Effect of Boron Neutron Capture Therapy (BNCT) on normal liver regeneration: Towards a novel therapy for liver metastases

Autores
Cardoso, Jorge E.; Trivillin, Verónica Andrea; Heber, Elisa Mercedes; Nigg, David W.; Calzetta, Osvaldo; Blaumann, Herman Roberto; Longhino, Juan Manuel; Itoiz, María Elina; Bumaschny, Eduardo; Pozzi, Emiliano César Cayetano; Schwint, Amanda Elena
Año de publicación
2009
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Purpose: The effect of Boron Neutron Capture Therapy (BNCT) on normal liver regeneration was examined in the Wistar rat. The model used is clinically relevant to a novel technique proposed for the treatment of multifocal non-resectable liver metastases in man. The success of the technique also requires that BNCT should not significantly impair regeneration of normal hepatocytes.The effect of Boron Neutron Capture Therapy (BNCT) on normal liver regeneration was examined in the Wistar rat. The model used is clinically relevant to a novel technique proposed for the treatment of multifocal non-resectable liver metastases in man. The success of the technique also requires that BNCT should not significantly impair regeneration of normal hepatocytes. Materials and methods: The effect of therapeutic doses of boronophenylalanine (BPA), GB-10 (Na2 10B10H10) and (GB-10+BPA) and of BNCT mediated by these boron delivery agents on normal liver regeneration and liver function in the Wistar rat was examined using partial hepatectomy as the regenerative stimulus. The end-points evaluated were body weight, liver weight/body weight ratio, DNA synthesis in terms of 5-bromo-20-deoxyuridine incorporation, hemogram, kidney function in terms of blood urea nitrogen and creatinine levels, liver function in terms of serum albumin, total and direct bilirubin and liver enzymes (alanine transaminase and aspartate transaminase) and liver histology/architecture.The effect of therapeutic doses of boronophenylalanine (BPA), GB-10 (Na2 10B10H10) and (GB-10+BPA) and of BNCT mediated by these boron delivery agents on normal liver regeneration and liver function in the Wistar rat was examined using partial hepatectomy as the regenerative stimulus. The end-points evaluated were body weight, liver weight/body weight ratio, DNA synthesis in terms of 5-bromo-20-deoxyuridine incorporation, hemogram, kidney function in terms of blood urea nitrogen and creatinine levels, liver function in terms of serum albumin, total and direct bilirubin and liver enzymes (alanine transaminase and aspartate transaminase) and liver histology/architecture.B10H10) and (GB-10+BPA) and of BNCT mediated by these boron delivery agents on normal liver regeneration and liver function in the Wistar rat was examined using partial hepatectomy as the regenerative stimulus. The end-points evaluated were body weight, liver weight/body weight ratio, DNA synthesis in terms of 5-bromo-20-deoxyuridine incorporation, hemogram, kidney function in terms of blood urea nitrogen and creatinine levels, liver function in terms of serum albumin, total and direct bilirubin and liver enzymes (alanine transaminase and aspartate transaminase) and liver histology/architecture.0-deoxyuridine incorporation, hemogram, kidney function in terms of blood urea nitrogen and creatinine levels, liver function in terms of serum albumin, total and direct bilirubin and liver enzymes (alanine transaminase and aspartate transaminase) and liver histology/architecture. Results: BNCT mediated by BPA, GB-10 or (GB-10+BPA) did not cause alterations in the outcome of normal liver regeneration, regenerated liver function/proliferation or histology/architecture. BNCT mediated by BPA, GB-10 or (GB-10+BPA) did not cause alterations in the outcome of normal liver regeneration, regenerated liver function/proliferation or histology/architecture. Conclusion: The BNCT protocols, at the physical doses selected, did not impair the capacity of normal liver hepatocytes to regenerate.The BNCT protocols, at the physical doses selected, did not impair the capacity of normal liver hepatocytes to regenerate.
