From Mechanisms to Implications: Understanding the Molecular Neurotoxicity of Titanium Dioxide Nanoparticles
- Autores
- Aschner, Michael; Skalny, Anatoly V.; Santamaria, Abel; Buha Djordjevic, Aleksandra; Tizabi, Yousef; Jiang, Yueming; Lu, Rongzhu; Virgolini, Miriam Beatriz; Tinkov, Alexey A.
- Año de publicación
- 2023
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Titanium dioxide nanoparticles (TiO2NPs) are widely produced and used nanoparticles. Yet, TiO2NP exposure may possess toxic effects to different cells and tissues, including the brain. Recent studies significantly expanded the understanding of the molecular mechanisms underlying TiO2NP neurotoxicity implicating a number of both direct and indirect mechanisms. In view of the significant recent progress in research on TiO2NP neurotoxicity, the objective of the present study is to provide a narrative review on the molecular mechanisms involved in its neurotoxicity, with a special focus on the studies published in the last decade. The existing data demosntrate that although TiO2NP may cross blood-brain barrier and accumulate in brain, its neurotoxic effects may be mediated by systemic toxicity. In addition to neuronal damage and impaired neurogenesis, TiO2NP exposure also results in reduced neurite outgrowth and impaired neurotransmitter metabolism, especially dopamine and glutamate. TiO2NP exposure was also shown to promote α-synuclein and β-amyloid aggregation, thus increasing its toxicity. Recent findings also suggest that epigenetic effects and alterations in gut microbiota biodiversity contribute to TiO2NP neurotoxicity. Correspondingly, in vivo studies demosntrated that TiO2NPs induce a wide spectrum of adverse neurobehavioral effects, while epidemiological data are lacking. In addition, TiO2NPs were shown to promote neurotoxic effects of other toxic compounds. Here we show the contribution of a wide spectrum of molecular mechanisms to TiO2NP-induced neurotoxicity; yet, the role of TiO2NP exposure in adverse neurological outcomes in humans has yet to be fully appreciated.
Fil: Aschner, Michael. Albert Einstein College of Medicine; Estados Unidos
Fil: Skalny, Anatoly V.. Yaroslavl State University; Rusia
Fil: Santamaria, Abel. Universidad Nacional Autónoma de México; México
Fil: Buha Djordjevic, Aleksandra. University Of Belgrade; Serbia
Fil: Tizabi, Yousef. Howard University College of Medicine; Estados Unidos
Fil: Jiang, Yueming. Guangxi Medical University; China
Fil: Lu, Rongzhu. Jiangsu University; China
Fil: Virgolini, Miriam Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Farmacología Experimental de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Farmacología Experimental de Córdoba; Argentina
Fil: Tinkov, Alexey A.. Yaroslavl State University; Rusia - Materia
-
BRAIN
NANOPARTICLE
NEURODEGENERATION
NEUROINFLAMMATION
NEUROTOXICITY
TITANIUM - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/229939
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From Mechanisms to Implications: Understanding the Molecular Neurotoxicity of Titanium Dioxide NanoparticlesAschner, MichaelSkalny, Anatoly V.Santamaria, AbelBuha Djordjevic, AleksandraTizabi, YousefJiang, YuemingLu, RongzhuVirgolini, Miriam BeatrizTinkov, Alexey A.BRAINNANOPARTICLENEURODEGENERATIONNEUROINFLAMMATIONNEUROTOXICITYTITANIUMhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Titanium dioxide nanoparticles (TiO2NPs) are widely produced and used nanoparticles. Yet, TiO2NP exposure may possess toxic effects to different cells and tissues, including the brain. Recent studies significantly expanded the understanding of the molecular mechanisms underlying TiO2NP neurotoxicity implicating a number of both direct and indirect mechanisms. In view of the significant recent progress in research on TiO2NP neurotoxicity, the objective of the present study is to provide a narrative review on the molecular mechanisms involved in its neurotoxicity, with a special focus on the studies published in the last decade. The existing data demosntrate that although TiO2NP may cross blood-brain barrier and accumulate in brain, its neurotoxic effects may be mediated by systemic toxicity. In addition to neuronal damage and impaired neurogenesis, TiO2NP exposure also results in reduced neurite outgrowth and impaired neurotransmitter metabolism, especially dopamine and glutamate. TiO2NP exposure was also shown to promote α-synuclein and β-amyloid aggregation, thus increasing its toxicity. Recent findings also suggest that epigenetic effects and alterations in gut microbiota biodiversity contribute to TiO2NP