Oxidovanadium(IV) complexes with chrysin and silibinin: anticancer activity and mechanisms of action in a human colon adenocarcinoma model
- Autores
- Leon, Ignacio Esteban; Cadavid Vargas, Juan Fernando; Tiscornia, Ines Silvia; Porro, V.; Castelli, S.; Katkar, P.; Desideri, A.; Bollati Fogolin, M.; Etcheverry, Susana Beatriz
- Año de publicación
- 2015
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Vanadium compounds were studied duringrecent years to be considered as a representative of a newclass of nonplatinum metal antitumor agents in combinationto its low toxicity. On the other hand, flavonoids area wide family of polyphenolic compounds synthesizedby plants that display many interesting biological effects.Since coordination of ligands to metals can improve thepharmacological properties, we report herein, for the firsttime, a exhaustive study of the mechanisms of action oftwo oxidovanadium(IV) complexes with the flavonoids:silibinin Na2[VO(silibinin)2]·6H2O (VOsil) and chrysin[VO(chrysin)2EtOH]2 (VOchrys) on human colonadenocarcinoma derived cell line HT-29. The complexesinhibited the cell viability of colon adenocarcinoma cellsin a dose dependent manner with a greater potency thanthat the free ligands and free metal, demonstrating thebenefit of complexation. The decrease of the ratio of theamount of reduced glutathione to the amount of oxidized glutathione were involved in the deleterious effects of bothcomplexes. Besides, VOchrys caused cell cycle arrest inG2/M phase while VOsil activated caspase 3 and triggeringthe cells directly to apoptosis. Moreover, VOsil diminishedthe NF-kB activation via increasing the sensitivity ofcells to apoptosis. On the other hand, VOsil inhibited thetopoisomerase IB activity concluding that this is importanttarget involved in the anticancer vanadium effects.As a whole, the results presented herein demonstrate thatVOsil has a stronger deleterious action than VOchrys onHT-29 cells, whereby suggesting that Vosil is the potentiallybest candidate for future use in alternative anti-tumortreatments.
Fil: Leon, Ignacio Esteban. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica "Dr. Pedro J. Aymonino". Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica "Dr. Pedro J. Aymonino"; Argentina. Universidad Nacional de la Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Cátedra Bioquímica Patologica; Argentina
Fil: Cadavid Vargas, Juan Fernando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica "Dr. Pedro J. Aymonino". Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica "Dr. Pedro J. Aymonino"; Argentina. Universidad Nacional de la Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Cátedra Bioquímica Patologica; Argentina
Fil: Tiscornia, Ines Silvia. Instituto Pasteur de Montevideo; Uruguay
Fil: Porro, V.. Instituto Pasteur de Montevideo; Uruguay
Fil: Castelli, S.. Universita Tor Vergata; Italia
Fil: Katkar, P.. Universita Tor Vergata; Italia
Fil: Desideri, A.. Universita Tor Vergata; Italia
Fil: Bollati Fogolin, M.. Instituto Pasteur de Montevideo; Uruguay
Fil: Etcheverry, Susana Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica "Dr. Pedro J. Aymonino". Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica "Dr. Pedro J. Aymonino"; Argentina. Universidad Nacional de la Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Cátedra Bioquímica Patologica; Argentina - Materia
-
Metal Based Drug ·
Ht-29 Cells
· Flavonoids ·
Vanadium - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/48372
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Oxidovanadium(IV) complexes with chrysin and silibinin: anticancer activity and mechanisms of action in a human colon adenocarcinoma modelLeon, Ignacio EstebanCadavid Vargas, Juan FernandoTiscornia, Ines SilviaPorro, V.Castelli, S.Katkar, P.Desideri, A.Bollati Fogolin, M.Etcheverry, Susana BeatrizMetal Based Drug ·Ht-29 Cells· Flavonoids ·Vanadiumhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Vanadium compounds were studied duringrecent years to be considered as a representative of a newclass of nonplatinum metal antitumor agents in combinationto its low toxicity. On the other hand, flavonoids area wide family of polyphenolic compounds synthesizedby plants that display many interesting biological effects.Since coordination of ligands to metals can improve thepharmacological properties, we report herein, for the firsttime, a exhaustive study of the mechanisms of action oftwo oxidovanadium(IV) complexes with the flavonoids:silibinin Na2[VO(silibinin)2]·6H2O (VOsil) and chrysin[VO(chrysin)2EtOH]2 (VOchrys) on human colonadenocarcinoma derived cell line HT-29. The complexesinhibited the cell viability of colon adenocarcinoma cellsin a dose dependent manner with a greater potency thanthat the free ligands and free metal, demonstrating thebenefit of complexation. The decrease of the ratio of theamount of reduced glutathione to the amount of oxidized glutathione were involved in the deleterious effects of bothcomplexes. Besides, VOchrys caused cell cycle arrest inG2/M phase while VOsil activated caspase 3 and triggeringthe cells directly to apoptosis. Moreover, VOsil diminishedthe NF-kB activation via increasing the sensitivity ofcells to apoptosis. On the other hand, VOsil inhibited thetopoisomerase IB activity concluding that this is importanttarget involved in the anticancer vanadium effects.As a whole, the results presented herein demonstrate thatVOsil has a stronger deleterious action than VOchrys onHT-29 cells, whereby suggesting that Vosil is the potentiallybest candidate for future use in alternative anti-tumortreatments.Fil: Leon, Ignacio Esteban. