Migration of titanium dioxide microparticles and nanoparticles through the body and deposition in the gingiva: an experimental study in rats

Autores
Guglielmotti, Maria Beatriz; Domingo, Mariela G.; Steimetz, Tammy; Ramos, Emilio; Paparella, María L.; Olmedo, Daniel Gustavo
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The aim of this experimental work was to evaluate deposition of titanium dioxide (TiO2) microparticles and nanoparticles, which could originate from titanium bioimplants, in the gingiva. Wistar rats were injected intraperitoneally (i.p.) with a suspension of TiO2 particles of different sizes (150, 10, or 5 nm). The rats were killed 12 months post-injection, and the buccal and lingual gingivae were resected and evaluated using light and scanning electron microscopy. Energy-dispersive X-ray spectroscopy (EDS) was used to confirm the presence of titanium in deposits of microparticles and nanoparticles, and the concentration of titanium in tissues was measured using inductively coupled plasma–mass spectrometry (ICP-MS). Histological examination showed that all experimental groups exhibited agglomerates, in the gingiva, of titanium particles of micrometer size range, with no associated inflammatory response. Higher concentrations of titanium traces were shown, by ICP-MS, in both buccal and lingual tissues of all experimental groups compared with their matched controls. Titanium concentrations were significantly higher in the buccal gingiva than in the lingual gingiva, and after injection with 5-nm particles than with 10-nm particles in both localizations. Titanium microparticles and nanoparticles deposit in the gingiva, and mostly on the buccal side. Gingival deposition of titanium could be considered a tissue indicator of tribocorrosion processes of titanium bioimplants.
Fil: Guglielmotti, Maria Beatriz. Universidad de Buenos Aires. Facultad de Odontología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Domingo, Mariela G.. Universidad de Buenos Aires. Facultad de Odontología; Argentina. Consejo Interuniversitario Nacional; Argentina
Fil: Steimetz, Tammy. Universidad de Buenos Aires. Facultad de Odontología; Argentina
Fil: Ramos, Emilio. Universidad de Buenos Aires. Facultad de Odontología; Argentina
Fil: Paparella, María L.. Universidad de Buenos Aires. Facultad de Odontología; Argentina
Fil: Olmedo, Daniel Gustavo. Universidad de Buenos Aires. Facultad de Odontología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
Corrosion
Gingiva
Microparticles
Nanoparticles
Titanium
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/15956
Acceder
id CONICETDig_413953e1ae7e9b90e5c8ccc1bf211076
oai_identifier_str oai:ri.conicet.gov.ar:11336/15956
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Migration of titanium dioxide microparticles and nanoparticles through the body and deposition in the gingiva: an experimental study in ratsGuglielmotti, Maria BeatrizDomingo, Mariela G.Steimetz, TammyRamos, EmilioPaparella, María L.Olmedo, Daniel GustavoCorrosionGingivaMicroparticlesNanoparticlesTitaniumhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3The aim of this experimental work was to evaluate deposition of titanium dioxide (TiO2) microparticles and nanoparticles, which could originate from titanium bioimplants, in the gingiva. Wistar rats were injected intraperitoneally (i.p.) with a suspension of TiO2 particles of different sizes (150, 10, or 5 nm). The rats were killed 12 months post-injection, and the buccal and lingual gingivae were resected and evaluated using light and scanning electron microscopy. Energy-dispersive X-ray spectroscopy (EDS) was used to confirm the presence of titanium in deposits of microparticles and nanoparticles, and the concentration of titanium in tissues was measured using inductively coupled plasma–mass spectrometry (ICP-MS). Histological examination