From Mechanisms to Implications: Understanding the Molecular Neurotoxicity of Titanium Dioxide Nanoparticles

Autores
Aschner, Michael; Skalny, Anatoly V.; Santamaria, Abel; Buha Djordjevic, Aleksandra; Tizabi, Yousef; Jiang, Yueming; Lu, Rongzhu; Virgolini, Miriam Beatriz; Tinkov, Alexey A.
Año de publicación
2023
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Titanium dioxide nanoparticles (TiO2NPs) are widely produced and used nanoparticles. Yet, TiO2NP exposure may possess toxic effects to different cells and tissues, including the brain. Recent studies significantly expanded the understanding of the molecular mechanisms underlying TiO2NP neurotoxicity implicating a number of both direct and indirect mechanisms. In view of the significant recent progress in research on TiO2NP neurotoxicity, the objective of the present study is to provide a narrative review on the molecular mechanisms involved in its neurotoxicity, with a special focus on the studies published in the last decade. The existing data demosntrate that although TiO2NP may cross blood-brain barrier and accumulate in brain, its neurotoxic effects may be mediated by systemic toxicity. In addition to neuronal damage and impaired neurogenesis, TiO2NP exposure also results in reduced neurite outgrowth and impaired neurotransmitter metabolism, especially dopamine and glutamate. TiO2NP exposure was also shown to promote α-synuclein and β-amyloid aggregation, thus increasing its toxicity. Recent findings also suggest that epigenetic effects and alterations in gut microbiota biodiversity contribute to TiO2NP neurotoxicity. Correspondingly, in vivo studies demosntrated that TiO2NPs induce a wide spectrum of adverse neurobehavioral effects, while epidemiological data are lacking. In addition, TiO2NPs were shown to promote neurotoxic effects of other toxic compounds. Here we show the contribution of a wide spectrum of molecular mechanisms to TiO2NP-induced neurotoxicity; yet, the role of TiO2NP exposure in adverse neurological outcomes in humans has yet to be fully appreciated.
Fil: Aschner, Michael. Albert Einstein College of Medicine; Estados Unidos
Fil: Skalny, Anatoly V.. Yaroslavl State University; Rusia
Fil: Santamaria, Abel. Universidad Nacional Autónoma de México; México
Fil: Buha Djordjevic, Aleksandra. University Of Belgrade; Serbia
Fil: Tizabi, Yousef. Howard University College of Medicine; Estados Unidos
Fil: Jiang, Yueming. Guangxi Medical University; China
Fil: Lu, Rongzhu. Jiangsu University; China
Fil: Virgolini, Miriam Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Farmacología Experimental de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Farmacología Experimental de Córdoba; Argentina
Fil: Tinkov, Alexey A.. Yaroslavl State University; Rusia
Materia
BRAIN
NANOPARTICLE
NEURODEGENERATION
NEUROINFLAMMATION
NEUROTOXICITY
TITANIUM
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/229939

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network_name_str CONICET Digital (CONICET)
spelling From Mechanisms to Implications: Understanding the Molecular Neurotoxicity of Titanium Dioxide NanoparticlesAschner, MichaelSkalny, Anatoly V.Santamaria, AbelBuha Djordjevic, AleksandraTizabi, YousefJiang, YuemingLu, RongzhuVirgolini, Miriam BeatrizTinkov, Alexey A.BRAINNANOPARTICLENEURODEGENERATIONNEUROINFLAMMATIONNEUROTOXICITYTITANIUMhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Titanium dioxide nanoparticles (TiO2NPs) are widely produced and used nanoparticles. Yet, TiO2NP exposure may possess toxic effects to different cells and tissues, including the brain. Recent studies significantly expanded the understanding of the molecular mechanisms underlying TiO2NP neurotoxicity implicating a number of both direct and indirect mechanisms. In view of the significant recent progress in research on TiO2NP neurotoxicity, the objective of the present study is to provide a narrative review on the molecular mechanisms involved in its neurotoxicity, with a special focus on the studies published in the last decade. The