Social networking in tumor cell communities is associated with increased aggressiveness

Autores
Lodillinsky, Catalina; Podsypanina, Katrina; Chavrier, Philippe
Año de publicación
2016
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Extracellular vesicles (EVs) are lipid-bilayer-enclosed vesicles that contain proteins, lipids and nucleic acids. EVs produced by cells from healthy tissues circulate in the blood and body fluids, and can be taken up by unrelated cells. As they have the capacity to transfer cargo proteins, lipids and nucleic acids (mostly mRNAs and miRNAs) between different cells in the body, EVs are emerging as mediators of intercellular communication that could modulate cell behavior, tissue homeostasis and regulation of physiological functions. EV-mediated cell-cell communications are also proposed to play a role in disease, for example, cancer, where they could contribute to transfer of traits required for tumor progression and metastasis. However, direct evidence for EV-mediated mRNA transfer to individual cells and for its biological consequences in vivo has been missing until recently. Recent studies have reported elegant experiments using genetic tracing with the Cre recombinase system and intravital imaging that visualize and quantify functional transfer of mRNA mediated by EVs in the context of cancer and metastasis.
Fil: Lodillinsky, Catalina. Institute Curie; Francia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Podsypanina, Katrina. Institute Curie; Francia
Fil: Chavrier, Philippe. Institute Curie; Francia
Materia
Extracellular Vesicles
Cell-Cell Comunication
Metastasis
Intravital Microscopy
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/39300
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/39300
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network_name_str CONICET Digital (CONICET)
spelling Social networking in tumor cell communities is associated with increased aggressivenessLodillinsky, CatalinaPodsypanina, KatrinaChavrier, PhilippeExtracellular VesiclesCell-Cell ComunicationMetastasisIntravital Microscopyhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Extracellular vesicles (EVs) are lipid-bilayer-enclosed vesicles that contain proteins, lipids and nucleic acids. EVs produced by cells from healthy tissues circulate in the blood and body fluids, and can be taken up by unrelated cells. As they have the capacity to transfer cargo proteins, lipids and nucleic acids (mostly mRNAs and miRNAs) between different cells in the body, EVs are emerging as mediators of intercellular communication that could modulate cell behavior, tissue homeostasis and regulation of physiological functions. EV-mediated cell-cell communications are also proposed to play a role in disease, for example, cancer, where they could contribute to transfer of traits required for tumor progression and metastasis. However, direct evidence for EV-mediated mRNA transfer to individual cells and for its biological consequences in vivo has been missing until recently. Recent studies have reported elegant experiments using genetic tracing with the Cre recombinase system and intravital imaging that visualize and quantify functional transfer of mRNA mediated by EVs in the context of cancer and metastasis.Fil: Lodillinsky, Catalina. Institute Curie; Francia. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Podsypanina, Katrina. Institute Curie; FranciaFil: Chavrier, Philippe. Institute Curie; FranciaTaylor & Francis2016info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/39300Lodillinsky, Catalina; Podsypanina, Katrina; Chavrier, Philippe; Social networking in tumor cell communities is associated with increased aggressiveness; Taylor & Francis; IntraVital; 5; 1; 2016; 1-4; e11124762165-9087CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1080/21659087.2015.1112476info:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/full/10.1080/21659087.2015.1112476info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:52:02Zoai:ri.conicet.gov.ar:11336/39300instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:52:03.102CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Social networking in tumor cell communities is associated with increased aggressiveness
title Social networking in tumor cell communities is associated with increased aggressiveness
spellingShingle Social networking in tumor cell communities is associated with increased aggressiveness
Lodillinsky, Catalina
Extracellular Vesicles
Cell-Cell Comunication
Metastasis
Intravital Microscopy
title_short Social networking in tumor cell communities is associated with increased aggressiveness
title_full Social networking in tumor cell communities is associated with increased aggressiveness
title_fullStr Social networking in tumor cell communities is associated with increased aggressiveness
title_full_unstemmed Social networking in tumor cell communities is associated with increased aggressiveness
title_sort Social networking in tumor cell communities is associated with increased aggressiveness
dc.creator.none.fl_str_mv Lodillinsky, Catalina
Podsypanina, Katrina
Chavrier, Philippe
author Lodillinsky, Catalina
author_facet Lodillinsky, Catalina
Podsypanina, Katrina
Chavrier, Philippe
author_role author
author2 Podsypanina, Katrina
Chavrier, Philippe
author2_role author
author
dc.subject.none.fl_str_mv Extracellular Vesicles
Cell-Cell Comunication
Metastasis
Intravital Microscopy
topic Extracellular Vesicles
Cell-Cell Comunication
Metastasis
Intravital Microscopy
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Extracellular vesicles (EVs) are lipid-bilayer-enclosed vesicles that contain proteins, lipids and nucleic acids. EVs produced by cells from healthy tissues circulate in the blood and body fluids, and can be taken up by unrelated cells. As they have the capacity to transfer cargo proteins, lipids and nucleic acids (mostly mRNAs and miRNAs) between different cells in the body, EVs are emerging as mediators of intercellular communication that could modulate cell behavior, tissue homeostasis and regulation of physiological functions. EV-mediated cell-cell communications are also proposed to play a role in disease, for example, cancer, where they could contribute to transfer of traits required for tumor progression and metastasis. However, direct evidence for EV-mediated mRNA transfer to individual cells and for its biological consequences in vivo has been missing until recently. Recent studies have reported elegant experiments using genetic tracing with the Cre recombinase system and intravital imaging that visualize and quantify functional transfer of mRNA mediated by EVs in the context of cancer and metastasis.
Fil: Lodillinsky, Catalina. Institute Curie; Francia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Podsypanina, Katrina. Institute Curie; Francia
Fil: Chavrier, Philippe. Institute Curie; Francia
description Extracellular vesicles (EVs) are lipid-bilayer-enclosed vesicles that contain proteins, lipids and nucleic acids. EVs produced by cells from healthy tissues circulate in the blood and body fluids, and can be taken up by unrelated cells. As they have the capacity to transfer cargo proteins, lipids and nucleic acids (mostly mRNAs and miRNAs) between different cells in the body, EVs are emerging as mediators of intercellular communication that could modulate cell behavior, tissue homeostasis and regulation of physiological functions. EV-mediated cell-cell communications are also proposed to play a role in disease, for example, cancer, where they could contribute to transfer of traits required for tumor progression and metastasis. However, direct evidence for EV-mediated mRNA transfer to individual cells and for its biological consequences in vivo has been missing until recently. Recent studies have reported elegant experiments using genetic tracing with the Cre recombinase system and intravital imaging that visualize and quantify functional transfer of mRNA mediated by EVs in the context of cancer and metastasis.
publishDate 2016
dc.date.none.fl_str_mv 2016
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/39300
Lodillinsky, Catalina; Podsypanina, Katrina; Chavrier, Philippe; Social networking in tumor cell communities is associated with increased aggressiveness; Taylor & Francis; IntraVital; 5; 1; 2016; 1-4; e1112476
2165-9087
CONICET Digital
CONICET
url http://hdl.handle.net/11336/39300
identifier_str_mv Lodillinsky, Catalina; Podsypanina, Katrina; Chavrier, Philippe; Social networking in tumor cell communities is associated with increased aggressiveness; Taylor & Francis; IntraVital; 5; 1; 2016; 1-4; e1112476
2165-9087
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1080/21659087.2015.1112476
info:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/full/10.1080/21659087.2015.1112476
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Taylor & Francis
publisher.none.fl_str_mv Taylor & Francis
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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