Effect of selective ET A receptor blockade on natriuretic peptide gene expression in DOCA-salt hypertension
- Autores
- Bianciotti, Liliana Graciela; de Bold, Adolfo
- Año de publicación
- 2000
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- To determine the role of endothelin-1 (ET-1) in the upregulation of atrial natriuretic factor (ANF) and brain natriuretic peptide (BNP) observed in deoxycorticosterone acetate (DOCA)-salt hypertension, the selective ET-1 type-A receptor (ETA) antagonist ABT-627 was chronically administered to normal controls and hypertensive rats. Chronic ETA blockade in DOCA-salt-treated rats prevented the increase in blood pressure and circulating natriuretic protein (NP) levels and partially prevented left ventricular hypertrophy. The changes observed in NP gene expression in the atria were not affected by ABT-627. In the ventricles, ABT-627 reduced NP gene expression. Rats receiving the ETA antagonist alone showed reduced left ventricular NP gene expression. ABT-627 did not affect ventricular collagen III gene expression but enhanced left ventricular α-myosin heavy chain expression. These findings suggest that in vivo, ventricular but not atrial NP production is regulated by ET-1. This difference in response between atrial and ventricular NP gene expression to ETA receptor blockade is similar to that observed by us after applying angiotensin-converting enzyme inhibitors in other hypertensive models. In general therefore, atrial NP gene expression may not be as sensitive to the endocrine environment as is ventricular NP gene expression.
Fil: Bianciotti, Liliana Graciela. University of Ottawa; Canadá. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
Fil: de Bold, Adolfo. University of Ottawa; Canadá. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina - Materia
-
Doca-Salt Hypertension
Natriuretic Peptide
Eta Endothelin Receptor - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/40464
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Effect of selective ET A receptor blockade on natriuretic peptide gene expression in DOCA-salt hypertensionBianciotti, Liliana Gracielade Bold, AdolfoDoca-Salt HypertensionNatriuretic PeptideEta Endothelin Receptorhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3To determine the role of endothelin-1 (ET-1) in the upregulation of atrial natriuretic factor (ANF) and brain natriuretic peptide (BNP) observed in deoxycorticosterone acetate (DOCA)-salt hypertension, the selective ET-1 type-A receptor (ETA) antagonist ABT-627 was chronically administered to normal controls and hypertensive rats. Chronic ETA blockade in DOCA-salt-treated rats prevented the increase in blood pressure and circulating natriuretic protein (NP) levels and partially prevented left ventricular hypertrophy. The changes observed in NP gene expression in the atria were not affected by ABT-627. In the ventricles, ABT-627 reduced NP gene expression. Rats receiving the ETA antagonist alone showed reduced left ventricular NP gene expression. ABT-627 did not affect ventricular collagen III gene expression but enhanced left ventricular α-myosin heavy chain expression. These findings suggest that in vivo, ventricular but not atrial NP production is regulated by ET-1. This difference in response between atrial and ventricular NP gene expression to ETA receptor blockade is similar to that observed by us after applying angiotensin-converting enzyme inhibitors in other hypertensive models. In general therefore, atrial NP gene expression may not be as sensitive to the endocrine environment as is ventricular NP gene expression.Fil: Bianciotti, Liliana Graciela. University of Ottawa; Canadá. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; ArgentinaFil: de Bold, Adolfo. University of Ottawa; Canadá. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; ArgentinaAmerican Physiological Society2000-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/40464Bianciotti, Liliana Graciela; de Bold, Adolfo; Effect of selective ET A receptor blockade on natriuretic peptide gene expression in DOCA-salt hypertension; American Physiological Society; American Journal of Physiology - Heart and Circulatory Physiology; 279; 1; 7-2000; H93-H1010363-6135CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.physiology.org/doi/abs/10.1152/ajpheart.2000.279.1.H93info:eu-repo/semantics/altIdentifier/doi/10.1152/ajpheart.2000.279.1.H93info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:08:15Zoai:ri.conicet.gov.ar:11336/40464instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:08:15.432CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Effect of selective ET A receptor blockade on natriuretic peptide gene expression in DOCA-salt hypertension |
title |
Effect of selective ET A receptor blockade on natriuretic peptide gene expression in DOCA-salt hypertension |
spellingShingle |
Effect of selective ET A receptor blockade on natriuretic peptide gene expression in DOCA-salt hypertension Bianciotti, Liliana Graciela Doca-Salt Hypertension Natriuretic Peptide Eta Endothelin Receptor |
title_short |
Effect of selective ET A receptor blockade on natriuretic peptide gene expression in DOCA-salt hypertension |
