Amitriptyline treatment under chronic stress conditions: Effect on circulating catecholamines and anxiety in early maternally separated rats

Autores
Cotella, Evelin Mariel; Mestres Lascano, Ivan; Levin, Gloria Mabel; Suarez, Marta Magdalena
Año de publicación
2009
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The aim of this work was to determine the effect of amitriptyline (AMI) on peripheral outcomes such as plasma epinephrine (E) and norepinephrine (NE) concentration and anxiety-like behavior displayed in the plus maze test in adult male Wistar rats under variable chronic stress and daily oral administration of AMI (5 mg/kg). Animals were previously isolated from the mother for 4.5 hr every day for the first 3 weeks of life. Administration of the antidepressant AMI reduced anxiety-like behavior in animals submitted only to chronic stress but not in early maternally separated (MS) subjects or in animals subjected to the two types of stresses.
Fil: Cotella, Evelin Mariel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
Fil: Mestres Lascano, Ivan. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
Fil: Levin, Gloria Mabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Gobierno de la Ciudad de Buenos Aires. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Fundación de Endocrinología Infantil. Centro de Investigaciones Endocrinológicas "Dr. César Bergada"; Argentina
Fil: Suarez, Marta Magdalena. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
AMITRIPTYLINE
ANXIETY
CATECHOLAMINES
EARLY MATERNAL SEPARATION
PLUS MAZE TEST
VARIABLE CHRONIC STRESS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/96871
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/96871
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repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Amitriptyline treatment under chronic stress conditions: Effect on circulating catecholamines and anxiety in early maternally separated ratsCotella, Evelin MarielMestres Lascano, IvanLevin, Gloria MabelSuarez, Marta MagdalenaAMITRIPTYLINEANXIETYCATECHOLAMINESEARLY MATERNAL SEPARATIONPLUS MAZE TESTVARIABLE CHRONIC STRESShttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1The aim of this work was to determine the effect of amitriptyline (AMI) on peripheral outcomes such as plasma epinephrine (E) and norepinephrine (NE) concentration and anxiety-like behavior displayed in the plus maze test in adult male Wistar rats under variable chronic stress and daily oral administration of AMI (5 mg/kg). Animals were previously isolated from the mother for 4.5 hr every day for the first 3 weeks of life. Administration of the antidepressant AMI reduced anxiety-like behavior in animals submitted only to chronic stress but not in early maternally separated (MS) subjects or in animals subjected to the two types of stresses.Fil: Cotella, Evelin Mariel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; ArgentinaFil: Mestres Lascano, Ivan. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; ArgentinaFil: Levin, Gloria Mabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Gobierno de la Ciudad de Buenos Aires. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Fundación de Endocrinología Infantil. Centro de Investigaciones Endocrinológicas "Dr. César Bergada"; ArgentinaFil: Suarez, Marta Magdalena. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaTaylor & Francis2009-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/96871Cotella, Evelin Mariel; Mestres Lascano, Ivan; Levin, Gloria Mabel; Suarez, Marta Magdalena; Amitriptyline treatment under chronic stress conditions: Effect on circulating catecholamines and anxiety in early maternally separated rats; Taylor & Francis; The International Journal Of Neuroscience.; 119; 5; 12-2009; 664-6800020-74541543-5245CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1080/00207450802330611info:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/full/10.1080/00207450802330611info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:59:14Zoai:ri.conicet.gov.ar:11336/96871instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:59:14.418CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Amitriptyline treatment under chronic stress conditions: Effect on circulating catecholamines and anxiety in early maternally separated rats
title Amitriptyline treatment under chronic stress conditions: Effect on circulating catecholamines and anxiety in early maternally separated rats
spellingShingle Amitriptyline treatment under chronic stress conditions: Effect on circulating catecholamines and anxiety in early maternally separated rats
Cotella, Evelin Mariel
