Evolution of Trypanosoma cruzi: clarifying hybridisations, mitochondrial introgressions and phylogenetic relationships between major lineages

Autores
Tomasini, Nicolás; Diosque, Patricio
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Different models of evolution of Trypanosoma cruzi have been proposed. These models suggest scarce events of genetic exchange in the evolutionary history of this parasite. In addition, the debate focused on the existence of one or two hybridization events during the evolution of T. cruzi lineages. Here we reviewed literature and analyzed available sequence data in order to clarify the phylogenetic relationships among lineages. We observed that TcI, TcIII and TcIV form a monophyletic group and consequently TcIII and TcIV are not, as previously suggested, TcI-TcII hybrids. Particularly, TcI and TcIII are sister groups that diverged around the same time that a widely distributed TcIV was splitted into two clades (TcIVS and TcIVN). In addition, we collected evidence that TcIII received the TcIVS kDNA by introgression at several opportunities. Different demographic hypotheses (surfing and asymmetrical introgression) may explain the origin and expansion of the TcIII group. Considering these hypotheses, genetic exchange should have been relatively frequent between TcIII and TcIVS in the geographic area in which their distributions were superimposed. In addition, our results support the hypothesis that two independent hybridization events gave origin to TcV and TcVI. Consequently, TcIVS kDNA was first transferred to TcIII and later to TcV and TcVI in TcII/TcIII hybridization events.
Fil: Tomasini, Nicolás. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Salta. Instituto de Patología Experimental; Argentina
Fil: Diosque, Patricio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Salta. Instituto de Patología Experimental; Argentina
Materia
TRYPANOSOMA CRUZI
EVOLUTION
HYBRIDISATION
PHYLOGENY
DISCRETE TYPING UNITS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/7001
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Evolution of Trypanosoma cruzi: clarifying hybridisations, mitochondrial introgressions and phylogenetic relationships between major lineagesTomasini, NicolásDiosque, PatricioTRYPANOSOMA CRUZIEVOLUTIONHYBRIDISATIONPHYLOGENYDISCRETE TYPING UNITShttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Different models of evolution of Trypanosoma cruzi have been proposed. These models suggest scarce events of genetic exchange in the evolutionary history of this parasite. In addition, the debate focused on the existence of one or two hybridization events during the evolution of T. cruzi lineages. Here we reviewed literature and analyzed available sequence data in order to clarify the phylogenetic relationships among lineages. We observed that TcI, TcIII and TcIV form a monophyletic group and consequently TcIII and TcIV are not, as previously suggested, TcI-TcII hybrids. Particularly, TcI and TcIII are sister groups that diverged around the same time that a widely distributed TcIV was splitted into two clades (TcIVS and TcIVN). In addition, we collected evidence that TcIII received the TcIVS kDNA by introgression at several opportunities. Different demographic hypotheses (surfing and asymmetrical introgression) may explain the origin and expansion of the TcIII group. Considering these hypotheses, genetic exchange should have been relatively frequent between TcIII and TcIVS in the geographic area in which their distributions were superimposed. In addition, our results support the hypothesis that two independent hybridization events gave origin to TcV and TcVI. Consequently, TcIVS kDNA was first transferred to TcIII and later to TcV and TcVI in TcII/TcIII hybridization events.Fil: Tomasini, Nicolás. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Salta. Instituto de Patología Experimental; ArgentinaFil: Diosque, Patricio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Salta. Instituto de Patología Experimental; ArgentinaFundacao Oswaldo Cruz2015-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/7001Tomasini, Nicolás; Diosque, Patricio; Evolution of Trypanosoma cruzi: clarifying hybridisations, mitochondrial introgressions and phylogenetic relationships between major lineages; Fundacao Oswaldo Cruz; Memórias Do Instituto Oswaldo Cruz; 110; 3; 2-2015; 403-4130074-02761678-8060enginfo:eu-repo/semantics/altIdentifier/doi/10.1590/0074-02760140401info:eu-repo/semantics/altIdentifier/doi/info:eu-repo/semantics/altIdentifier/url/http://ref.scielo.org/sp2phcinfo:eu-repo/semantics/altIdentifier/url/http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4489478/info:eu-repo/semantics/altIdentifier/pmid/PMC4489478info:eu-repo/semantics/altIdentifier/url/http://memorias.ioc.fiocruz.br/issues/past-issues/item/3517-0401_evolution-of-trypanosoma-cruzi-clarifying-hybridisations-mitochondrial-introgressions-and-phylogenetic-relationships-between-major-lineagesinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-10T13:19:09Zoai:ri.conicet.gov.ar:11336/7001instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-10 13:19:09.823CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Evolution of Trypanosoma cruzi: clarifying hybridisations, mitochondrial introgressions and phylogenetic relationships between major lineages
title Evolution of Trypanosoma cruzi: clarifying hybridisations, mitochondrial introgressions and phylogenetic relationships between major lineages
spellingShingle Evolution of Trypanosoma cruzi: clarifying hybridisations, mitochondrial introgressions and phylogenetic relationships between major lineages
Tomasini, Nicolás
TRYPANOSOMA CRUZI
EVOLUTION
HYBRIDISATION
PHYLOGENY
DISCRETE TYPING UNITS
