Long-term effects of maternal separation on chronic stress response suppressed by amitriptyline treatment

Autores
Cotella, Evelin Mariel; Mestres Lascano, Ivan; Franchioni, L.; Levin, Gloria Mabel; Suarez, M. M.
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The early-life environment has many long-term effects on mammals. Maternal interaction and early stressful events may affect regulation of the HPA axis during adulthood, leading to differential glucocorticoid secretion in response to stressful situations. These adverse experiences during postnatal development may even sensitize specific neurocircuits to subsequent stressors. Later in life, the overreaction of the HPA axis to stress can constitute a risk factor for metabolic and mental diseases. As tricyclic antidepressants are known to correct glucocorticoid hypersecretion during depression, we treated maternally separated animals with amitriptyline, at a lower dose than habitually used in depression models, to prevent the response to chronic stress during adulthood. Male Wistar rats were separated from the mother for 4.5 h every day for the first 3 weeks of life. From postnatal day 50, animals were subjected to chronic variable stress during 24 d (five types of stressors at different times of day). During the stress, protocol rats were orally administered amitriptyline (5 mg/kg) daily. We observed that maternal separation caused a reduction in plasma ACTH levels (p < 0.05), but evoked hypersecretion of corticosterone (p < 0.05) when it was combined with stress in adulthood. This rise was completely prevented by antidepressant treatment with amitriptyline.
Fil: Cotella, Evelin Mariel. Universidad Nacional de Cordoba. Facultad de Cs.exactas Fisicas y Naturales. Departamento de Fisiologia Animal; Argentina
Fil: Mestres Lascano, Ivan. Universidad Nacional de Cordoba. Facultad de Cs.exactas Fisicas y Naturales. Departamento de Fisiologia Animal; Argentina
Fil: Franchioni, L.. Hospital de Niños de La Santísima Trinidad; Argentina
Fil: Levin, Gloria Mabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas; Argentina
Fil: Suarez, M. M.. Universidad Nacional de Cordoba. Facultad de Cs.exactas Fisicas y Naturales. Departamento de Fisiologia Animal; Argentina
Materia
Stress
Maternal Separation
Antidepressants
Acth
Corticosterone
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/8124
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Long-term effects of maternal separation on chronic stress response suppressed by amitriptyline treatmentCotella, Evelin MarielMestres Lascano, IvanFranchioni, L.Levin, Gloria MabelSuarez, M. M.StressMaternal SeparationAntidepressantsActhCorticosteronehttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3The early-life environment has many long-term effects on mammals. Maternal interaction and early stressful events may affect regulation of the HPA axis during adulthood, leading to differential glucocorticoid secretion in response to stressful situations. These adverse experiences during postnatal development may even sensitize specific neurocircuits to subsequent stressors. Later in life, the overreaction of the HPA axis to stress can constitute a risk factor for metabolic and mental diseases. As tricyclic antidepressants are known to correct glucocorticoid hypersecretion during depression, we treated maternally separated animals with amitriptyline, at a lower dose than habitually used in depression models, to prevent the response to chronic stress during adulthood. Male Wistar rats were separated from the mother for 4.5 h every day for the first 3 weeks of life. From postnatal day 50, animals were subjected to chronic variable stress during 24 d (five types of stressors at different times of day). During the stress, protocol rats were orally administered amitriptyline (5 mg/kg) daily. We observed that maternal separation caused a reduction in plasma ACTH levels (p < 0.05), but evoked hypersecretion of corticosterone (p < 0.05) when it was combined with stress in adulthood. This rise was completely prevented by antidepressant treatment with amitriptyline.Fil: Cotella, Evelin Mariel. Universidad Nacional de Cordoba. Facultad de Cs.exactas Fisicas y Naturales. Departamento de Fisiologia Animal; ArgentinaFil: Mestres Lascano, Ivan. Universidad Nacional de Cordoba. Facultad de Cs.exactas Fisicas y Naturales. Departamento de Fisiologia Animal; ArgentinaFil: Franchioni, L.. Hospital de Niños de La Santísima Trinidad; ArgentinaFil: Levin, Gloria Mabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas; ArgentinaFil: Suarez, M. M.. Universidad Nacional de Cordoba. Facultad de Cs.exactas Fisicas y Naturales. Departamento de Fisiologia Animal; ArgentinaTaylor & Francis2013-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/8124Cotella, Evelin Mariel; Mestres Lascano, Ivan; Franchioni, L.; Levin, Gloria Mabel; Suarez, M. M.; Long-term effects of maternal separation on chronic stress response suppressed by amitriptyline treatment; Taylor & Francis; Stress; 16; 4; 7-2013; 477-4811025-3890enginfo:eu-repo/semantics/altIdentifier/url/http://www.tandfonline.com/doi/full/10.3109/10253890.2013.775241info:eu-repo/semantics/altIdentifier/doi/10.3109/10253890.2013.775241info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:03:28Zoai:ri.conicet.gov.ar:11336/8124instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:03:28.401CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Long-term effects of maternal separation on chronic stress response suppressed by amitriptyline treatment
title Long-term effects of maternal separation on chronic stress response suppressed by amitriptyline treatment
spellingShingle Long-term effects of maternal separation on chronic stress response suppressed by amitriptyline treatment
Cotella, Evelin Mariel
Stress
Maternal Separation
Antidepressants
Acth
Corticosterone
title_short Long-term effects of maternal separation on chronic stress response suppressed by amitriptyline treatment
title_full Long-term effects of maternal separation on chronic stress response suppressed by amitriptyline treatment
title_fullStr Long-term effects of maternal separation on chronic stress response suppressed by amitriptyline treatment
title_full_unstemmed Long-term effects of maternal separation on chronic stress response suppressed by amitriptyline treatment
title_sort Long-term effects of maternal separation on chronic stress response suppressed by amitriptyline treatment
dc.creator.none.fl_str_mv Cotella, Evelin Mariel
Mestres Lascano, Ivan
Franchioni, L.