showed that all experimental groups exhibited agglomerates, in the gingiva, of titanium particles of micrometer size range, with no associated inflammatory response. Higher concentrations of titanium traces were shown, by ICP-MS, in both buccal and lingual tissues of all experimental groups compared with their matched controls. Titanium concentrations were significantly higher in the buccal gingiva than in the lingual gingiva, and after injection with 5-nm particles than with 10-nm particles in both localizations. Titanium microparticles and nanoparticles deposit in the gingiva, and mostly on the buccal side. Gingival deposition of titanium could be considered a tissue indicator of tribocorrosion processes of titanium bioimplants.Fil: Guglielmotti, Maria Beatriz. Universidad de Buenos Aires. Facultad de Odontología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Domingo, Mariela G.. Universidad de Buenos Aires. Facultad de Odontología; Argentina. Consejo Interuniversitario Nacional; ArgentinaFil: Steimetz, Tammy. Universidad de Buenos Aires. Facultad de Odontología; ArgentinaFil: Ramos, Emilio. Universidad de Buenos Aires. Facultad de Odontología; ArgentinaFil: Paparella, María L.. Universidad de Buenos Aires. Facultad de Odontología; ArgentinaFil: Olmedo, Daniel Gustavo. Universidad de Buenos Aires. Facultad de Odontología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaWiley2015-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/15956Guglielmotti, Maria Beatriz; Domingo, Mariela G.; Steimetz, Tammy; Ramos, Emilio; Paparella, María L.; et al.; Migration of titanium dioxide microparticles and nanoparticles through the body and deposition in the gingiva: an experimental study in rats; Wiley; European Journal Of Oral Sciences; 123; 4; 8-2015; 242-2480909-88361600-0722enginfo:eu-repo/semantics/altIdentifier/doi/10.1111/eos.12190info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1111/eos.12190/abstractinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:50:40Zoai:ri.conicet.gov.ar:11336/15956instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:50:40.851CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Migration of titanium dioxide microparticles and nanoparticles through the body and deposition in the gingiva: an experimental study in rats
title Migration of titanium dioxide microparticles and nanoparticles through the body and deposition in the gingiva: an experimental study in rats
spellingShingle Migration of titanium dioxide microparticles and nanoparticles through the body and deposition in the gingiva: an experimental study in rats
Guglielmotti, Maria Beatriz
Corrosion
Gingiva
Microparticles
Nanoparticles
Titanium
title_short Migration of titanium dioxide microparticles and nanoparticles through the body and deposition in the gingiva: an experimental study in rats
title_full Migration of titanium dioxide microparticles and nanoparticles through the body and deposition in the gingiva: an experimental study in rats
title_fullStr Migration of titanium dioxide microparticles and nanoparticles through the body and deposition in the gingiva: an experimental study in rats
title_full_unstemmed Migration of titanium dioxide microparticles and nanoparticles through the body and deposition in the gingiva: an experimental study in rats
title_sort Migration of titanium dioxide microparticles and nanoparticles through the body and deposition in the gingiva: an experimental study in rats
dc.creator.none.fl_str_mv Guglielmotti, Maria Beatriz
Domingo, Mariela G.
Steimetz, Tammy
Ramos, Emilio
Paparella, María L.
Olmedo, Daniel Gustavo
author Guglielmotti, Maria Beatriz
author_facet Guglielmotti, Maria Beatriz
Domingo, Mariela G.
Steimetz, Tammy
Ramos, Emilio
Paparella, María L.
Olmedo, Daniel Gustavo
author_role author
author2 Domingo, Mariela G.
Steimetz, Tammy
Ramos, Emilio
Paparella, María L.