Fil: Cardoso, Jorge E.. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina
Fil: Trivillin, Verónica Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Comisión Nacional de Energía Atómica. Centro Atómico Constituyentes; Argentina
Fil: Heber, Elisa Mercedes. Comisión Nacional de Energía Atómica. Centro Atómico Constituyentes; Argentina
Fil: Nigg, David W.. Idaho National Laboratory; Estados Unidos
Fil: Calzetta, Osvaldo. Comisión Nacional de Energía Atómica. Centro Atómico Bariloche; Argentina
Fil: Blaumann, Herman Roberto. Comisión Nacional de Energía Atómica. Centro Atómico Bariloche; Argentina
Fil: Longhino, Juan Manuel. Comisión Nacional de Energía Atómica. Centro Atómico Bariloche; Argentina
Fil: Itoiz, María Elina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Comisión Nacional de Energía Atómica. Centro Atómico Constituyentes; Argentina. Universidad de Buenos Aires. Facultad de Odontología; Argentina
Fil: Bumaschny, Eduardo. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina
Fil: Pozzi, Emiliano César Cayetano. Comisión Nacional de Energía Atómica. Centro Atómico Constituyentes; Argentina. Comisión Nacional de Energía Atómica. Centro Atómico Ezeiza; Argentina
Fil: Schwint, Amanda Elena. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Comisión Nacional de Energía Atómica. Centro Atómico Constituyentes; Argentina
Materia
BNCT
RADIOTOXICITY
NORMAL LIVER
REGENERATION
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/241735
Acceder
id CONICETDig_450a32ceba6c7728b67aa1a8fe88a20b
oai_identifier_str oai:ri.conicet.gov.ar:11336/241735
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Effect of Boron Neutron Capture Therapy (BNCT) on normal liver regeneration: Towards a novel therapy for liver metastasesCardoso, Jorge E.Trivillin, Verónica AndreaHeber, Elisa MercedesNigg, David W.Calzetta, OsvaldoBlaumann, Herman RobertoLonghino, Juan ManuelItoiz, María ElinaBumaschny, EduardoPozzi, Emiliano César CayetanoSchwint, Amanda ElenaBNCTRADIOTOXICITYNORMAL LIVERREGENERATIONhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Purpose: The effect of Boron Neutron Capture Therapy (BNCT) on normal liver regeneration was examined in the Wistar rat. The model used is clinically relevant to a novel technique proposed for the treatment of multifocal non-resectable liver metastases in man. The success of the technique also requires that BNCT should not significantly impair regeneration of normal hepatocytes.The effect of Boron Neutron Capture Therapy (BNCT) on normal liver regeneration was examined in the Wistar rat. The model used is clinically relevant to a novel technique proposed for the treatment of multifocal non-resectable liver metastases in man. The success of the technique also requires that BNCT should not significantly impair regeneration of normal hepatocytes. Materials and methods: The effect of therapeutic doses of boronophenylalanine (BPA), GB-10 (Na2 10B10H10) and (GB-10+BPA) and of BNCT mediated by these boron delivery agents on normal liver regeneration and liver function in the Wistar rat was examined using partial hepatectomy as the regenerative stimulus. The end-points evaluated were body weight, liver weight/body weight ratio, DNA synthesis in terms of 5-bromo-20-deoxyuridine incorporation, hemogram, kidney function in terms of blood urea nitrogen and creatinine levels, liver function in terms of serum albumin, total and direct bilirubin and liver enzymes (alanine transaminase and aspartate transaminase) and liver histology/architecture.The effect of therapeutic doses of boronophenylalanine (BPA), GB-10 (Na2 10B10H10) and (GB-10+BPA) and of BNCT mediated by these boron delivery agents on normal liver regeneration and liver function in the Wistar rat was examined using partial hepatectomy as the regenerative stimulus. The end-points evaluated were body weight, liver weight/body weight ratio, DNA synthesis in terms of 5-bromo-20-deoxyuridine incorporation, hemogram, kidney function in terms of blood urea nitrogen and creatinine levels, liver function in terms of serum albumin, total and direct bilirubin and liver enzymes (alanine