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica "Dr. Pedro J. Aymonino". Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica "Dr. Pedro J. Aymonino"; Argentina. Universidad Nacional de la Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Cátedra Bioquímica Patologica; ArgentinaFil: Cadavid Vargas, Juan Fernando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica "Dr. Pedro J. Aymonino". Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica "Dr. Pedro J. Aymonino"; Argentina. Universidad Nacional de la Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Cátedra Bioquímica Patologica; ArgentinaFil: Tiscornia, Ines Silvia. Instituto Pasteur de Montevideo; UruguayFil: Porro, V.. Instituto Pasteur de Montevideo; UruguayFil: Castelli, S.. Universita Tor Vergata; ItaliaFil: Katkar, P.. Universita Tor Vergata; ItaliaFil: Desideri, A.. Universita Tor Vergata; ItaliaFil: Bollati Fogolin, M.. Instituto Pasteur de Montevideo; UruguayFil: Etcheverry, Susana Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica "Dr. Pedro J. Aymonino". Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica "Dr. Pedro J. Aymonino"; Argentina. Universidad Nacional de la Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Cátedra Bioquímica Patologica; ArgentinaSpringer2015-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/48372Leon, Ignacio Esteban; Cadavid Vargas, Juan Fernando; Tiscornia, Ines Silvia; Porro, V.; Castelli, S.; et al.; Oxidovanadium(IV) complexes with chrysin and silibinin: anticancer activity and mechanisms of action in a human colon adenocarcinoma model; Springer; Journal of Biological Inorganic Chemistry; 20; 7; 9-2015; 1175-11910949-8257CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1007/s00775-015-1298-7info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007%2Fs00775-015-1298-7info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:23:48Zoai:ri.conicet.gov.ar:11336/48372instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:23:48.439CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Oxidovanadium(IV) complexes with chrysin and silibinin: anticancer activity and mechanisms of action in a human colon adenocarcinoma model |
title |
Oxidovanadium(IV) complexes with chrysin and silibinin: anticancer activity and mechanisms of action in a human colon adenocarcinoma model |
spellingShingle |
Oxidovanadium(IV) complexes with chrysin and silibinin: anticancer activity and mechanisms of action in a human colon adenocarcinoma model Leon, Ignacio Esteban Metal Based Drug · Ht-29 Cells · Flavonoids · Vanadium |
title_short |
Oxidovanadium(IV) complexes with chrysin and silibinin: anticancer activity and mechanisms of action in a human colon adenocarcinoma model |
title_full |
Oxidovanadium(IV) complexes with chrysin and silibinin: anticancer activity and mechanisms of action in a human colon adenocarcinoma model |
title_fullStr |
Oxidovanadium(IV) complexes with chrysin and silibinin: anticancer activity and mechanisms of action in a human colon adenocarcinoma model |
title_full_unstemmed |
Oxidovanadium(IV) complexes with chrysin and silibinin: anticancer activity and mechanisms of action in a human colon adenocarcinoma model |
title_sort |
Oxidovanadium(IV) complexes with chrysin and silibinin: anticancer activity and mechanisms of action in a human colon adenocarcinoma model |
dc.creator.none.fl_str_mv |
Leon, Ignacio Esteban Cadavid Vargas, Juan Fernando Tiscornia, Ines Silvia Porro, V. Castelli, S. Katkar, P. Desideri, A. Bollati Fogolin, M. Etcheverry, Susana Beatriz |
author |
Leon, Ignacio Esteban |
author_facet |
Leon, Ignacio Esteban Cadavid Vargas, Juan Fernando Tiscornia, Ines Silvia Porro, V. Castelli, S. Katkar, P. Desideri, A. Bollati Fogolin, M. Etcheverry, Susana Beatriz |
author_role |
author |
author2 |
Cadavid Vargas, Juan Fernando Tiscornia, Ines Silvia Porro, V. Castelli, S. Katkar, P. Desideri, A. Bollati Fogolin, M. Etcheverry, Susana Beatriz |
author2_role |
author author author author author author author author |
dc.subject.none.fl_str_mv |
Metal Based Drug · Ht-29 Cells · Flavonoids · Vanadium |
topic |
Metal Based Drug · Ht-29 Cells · Flavonoids · Vanadium |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 |
dc.description.none.fl_txt_mv |
