Clinical aspects of c-type natriuretic peptide on the cardiovascular system

Autores
Cantú, Silvana María; Donoso, Adriana Susana; Kouyoumdzian, Nicolás Martín; Rukavina Mikusic, Natalia Lucía; Puyó, Ana María; Choi, Marcelo Roberto
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
C-type natriuretic peptide (CNP) is one of the three most important members of the human natriuretic peptide family, sharing with them a highly conserved 17-aminoacid ring structure, essential to elicit its biological actions by binding to its specific receptor NPR-B. CNP acts in a paracrine or autocrine way and it is cleared from plasma circulation by the NPR-C receptor. This is one of the reasons why its plasma levels are usually low. CNP is widely spread in human tissues, being localized in a variety of cells such as cardiac and vascular smooth muscle cells, chondrocytes, macrophages, glial cells, and renal, brain and reproductive tissues. In the cardiovascular system, CNP is stored in endothelial cells and exert different actions like vasodilation in large conduction vessels, and anti-proliferative, pro-apoptotic, anti-fibrotic and anti-hypertrophic properties in cardiomyocytes; it also inhibits neointimal restenosis and reduces cardiac ischemia-reperfusion injury and vascular constrictive remodeling. In addition, it has been suggested that CNP acts as an endothelium derived hyperpolarizing factor as a consequence of its hyperpolarizing action in resistance arterial smooth vessels muscle. Regarding its clinical aspects, it has been demonstrated the relation between CNP and different cardiovascular pathologies such as heart failure, myocardial infarction, cardiac remodeling, arterial hypertension, angiogenesis and revascularization, restenosis, atherosclerosis, pulmonary hypertension, and myocardial aging.
Fil: Cantú, Silvana María. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Instituto de Fisiopatología y Bioquímica Clínica; Argentina
Fil: Donoso, Adriana Susana. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Instituto de Fisiopatología y Bioquímica Clínica; Argentina
Fil: Kouyoumdzian, Nicolás Martín. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas (i); Argentina. Instituto de Fisiopatología y Bioquímica Clínica; Argentina
Fil: Rukavina Mikusic, Natalia Lucía. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas (i); Argentina. Instituto de Fisiopatología y Bioquímica Clínica; Argentina
Fil: Puyó, Ana María. Universidad de Buenos Aires. Facultad de Farmacia y Bioquimica. Departamento de Cs.biologicas. Catedra de Histologia y Biologia Celular; Argentina. Instituto de Fisiopatología y Bioquímica Clínica; Argentina
Fil: Choi, Marcelo Roberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas (i); Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Instituto de Fisiopatología y Bioquímica Clínica; Argentina
Materia
C TYPE NATRIURETIC PEPTIDE
CARDIOVASCULAR
CLINICAL
HYPERTENSION
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/7910
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Clinical aspects of c-type natriuretic peptide on the cardiovascular systemCantú, Silvana MaríaDonoso, Adriana SusanaKouyoumdzian, Nicolás MartínRukavina Mikusic, Natalia LucíaPuyó, Ana MaríaChoi, Marcelo RobertoC TYPE NATRIURETIC PEPTIDECARDIOVASCULARCLINICALHYPERTENSIONhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3C-type natriuretic peptide (CNP) is one of the three most important members of the human natriuretic peptide family, sharing with them a highly conserved 17-aminoacid ring structure, essential to elicit its biological actions by binding to its specific receptor NPR-B. CNP acts in a paracrine or autocrine way and it is cleared from plasma circulation by the NPR-C receptor. This is one of the reasons why its plasma levels are usually low. CNP is widely spread in human tissues, being localized in a variety of cells such as cardiac and vascular smooth muscle cells, chondrocytes, macrophages, glial cells, and renal, brain and reproductive tissues. In the cardiovascular system, CNP is stored in endothelial cells and exert different actions like vasodilation in large conduction vessels, and anti-proliferative, pro-apoptotic, anti-fibrotic and anti-hypertrophic properties in cardiomyocytes; it also inhibits neointimal restenosis and reduces cardiac ischemia-reperfusion injury and vascular constrictive remodeling. In addition, it has been suggested that CNP acts as an endothelium derived hyperpolarizing factor as a consequence of its hyperpolarizing action in resistance arterial smooth vessels muscle. Regarding its clinical aspects, it has been demonstrated the relation between CNP and different cardiovascular pathologies such as heart failure, myocardial infarction, cardiac remodeling, arterial hypertension, angiogenesis and revascularization, restenosis, atherosclerosis, pulmonary hypertension, and myocardial aging.Fil: Cantú, Silvana María. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Instituto de Fisiopatología y Bioquímica Clínica; ArgentinaFil: Donoso, Adriana Susana. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Instituto de Fisiopatología y Bioquímica Clínica; ArgentinaFil: Kouyoumdzian, Nicolás Martín. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas (i); Argentina. Instituto de Fisiopatología y Bioquímica Clínica; ArgentinaFil: Rukavina Mikusic, Natalia Lucía. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas (i); Argentina. Instituto de Fisiopatología y Bioquímica Clínica; ArgentinaFil: Puyó, Ana María. Universidad de Buenos Aires. Facultad de Farmacia y Bioquimica. Departamento de Cs.biologicas. Catedra de Histologia y Biologia Celular; Argentina. Instituto de Fisiopatología y Bioquímica Clínica; ArgentinaFil: Choi, Marcelo Roberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas (i); Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Instituto de Fisiopatología y Bioquímica Clínica; ArgentinaPeertechz2015-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/7910Cantú, Silvana María; Donoso, Adriana Susana; Kouyoumdzian, Nicolás Martín; Rukavina Mikusic, Natalia Lucía; Puyó, Ana María; et al.; Clinical aspects of c-type natriuretic peptide on the cardiovascular system; Peertechz; International Journal of Clinical Endocrinology and Metabolism; 1; 1; 11-2015; 31-361685-1250enginfo:eu-repo/semantics/altIdentifier/url/http://www.peertechz.com/Clinical-Endocrinology-Metabolism/pdf/IJCEM-1-107.pdfinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:39:15Zoai:ri.conicet.gov.ar:11336/7910instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:39:15.752CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Clinical aspects of c-type natriuretic peptide on the cardiovascular system
title Clinical aspects of c-type natriuretic peptide on the cardiovascular system
spellingShingle Clinical aspects of c-type natriuretic peptide on the cardiovascular system
Cantú, Silvana María
C TYPE NATRIURETIC PEPTIDE
CARDIOVASCULAR
CLINICAL
HYPERTENSION
title_short Clinical aspects of c-type natriuretic peptide on the cardiovascular system
title_full Clinical aspects of c-type natriuretic peptide on the cardiovascular system
title_fullStr Clinical aspects of c-type natriuretic peptide on the cardiovascular system
title_full_unstemmed Clinical aspects of c-type natriuretic peptide on the cardiovascular system
title_sort Clinical aspects of c-type natriuretic peptide on the cardiovascular system
dc.creator.none.fl_str_mv Cantú, Silvana María
Donoso, Adriana Susana
Kouyoumdzian, Nicolás Martín
Rukavina Mikusic, Natalia Lucía
Puyó, Ana María
Choi, Marcelo Roberto
author Cantú, Silvana María
author_facet Cantú, Silvana María
Donoso, Adriana Susana
Kouyoumdzian, Nicolás Martín
Rukavina Mikusic, Natalia Lucía
Puyó, Ana María
Choi, Marcelo Roberto
author_role author
author2 Donoso, Adriana Susana
Kouyoumdzian, Nicolás Martín
Rukavina Mikusic, Natalia Lucía
Puyó, Ana María
Choi, Marcelo Roberto
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv C TYPE NATRIURETIC PEPTIDE
CARDIOVASCULAR
CLINICAL
HYPERTENSION
topic C TYPE NATRIURETIC PEPTIDE
CARDIOVASCULAR
CLINICAL
HYPERTENSION
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv C-type natriuretic peptide (CNP) is one of the three most important members of the human natriuretic peptide family, sharing with them a highly conserved 17-aminoacid ring structure, essential to elicit its biological actions by binding to its specific receptor NPR-B. CNP acts in a paracrine or autocrine way and it is cleared from plasma circulation by the NPR-C receptor. This is one of the reasons why its plasma levels are usually low. CNP is widely spread in human tissues, being localized in a variety of cells such as cardiac and vascular smooth muscle cells, chondrocytes, macrophages, glial cells, and renal, brain and reproductive tissues. In the cardiovascular system, CNP is stored in endothelial cells and exert different actions like vasodilation in large conduction vessels, and anti-proliferative, pro-apoptotic, anti-fibrotic and anti-hypertrophic properties in cardiomyocytes; it also inhibits neointimal restenosis and reduces cardiac ischemia-reperfusion injury and vascular constrictive remodeling. In addition, it has been suggested that CNP acts as an endothelium derived hyperpolarizing factor as a consequence of its hyperpolarizing action in resistance arterial smooth vessels muscle. Regarding its clinical aspects, it has been demonstrated the relation between CNP and different cardiovascular pathologies such as heart failure, myocardial infarction, cardiac remodeling, arterial hypertension, angiogenesis and revascularization, restenosis, atherosclerosis, pulmonary hypertension, and myocardial aging.
