Prevalence of Intestinal Parasites, Protozoans and Soil-Transmitted Helminths, in Children from Communities of Northern Argentina after the Interruption of Deworming

Autores
Candela, Ernesto; Cimino, Rubén Oscar; Sandon, Leonardo; Muñoz Antoli, Carla; Periago, Maria Victoria
Año de publicación
2024
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Soil-transmitted helminths (STHs) are a group of parasites that are globally distributed and are the most prevalent neglected disease (NTD) in Latin America and the Caribbean (LAC); their presence is associated with health and development problems. In Argentina, their distribution is heterogenous, and there are highly endemic areas in the north of the country. The World Health Organization (WHO) recommends the mass deworming of children as a first-line strategy for the prevention and control of STHs and recently also encourage the development of more sensitive diagnostic tests. The aim of this study was to determine the prevalence of STHs in Tartagal (Salta, Argentina) after four years of deworming interruption with albendazole and ivermectin. A total of 437 fecal samples were analyzed using standard coprological techniques, a subset of which were selected to molecularly typify protozoan parasites; 257 blood samples were analyzed for the presence of specific antibodies to the STH Strongyloides stercoralis. The most prevalent protozoan species were G. intestinalis (19.6–49.2%) and B. hominis (19.1–38.5%). Molecular characterization allowed us to evidence possible zoonotic or human-to-human transmission pathways for Giardia intestinalis or Blastocystis spp., while serology for S. stercoralis proved to be a useful screening tool for monitoring this parasite after treatment. In general, a decrease in the prevalence of STHs was observed in the area, from 60% to 2.9–20% for hookworms and from 51% to 1–9.3% for S. stercoralis four years after treatment, demonstrating the effectiveness and duration of anthelmintic treatment with these two drugs.
Fil: Candela, Ernesto. Universidad de Valencia; España
Fil: Cimino, Rubén Oscar. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Salta. Sede Regional Orán. Instituto de Investigación de Enfermedades Tropicales; Argentina
Fil: Sandon, Leonardo. Fundación Mundo Sano; Argentina
Fil: Muñoz Antoli, Carla. Universidad de Valencia; España
Fil: Periago, Maria Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación Mundo Sano; Argentina
Materia
soil-transmitted helminths
intestinal parasites
NIE-ELISA
Giardia intestinalis
Blastocystis spp.
Tartagal
Salta
Argentina
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/247733
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/247733
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Prevalence of Intestinal Parasites, Protozoans and Soil-Transmitted Helminths, in Children from Communities of Northern Argentina after the Interruption of DewormingCandela, ErnestoCimino, Rubén OscarSandon, LeonardoMuñoz Antoli, CarlaPeriago, Maria Victoriasoil-transmitted helminthsintestinal parasitesNIE-ELISAGiardia intestinalisBlastocystis spp.TartagalSaltaArgentinahttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Soil-transmitted helminths (STHs) are a group of parasites that are globally distributed and are the most prevalent neglected disease (NTD) in Latin America and the Caribbean (LAC); their presence is associated with health and development problems. In Argentina, their distribution is heterogenous, and there are highly endemic areas in the north of the country. The World Health Organization (WHO) recommends the mass deworming of children as a first-line strategy for the prevention and control of STHs and recently also encourage the development of more sensitive diagnostic tests. The aim of this study was to determine the prevalence of STHs in Tartagal (Salta, Argentina) after four years of deworming interruption with albendazole and ivermectin. A total of 437 fecal samples were analyzed using standard coprological techniques, a subset of which were selected to molecularly typify protozoan parasites; 257 blood samples were analyzed