Electrosprayed poly(vinyl alcohol) particles: preparation and evaluation of their drug release profile

Autores
Felice, Betiana; Prabhakaran, Molamma P.; Zamani, Maedeh; Rodriguez, Andrea Paola; Ramakrishna, Seeram
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Encapsulation of bioactive molecules within polymeric particles is a challenge, due to several limitations including low drug-loading efficiency, unwanted release profile, polydispersity and batch to batch variation in reproducibility, along with the limitations to scale up the process. It is essential to control the morphology of pure polymer particles in the first instance, in order to obtain the desired release profile of the drugs from the particles during the later stage. Here, we present the preparation of electrosprayed particles from water soluble FDA-approved polymer, namely polyvinyl alcohol (PVA) as an approach towards short-term drug delivery vehicle. Through electrospraying and varying the solvent ratios, three different sizes of particles were prepared, with sizes ranging from 500 to 2000 nm. Insulin was chosen as a model bioactive molecule, and the release profile of the drug was studied after incorporation in PVA particles. Fractional release plots obtained showed short-term release of insulin, within the first 60 minutes. Release curves were analyzed according to Ritger-Peppas model, suggesting Fickian diffusion as the predominant insulin release mechanism from PVA particles. This work suggests electrosprayed PVA particles as an innovative drug delivery system for short-term administration of drugs.
Fil: Felice, Betiana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina. Universidad Nacional de Tucuman. Facultad de Ciencias Exactas y Tecnología. Departamento de Bioingeniería. Laboratorio de Medios e Interfases; Argentina
Fil: Prabhakaran, Molamma P.. National University of Singapore; Singapur
Fil: Zamani, Maedeh. National University of Singapore; Singapur
Fil: Rodriguez, Andrea Paola. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina. Universidad Nacional de Tucuman. Facultad de Ciencias Exactas y Tecnología. Departamento de Bioingeniería. Laboratorio de Medios e Interfases; Argentina
Fil: Ramakrishna, Seeram. National University of Singapore; Singapur
Materia
Electrospraying
Electrospinning
Drug Delivery
Particles
Pva
Insulin
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/48182
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/48182
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Electrosprayed poly(vinyl alcohol) particles: preparation and evaluation of their drug release profileFelice, BetianaPrabhakaran, Molamma P.Zamani, MaedehRodriguez, Andrea PaolaRamakrishna, SeeramElectrosprayingElectrospinningDrug DeliveryParticlesPvaInsulinhttps://purl.org/becyt/ford/2.5https://purl.org/becyt/ford/2Encapsulation of bioactive molecules within polymeric particles is a challenge, due to several limitations including low drug-loading efficiency, unwanted release profile, polydispersity and batch to batch variation in reproducibility, along with the limitations to scale up the process. It is essential to control the morphology of pure polymer particles in the first instance, in order to obtain the desired release profile of the drugs from the particles during the later stage. Here, we present the preparation of electrosprayed particles from water soluble FDA-approved polymer, namely polyvinyl alcohol (PVA) as an approach towards short-term drug delivery vehicle. Through electrospraying and varying the solvent ratios, three different sizes of particles were prepared, with sizes ranging from 500 to 2000 nm. Insulin was chosen as a model bioactive molecule, and the release profile of the drug was studied after incorporation in PVA particles. Fractional release plots obtained showed short-term release of insulin, within the first 60 minutes. Release curves were analyzed according to Ritger-Peppas model, suggesting Fickian diffusion as the predominant insulin release mechanism from PVA particles. This work suggests electrosprayed PVA particles as an innovative drug delivery system for short-term administration of drugs.Fil: Felice, Betiana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina. Universidad Nacional de Tucuman. Facultad de Ciencias Exactas y Tecnología. Departamento de Bioingeniería. Laboratorio de Medios e Interfases; ArgentinaFil: Prabhakaran, Molamma P.. National University of Singapore; SingapurFil: Zamani, Maedeh. National University of Singapore; SingapurFil: Rodriguez, Andrea Paola. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina. Universidad Nacional de Tucuman. Facultad de Ciencias Exactas y Tecnología. Departamento de Bioingeniería. Laboratorio de Medios e Interfases; ArgentinaFil: Ramakrishna, Seeram. National University of Singapore; SingapurJohn Wiley & Sons Ltd2015-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/48182Felice, Betiana; Prabhakaran, Molamma P.; Zamani, Maedeh; Rodriguez, Andrea Paola; Ramakrishna, Seeram; Electrosprayed poly(vinyl alcohol) particles: preparation and evaluation of their drug release profile; John Wiley & Sons Ltd; Polymer International; 64; 12; 12-2015; 1722-17320959-8103CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1002/pi.4972info:eu-repo/semantics/altIdentifier/doi/10.1002/pi.4972info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:03:08Zoai:ri.conicet.gov.ar:11336/48182instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:03:08.786CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Electrosprayed poly(vinyl alcohol) particles: preparation and evaluation of their drug release profile
title Electrosprayed poly(vinyl alcohol) particles: preparation and evaluation of their drug release profile
spellingShingle Electrosprayed poly(vinyl alcohol) particles: preparation and evaluation of their drug release profile
Felice, Betiana
Electrospraying
Electrospinning
Drug Delivery
Particles
Pva
Insulin
title_short Electrosprayed poly(vinyl alcohol) particles: preparation and evaluation of their drug release profile
title_full Electrosprayed poly(vinyl alcohol) particles: preparation and evaluation of their drug release profile
title_fullStr Electrosprayed poly(vinyl alcohol) particles: preparation and evaluation of their drug release profile
title_full_unstemmed Electrosprayed poly(vinyl alcohol) particles: preparation and evaluation of their drug release profile
title_sort Electrosprayed poly(vinyl alcohol) particles: preparation and evaluation of their drug release profile
dc.creator.none.fl_str_mv Felice, Betiana
Prabhakaran, Molamma P.
