Clinical aspects of c-type natriuretic peptide on the cardiovascular system
- Autores
- Cantú, Silvana María; Donoso, Adriana Susana; Kouyoumdzian, Nicolás Martín; Rukavina Mikusic, Natalia Lucía; Puyó, Ana María; Choi, Marcelo Roberto
- Año de publicación
- 2015
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- C-type natriuretic peptide (CNP) is one of the three most important members of the human natriuretic peptide family, sharing with them a highly conserved 17-aminoacid ring structure, essential to elicit its biological actions by binding to its specific receptor NPR-B. CNP acts in a paracrine or autocrine way and it is cleared from plasma circulation by the NPR-C receptor. This is one of the reasons why its plasma levels are usually low. CNP is widely spread in human tissues, being localized in a variety of cells such as cardiac and vascular smooth muscle cells, chondrocytes, macrophages, glial cells, and renal, brain and reproductive tissues. In the cardiovascular system, CNP is stored in endothelial cells and exert different actions like vasodilation in large conduction vessels, and anti-proliferative, pro-apoptotic, anti-fibrotic and anti-hypertrophic properties in cardiomyocytes; it also inhibits neointimal restenosis and reduces cardiac ischemia-reperfusion injury and vascular constrictive remodeling. In addition, it has been suggested that CNP acts as an endothelium derived hyperpolarizing factor as a consequence of its hyperpolarizing action in resistance arterial smooth vessels muscle. Regarding its clinical aspects, it has been demonstrated the relation between CNP and different cardiovascular pathologies such as heart failure, myocardial infarction, cardiac remodeling, arterial hypertension, angiogenesis and revascularization, restenosis, atherosclerosis, pulmonary hypertension, and myocardial aging.
Fil: Cantú, Silvana María. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Instituto de Fisiopatología y Bioquímica Clínica; Argentina
Fil: Donoso, Adriana Susana. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Instituto de Fisiopatología y Bioquímica Clínica; Argentina
Fil: Kouyoumdzian, Nicolás Martín. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas (i); Argentina. Instituto de Fisiopatología y Bioquímica Clínica; Argentina
Fil: Rukavina Mikusic, Natalia Lucía. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas (i); Argentina. Instituto de Fisiopatología y Bioquímica Clínica; Argentina
Fil: Puyó, Ana María. Universidad de Buenos Aires. Facultad de Farmacia y Bioquimica. Departamento de Cs.biologicas. Catedra de Histologia y Biologia Celular; Argentina. Instituto de Fisiopatología y Bioquímica Clínica; Argentina
Fil: Choi, Marcelo Roberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas (i); Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Instituto de Fisiopatología y Bioquímica Clínica; Argentina - Materia
-
C TYPE NATRIURETIC PEPTIDE
CARDIOVASCULAR
CLINICAL
HYPERTENSION - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/7910
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Clinical aspects of c-type natriuretic peptide on the cardiovascular systemCantú, Silvana MaríaDonoso, Adriana SusanaKouyoumdzian, Nicolás MartínRukavina Mikusic, Natalia LucíaPuyó, Ana MaríaChoi, Marcelo RobertoC TYPE NATRIURETIC PEPTIDECARDIOVASCULARCLINICALHYPERTENSIONhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3C-type natriuretic peptide (CNP) is one of the three most important members of the human natriuretic peptide family, sharing with them a highly conserved 17-aminoacid ring structure, essential to elicit its biological actions by binding to its specific receptor NPR-B. CNP acts in a paracrine or autocrine way and it is cleared from plasma circulation by the NPR-C receptor. This is one of the reasons why its plasma levels are usually low. CNP is widely spread in human tissues, being localized in a variety of cells such as cardiac and vascular smooth muscle cells, chondrocytes, macrophages, glial cells, and renal, brain and reproductive tissues. In the cardiovascular system, CNP is stored in endothelial cells and exert different actions like vasodilation in large conduction vessels, and anti-proliferative, pro-apoptotic, anti-fibrotic and anti-hypertrophic properties in cardiomyocytes; it also inhibits neointimal restenosis and reduces cardiac ischemia-reperfusion injury and vascular constrictive remodeling. In addition, it has been suggested that CNP acts as an endothelium derived hyperpolarizing factor as a consequence of its hyperpolarizing action in resistance arterial smooth vessels muscle. Regarding its clinical aspects, it has been demonstrated the relation between CNP and different cardiovascular pathologies such as heart failure, myocardial infarction, cardiac remodeling, arterial hypertension, angiogenesis and revascularization, restenosis, atherosclerosis, pulmonary hypertension, and myocardial aging.Fil: Cantú, Silvana María. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Instituto de Fisiopatología y Bioquímica Clínica; ArgentinaFil: Donoso, Adriana Susana. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Instituto de Fisiopatología y Bioquímica Clínica; ArgentinaFil: Kouyoumdzian, Nicolás Martín. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas (i); Argentina. Instituto de Fisiopatología y Bioquímica Clínica; ArgentinaFil: Rukavina Mikusic, Natalia Lucía. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas (i); Argentina. Instituto de Fisiopatología y Bioquímica Clínica; ArgentinaFil: Puyó, Ana María. Universidad de Buenos Aires. Facultad de Farmacia y Bioquimica. Departamento de Cs.biologicas. Catedra de Histologia y Biologia Celular; Argentina. Instituto de Fisiopatología y Bioquímica Clínica; ArgentinaFil: Choi, Marcelo Roberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas (i); Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Instituto de Fisiopatología y Bioquímica Clínica; ArgentinaPeertechz2015-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/7910Cantú, Silvana María; Donoso, Adriana Susana; Kouyoumdzian, Nicolás Martín; Rukavina Mikusic, Natalia Lucía; Puyó, Ana María; et al.; Clinical aspects of c-type natriuretic peptide on the cardiovascular system; Peertechz; International Journal of Clinical Endocrinology and Metabolism; 1; 1; 11-2015; 31-361685-1250enginfo:eu-repo/semantics/altIdentifier/url/http://www.peertechz.com/Clinical-Endocrinology-Metabolism/pdf/IJCEM-1-107.pdfinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:09:11Zoai:ri.conicet.gov.ar:11336/7910instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:09:11.951CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Clinical aspects of c-type natriuretic peptide on the cardiovascular system |
title |
Clinical aspects of c-type natriuretic peptide on the cardiovascular system |
spellingShingle |
Clinical aspects of c-type natriuretic peptide on the cardiovascular system Cantú, Silvana María C TYPE NATRIURETIC PEPTIDE CARDIOVASCULAR CLINICAL HYPERTENSION |
title_short |
Clinical aspects of c-type natriuretic peptide on the cardiovascular system |
title_full |
Clinical aspects of c-type natriuretic peptide on the cardiovascular system |
title_fullStr |
Clinical aspects of c-type natriuretic peptide on the cardiovascular system |
title_full_unstemmed |
Clinical aspects of c-type natriuretic peptide on the cardiovascular system |
title_sort |
Clinical aspects of c-type natriuretic peptide on the cardiovascular system |
dc.creator.none.fl_str_mv |
Cantú, Silvana María Donoso, Adriana Susana Kouyoumdzian, Nicolás Martín Rukavina Mikusic, Natalia Lucía Puyó, Ana María Choi, Marcelo Roberto |
author |
Cantú, Silvana María |
author_facet |
Cantú, Silvana María Donoso, Adriana Susana Kouyoumdzian, Nicolás Martín Rukavina Mikusic, Natalia Lucía Puyó, Ana María Choi, Marcelo Roberto |
author_role |
author |
author2 |
Donoso, Adriana Susana Kouyoumdzian, Nicolás Martín Rukavina Mikusic, Natalia Lucía Puyó, Ana María Choi, Marcelo Roberto |
author2_role |
author author author author author |
dc.subject.none.fl_str_mv |
C TYPE NATRIURETIC PEPTIDE CARDIOVASCULAR CLINICAL HYPERTENSION |
topic |
C TYPE NATRIURETIC PEPTIDE CARDIOVASCULAR CLINICAL HYPERTENSION |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
C-type natriuretic peptide (CNP) is one of the three most important members of the human natriuretic peptide family, sharing with them a highly conserved 17-aminoacid ring structure, essential to elicit its biological actions by binding to its specific receptor NPR-B. CNP acts in a paracrine or autocrine way and it is cleared from plasma circulation by the NPR-C receptor. This is one of the reasons why its plasma levels are usually low. CNP is widely spread in human tissues, being localized in a variety of cells such as cardiac and vascular smooth muscle cells, chondrocytes, macrophages, glial cells, and renal, brain and reproductive tissues. In the cardiovascular system, CNP is stored in endothelial cells and exert different actions like vasodilation in large conduction vessels, and anti-proliferative, pro-apoptotic, anti-fibrotic and anti-hypertrophic properties in cardiomyocytes; it also inhibits neointimal restenosis and reduces cardiac ischemia-reperfusion injury and vascular constrictive remodeling. In addition, it has been suggested that CNP acts as an endothelium derived hyperpolarizing factor as a consequence of its hyperpolarizing action in resistance arterial smooth vessels muscle. Regarding its clinical aspects, it has been demonstrated the relation between CNP and different cardiovascular pathologies such as heart failure, myocardial infarction, cardiac remodeling, arterial hypertension, angiogenesis and revascularization, restenosis, atherosclerosis, pulmonary hypertension, and myocardial aging. Fil: Cantú, Silvana María. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Instituto de Fisiopatología y Bioquímica Clínica; Argentina Fil: Donoso, Adriana Susana. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Instituto de Fisiopatología y Bioquímica Clínica; Argentina Fil: Kouyoumdzian, Nicolás Martín. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas (i); Argentina. Instituto de Fisiopatología y Bioquímica Clínica; Argentina Fil: Rukavina Mikusic, Natalia Lucía. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas (i); Argentina. Instituto de Fisiopatología y Bioquímica Clínica; Argentina Fil: Puyó, Ana María. Universidad de Buenos Aires. Facultad de Farmacia y Bioquimica. Departamento de Cs.biologicas. Catedra de Histologia y Biologia Celular; Argentina. Instituto de Fisiopatología y Bioquímica Clínica; Argentina Fil: Choi, Marcelo Roberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas (i); Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Instituto de Fisiopatología y Bioquímica Clínica; Argentina |
description |
C-type natriuretic peptide (CNP) is one of the three most important members of the human natriuretic peptide family, sharing with them a highly conserved 17-aminoacid ring structure, essential to elicit its biological actions by binding to its specific receptor NPR-B. CNP acts in a paracrine or autocrine way and it is cleared from plasma circulation by the NPR-C receptor. This is one of the reasons why its plasma levels are usually low. CNP is widely spread in human tissues, being localized in a variety of cells such as cardiac and vascular smooth muscle cells, chondrocytes, macrophages, glial cells, and renal, brain and reproductive tissues. In the cardiovascular system, CNP is stored in endothelial cells and exert different actions like vasodilation in large conduction vessels, and anti-proliferative, pro-apoptotic, anti-fibrotic and anti-hypertrophic properties in cardiomyocytes; it also inhibits neointimal restenosis and reduces cardiac ischemia-reperfusion injury and vascular constrictive remodeling. In addition, it has been suggested that CNP acts as an endothelium derived hyperpolarizing factor as a consequence of its hyperpolarizing action in resistance arterial smooth vessels muscle. Regarding its clinical aspects, it has been demonstrated the relation between CNP and different cardiovascular pathologies such as heart failure, myocardial infarction, cardiac remodeling, arterial hypertension, angiogenesis and revascularization, restenosis, atherosclerosis, pulmonary hypertension, and myocardial aging. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-11 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/7910 Cantú, Silvana María; Donoso, Adriana Susana; Kouyoumdzian, Nicolás Martín; Rukavina Mikusic, Natalia Lucía; Puyó, Ana María; et al.; Clinical aspects of c-type natriuretic peptide on the cardiovascular system; Peertechz; International Journal of Clinical Endocrinology and Metabolism; 1; 1; 11-2015; 31-36 1685-1250 |
url |
http://hdl.handle.net/11336/7910 |
identifier_str_mv |
Cantú, Silvana María; Donoso, Adriana Susana; Kouyoumdzian, Nicolás Martín; Rukavina Mikusic, Natalia Lucía; Puyó, Ana María; et al.; Clinical aspects of c-type natriuretic peptide on the cardiovascular system; Peertechz; International Journal of Clinical Endocrinology and Metabolism; 1; 1; 11-2015; 31-36 1685-1250 |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/http://www.peertechz.com/Clinical-Endocrinology-Metabolism/pdf/IJCEM-1-107.pdf |
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info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
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openAccess |
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application/pdf application/pdf |
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Peertechz |
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Peertechz |
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CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
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