Olmedo, Daniel Gustavo
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Corrosion
Gingiva
Microparticles
Nanoparticles
Titanium
topic Corrosion
Gingiva
Microparticles
Nanoparticles
Titanium
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The aim of this experimental work was to evaluate deposition of titanium dioxide (TiO2) microparticles and nanoparticles, which could originate from titanium bioimplants, in the gingiva. Wistar rats were injected intraperitoneally (i.p.) with a suspension of TiO2 particles of different sizes (150, 10, or 5 nm). The rats were killed 12 months post-injection, and the buccal and lingual gingivae were resected and evaluated using light and scanning electron microscopy. Energy-dispersive X-ray spectroscopy (EDS) was used to confirm the presence of titanium in deposits of microparticles and nanoparticles, and the concentration of titanium in tissues was measured using inductively coupled plasma–mass spectrometry (ICP-MS). Histological examination showed that all experimental groups exhibited agglomerates, in the gingiva, of titanium particles of micrometer size range, with no associated inflammatory response. Higher concentrations of titanium traces were shown, by ICP-MS, in both buccal and lingual tissues of all experimental groups compared with their matched controls. Titanium concentrations were significantly higher in the buccal gingiva than in the lingual gingiva, and after injection with 5-nm particles than with 10-nm particles in both localizations. Titanium microparticles and nanoparticles deposit in the gingiva, and mostly on the buccal side. Gingival deposition of titanium could be considered a tissue indicator of tribocorrosion processes of titanium bioimplants.
Fil: Guglielmotti, Maria Beatriz. Universidad de Buenos Aires. Facultad de Odontología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Domingo, Mariela G.. Universidad de Buenos Aires. Facultad de Odontología; Argentina. Consejo Interuniversitario Nacional; Argentina
Fil: Steimetz, Tammy. Universidad de Buenos Aires. Facultad de Odontología; Argentina
Fil: Ramos, Emilio. Universidad de Buenos Aires. Facultad de Odontología; Argentina
Fil: Paparella, María L.. Universidad de Buenos Aires. Facultad de Odontología; Argentina
Fil: Olmedo, Daniel Gustavo. Universidad de Buenos Aires. Facultad de Odontología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description The aim of this experimental work was to evaluate deposition of titanium dioxide (TiO2) microparticles and nanoparticles, which could originate from titanium bioimplants, in the gingiva. Wistar rats were injected intraperitoneally (i.p.) with a suspension of TiO2 particles of different sizes (150, 10, or 5 nm). The rats were killed 12 months post-injection, and the buccal and lingual gingivae were resected and evaluated using light and scanning electron microscopy. Energy-dispersive X-ray spectroscopy (EDS) was used to confirm the presence of titanium in deposits of microparticles and nanoparticles, and the concentration of titanium in tissues was measured using inductively coupled plasma–mass spectrometry (ICP-MS). Histological examination showed that all experimental groups exhibited agglomerates, in the gingiva, of titanium particles of micrometer size range, with no associated inflammatory response. Higher concentrations of titanium traces were shown, by ICP-MS, in both buccal and lingual tissues of all experimental groups compared with their matched controls. Titanium concentrations were significantly higher in the buccal gingiva than in the lingual gingiva, and after injection with 5-nm particles than with 10-nm particles in both localizations. Titanium microparticles and nanoparticles deposit in the gingiva, and mostly on the buccal side. Gingival deposition of titanium could be considered a tissue indicator of tribocorrosion processes of titanium bioimplants.
publishDate 2015
dc.date.none.fl_str_mv 2015-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/15956
Guglielmotti, Maria Beatriz; Domingo, Mariela G.; Steimetz, Tammy; Ramos, Emilio; Paparella, María L.; et al.; Migration of titanium dioxide microparticles and nanoparticles through the body and deposition in the gingiva: an experimental study in rats; Wiley; European Journal Of Oral Sciences; 123; 4; 8-2015; 242-248
0909-8836
1600-0722
url http://hdl.handle.net/11336/15956
identifier_str_mv Guglielmotti, Maria Beatriz; Domingo, Mariela G.; Steimetz, Tammy; Ramos, Emilio; Paparella, María L.; et al.; Migration of titanium dioxide microparticles and nanoparticles through the body and deposition in the gingiva: an experimental study in rats; Wiley; European Journal Of Oral Sciences; 123; 4; 8-2015; 242-248
0909-8836
1600-0722
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1111/eos.12190
info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1111/eos.12190/abstract
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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