Reducing risks in type 1 diabetes using H∞ Control

Autores
Colmegna, Patricio Hernán; Sanchez Peña, Ricardo Salvador; Gondhalekar, Ravi; Dassau, Eyal; Doyle, Francis J.
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
A control scheme was designed in order to reduce the risks of hyperglycemia and hypoglycemia in type 1 diabetes mellitus (T1DM). This structure is composed of three main components: an H∞ robust controller, an insulin feedback loop (IFL), and a safety mechanism (SM). A control-relevant model that is employed to design the robust controller is identified. The identification procedure is based on the distribution version of the UVA/Padova metabolic simulator using the simulation adult cohort. The SM prevents dangerous scenarios by acting upon a prediction of future glucose levels, and the IFL modifies the loop gain in order to reduce postprandial hypoglycemia risks. The procedure is tested on the complete in silico adult cohort of the UVA/Padova metabolic simulator, which has been accepted by the Food and Drug Administration (FDA) in lieu of animal trials.
Fil: Colmegna, Patricio Hernán. Instituto Tecnológico de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Sanchez Peña, Ricardo Salvador. Instituto Tecnológico de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Gondhalekar, Ravi. University of California; Estados Unidos. Sansum Diabetes Research Institute; Estados Unidos
Fil: Dassau, Eyal. University of California; Estados Unidos. Sansum Diabetes Research Institute; Estados Unidos
Fil: Doyle, Francis J.. University of California; Estados Unidos. Sansum Diabetes Research Institute; Estados Unidos
Materia
Hyperglycemia
Hypoglycemia
H&Infin; Control
Type 1 Diabetes
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/37124
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Reducing risks in type 1 diabetes using H∞ ControlColmegna, Patricio HernánSanchez Peña, Ricardo SalvadorGondhalekar, RaviDassau, EyalDoyle, Francis J.HyperglycemiaHypoglycemiaH&Infin; ControlType 1 Diabeteshttps://purl.org/becyt/ford/2.2https://purl.org/becyt/ford/2A control scheme was designed in order to reduce the risks of hyperglycemia and hypoglycemia in type 1 diabetes mellitus (T1DM). This structure is composed of three main components: an H∞ robust controller, an insulin feedback loop (IFL), and a safety mechanism (SM). A control-relevant model that is employed to design the robust controller is identified. The identification procedure is based on the distribution version of the UVA/Padova metabolic simulator using the simulation adult cohort. The SM prevents dangerous scenarios by acting upon a prediction of future glucose levels, and the IFL modifies the loop gain in order to reduce postprandial hypoglycemia risks. The procedure is tested on the complete in silico adult cohort of the UVA/Padova metabolic simulator, which has been accepted by the Food and Drug Administration (FDA) in lieu of animal trials.Fil: Colmegna, Patricio Hernán. Instituto Tecnológico de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Sanchez Peña, Ricardo Salvador. Instituto Tecnológico de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Gondhalekar, Ravi. University of California; Estados Unidos. Sansum Diabetes Research Institute; Estados UnidosFil: Dassau, Eyal. University of California; Estados Unidos. Sansum Diabetes Research Institute; Estados UnidosFil: Doyle, Francis J.. University of California; Estados Unidos. Sansum Diabetes Research Institute; Estados UnidosInstitute of Electrical and Electronics Engineers2014-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/37124Colmegna, Patricio Hernán; Sanchez Peña, Ricardo Salvador; Gondhalekar, Ravi; Dassau, Eyal; Doyle, Francis J.; Reducing risks in type 1 diabetes using H∞ Control; Institute of Electrical and Electronics Engineers; Ieee Transactions On Bio-medical Engineering; 61; 12; 12-2014; 2939-29470018-9294CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1109/TBME.2014.2336772info:eu-repo/semantics/altIdentifier/url/http://ieeexplore.ieee.org/document/6851161/info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:44:40Zoai:ri.conicet.gov.ar:11336/37124instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:44:40.771CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Reducing risks in type 1 diabetes using H∞ Control
title Reducing risks in type 1 diabetes using H∞ Control
spellingShingle Reducing risks in type 1 diabetes using H∞ Control
Colmegna, Patricio Hernán
Hyperglycemia
Hypoglycemia
H&Infin; Control
Type 1 Diabetes
title_short Reducing risks in type 1 diabetes using H∞ Control
title_full Reducing risks in type 1 diabetes using H∞ Control
title_fullStr Reducing risks in type 1 diabetes using H∞ Control
title_full_unstemmed Reducing risks in type 1 diabetes using H∞ Control
title_sort Reducing risks in type 1 diabetes using H∞ Control
dc.creator.none.fl_str_mv Colmegna, Patricio Hernán
Sanchez Peña, Ricardo Salvador
Gondhalekar, Ravi
Dassau, Eyal
Doyle, Francis J.
