicas Dr. Manuel Quintela; UruguayFil: Borzi, Silvia Mabel. Hospital Prof. Rodolfo Rossi; ArgentinaFil: Stieben, Teodoro Eduardo. Provincia de Entre Rios. Hospital San Martin; ArgentinaFil: Masola, Adriano Carlos. Provincia de Entre Rios. Hospital San Martin; ArgentinaFil: Tomatis, Jesica. Hospital Privado de Rosario; ArgentinaFil: Pages, Josefina. Universidad Austral; ArgentinaFil: Tevez, Silvina. Sanatorio Guemes; ArgentinaFil: Gadano, Adrián Carlos. Hospital Italiano; ArgentinaFil: Giunta, Diego Hernan. Hospital Italiano; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Marciano, Sebastián. Hospital Italiano; ArgentinaMexican Association of Hepatology2023-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/221031Vazquez, Carolina; Gutierrez-Acevedo, María Nelly; Barbero, Sabrina; Notari, Lorena del Carmen; Agozino, Marina; et al.; Clinical and microbiological characteristics of bacterial infections in patients with cirrhosis. A prospective cohort study from Argentina and Uruguay; Mexican Association of Hepatology; Annals of Hepatology; 28; 4; 7-2023; 1-81665-2681CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.aohep.2023.101097info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1665268123002016info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:37:32Zoai:ri.conicet.gov.ar:11336/221031instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:37:33.284CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
| dc.title.none.fl_str_mv |
Clinical and microbiological characteristics of bacterial infections in patients with cirrhosis. A prospective cohort study from Argentina and Uruguay |
| title |
Clinical and microbiological characteristics of bacterial infections in patients with cirrhosis. A prospective cohort study from Argentina and Uruguay |
| spellingShingle |
Clinical and microbiological characteristics of bacterial infections in patients with cirrhosis. A prospective cohort study from Argentina and Uruguay Vazquez, Carolina ANTIBIOTICS ANTIMICROBIAL AGENTS MULTIDRUG RESISTANCE |
| title_short |
Clinical and microbiological characteristics of bacterial infections in patients with cirrhosis. A prospective cohort study from Argentina and Uruguay |
| title_full |
Clinical and microbiological characteristics of bacterial infections in patients with cirrhosis. A prospective cohort study from Argentina and Uruguay |
| title_fullStr |
Clinical and microbiological characteristics of bacterial infections in patients with cirrhosis. A prospective cohort study from Argentina and Uruguay |
| title_full_unstemmed |
Clinical and microbiological characteristics of bacterial infections in patients with cirrhosis. A prospective cohort study from Argentina and Uruguay |
| title_sort |
Clinical and microbiological characteristics of bacterial infections in patients with cirrhosis. A prospective cohort study from Argentina and Uruguay |
| dc.creator.none.fl_str_mv |
Vazquez, Carolina Gutierrez-Acevedo, María Nelly Barbero, Sabrina Notari, Lorena del Carmen Agozino, Marina Fernandez, José Luis Anders, María Margarita Grigera, Nadia Lorena Antinucci, Florencia Orozco Ganem, Orlando Nicolas Federico Murga, María Dolores Perez, María Daniela Palazzo, Ana Gracia Rejtman, Liria Martinez Duarte, Ivonne Giselle Vorobioff, Julio Daniel Trevizan, Victoria Bulaty, Sofía Bessone, Fernando Valverde, Marcelo Elizondo, Martín Borzi, Silvia Mabel Stieben, Teodoro Eduardo Masola, Adriano Carlos Tomatis, Jesica Pages, Josefina Tevez, Silvina Gadano, Adrián Carlos Giunta, Diego Hernan Marciano, Sebastián |
| author |
Vazquez, Carolina |
| author_facet |
Vazquez, Carolina Gutierrez-Acevedo, María Nelly Barbero, Sabrina Notari, Lorena del Carmen Agozino, Marina Fernandez, José Luis Anders, María Margarita Grigera, Nadia Lorena Antinucci, Florencia Orozco Ganem, Orlando Nicolas Federico Murga, María Dolores Perez, María Daniela Palazzo, Ana Gracia Rejtman, Liria Martinez Duarte, Ivonne Giselle Vorobioff, Julio Daniel Trevizan, Victoria Bulaty, Sofía Bessone, Fernando Valverde, Marcelo Elizondo, Martín Borzi, Silvia Mabel Stieben, Teodoro Eduardo Masola, Adriano Carlos Tomatis, Jesica Pages, Josefina Tevez, Silvina Gadano, Adrián Carlos Giunta, Diego Hernan Marciano, Sebastián |
| author_role |
author |
| author2 |