transaminase and aspartate transaminase) and liver histology/architecture.B10H10) and (GB-10+BPA) and of BNCT mediated by these boron delivery agents on normal liver regeneration and liver function in the Wistar rat was examined using partial hepatectomy as the regenerative stimulus. The end-points evaluated were body weight, liver weight/body weight ratio, DNA synthesis in terms of 5-bromo-20-deoxyuridine incorporation, hemogram, kidney function in terms of blood urea nitrogen and creatinine levels, liver function in terms of serum albumin, total and direct bilirubin and liver enzymes (alanine transaminase and aspartate transaminase) and liver histology/architecture.0-deoxyuridine incorporation, hemogram, kidney function in terms of blood urea nitrogen and creatinine levels, liver function in terms of serum albumin, total and direct bilirubin and liver enzymes (alanine transaminase and aspartate transaminase) and liver histology/architecture. Results: BNCT mediated by BPA, GB-10 or (GB-10+BPA) did not cause alterations in the outcome of normal liver regeneration, regenerated liver function/proliferation or histology/architecture. BNCT mediated by BPA, GB-10 or (GB-10+BPA) did not cause alterations in the outcome of normal liver regeneration, regenerated liver function/proliferation or histology/architecture. Conclusion: The BNCT protocols, at the physical doses selected, did not impair the capacity of normal liver hepatocytes to regenerate.The BNCT protocols, at the physical doses selected, did not impair the capacity of normal liver hepatocytes to regenerate.Fil: Cardoso, Jorge E.. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; ArgentinaFil: Trivillin, Verónica Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Comisión Nacional de Energía Atómica. Centro Atómico Constituyentes; ArgentinaFil: Heber, Elisa Mercedes. Comisión Nacional de Energía Atómica. Centro Atómico Constituyentes; ArgentinaFil: Nigg, David W.. Idaho National Laboratory; Estados UnidosFil: Calzetta, Osvaldo. Comisión Nacional de Energía Atómica. Centro Atómico Bariloche; ArgentinaFil: Blaumann, Herman Roberto. Comisión Nacional de Energía Atómica. Centro Atómico Bariloche; ArgentinaFil: Longhino, Juan Manuel. Comisión Nacional de Energía Atómica. Centro Atómico Bariloche; ArgentinaFil: Itoiz, María Elina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Comisión Nacional de Energía Atómica. Centro Atómico Constituyentes; Argentina. Universidad de Buenos Aires. Facultad de Odontología; ArgentinaFil: Bumaschny, Eduardo. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; ArgentinaFil: Pozzi, Emiliano César Cayetano. Comisión Nacional de Energía Atómica. Centro Atómico Constituyentes; Argentina. Comisión Nacional de Energía Atómica. Centro Atómico Ezeiza; ArgentinaFil: Schwint, Amanda Elena. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Comisión Nacional de Energía Atómica. Centro Atómico Constituyentes; ArgentinaTaylor & Francis Ltd2009-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/241735Cardoso, Jorge E.; Trivillin, Verónica Andrea; Heber, Elisa Mercedes; Nigg, David W.; Calzetta, Osvaldo; et al.; Effect of Boron Neutron Capture Therapy (BNCT) on normal liver regeneration: Towards a novel therapy for liver metastases; Taylor & Francis Ltd; International Journal Of Radiation Biology; 83; 10; 7-2009; 699-7060955-3002CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/full/10.1080/09553000701570212info:eu-repo/semantics/altIdentifier/doi/10.1080/09553000701570212info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:59:12Zoai:ri.conicet.gov.ar:11336/241735instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:59:12.824CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Effect of Boron Neutron Capture Therapy (BNCT) on normal liver regeneration: Towards a novel therapy for liver metastases
title Effect of Boron Neutron Capture Therapy (BNCT) on normal liver regeneration: Towards a novel therapy for liver metastases
spellingShingle Effect of Boron Neutron Capture Therapy (BNCT) on normal liver regeneration: Towards a novel therapy for liver metastases
Cardoso, Jorge E.