for the presence of specific antibodies to the STH Strongyloides stercoralis. The most prevalent protozoan species were G. intestinalis (19.6–49.2%) and B. hominis (19.1–38.5%). Molecular characterization allowed us to evidence possible zoonotic or human-to-human transmission pathways for Giardia intestinalis or Blastocystis spp., while serology for S. stercoralis proved to be a useful screening tool for monitoring this parasite after treatment. In general, a decrease in the prevalence of STHs was observed in the area, from 60% to 2.9–20% for hookworms and from 51% to 1–9.3% for S. stercoralis four years after treatment, demonstrating the effectiveness and duration of anthelmintic treatment with these two drugs.Fil: Candela, Ernesto. Universidad de Valencia; EspañaFil: Cimino, Rubén Oscar. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Salta. Sede Regional Orán. Instituto de Investigación de Enfermedades Tropicales; ArgentinaFil: Sandon, Leonardo. Fundación Mundo Sano; ArgentinaFil: Muñoz Antoli, Carla. Universidad de Valencia; EspañaFil: Periago, Maria Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación Mundo Sano; ArgentinaMDPI2024-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/247733Candela, Ernesto; Cimino, Rubén Oscar; Sandon, Leonardo; Muñoz Antoli, Carla; Periago, Maria Victoria; Prevalence of Intestinal Parasites, Protozoans and Soil-Transmitted Helminths, in Children from Communities of Northern Argentina after the Interruption of Deworming; MDPI; Parasitologia; 4; 2; 6-2024; 172-1832673-6772CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2673-6772/4/2/15info:eu-repo/semantics/altIdentifier/doi/10.3390/parasitologia4020015info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-10T13:23:07Zoai:ri.conicet.gov.ar:11336/247733instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-10 13:23:07.6CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Prevalence of Intestinal Parasites, Protozoans and Soil-Transmitted Helminths, in Children from Communities of Northern Argentina after the Interruption of Deworming
title Prevalence of Intestinal Parasites, Protozoans and Soil-Transmitted Helminths, in Children from Communities of Northern Argentina after the Interruption of Deworming
spellingShingle Prevalence of Intestinal Parasites, Protozoans and Soil-Transmitted Helminths, in Children from Communities of Northern Argentina after the Interruption of Deworming
Candela, Ernesto
soil-transmitted helminths
intestinal parasites
NIE-ELISA
Giardia intestinalis
Blastocystis spp.
Tartagal
Salta
Argentina
title_short Prevalence of Intestinal Parasites, Protozoans and Soil-Transmitted Helminths, in Children from Communities of Northern Argentina after the Interruption of Deworming
title_full Prevalence of Intestinal Parasites, Protozoans and Soil-Transmitted Helminths, in Children from Communities of Northern Argentina after the Interruption of Deworming
title_fullStr Prevalence of Intestinal Parasites, Protozoans and Soil-Transmitted Helminths, in Children from Communities of Northern Argentina after the Interruption of Deworming
title_full_unstemmed Prevalence of Intestinal Parasites, Protozoans and Soil-Transmitted Helminths, in Children from Communities of Northern Argentina after the Interruption of Deworming
title_sort Prevalence of Intestinal Parasites, Protozoans and Soil-Transmitted Helminths, in Children from Communities of Northern Argentina after the Interruption of Deworming
dc.creator.none.fl_str_mv Candela, Ernesto
Cimino, Rubén Oscar
Sandon, Leonardo
Muñoz Antoli, Carla
Periago, Maria Victoria
author Candela, Ernesto
author_facet Candela, Ernesto
Cimino, Rubén Oscar
Sandon, Leonardo
Muñoz Antoli, Carla
Periago, Maria Victoria
author_role author
author2 Cimino, Rubén Oscar
Sandon, Leonardo
Muñoz Antoli, Carla
Periago, Maria Victoria
author2_role author
author
author
author
dc.subject.none.fl_str_mv soil-transmitted helminths
intestinal parasites
NIE-ELISA
Giardia intestinalis
Blastocystis spp.
Tartagal
Salta
Argentina
topic soil-transmitted helminths
intestinal parasites
NIE-ELISA
Giardia intestinalis
Blastocystis spp.
