Cryptococcosis: Unusual Presentation in A Patient Suffering of Acute Lymphoblastic Leukemia; Case Report and Review of The Literature

Autores
Vitale, Roxana Gabriela; Giudicessi, Silvana Laura; Rey, I. H.; Mazzeo, M. A.; Rivera, M. J.; Afeltra, Javier
Año de publicación
2023
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Cryptococcosis is a disseminated fungal disease especially described in HIV patients, although in other non-HIV hosts such as those with other immunosuppression’s were also described. Cryptococcus neoformans has been reported to be isolated from blood cultures in around 20% of patients with cryptococcosis being correlated with poor prognosis. We report a case of HIV negative patient suffering from acute lymphoblastic leukemia (ALL) CD20+, treated with GATLA 2020 AYA protocol that developed disseminated cryptococcosis. Liposomal amphotericin was initiated to treat the fungal disease. However, despite antifungal therapy the patient died within 5 days. Literature on invasive fungal infections in ALL cases is also reviewed, with particular attention to cryptococcosis.
Fil: Vitale, Roxana Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Ramos Mejía"; Argentina
Fil: Giudicessi, Silvana Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Nanobiotecnología. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Nanobiotecnología; Argentina
Fil: Rey, I. H.. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Ramos Mejía"; Argentina
Fil: Mazzeo, M. A.. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Ramos Mejía"; Argentina
Fil: Rivera, M. J.. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Ramos Mejía"; Argentina
Fil: Afeltra, Javier. Gobierno de la Ciudad de Buenos Aires. Hospital Gral.de Agudos "ramos Mejia". Departamento de Diagnostico y Tratamiento; Argentina
Materia
CRYPTOCOCCOSIS
ACUTE
LEUKEMIA
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/235532
Acceder
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spelling Cryptococcosis: Unusual Presentation in A Patient Suffering of Acute Lymphoblastic Leukemia; Case Report and Review of The LiteratureVitale, Roxana GabrielaGiudicessi, Silvana LauraRey, I. H.Mazzeo, M. A.Rivera, M. J.Afeltra, JavierCRYPTOCOCCOSISACUTELEUKEMIAhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Cryptococcosis is a disseminated fungal disease especially described in HIV patients, although in other non-HIV hosts such as those with other immunosuppression’s were also described. Cryptococcus neoformans has been reported to be isolated from blood cultures in around 20% of patients with cryptococcosis being correlated with poor prognosis. We report a case of HIV negative patient suffering from acute lymphoblastic leukemia (ALL) CD20+, treated with GATLA 2020 AYA protocol that developed disseminated cryptococcosis. Liposomal amphotericin was initiated to treat the fungal disease. However, despite antifungal therapy the patient died within 5 days. Literature on invasive fungal infections in ALL cases is also reviewed, with particular attention to cryptococcosis.Fil: Vitale, Roxana Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Ramos Mejía"; ArgentinaFil: Giudicessi, Silvana Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Nanobiotecnología. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Nanobiotecnología; ArgentinaFil: Rey, I. H.. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Ramos Mejía"; ArgentinaFil: Mazzeo, M. A.. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Ramos Mejía"; ArgentinaFil: Rivera, M. J.. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Ramos Mejía"; ArgentinaFil: Afeltra, Javier. Gobierno de la Ciudad de Buenos Aires. Hospital Gral.de Agudos "ramos Mejia". Departamento de Diagnostico y Tratamiento; ArgentinaAuctores Publishing LLC2023-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/235532Vitale, Roxana Gabriela; Giudicessi, Silvana Laura; Rey, I. H.; Mazzeo, M. A.; Rivera, M. J.; et al.; Cryptococcosis: Unusual Presentation in A Patient Suffering of Acute Lymphoblastic Leukemia; Case Report and Review of The Literature; Auctores Publishing LLC; International Journal of Clinical Case Reports and Reviews; 16; 1; 12-2023; 1-52690-4861CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.31579/2690-4861/372info:eu-repo/semantics/altIdentifier/url/https://www.auctoresonline.org/article/cryptococcosis-unusual-presentation-in-a-patient-suffering-of-acute-lymphoblastic-leukemia-case-report-and-review-of-the-literatureinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-17T11:34:55Zoai:ri.conicet.gov.ar:11336/235532instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-17 11:34:55.948CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Cryptococcosis: Unusual Presentation in A Patient Suffering of Acute Lymphoblastic Leukemia; Case Report and Review of The Literature
title Cryptococcosis: Unusual Presentation in A Patient Suffering of Acute Lymphoblastic Leukemia; Case Report and Review of The Literature
spellingShingle Cryptococcosis: Unusual Presentation in A Patient Suffering of Acute Lymphoblastic Leukemia; Case Report and Review of The Literature
Vitale, Roxana Gabriela
CRYPTOCOCCOSIS
ACUTE
LEUKEMIA
title_short Cryptococcosis: Unusual Presentation in A Patient Suffering of Acute Lymphoblastic Leukemia; Case Report and Review of The Literature
title_full Cryptococcosis: Unusual Presentation in A Patient Suffering of Acute Lymphoblastic Leukemia; Case Report and Review of The Literature
title_fullStr Cryptococcosis: Unusual Presentation in A Patient Suffering of Acute Lymphoblastic Leukemia; Case Report and Review of The Literature
title_full_unstemmed Cryptococcosis: Unusual Presentation in A Patient Suffering of Acute Lymphoblastic Leukemia; Case Report and Review of The Literature
title_sort Cryptococcosis: Unusual Presentation in A Patient Suffering of Acute Lymphoblastic Leukemia; Case Report and Review of The Literature
dc.creator.none.fl_str_mv Vitale, Roxana Gabriela
Giudicessi, Silvana Laura
Rey, I. H.
