Di(ethylene glycol) methyl ether methacrylate (DEGMEMA)-derived gels align small organic molecules in methanol

Autores
García, Manuela Emila; Woodruff, Shannon R.; Hellemann, Erich; Tsarevsky, Nicolay V.; Gil, Roberto Ricardo
Año de publicación
2017
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Residual dipolar couplings (RDCs) constitute an important NMR parameter for structural elucidation in all areas of chemistry. In this study, di(ethylene glycol) methyl ether methacrylate (DEGMEMA)-basedgelsare introduced as alignment media for the measurement of RDCs of small organic molecules in polar solvents such as methanol. The low viscosity of methanol permits the execution of J-scaled BIRD HSQC experimentsthat yield very sharp lines in anisotropic conditions. The gels have excellent mechanical properties, and their compression and expansion in the swollen state can be reversed and performed multiple times. This process enables the easy loading and release of analytes. The excellent performance of these new aligning gels is demonstrated by analyzing the structure of the alkaloid retrorsine.
Fil: García, Manuela Emila. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Química Orgánica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; Argentina. University Of Carnegie Mellon; Estados Unidos
Fil: Woodruff, Shannon R.. University Of Carnegie Mellon; Estados Unidos. Southern Methodist University; Estados Unidos
Fil: Hellemann, Erich. University Of Carnegie Mellon; Estados Unidos
Fil: Tsarevsky, Nicolay V.. University Of Carnegie Mellon; Estados Unidos
Fil: Gil, Roberto Ricardo. University Of Carnegie Mellon; Estados Unidos
Materia
J-Scaled Bird Hsqc
Residual Dipolar Couplings
Degmema Gels
Alignment Media
Retrorsine
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/34271
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/34271
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Di(ethylene glycol) methyl ether methacrylate (DEGMEMA)-derived gels align small organic molecules in methanolGarcía, Manuela EmilaWoodruff, Shannon R.Hellemann, ErichTsarevsky, Nicolay V.Gil, Roberto RicardoJ-Scaled Bird HsqcResidual Dipolar CouplingsDegmema GelsAlignment MediaRetrorsinehttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1Residual dipolar couplings (RDCs) constitute an important NMR parameter for structural elucidation in all areas of chemistry. In this study, di(ethylene glycol) methyl ether methacrylate (DEGMEMA)-basedgelsare introduced as alignment media for the measurement of RDCs of small organic molecules in polar solvents such as methanol. The low viscosity of methanol permits the execution of J-scaled BIRD HSQC experimentsthat yield very sharp lines in anisotropic conditions. The gels have excellent mechanical properties, and their compression and expansion in the swollen state can be reversed and performed multiple times. This process enables the easy loading and release of analytes. The excellent performance of these new aligning gels is demonstrated by analyzing the structure of the alkaloid retrorsine.Fil: García, Manuela Emila. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Química Orgánica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; Argentina. University Of Carnegie Mellon; Estados UnidosFil: Woodruff, Shannon R.. University Of Carnegie Mellon; Estados Unidos. Southern Methodist University; Estados UnidosFil: Hellemann, Erich. University Of Carnegie Mellon; Estados UnidosFil: Tsarevsky, Nicolay V.. University Of Carnegie Mellon; Estados UnidosFil: Gil, Roberto Ricardo. University Of Carnegie Mellon; Estados UnidosJohn Wiley & Sons Ltd2017-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/34271García, Manuela Emila; Woodruff, Shannon R.; Hellemann, Erich; Tsarevsky, Nicolay V.; Gil, Roberto Ricardo; Di(ethylene glycol) methyl ether methacrylate (DEGMEMA)-derived gels align small organic molecules in methanol; John Wiley & Sons Ltd; Magnetic Resonance in Chemistry; 55; 3; 3-2017; 206-2090749-15811097-458XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1002/mrc.4400/fullinfo:eu-repo/semantics/altIdentifier/doi/10.1002/mrc.4400info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:49:46Zoai:ri.conicet.gov.ar:11336/34271instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:49:46.961CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Di(ethylene glycol) methyl ether methacrylate (DEGMEMA)-derived gels align small organic molecules in methanol
title Di(ethylene glycol) methyl ether methacrylate (DEGMEMA)-derived gels align small organic molecules in methanol
spellingShingle Di(ethylene glycol) methyl ether methacrylate (DEGMEMA)-derived gels align small organic molecules in methanol
García, Manuela Emila
J-Scaled Bird Hsqc
Residual Dipolar Couplings
Degmema Gels
Alignment Media
Retrorsine
title_short Di(ethylene glycol) methyl ether methacrylate (DEGMEMA)-derived gels align small organic molecules in methanol
title_full Di(ethylene glycol) methyl ether methacrylate (DEGMEMA)-derived gels align small organic molecules in methanol
title_fullStr Di(ethylene glycol) methyl ether methacrylate (DEGMEMA)-derived gels align small organic molecules in methanol
title_full_unstemmed Di(ethylene glycol) methyl ether methacrylate (DEGMEMA)-derived gels align small organic molecules in methanol
title_sort Di(ethylene glycol) methyl ether methacrylate (DEGMEMA)-derived gels align small organic molecules in methanol
dc.creator.none.fl_str_mv García, Manuela Emila
Woodruff, Shannon R.