Fil: Cantú, Silvana María. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Instituto de Fisiopatología y Bioquímica Clínica; Argentina
Fil: Donoso, Adriana Susana. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Instituto de Fisiopatología y Bioquímica Clínica; Argentina
Fil: Kouyoumdzian, Nicolás Martín. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas (i); Argentina. Instituto de Fisiopatología y Bioquímica Clínica; Argentina
Fil: Rukavina Mikusic, Natalia Lucía. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas (i); Argentina. Instituto de Fisiopatología y Bioquímica Clínica; Argentina
Fil: Puyó, Ana María. Universidad de Buenos Aires. Facultad de Farmacia y Bioquimica. Departamento de Cs.biologicas. Catedra de Histologia y Biologia Celular; Argentina. Instituto de Fisiopatología y Bioquímica Clínica; Argentina
Fil: Choi, Marcelo Roberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas (i); Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Instituto de Fisiopatología y Bioquímica Clínica; Argentina
description C-type natriuretic peptide (CNP) is one of the three most important members of the human natriuretic peptide family, sharing with them a highly conserved 17-aminoacid ring structure, essential to elicit its biological actions by binding to its specific receptor NPR-B. CNP acts in a paracrine or autocrine way and it is cleared from plasma circulation by the NPR-C receptor. This is one of the reasons why its plasma levels are usually low. CNP is widely spread in human tissues, being localized in a variety of cells such as cardiac and vascular smooth muscle cells, chondrocytes, macrophages, glial cells, and renal, brain and reproductive tissues. In the cardiovascular system, CNP is stored in endothelial cells and exert different actions like vasodilation in large conduction vessels, and anti-proliferative, pro-apoptotic, anti-fibrotic and anti-hypertrophic properties in cardiomyocytes; it also inhibits neointimal restenosis and reduces cardiac ischemia-reperfusion injury and vascular constrictive remodeling. In addition, it has been suggested that CNP acts as an endothelium derived hyperpolarizing factor as a consequence of its hyperpolarizing action in resistance arterial smooth vessels muscle. Regarding its clinical aspects, it has been demonstrated the relation between CNP and different cardiovascular pathologies such as heart failure, myocardial infarction, cardiac remodeling, arterial hypertension, angiogenesis and revascularization, restenosis, atherosclerosis, pulmonary hypertension, and myocardial aging.
publishDate 2015
dc.date.none.fl_str_mv 2015-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/7910
Cantú, Silvana María; Donoso, Adriana Susana; Kouyoumdzian, Nicolás Martín; Rukavina Mikusic, Natalia Lucía; Puyó, Ana María; et al.; Clinical aspects of c-type natriuretic peptide on the cardiovascular system; Peertechz; International Journal of Clinical Endocrinology and Metabolism; 1; 1; 11-2015; 31-36
1685-1250
url http://hdl.handle.net/11336/7910
identifier_str_mv Cantú, Silvana María; Donoso, Adriana Susana; Kouyoumdzian, Nicolás Martín; Rukavina Mikusic, Natalia Lucía; Puyó, Ana María; et al.; Clinical aspects of c-type natriuretic peptide on the cardiovascular system; Peertechz; International Journal of Clinical Endocrinology and Metabolism; 1; 1; 11-2015; 31-36
1685-1250
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.peertechz.com/Clinical-Endocrinology-Metabolism/pdf/IJCEM-1-107.pdf
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Peertechz
publisher.none.fl_str_mv Peertechz
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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