existing data demosntrate that although TiO2NP may cross blood-brain barrier and accumulate in brain, its neurotoxic effects may be mediated by systemic toxicity. In addition to neuronal damage and impaired neurogenesis, TiO2NP exposure also results in reduced neurite outgrowth and impaired neurotransmitter metabolism, especially dopamine and glutamate. TiO2NP exposure was also shown to promote α-synuclein and β-amyloid aggregation, thus increasing its toxicity. Recent findings also suggest that epigenetic effects and alterations in gut microbiota biodiversity contribute to TiO2NP neurotoxicity. Correspondingly, in vivo studies demosntrated that TiO2NPs induce a wide spectrum of adverse neurobehavioral effects, while epidemiological data are lacking. In addition, TiO2NPs were shown to promote neurotoxic effects of other toxic compounds. Here we show the contribution of a wide spectrum of molecular mechanisms to TiO2NP-induced neurotoxicity; yet, the role of TiO2NP exposure in adverse neurological outcomes in humans has yet to be fully appreciated.Fil: Aschner, Michael. Albert Einstein College of Medicine; Estados UnidosFil: Skalny, Anatoly V.. Yaroslavl State University; RusiaFil: Santamaria, Abel. Universidad Nacional Autónoma de México; MéxicoFil: Buha Djordjevic, Aleksandra. University Of Belgrade; SerbiaFil: Tizabi, Yousef. Howard University College of Medicine; Estados UnidosFil: Jiang, Yueming. Guangxi Medical University; ChinaFil: Lu, Rongzhu. Jiangsu University; ChinaFil: Virgolini, Miriam Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Farmacología Experimental de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Farmacología Experimental de Córdoba; ArgentinaFil: Tinkov, Alexey A.. Yaroslavl State University; RusiaIMR Press2023-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/229939Aschner, Michael; Skalny, Anatoly V.; Santamaria, Abel; Buha Djordjevic, Aleksandra; Tizabi, Yousef; et al.; From Mechanisms to Implications: Understanding the Molecular Neurotoxicity of Titanium Dioxide Nanoparticles; IMR Press; Frontiers in Bioscience - Landmark; 28; 9; 9-2023; 1-212768-67012768-6698CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.31083/j.fbl2809204info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:51:47Zoai:ri.conicet.gov.ar:11336/229939instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:51:48.008CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv From Mechanisms to Implications: Understanding the Molecular Neurotoxicity of Titanium Dioxide Nanoparticles
title From Mechanisms to Implications: Understanding the Molecular Neurotoxicity of Titanium Dioxide Nanoparticles
spellingShingle From Mechanisms to Implications: Understanding the Molecular Neurotoxicity of Titanium Dioxide Nanoparticles
Aschner, Michael
BRAIN
NANOPARTICLE
NEURODEGENERATION
NEUROINFLAMMATION
NEUROTOXICITY
TITANIUM
title_short From Mechanisms to Implications: Understanding the Molecular Neurotoxicity of Titanium Dioxide Nanoparticles
title_full From Mechanisms to Implications: Understanding the Molecular Neurotoxicity of Titanium Dioxide Nanoparticles
title_fullStr From Mechanisms to Implications: Understanding the Molecular Neurotoxicity of Titanium Dioxide Nanoparticles
title_full_unstemmed From Mechanisms to Implications: Understanding the Molecular Neurotoxicity of Titanium Dioxide Nanoparticles
title_sort From Mechanisms to Implications: Understanding the Molecular Neurotoxicity of Titanium Dioxide Nanoparticles
dc.creator.none.fl_str_mv Aschner, Michael
Skalny, Anatoly V.
Santamaria, Abel
Buha Djordjevic, Aleksandra
Tizabi, Yousef
Jiang, Yueming
Lu, Rongzhu
Virgolini, Miriam Beatriz
Tinkov, Alexey A.
author Aschner, Michael
author_facet Aschner, Michael
Skalny, Anatoly V.
Santamaria, Abel
Buha Djordjevic, Aleksandra
Tizabi, Yousef
Jiang, Yueming
Lu, Rongzhu
Virgolini, Miriam Beatriz
Tinkov, Alexey A.
author_role author
author2 Skalny, Anatoly V.
Santamaria, Abel
Buha Djordjevic, Aleksandra
Tizabi, Yousef
Jiang, Yueming
Lu, Rongzhu
Virgolini, Miriam Beatriz
Tinkov, Alexey A.
