Polyvinyl alcohol–pectin cryogel films for controlled release of enrofloxacin

Autores
Martínez, Yanina; Piñuel, Lucrecia; Castro, Guillermo Raúl; Breccia, Javier D.
Año de publicación
2012
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The release of enrofloxacin entrapped in polyvinyl alcohol (PVA) cryogel at pH 5.5 showed a first-order kinetic, releasing 69.7% of the antibiotic after 4.5 h at 37 °C. In order to slow down the fluoroquinolone release rate, high-methoxylated pectin was added into the cryogel (PVA–P). A film containing 1.0% (w/v) HM pectin and 5.0 μg/ml enrofloxacin released only 3.7% of the antibiotic after 4.5 h. Since the FTIR spectrum showed that most of the interactions between PVA–P matrix and enrofloxacin were due to polar groups (carboxylate and amine), a two-layer film system was designed to modulate the releasing rate of the drug. The top film equilibrated with 0.75 or 1.5 M NaCl release up to 41.9% and 89.0% of the enrofloxacin in 4 h, respectively. The release rate of enrofloxacin was found dependent on NaCl concentration in the upper gel layer. The two-layer cryogel system showed attractive features for transcutaneous antibiotic delivery.
Centro de Investigación y Desarrollo en Fermentaciones Industriales
Materia
Bioquímica
Transcutaneous delivery
Enrofloxacin
PVA
Pectin
Films
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/153289
Acceder
id SEDICI_1d6fbe1f871b447f04f2c98d0f100579
oai_identifier_str oai:sedici.unlp.edu.ar:10915/153289
network_acronym_str SEDICI
repository_id_str 1329
network_name_str SEDICI (UNLP)
spelling Polyvinyl alcohol–pectin cryogel films for controlled release of enrofloxacinMartínez, YaninaPiñuel, LucreciaCastro, Guillermo RaúlBreccia, Javier D.BioquímicaTranscutaneous deliveryEnrofloxacinPVAPectinFilmsThe release of enrofloxacin entrapped in polyvinyl alcohol (PVA) cryogel at pH 5.5 showed a first-order kinetic, releasing 69.7% of the antibiotic after 4.5 h at 37 °C. In order to slow down the fluoroquinolone release rate, high-methoxylated pectin was added into the cryogel (PVA–P). A film containing 1.0% (w/v) HM pectin and 5.0 μg/ml enrofloxacin released only 3.7% of the antibiotic after 4.5 h. Since the FTIR spectrum showed that most of the interactions between PVA–P matrix and enrofloxacin were due to polar groups (carboxylate and amine), a two-layer film system was designed to modulate the releasing rate of the drug. The top film equilibrated with 0.75 or 1.5 M NaCl release up to 41.9% and 89.0% of the enrofloxacin in 4 h, respectively. The release rate of enrofloxacin was found dependent on NaCl concentration in the upper gel layer. The two-layer cryogel system showed attractive features for transcutaneous antibiotic delivery.Centro de Investigación y Desarrollo en Fermentaciones Industriales2012info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf1421-1429http://sedici.unlp.edu.ar/handle/10915/153289enginfo:eu-repo/semantics/altIdentifier/issn/1559-0291info:eu-repo/semantics/altIdentifier/issn/0273-2289info:eu-repo/semantics/altIdentifier/doi/10.1007/s12010-012-9554-6info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-29T11:39:38Zoai:sedici.unlp.edu.ar:10915/153289Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-29 11:39:38.629SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Polyvinyl alcohol–pectin cryogel films for controlled release of enrofloxacin
title Polyvinyl alcohol–pectin cryogel films for controlled release of enrofloxacin
spellingShingle Polyvinyl alcohol–pectin cryogel films for controlled release of enrofloxacin
Martínez, Yanina
Bioquímica
Transcutaneous delivery
Enrofloxacin
PVA
Pectin
Films
title_short Polyvinyl alcohol–pectin cryogel films for controlled release of enrofloxacin
title_full Polyvinyl alcohol–pectin cryogel films for controlled release of enrofloxacin
title_fullStr Polyvinyl alcohol–pectin cryogel films for controlled release of enrofloxacin
title_full_unstemmed Polyvinyl alcohol–pectin cryogel films for controlled release of enrofloxacin
title_sort Polyvinyl alcohol–pectin cryogel films for controlled release of enrofloxacin
dc.creator.none.fl_str_mv Martínez, Yanina
Piñuel, Lucrecia
Castro, Guillermo Raúl
Breccia, Javier D.
author Martínez, Yanina
author_facet Martínez, Yanina
Piñuel, Lucrecia
Castro, Guillermo Raúl
Breccia, Javier D.
author_role author
author2 Piñuel, Lucrecia
Castro, Guillermo Raúl
Breccia, Javier D.
author2_role author
author
author
dc.subject.none.fl_str_mv Bioquímica
Transcutaneous delivery
Enrofloxacin
PVA
Pectin
Films
topic Bioquímica
Transcutaneous delivery
Enrofloxacin
PVA
Pectin
Films
dc.description.none.fl_txt_mv The release of enrofloxacin entrapped in polyvinyl alcohol (PVA) cryogel at pH 5.5 showed a first-order kinetic, releasing 69.7% of the antibiotic after 4.5 h at 37 °C. In order to slow down the fluoroquinolone release rate, high-methoxylated pectin was added into the cryogel (PVA–P). A film containing 1.0% (w/v) HM pectin and 5.0 μg/ml enrofloxacin released only 3.7% of the antibiotic after 4.5 h. Since the FTIR spectrum showed that most of the interactions between PVA–P matrix and enrofloxacin were due to polar groups (carboxylate and amine), a two-layer film system was designed to modulate the releasing rate of the drug. The top film equilibrated with 0.75 or 1.5 M NaCl release up to 41.9% and 89.0% of the enrofloxacin in 4 h, respectively. The release rate of enrofloxacin was found dependent on NaCl concentration in the upper gel layer. The two-layer cryogel system showed attractive features for transcutaneous antibiotic delivery.
Centro de Investigación y Desarrollo en Fermentaciones Industriales
description The release of enrofloxacin entrapped in polyvinyl alcohol (PVA) cryogel at pH 5.5 showed a first-order kinetic, releasing 69.7% of the antibiotic after 4.5 h at 37 °C. In order to slow down the fluoroquinolone release rate, high-methoxylated pectin was added into the cryogel (PVA–P). A film containing 1.0% (w/v) HM pectin and 5.0 μg/ml enrofloxacin released only 3.7% of the antibiotic after 4.5 h. Since the FTIR spectrum showed that most of the interactions between PVA–P matrix and enrofloxacin were due to polar groups (carboxylate and amine), a two-layer film system was designed to modulate the releasing rate of the drug. The top film equilibrated with 0.75 or 1.5 M NaCl release up to 41.9% and 89.0% of the enrofloxacin in 4 h, respectively. The release rate of enrofloxacin was found dependent on NaCl concentration in the upper gel layer. The two-layer cryogel system showed attractive features for transcutaneous antibiotic delivery.
publishDate 2012
dc.date.none.fl_str_mv 2012
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/153289
url http://sedici.unlp.edu.ar/handle/10915/153289
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/issn/1559-0291
info:eu-repo/semantics/altIdentifier/issn/0273-2289
info:eu-repo/semantics/altIdentifier/doi/10.1007/s12010-012-9554-6
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv application/pdf
1421-1429
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
instacron:UNLP
reponame_str SEDICI (UNLP)
collection SEDICI (UNLP)
instname_str Universidad Nacional de La Plata
instacron_str UNLP
institution UNLP
repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
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score 13.070432

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