In vivo comparative biokinetics and biocompatibility of titanium and zirconium microparticles.

Autores
Olmedo, Daniel Gustavo; Tasat, Deborah R.; Evelson, Pablo Andres; Rebagliatti, Raúl; Guglielmotti, Maria Beatriz; Cabrini, Rómulo L.
Año de publicación
2011
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Titanium and zirconium are biomaterials that present a layer of titanium dioxide (TiO(2)) or zirconium dioxide (ZrO(2)). As a result of corrosion, microparticles can be released into the bioenvironment, and their effect on tissues is seemingly associated with differences in the physicochemical properties of these metals. The aim of this study was to perform a long-term evaluation of the distribution, destination, and potential risk of TiO(2) and ZrO(2) microparticles that might result from the corrosion process. Wistar rats were i.p. injected with an equal dose of either TiO(2) or ZrO(2) suspension. The following end-points were evaluated at 3, 6, and 18 months: (a) the presence of particles in blood cells and liver and lung tissue, (b) Ti and Zr deposit quantitation, (c) oxidant-antioxidant balance in tissues, and (d) O(2)(-) generation in alveolar macrophages. Ti and Zr particles were detected in blood mononuclear cells and in organ parenchyma. At equal doses and times postadministration, Ti content in organs was consistently higher than Zr content. Ti elicited a significant increase in O(2)(-) generation in the lung compared to Zr. The consumption of antioxidant enzymes was greater in the Ti than in the Zr group. The present study shows that the biokinetics of TiO(2) and ZrO(2) depends on particle size, shape, and/or crystal structure.
Fil: Olmedo, Daniel Gustavo. Universidad de Buenos Aires. Facultad de Odontología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
Fil: Tasat, Deborah R.. Universidad de Buenos Aires. Facultad de Odontología; Argentina. Universidad Nacional de San Martín; Argentina
Fil: Evelson, Pablo Andres. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Rebagliatti, Raúl. Comision Nacional de Energia Atomica; Argentina
Fil: Guglielmotti, Maria Beatriz. Universidad de Buenos Aires. Facultad de Odontología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
Fil: Cabrini, Rómulo L.. Comision Nacional de Energia Atomica; Argentina. Universidad de Buenos Aires. Facultad de Odontología; Argentina
Materia
Titanium
Zirconium
Microparticles
Biokinetics
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/13311
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/13311
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling In vivo comparative biokinetics and biocompatibility of titanium and zirconium microparticles.Olmedo, Daniel GustavoTasat, Deborah R.Evelson, Pablo AndresRebagliatti, RaúlGuglielmotti, Maria BeatrizCabrini, Rómulo L.TitaniumZirconiumMicroparticlesBiokineticshttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Titanium and zirconium are biomaterials that present a layer of titanium dioxide (TiO(2)) or zirconium dioxide (ZrO(2)). As a result of corrosion, microparticles can be released into the bioenvironment, and their effect on tissues is seemingly associated with differences in the physicochemical properties of these metals. The aim of this study was to perform a long-term evaluation of the distribution, destination, and potential risk of TiO(2) and ZrO(2) microparticles that might result from the corrosion process. Wistar rats were i.p. injected with an equal dose of either TiO(2) or ZrO(2) suspension. The following end-points were evaluated at 3, 6, and 18 months: (a) the presence of particles in blood cells and liver and lung tissue, (b) Ti and Zr deposit quantitation, (c) oxidant-antioxidant balance in tissues, and (d) O(2)(-) generation in alveolar macrophages. Ti and Zr particles were detected in blood mononuclear cells and in organ parenchyma. At equal doses and times postadministration, Ti content in organs was consistently higher than Zr content. Ti elicited a significant increase in O(2)(-) generation in the lung compared to Zr. The consumption of antioxidant enzymes was greater in the Ti than in the Zr group. The present study shows that the biokinetics of TiO(2) and ZrO(2) depends on particle size, shape, and/or crystal structure.Fil: Olmedo, Daniel Gustavo. Universidad de Buenos Aires. Facultad de Odontología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; ArgentinaFil: Tasat, Deborah R.. Universidad de Buenos Aires. Facultad de Odontología; Argentina. Universidad Nacional de San Martín; ArgentinaFil: Evelson, Pablo Andres. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; ArgentinaFil: Rebagliatti, Raúl. Comision Nacional de Energia Atomica; ArgentinaFil: Guglielmotti, Maria Beatriz. Universidad de Buenos Aires. Facultad de Odontología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; ArgentinaFil: Cabrini, Rómulo L.. Comision Nacional de Energia Atomica; Argentina. Universidad de Buenos Aires. Facultad de Odontología; ArgentinaWiley2011-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/13311Olmedo, Daniel Gustavo; Tasat, Deborah R.; Evelson, Pablo Andres; Rebagliatti, Raúl; Guglielmotti, Maria Beatriz; et al.; In vivo comparative biokinetics and biocompatibility of titanium and zirconium microparticles.; Wiley; Journal Of Biomedical Materials Research Part A; 98A; 4; 9-2011; 604-6131549-3296enginfo:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1002/jbm.a.33145/abstractinfo:eu-repo/semantics/altIdentifier/doi/10.1002/jbm.a.33145info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:49:14Zoai:ri.conicet.gov.ar:11336/13311instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:49:14.335CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv In vivo comparative biokinetics and biocompatibility of titanium and zirconium microparticles.
title In vivo comparative biokinetics and biocompatibility of titanium and zirconium microparticles.
spellingShingle In vivo comparative biokinetics and biocompatibility of titanium and zirconium microparticles.