AMITRIPTYLINE
ANXIETY
CATECHOLAMINES
EARLY MATERNAL SEPARATION
PLUS MAZE TEST
VARIABLE CHRONIC STRESS
title_short Amitriptyline treatment under chronic stress conditions: Effect on circulating catecholamines and anxiety in early maternally separated rats
title_full Amitriptyline treatment under chronic stress conditions: Effect on circulating catecholamines and anxiety in early maternally separated rats
title_fullStr Amitriptyline treatment under chronic stress conditions: Effect on circulating catecholamines and anxiety in early maternally separated rats
title_full_unstemmed Amitriptyline treatment under chronic stress conditions: Effect on circulating catecholamines and anxiety in early maternally separated rats
title_sort Amitriptyline treatment under chronic stress conditions: Effect on circulating catecholamines and anxiety in early maternally separated rats
dc.creator.none.fl_str_mv Cotella, Evelin Mariel
Mestres Lascano, Ivan
Levin, Gloria Mabel
Suarez, Marta Magdalena
author Cotella, Evelin Mariel
author_facet Cotella, Evelin Mariel
Mestres Lascano, Ivan
Levin, Gloria Mabel
Suarez, Marta Magdalena
author_role author
author2 Mestres Lascano, Ivan
Levin, Gloria Mabel
Suarez, Marta Magdalena
author2_role author
author
author
dc.subject.none.fl_str_mv AMITRIPTYLINE
ANXIETY
CATECHOLAMINES
EARLY MATERNAL SEPARATION
PLUS MAZE TEST
VARIABLE CHRONIC STRESS
topic AMITRIPTYLINE
ANXIETY
CATECHOLAMINES
EARLY MATERNAL SEPARATION
PLUS MAZE TEST
VARIABLE CHRONIC STRESS
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The aim of this work was to determine the effect of amitriptyline (AMI) on peripheral outcomes such as plasma epinephrine (E) and norepinephrine (NE) concentration and anxiety-like behavior displayed in the plus maze test in adult male Wistar rats under variable chronic stress and daily oral administration of AMI (5 mg/kg). Animals were previously isolated from the mother for 4.5 hr every day for the first 3 weeks of life. Administration of the antidepressant AMI reduced anxiety-like behavior in animals submitted only to chronic stress but not in early maternally separated (MS) subjects or in animals subjected to the two types of stresses.
Fil: Cotella, Evelin Mariel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
Fil: Mestres Lascano, Ivan. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
Fil: Levin, Gloria Mabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Gobierno de la Ciudad de Buenos Aires. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Fundación de Endocrinología Infantil. Centro de Investigaciones Endocrinológicas "Dr. César Bergada"; Argentina
Fil: Suarez, Marta Magdalena. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description The aim of this work was to determine the effect of amitriptyline (AMI) on peripheral outcomes such as plasma epinephrine (E) and norepinephrine (NE) concentration and anxiety-like behavior displayed in the plus maze test in adult male Wistar rats under variable chronic stress and daily oral administration of AMI (5 mg/kg). Animals were previously isolated from the mother for 4.5 hr every day for the first 3 weeks of life. Administration of the antidepressant AMI reduced anxiety-like behavior in animals submitted only to chronic stress but not in early maternally separated (MS) subjects or in animals subjected to the two types of stresses.
publishDate 2009
dc.date.none.fl_str_mv 2009-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/96871
Cotella, Evelin Mariel; Mestres Lascano, Ivan; Levin, Gloria Mabel; Suarez, Marta Magdalena; Amitriptyline treatment under chronic stress conditions: Effect on circulating catecholamines and anxiety in early maternally separated rats; Taylor & Francis; The International Journal Of Neuroscience.; 119; 5; 12-2009; 664-680
0020-7454
1543-5245
CONICET Digital
CONICET
url http://hdl.handle.net/11336/96871
identifier_str_mv Cotella, Evelin Mariel; Mestres Lascano, Ivan; Levin, Gloria Mabel; Suarez, Marta Magdalena; Amitriptyline treatment under chronic stress conditions: Effect on circulating catecholamines and anxiety in early maternally separated rats; Taylor & Francis; The International Journal Of Neuroscience.; 119; 5; 12-2009; 664-680
0020-7454
1543-5245
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1080/00207450802330611
info:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/full/10.1080/00207450802330611
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Taylor & Francis
publisher.none.fl_str_mv Taylor & Francis
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269569366884352
score 13.13397

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