Tartagal
Salta
Argentina
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Soil-transmitted helminths (STHs) are a group of parasites that are globally distributed and are the most prevalent neglected disease (NTD) in Latin America and the Caribbean (LAC); their presence is associated with health and development problems. In Argentina, their distribution is heterogenous, and there are highly endemic areas in the north of the country. The World Health Organization (WHO) recommends the mass deworming of children as a first-line strategy for the prevention and control of STHs and recently also encourage the development of more sensitive diagnostic tests. The aim of this study was to determine the prevalence of STHs in Tartagal (Salta, Argentina) after four years of deworming interruption with albendazole and ivermectin. A total of 437 fecal samples were analyzed using standard coprological techniques, a subset of which were selected to molecularly typify protozoan parasites; 257 blood samples were analyzed for the presence of specific antibodies to the STH Strongyloides stercoralis. The most prevalent protozoan species were G. intestinalis (19.6–49.2%) and B. hominis (19.1–38.5%). Molecular characterization allowed us to evidence possible zoonotic or human-to-human transmission pathways for Giardia intestinalis or Blastocystis spp., while serology for S. stercoralis proved to be a useful screening tool for monitoring this parasite after treatment. In general, a decrease in the prevalence of STHs was observed in the area, from 60% to 2.9–20% for hookworms and from 51% to 1–9.3% for S. stercoralis four years after treatment, demonstrating the effectiveness and duration of anthelmintic treatment with these two drugs.
Fil: Candela, Ernesto. Universidad de Valencia; España
Fil: Cimino, Rubén Oscar. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Salta. Sede Regional Orán. Instituto de Investigación de Enfermedades Tropicales; Argentina
Fil: Sandon, Leonardo. Fundación Mundo Sano; Argentina
Fil: Muñoz Antoli, Carla. Universidad de Valencia; España
Fil: Periago, Maria Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación Mundo Sano; Argentina
description Soil-transmitted helminths (STHs) are a group of parasites that are globally distributed and are the most prevalent neglected disease (NTD) in Latin America and the Caribbean (LAC); their presence is associated with health and development problems. In Argentina, their distribution is heterogenous, and there are highly endemic areas in the north of the country. The World Health Organization (WHO) recommends the mass deworming of children as a first-line strategy for the prevention and control of STHs and recently also encourage the development of more sensitive diagnostic tests. The aim of this study was to determine the prevalence of STHs in Tartagal (Salta, Argentina) after four years of deworming interruption with albendazole and ivermectin. A total of 437 fecal samples were analyzed using standard coprological techniques, a subset of which were selected to molecularly typify protozoan parasites; 257 blood samples were analyzed for the presence of specific antibodies to the STH Strongyloides stercoralis. The most prevalent protozoan species were G. intestinalis (19.6–49.2%) and B. hominis (19.1–38.5%). Molecular characterization allowed us to evidence possible zoonotic or human-to-human transmission pathways for Giardia intestinalis or Blastocystis spp., while serology for S. stercoralis proved to be a useful screening tool for monitoring this parasite after treatment. In general, a decrease in the prevalence of STHs was observed in the area, from 60% to 2.9–20% for hookworms and from 51% to 1–9.3% for S. stercoralis four years after treatment, demonstrating the effectiveness and duration of anthelmintic treatment with these two drugs.
publishDate 2024
dc.date.none.fl_str_mv 2024-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/247733
Candela, Ernesto; Cimino, Rubén Oscar; Sandon, Leonardo; Muñoz Antoli, Carla; Periago, Maria Victoria; Prevalence of Intestinal Parasites, Protozoans and Soil-Transmitted Helminths, in Children from Communities of Northern Argentina after the Interruption of Deworming; MDPI; Parasitologia; 4; 2; 6-2024; 172-183
2673-6772
CONICET Digital
CONICET
url http://hdl.handle.net/11336/247733
identifier_str_mv Candela, Ernesto; Cimino, Rubén Oscar; Sandon, Leonardo; Muñoz Antoli, Carla; Periago, Maria Victoria; Prevalence of Intestinal Parasites, Protozoans and Soil-Transmitted Helminths, in Children from Communities of Northern Argentina after the Interruption of Deworming; MDPI; Parasitologia; 4; 2; 6-2024; 172-183
2673-6772
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2673-6772/4/2/15
info:eu-repo/semantics/altIdentifier/doi/10.3390/parasitologia4020015
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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