Vanadium compounds were studied duringrecent years to be considered as a representative of a newclass of nonplatinum metal antitumor agents in combinationto its low toxicity. On the other hand, flavonoids area wide family of polyphenolic compounds synthesizedby plants that display many interesting biological effects.Since coordination of ligands to metals can improve thepharmacological properties, we report herein, for the firsttime, a exhaustive study of the mechanisms of action oftwo oxidovanadium(IV) complexes with the flavonoids:silibinin Na2[VO(silibinin)2]·6H2O (VOsil) and chrysin[VO(chrysin)2EtOH]2 (VOchrys) on human colonadenocarcinoma derived cell line HT-29. The complexesinhibited the cell viability of colon adenocarcinoma cellsin a dose dependent manner with a greater potency thanthat the free ligands and free metal, demonstrating thebenefit of complexation. The decrease of the ratio of theamount of reduced glutathione to the amount of oxidized glutathione were involved in the deleterious effects of bothcomplexes. Besides, VOchrys caused cell cycle arrest inG2/M phase while VOsil activated caspase 3 and triggeringthe cells directly to apoptosis. Moreover, VOsil diminishedthe NF-kB activation via increasing the sensitivity ofcells to apoptosis. On the other hand, VOsil inhibited thetopoisomerase IB activity concluding that this is importanttarget involved in the anticancer vanadium effects.As a whole, the results presented herein demonstrate thatVOsil has a stronger deleterious action than VOchrys onHT-29 cells, whereby suggesting that Vosil is the potentiallybest candidate for future use in alternative anti-tumortreatments. Fil: Leon, Ignacio Esteban. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica "Dr. Pedro J. Aymonino". Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica "Dr. Pedro J. Aymonino"; Argentina. Universidad Nacional de la Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Cátedra Bioquímica Patologica; Argentina Fil: Cadavid Vargas, Juan Fernando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica "Dr. Pedro J. Aymonino". Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica "Dr. Pedro J. Aymonino"; Argentina. Universidad Nacional de la Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Cátedra Bioquímica Patologica; Argentina Fil: Tiscornia, Ines Silvia. Instituto Pasteur de Montevideo; Uruguay Fil: Porro, V.. Instituto Pasteur de Montevideo; Uruguay Fil: Castelli, S.. Universita Tor Vergata; Italia Fil: Katkar, P.. Universita Tor Vergata; Italia Fil: Desideri, A.. Universita Tor Vergata; Italia Fil: Bollati Fogolin, M.. Instituto Pasteur de Montevideo; Uruguay Fil: Etcheverry, Susana Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica "Dr. Pedro J. Aymonino". Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica "Dr. Pedro J. Aymonino"; Argentina. Universidad Nacional de la Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Cátedra Bioquímica Patologica; Argentina |
description |
Vanadium compounds were studied duringrecent years to be considered as a representative of a newclass of nonplatinum metal antitumor agents in combinationto its low toxicity. On the other hand, flavonoids area wide family of polyphenolic compounds synthesizedby plants that display many interesting biological effects.Since coordination of ligands to metals can improve thepharmacological properties, we report herein, for the firsttime, a exhaustive study of the mechanisms of action oftwo oxidovanadium(IV) complexes with the flavonoids:silibinin Na2[VO(silibinin)2]·6H2O (VOsil) and chrysin[VO(chrysin)2EtOH]2 (VOchrys) on human colonadenocarcinoma derived cell line HT-29. The complexesinhibited the cell viability of colon adenocarcinoma cellsin a dose dependent manner with a greater potency thanthat the free ligands and free metal, demonstrating thebenefit of complexation. The decrease of the ratio of theamount of reduced glutathione to the amount of oxidized glutathione were involved in the deleterious effects of bothcomplexes. Besides, VOchrys caused cell cycle arrest inG2/M phase while VOsil activated caspase 3 and triggeringthe cells directly to apoptosis. Moreover, VOsil diminishedthe NF-kB activation via increasing the sensitivity ofcells to apoptosis. On the other hand, VOsil inhibited thetopoisomerase IB activity concluding that this is importanttarget involved in the anticancer vanadium effects.As a whole, the results presented herein demonstrate thatVOsil has a stronger deleterious action than VOchrys onHT-29 cells, whereby suggesting that Vosil is the potentiallybest candidate for future use in alternative anti-tumortreatments. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-09 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/48372 Leon, Ignacio Esteban; Cadavid Vargas, Juan Fernando; Tiscornia, Ines Silvia; Porro, V.; Castelli, S.; et al.; Oxidovanadium(IV) complexes with chrysin and silibinin: anticancer activity and mechanisms of action in a human colon adenocarcinoma model; Springer; Journal of Biological Inorganic Chemistry; 20; 7; 9-2015; 1175-1191 0949-8257 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/48372 |
identifier_str_mv |
Leon, Ignacio Esteban; Cadavid Vargas, Juan Fernando; Tiscornia, Ines Silvia; Porro, V.; Castelli, S.; et al.; Oxidovanadium(IV) complexes with chrysin and silibinin: anticancer activity and mechanisms of action in a human colon adenocarcinoma model; Springer; Journal of Biological Inorganic Chemistry; 20; 7; 9-2015; 1175-1191 0949-8257 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.1007/s00775-015-1298-7 info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007%2Fs00775-015-1298-7 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Springer |
publisher.none.fl_str_mv |
Springer |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1846083385158533120 |
score |
13.22299 |