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv BRAIN
NANOPARTICLE
NEURODEGENERATION
NEUROINFLAMMATION
NEUROTOXICITY
TITANIUM
topic BRAIN
NANOPARTICLE
NEURODEGENERATION
NEUROINFLAMMATION
NEUROTOXICITY
TITANIUM
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Titanium dioxide nanoparticles (TiO2NPs) are widely produced and used nanoparticles. Yet, TiO2NP exposure may possess toxic effects to different cells and tissues, including the brain. Recent studies significantly expanded the understanding of the molecular mechanisms underlying TiO2NP neurotoxicity implicating a number of both direct and indirect mechanisms. In view of the significant recent progress in research on TiO2NP neurotoxicity, the objective of the present study is to provide a narrative review on the molecular mechanisms involved in its neurotoxicity, with a special focus on the studies published in the last decade. The existing data demosntrate that although TiO2NP may cross blood-brain barrier and accumulate in brain, its neurotoxic effects may be mediated by systemic toxicity. In addition to neuronal damage and impaired neurogenesis, TiO2NP exposure also results in reduced neurite outgrowth and impaired neurotransmitter metabolism, especially dopamine and glutamate. TiO2NP exposure was also shown to promote α-synuclein and β-amyloid aggregation, thus increasing its toxicity. Recent findings also suggest that epigenetic effects and alterations in gut microbiota biodiversity contribute to TiO2NP neurotoxicity. Correspondingly, in vivo studies demosntrated that TiO2NPs induce a wide spectrum of adverse neurobehavioral effects, while epidemiological data are lacking. In addition, TiO2NPs were shown to promote neurotoxic effects of other toxic compounds. Here we show the contribution of a wide spectrum of molecular mechanisms to TiO2NP-induced neurotoxicity; yet, the role of TiO2NP exposure in adverse neurological outcomes in humans has yet to be fully appreciated.
Fil: Aschner, Michael. Albert Einstein College of Medicine; Estados Unidos
Fil: Skalny, Anatoly V.. Yaroslavl State University; Rusia
Fil: Santamaria, Abel. Universidad Nacional Autónoma de México; México
Fil: Buha Djordjevic, Aleksandra. University Of Belgrade; Serbia
Fil: Tizabi, Yousef. Howard University College of Medicine; Estados Unidos
Fil: Jiang, Yueming. Guangxi Medical University; China
Fil: Lu, Rongzhu. Jiangsu University; China
Fil: Virgolini, Miriam Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Farmacología Experimental de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Farmacología Experimental de Córdoba; Argentina
Fil: Tinkov, Alexey A.. Yaroslavl State University; Rusia
description Titanium dioxide nanoparticles (TiO2NPs) are widely produced and used nanoparticles. Yet, TiO2NP exposure may possess toxic effects to different cells and tissues, including the brain. Recent studies significantly expanded the understanding of the molecular mechanisms underlying TiO2NP neurotoxicity implicating a number of both direct and indirect mechanisms. In view of the significant recent progress in research on TiO2NP neurotoxicity, the objective of the present study is to provide a narrative review on the molecular mechanisms involved in its neurotoxicity, with a special focus on the studies published in the last decade. The existing data demosntrate that although TiO2NP may cross blood-brain barrier and accumulate in brain, its neurotoxic effects may be mediated by systemic toxicity. In addition to neuronal damage and impaired neurogenesis, TiO2NP exposure also results in reduced neurite outgrowth and impaired neurotransmitter metabolism, especially dopamine and glutamate. TiO2NP exposure was also shown to promote α-synuclein and β-amyloid aggregation, thus increasing its toxicity. Recent findings also suggest that epigenetic effects and alterations in gut microbiota biodiversity contribute to TiO2NP neurotoxicity. Correspondingly, in vivo studies demosntrated that TiO2NPs induce a wide spectrum of adverse neurobehavioral effects, while epidemiological data are lacking. In addition, TiO2NPs were shown to promote neurotoxic effects of other toxic compounds. Here we show the contribution of a wide spectrum of molecular mechanisms to TiO2NP-induced neurotoxicity; yet, the role of TiO2NP exposure in adverse neurological outcomes in humans has yet to be fully appreciated.
publishDate 2023
dc.date.none.fl_str_mv 2023-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/229939
Aschner, Michael; Skalny, Anatoly V.; Santamaria, Abel; Buha Djordjevic, Aleksandra; Tizabi, Yousef; et al.; From Mechanisms to Implications: Understanding the Molecular Neurotoxicity of Titanium Dioxide Nanoparticles; IMR Press; Frontiers in Bioscience - Landmark; 28; 9; 9-2023; 1-21
2768-6701
2768-6698
CONICET Digital
CONICET
url http://hdl.handle.net/11336/229939
identifier_str_mv Aschner, Michael; Skalny, Anatoly V.; Santamaria, Abel; Buha Djordjevic, Aleksandra; Tizabi, Yousef; et al.; From Mechanisms to Implications: Understanding the Molecular Neurotoxicity of Titanium Dioxide Nanoparticles; IMR Press; Frontiers in Bioscience - Landmark; 28; 9; 9-2023; 1-21
2768-6701
2768-6698
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.31083/j.fbl2809204
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv IMR Press
publisher.none.fl_str_mv IMR Press
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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