BNCT
RADIOTOXICITY
NORMAL LIVER
REGENERATION
title_short Effect of Boron Neutron Capture Therapy (BNCT) on normal liver regeneration: Towards a novel therapy for liver metastases
title_full Effect of Boron Neutron Capture Therapy (BNCT) on normal liver regeneration: Towards a novel therapy for liver metastases
title_fullStr Effect of Boron Neutron Capture Therapy (BNCT) on normal liver regeneration: Towards a novel therapy for liver metastases
title_full_unstemmed Effect of Boron Neutron Capture Therapy (BNCT) on normal liver regeneration: Towards a novel therapy for liver metastases
title_sort Effect of Boron Neutron Capture Therapy (BNCT) on normal liver regeneration: Towards a novel therapy for liver metastases
dc.creator.none.fl_str_mv Cardoso, Jorge E.
Trivillin, Verónica Andrea
Heber, Elisa Mercedes
Nigg, David W.
Calzetta, Osvaldo
Blaumann, Herman Roberto
Longhino, Juan Manuel
Itoiz, María Elina
Bumaschny, Eduardo
Pozzi, Emiliano César Cayetano
Schwint, Amanda Elena
author Cardoso, Jorge E.
author_facet Cardoso, Jorge E.
Trivillin, Verónica Andrea
Heber, Elisa Mercedes
Nigg, David W.
Calzetta, Osvaldo
Blaumann, Herman Roberto
Longhino, Juan Manuel
Itoiz, María Elina
Bumaschny, Eduardo
Pozzi, Emiliano César Cayetano
Schwint, Amanda Elena
author_role author
author2 Trivillin, Verónica Andrea
Heber, Elisa Mercedes
Nigg, David W.
Calzetta, Osvaldo
Blaumann, Herman Roberto
Longhino, Juan Manuel
Itoiz, María Elina
Bumaschny, Eduardo
Pozzi, Emiliano César Cayetano
Schwint, Amanda Elena
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv BNCT
RADIOTOXICITY
NORMAL LIVER
REGENERATION
topic BNCT
RADIOTOXICITY
NORMAL LIVER
REGENERATION
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Purpose: The effect of Boron Neutron Capture Therapy (BNCT) on normal liver regeneration was examined in the Wistar rat. The model used is clinically relevant to a novel technique proposed for the treatment of multifocal non-resectable liver metastases in man. The success of the technique also requires that BNCT should not significantly impair regeneration of normal hepatocytes.The effect of Boron Neutron Capture Therapy (BNCT) on normal liver regeneration was examined in the Wistar rat. The model used is clinically relevant to a novel technique proposed for the treatment of multifocal non-resectable liver metastases in man. The success of the technique also requires that BNCT should not significantly impair regeneration of normal hepatocytes. Materials and methods: The effect of therapeutic doses of boronophenylalanine (BPA), GB-10 (Na2 10B10H10) and (GB-10+BPA) and of BNCT mediated by these boron delivery agents on normal liver regeneration and liver function in the Wistar rat was examined using partial hepatectomy as the regenerative stimulus. The end-points evaluated were body weight, liver weight/body weight ratio, DNA synthesis in terms of 5-bromo-20-deoxyuridine incorporation, hemogram, kidney function in terms of blood urea nitrogen and creatinine levels, liver function in terms of serum albumin, total and direct bilirubin and liver enzymes (alanine transaminase and aspartate transaminase) and liver histology/architecture.The effect of therapeutic doses of boronophenylalanine (BPA), GB-10 (Na2 10B10H10) and (GB-10+BPA) and of BNCT mediated by these boron delivery agents on normal liver regeneration and liver function in the Wistar rat was examined using partial hepatectomy as the regenerative stimulus. The end-points evaluated were body weight, liver weight/body weight ratio, DNA synthesis in terms of 5-bromo-20-deoxyuridine incorporation, hemogram, kidney function in terms of blood urea nitrogen and creatinine levels, liver function in terms of serum albumin, total and direct bilirubin and liver enzymes (alanine transaminase and aspartate transaminase) and liver histology/architecture.B10H10) and (GB-10+BPA) and of BNCT mediated by these boron delivery agents on normal liver regeneration and