Levin, Gloria Mabel
Suarez, M. M.
author Cotella, Evelin Mariel
author_facet Cotella, Evelin Mariel
Mestres Lascano, Ivan
Franchioni, L.
Levin, Gloria Mabel
Suarez, M. M.
author_role author
author2 Mestres Lascano, Ivan
Franchioni, L.
Levin, Gloria Mabel
Suarez, M. M.
author2_role author
author
author
author
dc.subject.none.fl_str_mv Stress
Maternal Separation
Antidepressants
Acth
Corticosterone
topic Stress
Maternal Separation
Antidepressants
Acth
Corticosterone
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The early-life environment has many long-term effects on mammals. Maternal interaction and early stressful events may affect regulation of the HPA axis during adulthood, leading to differential glucocorticoid secretion in response to stressful situations. These adverse experiences during postnatal development may even sensitize specific neurocircuits to subsequent stressors. Later in life, the overreaction of the HPA axis to stress can constitute a risk factor for metabolic and mental diseases. As tricyclic antidepressants are known to correct glucocorticoid hypersecretion during depression, we treated maternally separated animals with amitriptyline, at a lower dose than habitually used in depression models, to prevent the response to chronic stress during adulthood. Male Wistar rats were separated from the mother for 4.5 h every day for the first 3 weeks of life. From postnatal day 50, animals were subjected to chronic variable stress during 24 d (five types of stressors at different times of day). During the stress, protocol rats were orally administered amitriptyline (5 mg/kg) daily. We observed that maternal separation caused a reduction in plasma ACTH levels (p < 0.05), but evoked hypersecretion of corticosterone (p < 0.05) when it was combined with stress in adulthood. This rise was completely prevented by antidepressant treatment with amitriptyline.
Fil: Cotella, Evelin Mariel. Universidad Nacional de Cordoba. Facultad de Cs.exactas Fisicas y Naturales. Departamento de Fisiologia Animal; Argentina
Fil: Mestres Lascano, Ivan. Universidad Nacional de Cordoba. Facultad de Cs.exactas Fisicas y Naturales. Departamento de Fisiologia Animal; Argentina
Fil: Franchioni, L.. Hospital de Niños de La Santísima Trinidad; Argentina
Fil: Levin, Gloria Mabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas; Argentina
Fil: Suarez, M. M.. Universidad Nacional de Cordoba. Facultad de Cs.exactas Fisicas y Naturales. Departamento de Fisiologia Animal; Argentina
description The early-life environment has many long-term effects on mammals. Maternal interaction and early stressful events may affect regulation of the HPA axis during adulthood, leading to differential glucocorticoid secretion in response to stressful situations. These adverse experiences during postnatal development may even sensitize specific neurocircuits to subsequent stressors. Later in life, the overreaction of the HPA axis to stress can constitute a risk factor for metabolic and mental diseases. As tricyclic antidepressants are known to correct glucocorticoid hypersecretion during depression, we treated maternally separated animals with amitriptyline, at a lower dose than habitually used in depression models, to prevent the response to chronic stress during adulthood. Male Wistar rats were separated from the mother for 4.5 h every day for the first 3 weeks of life. From postnatal day 50, animals were subjected to chronic variable stress during 24 d (five types of stressors at different times of day). During the stress, protocol rats were orally administered amitriptyline (5 mg/kg) daily. We observed that maternal separation caused a reduction in plasma ACTH levels (p < 0.05), but evoked hypersecretion of corticosterone (p < 0.05) when it was combined with stress in adulthood. This rise was completely prevented by antidepressant treatment with amitriptyline.
publishDate 2013
dc.date.none.fl_str_mv 2013-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/8124
Cotella, Evelin Mariel; Mestres Lascano, Ivan; Franchioni, L.; Levin, Gloria Mabel; Suarez, M. M.; Long-term effects of maternal separation on chronic stress response suppressed by amitriptyline treatment; Taylor & Francis; Stress; 16; 4; 7-2013; 477-481
1025-3890
url http://hdl.handle.net/11336/8124
identifier_str_mv Cotella, Evelin Mariel; Mestres Lascano, Ivan; Franchioni, L.; Levin, Gloria Mabel; Suarez, M. M.; Long-term effects of maternal separation on chronic stress response suppressed by amitriptyline treatment; Taylor & Francis; Stress; 16; 4; 7-2013; 477-481
1025-3890
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.tandfonline.com/doi/full/10.3109/10253890.2013.775241
info:eu-repo/semantics/altIdentifier/doi/10.3109/10253890.2013.775241
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Taylor & Francis
publisher.none.fl_str_mv Taylor & Francis
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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