Gutierrez-Acevedo, María Nelly Barbero, Sabrina Notari, Lorena del Carmen Agozino, Marina Fernandez, José Luis Anders, María Margarita Grigera, Nadia Lorena Antinucci, Florencia Orozco Ganem, Orlando Nicolas Federico Murga, María Dolores Perez, María Daniela Palazzo, Ana Gracia Rejtman, Liria Martinez Duarte, Ivonne Giselle Vorobioff, Julio Daniel Trevizan, Victoria Bulaty, Sofía Bessone, Fernando Valverde, Marcelo Elizondo, Martín Borzi, Silvia Mabel Stieben, Teodoro Eduardo Masola, Adriano Carlos Tomatis, Jesica Pages, Josefina Tevez, Silvina Gadano, Adrián Carlos Giunta, Diego Hernan Marciano, Sebastián |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
ANTIBIOTICS ANTIMICROBIAL AGENTS MULTIDRUG RESISTANCE |
| topic |
ANTIBIOTICS ANTIMICROBIAL AGENTS MULTIDRUG RESISTANCE |
| purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.2 https://purl.org/becyt/ford/3 |
| dc.description.none.fl_txt_mv |
Introduction and Objectives: there is insufficient data regarding bacterial infections in patients with cirrhosis to support recommendations for empiric antibiotic treatments, particularly in Latin America. This study aimed to evaluate bacterial infection's clinical impact and microbiological characteristics, intending to serve as a platform to revise current practices. Materials and Methods: multicenter prospective cohort study of patients with cirrhosis and bacterial infections from Argentina and Uruguay. Patient and infection-related information were collected, focusing on microbiology, antibiotic susceptibility patterns, and outcomes. Results: 472 patients were included. Spontaneous bacterial infections and urinary tract infections (UTIs) were registered in 187 (39.6%) and 116 (24.6%) patients, respectively, representing the most common infections. Of the 256 culture-positive infections, 103 (40.2%) were caused by multidrug-resistant organisms (reaching 50% for UTI), and 181 (70.7%) received adequate initial antibiotic treatment. The coverage of cefepime and ceftriaxone was over 70% for the empirical treatment of community-acquired spontaneous infections, but ceftazidime´s coverage was only 40%. For all UTI cases and for healthcare-associated or nosocomial spontaneous bacterial infections, the lower-spectrum antibiotics that covered at least 70% of the isolations were imipenem and meropenem. During hospitalization, a second bacterial infection was diagnosed in 9.8% of patients, 23.9% required at least one organ support, and 19.5% died. Conclusions: short-term mortality of bacterial infections in patients with cirrhosis is very high, and a high percentage were caused by multidrug-resistant organisms, particularly in UTIs. The information provided might serve to adapt recommendations, particularly related to empirical antibiotic treatment in Argentina and Uruguay. The study was registered in Clinical Trials (NCT03919032). Fil: Vazquez, Carolina. Hospital Italiano; Argentina Fil: Gutierrez-Acevedo, María Nelly. Hospital 4 de Junio; Argentina Fil: Barbero, Sabrina. Complejo Medico Policial Bartolome Churruca Andres Visca; Argentina Fil: Notari, Lorena del Carmen. Complejo Medico Policial Bartolome Churruca Andres Visca; Argentina Fil: Agozino, Marina. Sanatorio Guemes; Argentina Fil: Fernandez, José Luis. Sanatorio Guemes; Argentina Fil: Anders, María Margarita. Hospital Alemán; Argentina Fil: Grigera, Nadia Lorena. Hospital Aleman; Argentina Fil: Antinucci, Florencia. Hospital Alemán; Argentina Fil: Orozco Ganem, Orlando Nicolas Federico. Hospital Alemán; Argentina Fil: Murga, María Dolores. Hospital A. C. Padilla; Argentina Fil: Perez, María Daniela. Hospital A. C. Padilla; Argentina Fil: Palazzo, Ana Gracia. Hospital A. C. Padilla; Argentina Fil: Rejtman, Liria Martinez. Hospital Teodoro J. Schestakow; Argentina Fil: Duarte, Ivonne Giselle. Hospital 4 de Junio; Argentina Fil: Vorobioff, Julio Daniel. Hospital Provincial del Centenario; Argentina Fil: Trevizan, Victoria. Hospital Provincial del Centenario; Argentina Fil: Bulaty, Sofía. Hospital Provincial del Centenario; Argentina Fil: Bessone, Fernando. Hospital Provincial del Centenario; Argentina Fil: Valverde, Marcelo. Hospital de Clinicas Dr. Manuel Quintela; Uruguay Fil: Elizondo, Martín. Hospital de Clinicas Dr. Manuel Quintela; Uruguay Fil: Borzi, Silvia Mabel. Hospital Prof. Rodolfo Rossi; Argentina Fil: Stieben, Teodoro Eduardo. Provincia de Entre Rios. Hospital San Martin; Argentina Fil: Masola, Adriano Carlos. Provincia de Entre Rios. Hospital San Martin; Argentina Fil: Tomatis, Jesica. Hospital Privado de Rosario; Argentina Fil: Pages, Josefina. Universidad Austral; Argentina Fil: Tevez, Silvina. Sanatorio Guemes; Argentina Fil: Gadano, Adrián Carlos. Hospital Italiano; Argentina Fil: Giunta, Diego Hernan. Hospital Italiano; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Marciano, Sebastián. Hospital Italiano; Argentina |