liver function in the Wistar rat was examined using partial hepatectomy as the regenerative stimulus. The end-points evaluated were body weight, liver weight/body weight ratio, DNA synthesis in terms of 5-bromo-20-deoxyuridine incorporation, hemogram, kidney function in terms of blood urea nitrogen and creatinine levels, liver function in terms of serum albumin, total and direct bilirubin and liver enzymes (alanine transaminase and aspartate transaminase) and liver histology/architecture.0-deoxyuridine incorporation, hemogram, kidney function in terms of blood urea nitrogen and creatinine levels, liver function in terms of serum albumin, total and direct bilirubin and liver enzymes (alanine transaminase and aspartate transaminase) and liver histology/architecture. Results: BNCT mediated by BPA, GB-10 or (GB-10+BPA) did not cause alterations in the outcome of normal liver regeneration, regenerated liver function/proliferation or histology/architecture. BNCT mediated by BPA, GB-10 or (GB-10+BPA) did not cause alterations in the outcome of normal liver regeneration, regenerated liver function/proliferation or histology/architecture. Conclusion: The BNCT protocols, at the physical doses selected, did not impair the capacity of normal liver hepatocytes to regenerate.The BNCT protocols, at the physical doses selected, did not impair the capacity of normal liver hepatocytes to regenerate.
Fil: Cardoso, Jorge E.. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina
Fil: Trivillin, Verónica Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Comisión Nacional de Energía Atómica. Centro Atómico Constituyentes; Argentina
Fil: Heber, Elisa Mercedes. Comisión Nacional de Energía Atómica. Centro Atómico Constituyentes; Argentina
Fil: Nigg, David W.. Idaho National Laboratory; Estados Unidos
Fil: Calzetta, Osvaldo. Comisión Nacional de Energía Atómica. Centro Atómico Bariloche; Argentina
Fil: Blaumann, Herman Roberto. Comisión Nacional de Energía Atómica. Centro Atómico Bariloche; Argentina
Fil: Longhino, Juan Manuel. Comisión Nacional de Energía Atómica. Centro Atómico Bariloche; Argentina
Fil: Itoiz, María Elina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Comisión Nacional de Energía Atómica. Centro Atómico Constituyentes; Argentina. Universidad de Buenos Aires. Facultad de Odontología; Argentina
Fil: Bumaschny, Eduardo. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina
Fil: Pozzi, Emiliano César Cayetano. Comisión Nacional de Energía Atómica. Centro Atómico Constituyentes; Argentina. Comisión Nacional de Energía Atómica. Centro Atómico Ezeiza; Argentina
Fil: Schwint, Amanda Elena. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Comisión Nacional de Energía Atómica. Centro Atómico Constituyentes; Argentina
description Purpose: The effect of Boron Neutron Capture Therapy (BNCT) on normal liver regeneration was examined in the Wistar rat. The model used is clinically relevant to a novel technique proposed for the treatment of multifocal non-resectable liver metastases in man. The success of the technique also requires that BNCT should not significantly impair regeneration of normal hepatocytes.The effect of Boron Neutron Capture Therapy (BNCT) on normal liver regeneration was examined in the Wistar rat. The model used is clinically relevant to a novel technique proposed for the treatment of multifocal non-resectable liver metastases in man. The success of the technique also requires that BNCT should not significantly impair regeneration of normal hepatocytes. Materials and methods: The effect of therapeutic doses of boronophenylalanine (BPA), GB-10 (Na2 10B10H10) and (GB-10+BPA) and of BNCT mediated by these boron delivery agents on normal liver regeneration and liver function in the Wistar rat was examined using partial hepatectomy as the regenerative stimulus. The end-points evaluated were body weight, liver weight/body weight ratio, DNA synthesis in terms of 5-bromo-20-deoxyuridine