Inhibition of cellular proliferation and enhancement of hydrogen peroxide production in fibrosarcoma cell line by weak radio frequency magnetic fields

Autores
Castello, Pablo Raul; Hill, Iain; Sivo, Frank; Portelli, Lucas; Barnes, Frank; Usselman, Robert; Martino, Carlos F.
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
This study presents experimental data for the effects of weak radio frequency (RF) magnetic fields on hydrogen peroxide (H2O2) production and cellular growth rates of fibrosarcoma HT1080 cells in vitro. Cells were exposed either to 45μT static magnetic fields (SMFs)-oriented vertical to the plane of growth or to SMFs combined with weak 5 and 10MHz RF magnetic fields of 10μTRMS intensity perpendicular to the static field. Cell numbers were reduced up to 30% on Day 2 for the cells exposed to the combination of SMF and a 10MHz RF magnetic field compared with the SMF control cells. In addition, cells exposed to 10MHz RF magnetic fields for 8h increased H2O2 production by 55%. The results demonstrate an overall magnetic field-induced biological effect that shows elevated H2O2 levels with accompanying decrease in cellular growth rates.
Fil: Castello, Pablo Raul. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; Argentina. Universidad de Nevada; Estados Unidos
Fil: Hill, Iain. Universidad de Nevada; Estados Unidos
Fil: Sivo, Frank. State University of Colorado at Boulder; Estados Unidos
Fil: Portelli, Lucas. State University of Colorado at Boulder; Estados Unidos
Fil: Barnes, Frank. State University of Colorado at Boulder; Estados Unidos
Fil: Usselman, Robert. National Institute of Standards and Technology; Estados Unidos
Fil: Martino, Carlos F.. Universidad de Nevada; Estados Unidos. University Hospital RWTH Aachen; Alemania
Materia
CANCER CELLS
CELLULAR GROWTH CURVES
HYDROGEN PEROXIDE
MAGNETIC FIELD EFFECTS
RADICAL PAIR MECHANISM
RADIO FREQUENCY
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/99233
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/99233
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Inhibition of cellular proliferation and enhancement of hydrogen peroxide production in fibrosarcoma cell line by weak radio frequency magnetic fieldsCastello, Pablo RaulHill, IainSivo, FrankPortelli, LucasBarnes, FrankUsselman, RobertMartino, Carlos F.CANCER CELLSCELLULAR GROWTH CURVESHYDROGEN PEROXIDEMAGNETIC FIELD EFFECTSRADICAL PAIR MECHANISMRADIO FREQUENCYhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1This study presents experimental data for the effects of weak radio frequency (RF) magnetic fields on hydrogen peroxide (H2O2) production and cellular growth rates of fibrosarcoma HT1080 cells in vitro. Cells were exposed either to 45μT static magnetic fields (SMFs)-oriented vertical to the plane of growth or to SMFs combined with weak 5 and 10MHz RF magnetic fields of 10μTRMS intensity perpendicular to the static field. Cell numbers were reduced up to 30% on Day 2 for the cells exposed to the combination of SMF and a 10MHz RF magnetic field compared with the SMF control cells. In addition, cells exposed to 10MHz RF magnetic fields for 8h increased H2O2 production by 55%. The results demonstrate an overall magnetic field-induced biological effect that shows elevated H2O2 levels with accompanying decrease in cellular growth rates.Fil: Castello, Pablo Raul. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; Argentina. Universidad de Nevada; Estados UnidosFil: Hill, Iain. Universidad de Nevada; Estados UnidosFil: Sivo, Frank. State University of Colorado at Boulder; Estados UnidosFil: Portelli, Lucas. State University of Colorado at Boulder; Estados UnidosFil: Barnes, Frank. State University of Colorado at Boulder; Estados UnidosFil: Usselman, Robert. National Institute of Standards and Technology; Estados UnidosFil: Martino, Carlos F.. Universidad de Nevada; Estados Unidos. University Hospital RWTH Aachen; AlemaniaWiley-liss, Div John Wiley & Sons Inc2014-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/99233Castello, Pablo Raul; Hill, Iain; Sivo, Frank; Portelli, Lucas; Barnes, Frank; et al.; Inhibition of cellular proliferation and enhancement of hydrogen peroxide production in fibrosarcoma cell line by weak radio frequency magnetic fields; Wiley-liss, Div John Wiley & Sons Inc; Bioelectromagnetics.; 35; 8; 12-2014; 598-6020197-8462CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/full/10.1002/bem.21858info:eu-repo/semantics/altIdentifier/doi/10.1002/bem.21858info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:35:26Zoai:ri.conicet.gov.ar:11336/99233instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:35:27.109CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Inhibition of cellular proliferation and enhancement of hydrogen peroxide production in fibrosarcoma cell line by weak radio frequency magnetic fields
title Inhibition of cellular proliferation and enhancement of hydrogen peroxide production in fibrosarcoma cell line by weak radio frequency magnetic fields
spellingShingle Inhibition of cellular proliferation and enhancement of hydrogen peroxide production in fibrosarcoma cell line by weak radio frequency magnetic fields
Castello, Pablo Raul
CANCER CELLS
CELLULAR GROWTH CURVES
HYDROGEN PEROXIDE
MAGNETIC FIELD EFFECTS
RADICAL PAIR MECHANISM
RADIO FREQUENCY
title_short Inhibition of cellular proliferation and enhancement of hydrogen peroxide production in fibrosarcoma cell line by weak radio frequency magnetic fields
title_full Inhibition of cellular proliferation and enhancement of hydrogen peroxide production in fibrosarcoma cell line by weak radio frequency magnetic fields
title_fullStr Inhibition of cellular proliferation and enhancement of hydrogen peroxide production in fibrosarcoma cell line by weak radio frequency magnetic fields
title_full_unstemmed Inhibition of cellular proliferation and enhancement of hydrogen peroxide production in fibrosarcoma cell line by weak radio frequency magnetic fields
title_sort Inhibition of cellular proliferation and enhancement of hydrogen peroxide production in fibrosarcoma cell line by weak radio frequency magnetic fields
dc.creator.none.fl_str_mv Castello, Pablo Raul
Hill, Iain
Sivo, Frank
Portelli, Lucas
Barnes, Frank
Usselman, Robert
Martino, Carlos F.