Hellemann, Erich
Tsarevsky, Nicolay V.
Gil, Roberto Ricardo
author García, Manuela Emila
author_facet García, Manuela Emila
Woodruff, Shannon R.
Hellemann, Erich
Tsarevsky, Nicolay V.
Gil, Roberto Ricardo
author_role author
author2 Woodruff, Shannon R.
Hellemann, Erich
Tsarevsky, Nicolay V.
Gil, Roberto Ricardo
author2_role author
author
author
author
dc.subject.none.fl_str_mv J-Scaled Bird Hsqc
Residual Dipolar Couplings
Degmema Gels
Alignment Media
Retrorsine
topic J-Scaled Bird Hsqc
Residual Dipolar Couplings
Degmema Gels
Alignment Media
Retrorsine
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Residual dipolar couplings (RDCs) constitute an important NMR parameter for structural elucidation in all areas of chemistry. In this study, di(ethylene glycol) methyl ether methacrylate (DEGMEMA)-basedgelsare introduced as alignment media for the measurement of RDCs of small organic molecules in polar solvents such as methanol. The low viscosity of methanol permits the execution of J-scaled BIRD HSQC experimentsthat yield very sharp lines in anisotropic conditions. The gels have excellent mechanical properties, and their compression and expansion in the swollen state can be reversed and performed multiple times. This process enables the easy loading and release of analytes. The excellent performance of these new aligning gels is demonstrated by analyzing the structure of the alkaloid retrorsine.
Fil: García, Manuela Emila. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Química Orgánica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; Argentina. University Of Carnegie Mellon; Estados Unidos
Fil: Woodruff, Shannon R.. University Of Carnegie Mellon; Estados Unidos. Southern Methodist University; Estados Unidos
Fil: Hellemann, Erich. University Of Carnegie Mellon; Estados Unidos
Fil: Tsarevsky, Nicolay V.. University Of Carnegie Mellon; Estados Unidos
Fil: Gil, Roberto Ricardo. University Of Carnegie Mellon; Estados Unidos
description Residual dipolar couplings (RDCs) constitute an important NMR parameter for structural elucidation in all areas of chemistry. In this study, di(ethylene glycol) methyl ether methacrylate (DEGMEMA)-basedgelsare introduced as alignment media for the measurement of RDCs of small organic molecules in polar solvents such as methanol. The low viscosity of methanol permits the execution of J-scaled BIRD HSQC experimentsthat yield very sharp lines in anisotropic conditions. The gels have excellent mechanical properties, and their compression and expansion in the swollen state can be reversed and performed multiple times. This process enables the easy loading and release of analytes. The excellent performance of these new aligning gels is demonstrated by analyzing the structure of the alkaloid retrorsine.
publishDate 2017
dc.date.none.fl_str_mv 2017-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/34271
García, Manuela Emila; Woodruff, Shannon R.; Hellemann, Erich; Tsarevsky, Nicolay V.; Gil, Roberto Ricardo; Di(ethylene glycol) methyl ether methacrylate (DEGMEMA)-derived gels align small organic molecules in methanol; John Wiley & Sons Ltd; Magnetic Resonance in Chemistry; 55; 3; 3-2017; 206-209
0749-1581
1097-458X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/34271
identifier_str_mv García, Manuela Emila; Woodruff, Shannon R.; Hellemann, Erich; Tsarevsky, Nicolay V.; Gil, Roberto Ricardo; Di(ethylene glycol) methyl ether methacrylate (DEGMEMA)-derived gels align small organic molecules in methanol; John Wiley & Sons Ltd; Magnetic Resonance in Chemistry; 55; 3; 3-2017; 206-209
0749-1581
1097-458X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1002/mrc.4400/full
info:eu-repo/semantics/altIdentifier/doi/10.1002/mrc.4400
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv John Wiley & Sons Ltd
publisher.none.fl_str_mv John Wiley & Sons Ltd
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844613538250752000
score 13.070432

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