title_short Evolution of Trypanosoma cruzi: clarifying hybridisations, mitochondrial introgressions and phylogenetic relationships between major lineages
title_full Evolution of Trypanosoma cruzi: clarifying hybridisations, mitochondrial introgressions and phylogenetic relationships between major lineages
title_fullStr Evolution of Trypanosoma cruzi: clarifying hybridisations, mitochondrial introgressions and phylogenetic relationships between major lineages
title_full_unstemmed Evolution of Trypanosoma cruzi: clarifying hybridisations, mitochondrial introgressions and phylogenetic relationships between major lineages
title_sort Evolution of Trypanosoma cruzi: clarifying hybridisations, mitochondrial introgressions and phylogenetic relationships between major lineages
dc.creator.none.fl_str_mv Tomasini, Nicolás
Diosque, Patricio
author Tomasini, Nicolás
author_facet Tomasini, Nicolás
Diosque, Patricio
author_role author
author2 Diosque, Patricio
author2_role author
dc.subject.none.fl_str_mv TRYPANOSOMA CRUZI
EVOLUTION
HYBRIDISATION
PHYLOGENY
DISCRETE TYPING UNITS
topic TRYPANOSOMA CRUZI
EVOLUTION
HYBRIDISATION
PHYLOGENY
DISCRETE TYPING UNITS
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Different models of evolution of Trypanosoma cruzi have been proposed. These models suggest scarce events of genetic exchange in the evolutionary history of this parasite. In addition, the debate focused on the existence of one or two hybridization events during the evolution of T. cruzi lineages. Here we reviewed literature and analyzed available sequence data in order to clarify the phylogenetic relationships among lineages. We observed that TcI, TcIII and TcIV form a monophyletic group and consequently TcIII and TcIV are not, as previously suggested, TcI-TcII hybrids. Particularly, TcI and TcIII are sister groups that diverged around the same time that a widely distributed TcIV was splitted into two clades (TcIVS and TcIVN). In addition, we collected evidence that TcIII received the TcIVS kDNA by introgression at several opportunities. Different demographic hypotheses (surfing and asymmetrical introgression) may explain the origin and expansion of the TcIII group. Considering these hypotheses, genetic exchange should have been relatively frequent between TcIII and TcIVS in the geographic area in which their distributions were superimposed. In addition, our results support the hypothesis that two independent hybridization events gave origin to TcV and TcVI. Consequently, TcIVS kDNA was first transferred to TcIII and later to TcV and TcVI in TcII/TcIII hybridization events.
Fil: Tomasini, Nicolás. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Salta. Instituto de Patología Experimental; Argentina
Fil: Diosque, Patricio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Salta. Instituto de Patología Experimental; Argentina
description Different models of evolution of Trypanosoma cruzi have been proposed. These models suggest scarce events of genetic exchange in the evolutionary history of this parasite. In addition, the debate focused on the existence of one or two hybridization events during the evolution of T. cruzi lineages. Here we reviewed literature and analyzed available sequence data in order to clarify the phylogenetic relationships among lineages. We observed that TcI, TcIII and TcIV form a monophyletic group and consequently TcIII and TcIV are not, as previously suggested, TcI-TcII hybrids. Particularly, TcI and TcIII are sister groups that diverged around the same time that a widely distributed TcIV was splitted into two clades (TcIVS and TcIVN). In addition, we collected evidence that TcIII received the TcIVS kDNA by introgression at several opportunities. Different demographic hypotheses (surfing and asymmetrical introgression) may explain the origin and expansion of the TcIII group. Considering these hypotheses, genetic exchange should have been relatively frequent between TcIII and TcIVS in the geographic area in which their distributions were superimposed. In addition, our results support the hypothesis that two independent hybridization events gave origin to TcV and TcVI. Consequently, TcIVS kDNA was first transferred to TcIII and later to TcV and TcVI in TcII/TcIII hybridization events.
publishDate 2015
dc.date.none.fl_str_mv 2015-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/7001
Tomasini, Nicolás; Diosque, Patricio; Evolution of Trypanosoma cruzi: clarifying hybridisations, mitochondrial introgressions and phylogenetic relationships between major lineages; Fundacao Oswaldo Cruz; Memórias Do Instituto Oswaldo Cruz; 110; 3; 2-2015; 403-413
0074-0276
1678-8060
url http://hdl.handle.net/11336/7001
identifier_str_mv Tomasini, Nicolás; Diosque, Patricio; Evolution of Trypanosoma cruzi: clarifying hybridisations, mitochondrial introgressions and phylogenetic relationships between major lineages; Fundacao Oswaldo Cruz; Memórias Do Instituto Oswaldo Cruz; 110; 3; 2-2015; 403-413
0074-0276
1678-8060
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1590/0074-02760140401
info:eu-repo/semantics/altIdentifier/doi/
info:eu-repo/semantics/altIdentifier/url/http://ref.scielo.org/sp2phc
info:eu-repo/semantics/altIdentifier/url/http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4489478/
info:eu-repo/semantics/altIdentifier/pmid/PMC4489478
info:eu-repo/semantics/altIdentifier/url/http://memorias.ioc.fiocruz.br/issues/past-issues/item/3517-0401_evolution-of-trypanosoma-cruzi-clarifying-hybridisations-mitochondrial-introgressions-and-phylogenetic-relationships-between-major-lineages
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Fundacao Oswaldo Cruz
publisher.none.fl_str_mv Fundacao Oswaldo Cruz
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.48226

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