| description |
Introduction and Objectives: there is insufficient data regarding bacterial infections in patients with cirrhosis to support recommendations for empiric antibiotic treatments, particularly in Latin America. This study aimed to evaluate bacterial infection's clinical impact and microbiological characteristics, intending to serve as a platform to revise current practices. Materials and Methods: multicenter prospective cohort study of patients with cirrhosis and bacterial infections from Argentina and Uruguay. Patient and infection-related information were collected, focusing on microbiology, antibiotic susceptibility patterns, and outcomes. Results: 472 patients were included. Spontaneous bacterial infections and urinary tract infections (UTIs) were registered in 187 (39.6%) and 116 (24.6%) patients, respectively, representing the most common infections. Of the 256 culture-positive infections, 103 (40.2%) were caused by multidrug-resistant organisms (reaching 50% for UTI), and 181 (70.7%) received adequate initial antibiotic treatment. The coverage of cefepime and ceftriaxone was over 70% for the empirical treatment of community-acquired spontaneous infections, but ceftazidime´s coverage was only 40%. For all UTI cases and for healthcare-associated or nosocomial spontaneous bacterial infections, the lower-spectrum antibiotics that covered at least 70% of the isolations were imipenem and meropenem. During hospitalization, a second bacterial infection was diagnosed in 9.8% of patients, 23.9% required at least one organ support, and 19.5% died. Conclusions: short-term mortality of bacterial infections in patients with cirrhosis is very high, and a high percentage were caused by multidrug-resistant organisms, particularly in UTIs. The information provided might serve to adapt recommendations, particularly related to empirical antibiotic treatment in Argentina and Uruguay. The study was registered in Clinical Trials (NCT03919032). |
| publishDate |
2023 |
| dc.date.none.fl_str_mv |
2023-07 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/221031 Vazquez, Carolina; Gutierrez-Acevedo, María Nelly; Barbero, Sabrina; Notari, Lorena del Carmen; Agozino, Marina; et al.; Clinical and microbiological characteristics of bacterial infections in patients with cirrhosis. A prospective cohort study from Argentina and Uruguay; Mexican Association of Hepatology; Annals of Hepatology; 28; 4; 7-2023; 1-8 1665-2681 CONICET Digital CONICET |
| url |
http://hdl.handle.net/11336/221031 |
| identifier_str_mv |
Vazquez, Carolina; Gutierrez-Acevedo, María Nelly; Barbero, Sabrina; Notari, Lorena del Carmen; Agozino, Marina; et al.; Clinical and microbiological characteristics of bacterial infections in patients with cirrhosis. A prospective cohort study from Argentina and Uruguay; Mexican Association of Hepatology; Annals of Hepatology; 28; 4; 7-2023; 1-8 1665-2681 CONICET Digital CONICET |
| dc.language.none.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.aohep.2023.101097 info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1665268123002016 |
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info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
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openAccess |
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https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
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application/pdf application/pdf |
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Mexican Association of Hepatology |
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Mexican Association of Hepatology |
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reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
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Consejo Nacional de Investigaciones Científicas y Técnicas |
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dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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