author Colmegna, Patricio Hernán
author_facet Colmegna, Patricio Hernán
Sanchez Peña, Ricardo Salvador
Gondhalekar, Ravi
Dassau, Eyal
Doyle, Francis J.
author_role author
author2 Sanchez Peña, Ricardo Salvador
Gondhalekar, Ravi
Dassau, Eyal
Doyle, Francis J.
author2_role author
author
author
author
dc.subject.none.fl_str_mv Hyperglycemia
Hypoglycemia
H&Infin; Control
Type 1 Diabetes
topic Hyperglycemia
Hypoglycemia
H&Infin; Control
Type 1 Diabetes
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.2
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv A control scheme was designed in order to reduce the risks of hyperglycemia and hypoglycemia in type 1 diabetes mellitus (T1DM). This structure is composed of three main components: an H∞ robust controller, an insulin feedback loop (IFL), and a safety mechanism (SM). A control-relevant model that is employed to design the robust controller is identified. The identification procedure is based on the distribution version of the UVA/Padova metabolic simulator using the simulation adult cohort. The SM prevents dangerous scenarios by acting upon a prediction of future glucose levels, and the IFL modifies the loop gain in order to reduce postprandial hypoglycemia risks. The procedure is tested on the complete in silico adult cohort of the UVA/Padova metabolic simulator, which has been accepted by the Food and Drug Administration (FDA) in lieu of animal trials.
Fil: Colmegna, Patricio Hernán. Instituto Tecnológico de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Sanchez Peña, Ricardo Salvador. Instituto Tecnológico de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Gondhalekar, Ravi. University of California; Estados Unidos. Sansum Diabetes Research Institute; Estados Unidos
Fil: Dassau, Eyal. University of California; Estados Unidos. Sansum Diabetes Research Institute; Estados Unidos
Fil: Doyle, Francis J.. University of California; Estados Unidos. Sansum Diabetes Research Institute; Estados Unidos
description A control scheme was designed in order to reduce the risks of hyperglycemia and hypoglycemia in type 1 diabetes mellitus (T1DM). This structure is composed of three main components: an H∞ robust controller, an insulin feedback loop (IFL), and a safety mechanism (SM). A control-relevant model that is employed to design the robust controller is identified. The identification procedure is based on the distribution version of the UVA/Padova metabolic simulator using the simulation adult cohort. The SM prevents dangerous scenarios by acting upon a prediction of future glucose levels, and the IFL modifies the loop gain in order to reduce postprandial hypoglycemia risks. The procedure is tested on the complete in silico adult cohort of the UVA/Padova metabolic simulator, which has been accepted by the Food and Drug Administration (FDA) in lieu of animal trials.
publishDate 2014
dc.date.none.fl_str_mv 2014-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/37124
Colmegna, Patricio Hernán; Sanchez Peña, Ricardo Salvador; Gondhalekar, Ravi; Dassau, Eyal; Doyle, Francis J.; Reducing risks in type 1 diabetes using H∞ Control; Institute of Electrical and Electronics Engineers; Ieee Transactions On Bio-medical Engineering; 61; 12; 12-2014; 2939-2947
0018-9294
CONICET Digital
CONICET
url http://hdl.handle.net/11336/37124
identifier_str_mv Colmegna, Patricio Hernán; Sanchez Peña, Ricardo Salvador; Gondhalekar, Ravi; Dassau, Eyal; Doyle, Francis J.; Reducing risks in type 1 diabetes using H∞ Control; Institute of Electrical and Electronics Engineers; Ieee Transactions On Bio-medical Engineering; 61; 12; 12-2014; 2939-2947
0018-9294
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1109/TBME.2014.2336772
info:eu-repo/semantics/altIdentifier/url/http://ieeexplore.ieee.org/document/6851161/
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Institute of Electrical and Electronics Engineers
publisher.none.fl_str_mv Institute of Electrical and Electronics Engineers
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844614485046722560
score 13.070432

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