incorporation, hemogram, kidney function in terms of blood urea nitrogen and creatinine levels, liver function in terms of serum albumin, total and direct bilirubin and liver enzymes (alanine transaminase and aspartate transaminase) and liver histology/architecture.The effect of therapeutic doses of boronophenylalanine (BPA), GB-10 (Na2 10B10H10) and (GB-10+BPA) and of BNCT mediated by these boron delivery agents on normal liver regeneration and liver function in the Wistar rat was examined using partial hepatectomy as the regenerative stimulus. The end-points evaluated were body weight, liver weight/body weight ratio, DNA synthesis in terms of 5-bromo-20-deoxyuridine incorporation, hemogram, kidney function in terms of blood urea nitrogen and creatinine levels, liver function in terms of serum albumin, total and direct bilirubin and liver enzymes (alanine transaminase and aspartate transaminase) and liver histology/architecture.B10H10) and (GB-10+BPA) and of BNCT mediated by these boron delivery agents on normal liver regeneration and liver function in the Wistar rat was examined using partial hepatectomy as the regenerative stimulus. The end-points evaluated were body weight, liver weight/body weight ratio, DNA synthesis in terms of 5-bromo-20-deoxyuridine incorporation, hemogram, kidney function in terms of blood urea nitrogen and creatinine levels, liver function in terms of serum albumin, total and direct bilirubin and liver enzymes (alanine transaminase and aspartate transaminase) and liver histology/architecture.0-deoxyuridine incorporation, hemogram, kidney function in terms of blood urea nitrogen and creatinine levels, liver function in terms of serum albumin, total and direct bilirubin and liver enzymes (alanine transaminase and aspartate transaminase) and liver histology/architecture. Results: BNCT mediated by BPA, GB-10 or (GB-10+BPA) did not cause alterations in the outcome of normal liver regeneration, regenerated liver function/proliferation or histology/architecture. BNCT mediated by BPA, GB-10 or (GB-10+BPA) did not cause alterations in the outcome of normal liver regeneration, regenerated liver function/proliferation or histology/architecture. Conclusion: The BNCT protocols, at the physical doses selected, did not impair the capacity of normal liver hepatocytes to regenerate.The BNCT protocols, at the physical doses selected, did not impair the capacity of normal liver hepatocytes to regenerate.
publishDate 2009
dc.date.none.fl_str_mv 2009-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/241735
Cardoso, Jorge E.; Trivillin, Verónica Andrea; Heber, Elisa Mercedes; Nigg, David W.; Calzetta, Osvaldo; et al.; Effect of Boron Neutron Capture Therapy (BNCT) on normal liver regeneration: Towards a novel therapy for liver metastases; Taylor & Francis Ltd; International Journal Of Radiation Biology; 83; 10; 7-2009; 699-706
0955-3002
CONICET Digital
CONICET
url http://hdl.handle.net/11336/241735
identifier_str_mv Cardoso, Jorge E.; Trivillin, Verónica Andrea; Heber, Elisa Mercedes; Nigg, David W.; Calzetta, Osvaldo; et al.; Effect of Boron Neutron Capture Therapy (BNCT) on normal liver regeneration: Towards a novel therapy for liver metastases; Taylor & Francis Ltd; International Journal Of Radiation Biology; 83; 10; 7-2009; 699-706
0955-3002
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/full/10.1080/09553000701570212
info:eu-repo/semantics/altIdentifier/doi/10.1080/09553000701570212
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
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eu_rights_str_mv openAccess
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dc.format.none.fl_str_mv application/pdf
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dc.publisher.none.fl_str_mv Taylor & Francis Ltd
publisher.none.fl_str_mv Taylor & Francis Ltd
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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