Zamani, Maedeh
Rodriguez, Andrea Paola
Ramakrishna, Seeram
author Felice, Betiana
author_facet Felice, Betiana
Prabhakaran, Molamma P.
Zamani, Maedeh
Rodriguez, Andrea Paola
Ramakrishna, Seeram
author_role author
author2 Prabhakaran, Molamma P.
Zamani, Maedeh
Rodriguez, Andrea Paola
Ramakrishna, Seeram
author2_role author
author
author
author
dc.subject.none.fl_str_mv Electrospraying
Electrospinning
Drug Delivery
Particles
Pva
Insulin
topic Electrospraying
Electrospinning
Drug Delivery
Particles
Pva
Insulin
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.5
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv Encapsulation of bioactive molecules within polymeric particles is a challenge, due to several limitations including low drug-loading efficiency, unwanted release profile, polydispersity and batch to batch variation in reproducibility, along with the limitations to scale up the process. It is essential to control the morphology of pure polymer particles in the first instance, in order to obtain the desired release profile of the drugs from the particles during the later stage. Here, we present the preparation of electrosprayed particles from water soluble FDA-approved polymer, namely polyvinyl alcohol (PVA) as an approach towards short-term drug delivery vehicle. Through electrospraying and varying the solvent ratios, three different sizes of particles were prepared, with sizes ranging from 500 to 2000 nm. Insulin was chosen as a model bioactive molecule, and the release profile of the drug was studied after incorporation in PVA particles. Fractional release plots obtained showed short-term release of insulin, within the first 60 minutes. Release curves were analyzed according to Ritger-Peppas model, suggesting Fickian diffusion as the predominant insulin release mechanism from PVA particles. This work suggests electrosprayed PVA particles as an innovative drug delivery system for short-term administration of drugs.
Fil: Felice, Betiana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina. Universidad Nacional de Tucuman. Facultad de Ciencias Exactas y Tecnología. Departamento de Bioingeniería. Laboratorio de Medios e Interfases; Argentina
Fil: Prabhakaran, Molamma P.. National University of Singapore; Singapur
Fil: Zamani, Maedeh. National University of Singapore; Singapur
Fil: Rodriguez, Andrea Paola. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina. Universidad Nacional de Tucuman. Facultad de Ciencias Exactas y Tecnología. Departamento de Bioingeniería. Laboratorio de Medios e Interfases; Argentina
Fil: Ramakrishna, Seeram. National University of Singapore; Singapur
description Encapsulation of bioactive molecules within polymeric particles is a challenge, due to several limitations including low drug-loading efficiency, unwanted release profile, polydispersity and batch to batch variation in reproducibility, along with the limitations to scale up the process. It is essential to control the morphology of pure polymer particles in the first instance, in order to obtain the desired release profile of the drugs from the particles during the later stage. Here, we present the preparation of electrosprayed particles from water soluble FDA-approved polymer, namely polyvinyl alcohol (PVA) as an approach towards short-term drug delivery vehicle. Through electrospraying and varying the solvent ratios, three different sizes of particles were prepared, with sizes ranging from 500 to 2000 nm. Insulin was chosen as a model bioactive molecule, and the release profile of the drug was studied after incorporation in PVA particles. Fractional release plots obtained showed short-term release of insulin, within the first 60 minutes. Release curves were analyzed according to Ritger-Peppas model, suggesting Fickian diffusion as the predominant insulin release mechanism from PVA particles. This work suggests electrosprayed PVA particles as an innovative drug delivery system for short-term administration of drugs.
publishDate 2015
dc.date.none.fl_str_mv 2015-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/48182
Felice, Betiana; Prabhakaran, Molamma P.; Zamani, Maedeh; Rodriguez, Andrea Paola; Ramakrishna, Seeram; Electrosprayed poly(vinyl alcohol) particles: preparation and evaluation of their drug release profile; John Wiley & Sons Ltd; Polymer International; 64; 12; 12-2015; 1722-1732
0959-8103
CONICET Digital
CONICET
url http://hdl.handle.net/11336/48182
identifier_str_mv Felice, Betiana; Prabhakaran, Molamma P.; Zamani, Maedeh; Rodriguez, Andrea Paola; Ramakrishna, Seeram; Electrosprayed poly(vinyl alcohol) particles: preparation and evaluation of their drug release profile; John Wiley & Sons Ltd; Polymer International; 64; 12; 12-2015; 1722-1732
0959-8103
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1002/pi.4972
info:eu-repo/semantics/altIdentifier/doi/10.1002/pi.4972
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv John Wiley & Sons Ltd
publisher.none.fl_str_mv John Wiley & Sons Ltd
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269784620662784
score 13.13397

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