author Castello, Pablo Raul
author_facet Castello, Pablo Raul
Hill, Iain
Sivo, Frank
Portelli, Lucas
Barnes, Frank
Usselman, Robert
Martino, Carlos F.
author_role author
author2 Hill, Iain
Sivo, Frank
Portelli, Lucas
Barnes, Frank
Usselman, Robert
Martino, Carlos F.
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv CANCER CELLS
CELLULAR GROWTH CURVES
HYDROGEN PEROXIDE
MAGNETIC FIELD EFFECTS
RADICAL PAIR MECHANISM
RADIO FREQUENCY
topic CANCER CELLS
CELLULAR GROWTH CURVES
HYDROGEN PEROXIDE
MAGNETIC FIELD EFFECTS
RADICAL PAIR MECHANISM
RADIO FREQUENCY
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv This study presents experimental data for the effects of weak radio frequency (RF) magnetic fields on hydrogen peroxide (H2O2) production and cellular growth rates of fibrosarcoma HT1080 cells in vitro. Cells were exposed either to 45μT static magnetic fields (SMFs)-oriented vertical to the plane of growth or to SMFs combined with weak 5 and 10MHz RF magnetic fields of 10μTRMS intensity perpendicular to the static field. Cell numbers were reduced up to 30% on Day 2 for the cells exposed to the combination of SMF and a 10MHz RF magnetic field compared with the SMF control cells. In addition, cells exposed to 10MHz RF magnetic fields for 8h increased H2O2 production by 55%. The results demonstrate an overall magnetic field-induced biological effect that shows elevated H2O2 levels with accompanying decrease in cellular growth rates.
Fil: Castello, Pablo Raul. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; Argentina. Universidad de Nevada; Estados Unidos
Fil: Hill, Iain. Universidad de Nevada; Estados Unidos
Fil: Sivo, Frank. State University of Colorado at Boulder; Estados Unidos
Fil: Portelli, Lucas. State University of Colorado at Boulder; Estados Unidos
Fil: Barnes, Frank. State University of Colorado at Boulder; Estados Unidos
Fil: Usselman, Robert. National Institute of Standards and Technology; Estados Unidos
Fil: Martino, Carlos F.. Universidad de Nevada; Estados Unidos. University Hospital RWTH Aachen; Alemania
description This study presents experimental data for the effects of weak radio frequency (RF) magnetic fields on hydrogen peroxide (H2O2) production and cellular growth rates of fibrosarcoma HT1080 cells in vitro. Cells were exposed either to 45μT static magnetic fields (SMFs)-oriented vertical to the plane of growth or to SMFs combined with weak 5 and 10MHz RF magnetic fields of 10μTRMS intensity perpendicular to the static field. Cell numbers were reduced up to 30% on Day 2 for the cells exposed to the combination of SMF and a 10MHz RF magnetic field compared with the SMF control cells. In addition, cells exposed to 10MHz RF magnetic fields for 8h increased H2O2 production by 55%. The results demonstrate an overall magnetic field-induced biological effect that shows elevated H2O2 levels with accompanying decrease in cellular growth rates.
publishDate 2014
dc.date.none.fl_str_mv 2014-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/99233
Castello, Pablo Raul; Hill, Iain; Sivo, Frank; Portelli, Lucas; Barnes, Frank; et al.; Inhibition of cellular proliferation and enhancement of hydrogen peroxide production in fibrosarcoma cell line by weak radio frequency magnetic fields; Wiley-liss, Div John Wiley & Sons Inc; Bioelectromagnetics.; 35; 8; 12-2014; 598-602
0197-8462
CONICET Digital
CONICET
url http://hdl.handle.net/11336/99233
identifier_str_mv Castello, Pablo Raul; Hill, Iain; Sivo, Frank; Portelli, Lucas; Barnes, Frank; et al.; Inhibition of cellular proliferation and enhancement of hydrogen peroxide production in fibrosarcoma cell line by weak radio frequency magnetic fields; Wiley-liss, Div John Wiley & Sons Inc; Bioelectromagnetics.; 35; 8; 12-2014; 598-602
0197-8462
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/full/10.1002/bem.21858
info:eu-repo/semantics/altIdentifier/doi/10.1002/bem.21858
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley-liss, Div John Wiley & Sons Inc
publisher.none.fl_str_mv Wiley-liss, Div John Wiley & Sons Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844614372816584704
score 13.070432

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