title_full |
Effect of selective ET A receptor blockade on natriuretic peptide gene expression in DOCA-salt hypertension |
title_fullStr |
Effect of selective ET A receptor blockade on natriuretic peptide gene expression in DOCA-salt hypertension |
title_full_unstemmed |
Effect of selective ET A receptor blockade on natriuretic peptide gene expression in DOCA-salt hypertension |
title_sort |
Effect of selective ET A receptor blockade on natriuretic peptide gene expression in DOCA-salt hypertension |
dc.creator.none.fl_str_mv |
Bianciotti, Liliana Graciela de Bold, Adolfo |
author |
Bianciotti, Liliana Graciela |
author_facet |
Bianciotti, Liliana Graciela de Bold, Adolfo |
author_role |
author |
author2 |
de Bold, Adolfo |
author2_role |
author |
dc.subject.none.fl_str_mv |
Doca-Salt Hypertension Natriuretic Peptide Eta Endothelin Receptor |
topic |
Doca-Salt Hypertension Natriuretic Peptide Eta Endothelin Receptor |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.2 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
To determine the role of endothelin-1 (ET-1) in the upregulation of atrial natriuretic factor (ANF) and brain natriuretic peptide (BNP) observed in deoxycorticosterone acetate (DOCA)-salt hypertension, the selective ET-1 type-A receptor (ETA) antagonist ABT-627 was chronically administered to normal controls and hypertensive rats. Chronic ETA blockade in DOCA-salt-treated rats prevented the increase in blood pressure and circulating natriuretic protein (NP) levels and partially prevented left ventricular hypertrophy. The changes observed in NP gene expression in the atria were not affected by ABT-627. In the ventricles, ABT-627 reduced NP gene expression. Rats receiving the ETA antagonist alone showed reduced left ventricular NP gene expression. ABT-627 did not affect ventricular collagen III gene expression but enhanced left ventricular α-myosin heavy chain expression. These findings suggest that in vivo, ventricular but not atrial NP production is regulated by ET-1. This difference in response between atrial and ventricular NP gene expression to ETA receptor blockade is similar to that observed by us after applying angiotensin-converting enzyme inhibitors in other hypertensive models. In general therefore, atrial NP gene expression may not be as sensitive to the endocrine environment as is ventricular NP gene expression. Fil: Bianciotti, Liliana Graciela. University of Ottawa; Canadá. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina Fil: de Bold, Adolfo. University of Ottawa; Canadá. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina |
description |
To determine the role of endothelin-1 (ET-1) in the upregulation of atrial natriuretic factor (ANF) and brain natriuretic peptide (BNP) observed in deoxycorticosterone acetate (DOCA)-salt hypertension, the selective ET-1 type-A receptor (ETA) antagonist ABT-627 was chronically administered to normal controls and hypertensive rats. Chronic ETA blockade in DOCA-salt-treated rats prevented the increase in blood pressure and circulating natriuretic protein (NP) levels and partially prevented left ventricular hypertrophy. The changes observed in NP gene expression in the atria were not affected by ABT-627. In the ventricles, ABT-627 reduced NP gene expression. Rats receiving the ETA antagonist alone showed reduced left ventricular NP gene expression. ABT-627 did not affect ventricular collagen III gene expression but enhanced left ventricular α-myosin heavy chain expression. These findings suggest that in vivo, ventricular but not atrial NP production is regulated by ET-1. This difference in response between atrial and ventricular NP gene expression to ETA receptor blockade is similar to that observed by us after applying angiotensin-converting enzyme inhibitors in other hypertensive models. In general therefore, atrial NP gene expression may not be as sensitive to the endocrine environment as is ventricular NP gene expression. |
publishDate |
2000 |
dc.date.none.fl_str_mv |
2000-07 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/40464 Bianciotti, Liliana Graciela; de Bold, Adolfo; Effect of selective ET A receptor blockade on natriuretic peptide gene expression in DOCA-salt hypertension; American Physiological Society; American Journal of Physiology - Heart and Circulatory Physiology; 279; 1; 7-2000; H93-H101 0363-6135 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/40464 |
identifier_str_mv |
Bianciotti, Liliana Graciela; de Bold, Adolfo; Effect of selective ET A receptor blockade on natriuretic peptide gene expression in DOCA-salt hypertension; American Physiological Society; American Journal of Physiology - Heart and Circulatory Physiology; 279; 1; 7-2000; H93-H101 0363-6135 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://www.physiology.org/doi/abs/10.1152/ajpheart.2000.279.1.H93 info:eu-repo/semantics/altIdentifier/doi/10.1152/ajpheart.2000.279.1.H93 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
American Physiological Society |
publisher.none.fl_str_mv |
American Physiological Society |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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13.13397 |