neurotoxicity. Correspondingly, in vivo studies demosntrated that TiO2NPs induce a wide spectrum of adverse neurobehavioral effects, while epidemiological data are lacking. In addition, TiO2NPs were shown to promote neurotoxic effects of other toxic compounds. Here we show the contribution of a wide spectrum of molecular mechanisms to TiO2NP-induced neurotoxicity; yet, the role of TiO2NP exposure in adverse neurological outcomes in humans has yet to be fully appreciated.Fil: Aschner, Michael. Albert Einstein College of Medicine; Estados UnidosFil: Skalny, Anatoly V.. Yaroslavl State University; RusiaFil: Santamaria, Abel. Universidad Nacional Autónoma de México; MéxicoFil: Buha Djordjevic, Aleksandra. University Of Belgrade; SerbiaFil: Tizabi, Yousef. Howard University College of Medicine; Estados UnidosFil: Jiang, Yueming. Guangxi Medical University; ChinaFil: Lu, Rongzhu. Jiangsu University; ChinaFil: Virgolini, Miriam Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Farmacología Experimental de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Farmacología Experimental de Córdoba; ArgentinaFil: Tinkov, Alexey A.. Yaroslavl State University; RusiaIMR Press2023-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/229939Aschner, Michael; Skalny, Anatoly V.; Santamaria, Abel; Buha Djordjevic, Aleksandra; Tizabi, Yousef; et al.; From Mechanisms to Implications: Understanding the Molecular Neurotoxicity of Titanium Dioxide Nanoparticles; IMR Press; Frontiers in Bioscience - Landmark; 28; 9; 9-2023; 1-212768-67012768-6698CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.31083/j.fbl2809204info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:51:47Zoai:ri.conicet.gov.ar:11336/229939instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:51:48.008CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
From Mechanisms to Implications: Understanding the Molecular Neurotoxicity of Titanium Dioxide Nanoparticles |
title |
From Mechanisms to Implications: Understanding the Molecular Neurotoxicity of Titanium Dioxide Nanoparticles |
spellingShingle |
From Mechanisms to Implications: Understanding the Molecular Neurotoxicity of Titanium Dioxide Nanoparticles Aschner, Michael BRAIN NANOPARTICLE NEURODEGENERATION NEUROINFLAMMATION NEUROTOXICITY TITANIUM |
title_short |
From Mechanisms to Implications: Understanding the Molecular Neurotoxicity of Titanium Dioxide Nanoparticles |
title_full |
From Mechanisms to Implications: Understanding the Molecular Neurotoxicity of Titanium Dioxide Nanoparticles |
title_fullStr |
From Mechanisms to Implications: Understanding the Molecular Neurotoxicity of Titanium Dioxide Nanoparticles |
title_full_unstemmed |
From Mechanisms to Implications: Understanding the Molecular Neurotoxicity of Titanium Dioxide Nanoparticles |
title_sort |
From Mechanisms to Implications: Understanding the Molecular Neurotoxicity of Titanium Dioxide Nanoparticles |
dc.creator.none.fl_str_mv |
Aschner, Michael Skalny, Anatoly V. Santamaria, Abel Buha Djordjevic, Aleksandra Tizabi, Yousef Jiang, Yueming Lu, Rongzhu Virgolini, Miriam Beatriz Tinkov, Alexey A. |
author |
Aschner, Michael |
author_facet |
Aschner, Michael Skalny, Anatoly V. Santamaria, Abel Buha Djordjevic, Aleksandra Tizabi, Yousef Jiang, Yueming Lu, Rongzhu Virgolini, Miriam Beatriz Tinkov, Alexey A. |
author_role |
author |
author2 |
Skalny, Anatoly V. Santamaria, Abel Buha Djordjevic, Aleksandra Tizabi, Yousef Jiang, Yueming Lu, Rongzhu Virgolini, Miriam Beatriz Tinkov, Alexey A. |
author2_role |
author author author author author author author author |
dc.subject.none.fl_str_mv |
BRAIN NANOPARTICLE NEURODEGENERATION NEUROINFLAMMATION NEUROTOXICITY TITANIUM |
topic |
BRAIN NANOPARTICLE NEURODEGENERATION NEUROINFLAMMATION NEUROTOXICITY TITANIUM |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
Titanium dioxide nanoparticles (TiO2NPs) are widely produced and used nanoparticles. Yet, TiO2NP exposure may possess toxic effects to different cells and tissues, including the brain. Recent studies significantly expanded the understanding of the molecular mechanisms underlying TiO2NP neurotoxicity implicating a number of both direct and indirect mechanisms. In view of the significant recent progress in research on TiO2NP neurotoxicity, the objective of the present study is to provide a narrative review on the molecular mechanisms involved in its neurotoxicity, with a special focus on the studies published in the last decade. The existing data demosntrate that although TiO2NP may cross blood-brain barrier and accumulate in brain, its neurotoxic effects may be mediated by systemic