Alloxan diabetes

Autores
Houssay, Bernardo Alberto
Año de publicación
1947
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The intravenous injection of alloxan induces a triphasic modification of the blood sugar level; (a) initial hiperglicemia; (b) secondary hypoglycemia; and (c) final hyperglycemia. The liver is essential for the initial hyperglycemia since this does not appear in hepatectomized dogs or toads or in eviscerated dogs. The initial hyperglycemia was observed in dogs after splanchnicectomy in adrenalectomized dogs or toads but not in adrenalectomized rats. In the dog the injection of alloxan produces a rise in blood pressure which is not due to the liberation of adrenaline as shown by suprareno-jugular anastomosis (Houssay and Rapela, unpublished data).
Fil: Houssay, Bernardo Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
papel
TIBYME
Unidad documental simple
Materia
HOUSSAY, BERNARDO A.
HOUSSAY EL INVESTIGADOR
EL INVESTIGADOR
PUBLICACIONES CIENTIFICAS
PUBLICACIONES
DIABETES
ALLOXAN
HYPERGLYCEMIA
HYPOGLYCEMIA
BLOOD SUGAR LEVEL
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/150366
Acceder
id CONICETDig_7223eaebafd31573dcfcae358f031816
oai_identifier_str oai:ri.conicet.gov.ar:11336/150366
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Alloxan diabetesHoussay, Bernardo AlbertoHOUSSAY, BERNARDO A.HOUSSAY EL INVESTIGADOREL INVESTIGADORPUBLICACIONES CIENTIFICASPUBLICACIONESDIABETESALLOXANHYPERGLYCEMIAHYPOGLYCEMIABLOOD SUGAR LEVELhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3https://purl.org/becyt/ford/6.3https://purl.org/becyt/ford/6The intravenous injection of alloxan induces a triphasic modification of the blood sugar level; (a) initial hiperglicemia; (b) secondary hypoglycemia; and (c) final hyperglycemia. The liver is essential for the initial hyperglycemia since this does not appear in hepatectomized dogs or toads or in eviscerated dogs. The initial hyperglycemia was observed in dogs after splanchnicectomy in adrenalectomized dogs or toads but not in adrenalectomized rats. In the dog the injection of alloxan produces a rise in blood pressure which is not due to the liberation of adrenaline as shown by suprareno-jugular anastomosis (Houssay and Rapela, unpublished data).Fil: Houssay, Bernardo Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinapapelTIBYMEUnidad documental simpleCanadian Medical Association1947info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articulotext/plainBlancoNegroSiapplication/pdfhttp://hdl.handle.net/11336/150366Houssay, Bernardo Alberto; Alloxan diabetes; Canadian Medical Association; Canadian Medical Association Journal; 56; 5; 1947; 519-5230008-44090008-4409enginfo:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1590737/?page=1info:eu-repo/semantics/altIdentifier/pmid/https://pubmed.ncbi.nlm.nih.gov/20294606/Ciudad de Buenos AiresFundacion Williams.Fundación de Instituto de Biología y Medicina ExperimentalConsejo Nacional de Investigaciones Científicas y TécnicasProyecto Houssay y LeloirIBYMEAR02675-3ACder-0331info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T12:04:27Zoai:ri.conicet.gov.ar:11336/150366instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 12:04:27.543CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Alloxan diabetes
title Alloxan diabetes
spellingShingle Alloxan diabetes
Houssay, Bernardo Alberto
HOUSSAY, BERNARDO A.
HOUSSAY EL INVESTIGADOR
EL INVESTIGADOR
PUBLICACIONES CIENTIFICAS
PUBLICACIONES
DIABETES
ALLOXAN
HYPERGLYCEMIA
HYPOGLYCEMIA
BLOOD SUGAR LEVEL
title_short Alloxan diabetes
title_full Alloxan diabetes
title_fullStr Alloxan diabetes
title_full_unstemmed Alloxan diabetes
title_sort Alloxan diabetes
dc.creator.none.fl_str_mv Houssay, Bernardo Alberto
author Houssay, Bernardo Alberto
author_facet Houssay, Bernardo Alberto
author_role author
dc.subject.none.fl_str_mv HOUSSAY, BERNARDO A.
HOUSSAY EL INVESTIGADOR
EL INVESTIGADOR
PUBLICACIONES CIENTIFICAS
PUBLICACIONES
DIABETES
ALLOXAN
HYPERGLYCEMIA
HYPOGLYCEMIA
BLOOD SUGAR LEVEL
topic HOUSSAY, BERNARDO A.
HOUSSAY EL INVESTIGADOR
EL INVESTIGADOR
PUBLICACIONES CIENTIFICAS
PUBLICACIONES
DIABETES
ALLOXAN
HYPERGLYCEMIA
HYPOGLYCEMIA
BLOOD SUGAR LEVEL
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
https://purl.org/becyt/ford/6.3
https://purl.org/becyt/ford/6
dc.description.none.fl_txt_mv The intravenous injection of alloxan induces a triphasic modification of the blood sugar level; (a) initial hiperglicemia; (b) secondary hypoglycemia; and (c) final hyperglycemia. The liver is essential for the initial hyperglycemia since this does not appear in hepatectomized dogs or toads or in eviscerated dogs. The initial hyperglycemia was observed in dogs after splanchnicectomy in adrenalectomized dogs or toads but not in adrenalectomized rats. In the dog the injection of alloxan produces a rise in blood pressure which is not due to the liberation of adrenaline as shown by suprareno-jugular anastomosis (Houssay and Rapela, unpublished data).
Fil: Houssay, Bernardo Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
papel
TIBYME
Unidad documental simple
description The intravenous injection of alloxan induces a triphasic modification of the blood sugar level; (a) initial hiperglicemia; (b) secondary hypoglycemia; and (c) final hyperglycemia. The liver is essential for the initial hyperglycemia since this does not appear in hepatectomized dogs or toads or in eviscerated dogs. The initial hyperglycemia was observed in dogs after splanchnicectomy in adrenalectomized dogs or toads but not in adrenalectomized rats. In the dog the injection of alloxan produces a rise in blood pressure which is not due to the liberation of adrenaline as shown by suprareno-jugular anastomosis (Houssay and Rapela, unpublished data).
publishDate 1947
dc.date.none.fl_str_mv 1947
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/150366
Houssay, Bernardo Alberto; Alloxan diabetes; Canadian Medical Association; Canadian Medical Association Journal; 56; 5; 1947; 519-523
0008-4409
0008-4409
url http://hdl.handle.net/11336/150366
identifier_str_mv Houssay, Bernardo Alberto; Alloxan diabetes; Canadian Medical Association; Canadian Medical Association Journal; 56; 5; 1947; 519-523
0008-4409
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1590737/?page=1
info:eu-repo/semantics/altIdentifier/pmid/https://pubmed.ncbi.nlm.nih.gov/20294606/
Ciudad de Buenos Aires
Fundacion Williams.
Fundación de Instituto de Biología y Medicina Experimental
Consejo Nacional de Investigaciones Científicas y Técnicas
Proyecto Houssay y Leloir
IBYME
AR02675-3ACder-0331
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv text/plain
BlancoNegro
Si
application/pdf
dc.publisher.none.fl_str_mv Canadian Medical Association
publisher.none.fl_str_mv Canadian Medical Association
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846782393085591552
score 12.982451

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