Mazzeo, M. A.
Rivera, M. J.
Afeltra, Javier
author Vitale, Roxana Gabriela
author_facet Vitale, Roxana Gabriela
Giudicessi, Silvana Laura
Rey, I. H.
Mazzeo, M. A.
Rivera, M. J.
Afeltra, Javier
author_role author
author2 Giudicessi, Silvana Laura
Rey, I. H.
Mazzeo, M. A.
Rivera, M. J.
Afeltra, Javier
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv CRYPTOCOCCOSIS
ACUTE
LEUKEMIA
topic CRYPTOCOCCOSIS
ACUTE
LEUKEMIA
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Cryptococcosis is a disseminated fungal disease especially described in HIV patients, although in other non-HIV hosts such as those with other immunosuppression’s were also described. Cryptococcus neoformans has been reported to be isolated from blood cultures in around 20% of patients with cryptococcosis being correlated with poor prognosis. We report a case of HIV negative patient suffering from acute lymphoblastic leukemia (ALL) CD20+, treated with GATLA 2020 AYA protocol that developed disseminated cryptococcosis. Liposomal amphotericin was initiated to treat the fungal disease. However, despite antifungal therapy the patient died within 5 days. Literature on invasive fungal infections in ALL cases is also reviewed, with particular attention to cryptococcosis.
Fil: Vitale, Roxana Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Ramos Mejía"; Argentina
Fil: Giudicessi, Silvana Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Nanobiotecnología. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Nanobiotecnología; Argentina
Fil: Rey, I. H.. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Ramos Mejía"; Argentina
Fil: Mazzeo, M. A.. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Ramos Mejía"; Argentina
Fil: Rivera, M. J.. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Ramos Mejía"; Argentina
Fil: Afeltra, Javier. Gobierno de la Ciudad de Buenos Aires. Hospital Gral.de Agudos "ramos Mejia". Departamento de Diagnostico y Tratamiento; Argentina
description Cryptococcosis is a disseminated fungal disease especially described in HIV patients, although in other non-HIV hosts such as those with other immunosuppression’s were also described. Cryptococcus neoformans has been reported to be isolated from blood cultures in around 20% of patients with cryptococcosis being correlated with poor prognosis. We report a case of HIV negative patient suffering from acute lymphoblastic leukemia (ALL) CD20+, treated with GATLA 2020 AYA protocol that developed disseminated cryptococcosis. Liposomal amphotericin was initiated to treat the fungal disease. However, despite antifungal therapy the patient died within 5 days. Literature on invasive fungal infections in ALL cases is also reviewed, with particular attention to cryptococcosis.
publishDate 2023
dc.date.none.fl_str_mv 2023-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/235532
Vitale, Roxana Gabriela; Giudicessi, Silvana Laura; Rey, I. H.; Mazzeo, M. A.; Rivera, M. J.; et al.; Cryptococcosis: Unusual Presentation in A Patient Suffering of Acute Lymphoblastic Leukemia; Case Report and Review of The Literature; Auctores Publishing LLC; International Journal of Clinical Case Reports and Reviews; 16; 1; 12-2023; 1-5
2690-4861
CONICET Digital
CONICET
url http://hdl.handle.net/11336/235532
identifier_str_mv Vitale, Roxana Gabriela; Giudicessi, Silvana Laura; Rey, I. H.; Mazzeo, M. A.; Rivera, M. J.; et al.; Cryptococcosis: Unusual Presentation in A Patient Suffering of Acute Lymphoblastic Leukemia; Case Report and Review of The Literature; Auctores Publishing LLC; International Journal of Clinical Case Reports and Reviews; 16; 1; 12-2023; 1-5
2690-4861
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.31579/2690-4861/372
info:eu-repo/semantics/altIdentifier/url/https://www.auctoresonline.org/article/cryptococcosis-unusual-presentation-in-a-patient-suffering-of-acute-lymphoblastic-leukemia-case-report-and-review-of-the-literature
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Auctores Publishing LLC
publisher.none.fl_str_mv Auctores Publishing LLC
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.001348

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