toxicity. In addition to neuronal damage and impaired neurogenesis, TiO2NP exposure also results in reduced neurite outgrowth and impaired neurotransmitter metabolism, especially dopamine and glutamate. TiO2NP exposure was also shown to promote α-synuclein and β-amyloid aggregation, thus increasing its toxicity. Recent findings also suggest that epigenetic effects and alterations in gut microbiota biodiversity contribute to TiO2NP neurotoxicity. Correspondingly, in vivo studies demosntrated that TiO2NPs induce a wide spectrum of adverse neurobehavioral effects, while epidemiological data are lacking. In addition, TiO2NPs were shown to promote neurotoxic effects of other toxic compounds. Here we show the contribution of a wide spectrum of molecular mechanisms to TiO2NP-induced neurotoxicity; yet, the role of TiO2NP exposure in adverse neurological outcomes in humans has yet to be fully appreciated. Fil: Aschner, Michael. Albert Einstein College of Medicine; Estados Unidos Fil: Skalny, Anatoly V.. Yaroslavl State University; Rusia Fil: Santamaria, Abel. Universidad Nacional Autónoma de México; México Fil: Buha Djordjevic, Aleksandra. University Of Belgrade; Serbia Fil: Tizabi, Yousef. Howard University College of Medicine; Estados Unidos Fil: Jiang, Yueming. Guangxi Medical University; China Fil: Lu, Rongzhu. Jiangsu University; China Fil: Virgolini, Miriam Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Farmacología Experimental de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Farmacología Experimental de Córdoba; Argentina Fil: Tinkov, Alexey A.. Yaroslavl State University; Rusia |
description |
Titanium dioxide nanoparticles (TiO2NPs) are widely produced and used nanoparticles. Yet, TiO2NP exposure may possess toxic effects to different cells and tissues, including the brain. Recent studies significantly expanded the understanding of the molecular mechanisms underlying TiO2NP neurotoxicity implicating a number of both direct and indirect mechanisms. In view of the significant recent progress in research on TiO2NP neurotoxicity, the objective of the present study is to provide a narrative review on the molecular mechanisms involved in its neurotoxicity, with a special focus on the studies published in the last decade. The existing data demosntrate that although TiO2NP may cross blood-brain barrier and accumulate in brain, its neurotoxic effects may be mediated by systemic toxicity. In addition to neuronal damage and impaired neurogenesis, TiO2NP exposure also results in reduced neurite outgrowth and impaired neurotransmitter metabolism, especially dopamine and glutamate. TiO2NP exposure was also shown to promote α-synuclein and β-amyloid aggregation, thus increasing its toxicity. Recent findings also suggest that epigenetic effects and alterations in gut microbiota biodiversity contribute to TiO2NP neurotoxicity. Correspondingly, in vivo studies demosntrated that TiO2NPs induce a wide spectrum of adverse neurobehavioral effects, while epidemiological data are lacking. In addition, TiO2NPs were shown to promote neurotoxic effects of other toxic compounds. Here we show the contribution of a wide spectrum of molecular mechanisms to TiO2NP-induced neurotoxicity; yet, the role of TiO2NP exposure in adverse neurological outcomes in humans has yet to be fully appreciated. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-09 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/229939 Aschner, Michael; Skalny, Anatoly V.; Santamaria, Abel; Buha Djordjevic, Aleksandra; Tizabi, Yousef; et al.; From Mechanisms to Implications: Understanding the Molecular Neurotoxicity of Titanium Dioxide Nanoparticles; IMR Press; Frontiers in Bioscience - Landmark; 28; 9; 9-2023; 1-21 2768-6701 2768-6698 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/229939 |
identifier_str_mv |
Aschner, Michael; Skalny, Anatoly V.; Santamaria, Abel; Buha Djordjevic, Aleksandra; Tizabi, Yousef; et al.; From Mechanisms to Implications: Understanding the Molecular Neurotoxicity of Titanium Dioxide Nanoparticles; IMR Press; Frontiers in Bioscience - Landmark; 28; 9; 9-2023; 1-21 2768-6701 2768-6698 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.31083/j.fbl2809204 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
IMR Press |
publisher.none.fl_str_mv |
IMR Press |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) |
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CONICET Digital (CONICET) |
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Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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13.070432 |