Olmedo, Daniel Gustavo
Titanium
Zirconium
Microparticles
Biokinetics
title_short In vivo comparative biokinetics and biocompatibility of titanium and zirconium microparticles.
title_full In vivo comparative biokinetics and biocompatibility of titanium and zirconium microparticles.
title_fullStr In vivo comparative biokinetics and biocompatibility of titanium and zirconium microparticles.
title_full_unstemmed In vivo comparative biokinetics and biocompatibility of titanium and zirconium microparticles.
title_sort In vivo comparative biokinetics and biocompatibility of titanium and zirconium microparticles.
dc.creator.none.fl_str_mv Olmedo, Daniel Gustavo
Tasat, Deborah R.
Evelson, Pablo Andres
Rebagliatti, Raúl
Guglielmotti, Maria Beatriz
Cabrini, Rómulo L.
author Olmedo, Daniel Gustavo
author_facet Olmedo, Daniel Gustavo
Tasat, Deborah R.
Evelson, Pablo Andres
Rebagliatti, Raúl
Guglielmotti, Maria Beatriz
Cabrini, Rómulo L.
author_role author
author2 Tasat, Deborah R.
Evelson, Pablo Andres
Rebagliatti, Raúl
Guglielmotti, Maria Beatriz
Cabrini, Rómulo L.
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Titanium
Zirconium
Microparticles
Biokinetics
topic Titanium
Zirconium
Microparticles
Biokinetics
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Titanium and zirconium are biomaterials that present a layer of titanium dioxide (TiO(2)) or zirconium dioxide (ZrO(2)). As a result of corrosion, microparticles can be released into the bioenvironment, and their effect on tissues is seemingly associated with differences in the physicochemical properties of these metals. The aim of this study was to perform a long-term evaluation of the distribution, destination, and potential risk of TiO(2) and ZrO(2) microparticles that might result from the corrosion process. Wistar rats were i.p. injected with an equal dose of either TiO(2) or ZrO(2) suspension. The following end-points were evaluated at 3, 6, and 18 months: (a) the presence of particles in blood cells and liver and lung tissue, (b) Ti and Zr deposit quantitation, (c) oxidant-antioxidant balance in tissues, and (d) O(2)(-) generation in alveolar macrophages. Ti and Zr particles were detected in blood mononuclear cells and in organ parenchyma. At equal doses and times postadministration, Ti content in organs was consistently higher than Zr content. Ti elicited a significant increase in O(2)(-) generation in the lung compared to Zr. The consumption of antioxidant enzymes was greater in the Ti than in the Zr group. The present study shows that the biokinetics of TiO(2) and ZrO(2) depends on particle size, shape, and/or crystal structure.
Fil: Olmedo, Daniel Gustavo. Universidad de Buenos Aires. Facultad de Odontología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
Fil: Tasat, Deborah R.. Universidad de Buenos Aires. Facultad de Odontología; Argentina. Universidad Nacional de San Martín; Argentina
Fil: Evelson, Pablo Andres. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Rebagliatti, Raúl. Comision Nacional de Energia Atomica; Argentina
Fil: Guglielmotti, Maria Beatriz. Universidad de Buenos Aires. Facultad de Odontología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
Fil: Cabrini, Rómulo L.. Comision Nacional de Energia Atomica; Argentina. Universidad de Buenos Aires. Facultad de Odontología; Argentina
description Titanium and zirconium are biomaterials that present a layer of titanium dioxide (TiO(2)) or zirconium dioxide (ZrO(2)). As a result of corrosion, microparticles can be released into the bioenvironment, and their effect on tissues is seemingly associated with differences in the physicochemical properties of these metals. The aim of this study was to perform a long-term evaluation of the distribution, destination, and potential risk of TiO(2) and ZrO(2) microparticles that might result from the corrosion process. Wistar rats were i.p. injected with an equal dose of either TiO(2) or ZrO(2) suspension. The following end-points were evaluated at 3, 6, and 18 months: (a) the presence of particles in blood cells and liver and lung tissue, (b) Ti and Zr deposit quantitation, (c) oxidant-antioxidant balance in tissues, and (d) O(2)(-) generation in alveolar macrophages. Ti and Zr particles were detected in blood mononuclear cells and in organ parenchyma. At equal doses and times postadministration, Ti content in organs was consistently higher than Zr content. Ti elicited a significant increase in O(2)(-) generation in the lung compared to Zr. The consumption of antioxidant enzymes was greater in the Ti than in the Zr group. The present study shows that the biokinetics of TiO(2) and ZrO(2) depends on particle size, shape, and/or crystal structure.
publishDate 2011
dc.date.none.fl_str_mv 2011-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/13311
Olmedo, Daniel Gustavo; Tasat, Deborah R.; Evelson, Pablo Andres; Rebagliatti, Raúl; Guglielmotti, Maria Beatriz; et al.; In vivo comparative biokinetics and biocompatibility of titanium and zirconium microparticles.; Wiley; Journal Of Biomedical Materials Research Part A; 98A; 4; 9-2011; 604-613
1549-3296
url http://hdl.handle.net/11336/13311
identifier_str_mv Olmedo, Daniel Gustavo; Tasat, Deborah R.; Evelson, Pablo Andres; Rebagliatti, Raúl; Guglielmotti, Maria Beatriz; et al.; In vivo comparative biokinetics and biocompatibility of titanium and zirconium microparticles.; Wiley; Journal Of Biomedical Materials Research Part A; 98A; 4; 9-2011; 604-613
1549-3296
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1002/jbm.a.33145/abstract
info:eu-repo/semantics/altIdentifier/doi/10.1002/jbm.a.33145
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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